JP2007505875A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007505875A5 JP2007505875A5 JP2006526686A JP2006526686A JP2007505875A5 JP 2007505875 A5 JP2007505875 A5 JP 2007505875A5 JP 2006526686 A JP2006526686 A JP 2006526686A JP 2006526686 A JP2006526686 A JP 2006526686A JP 2007505875 A5 JP2007505875 A5 JP 2007505875A5
- Authority
- JP
- Japan
- Prior art keywords
- quinazoline
- chloro
- piperidin
- oxy
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003246 quinazolines Chemical class 0.000 claims 46
- -1 cyano, nitro, hydroxy, amino, carboxy, sulfamoyl Chemical group 0.000 claims 31
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 18
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000524 functional group Chemical group 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000003282 alkyl amino group Chemical group 0.000 claims 9
- 125000001153 fluoro group Chemical group F* 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- SHSMZPYXZURMEE-UHFFFAOYSA-N 2-[4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-1-(4-methylpiperazin-1-yl)ethanone Chemical compound C=12C=C(OC3CCN(CC(=O)N4CCN(C)CC4)CC3)C(OC)=CC2=NC=NC=1NC1=CC=CC(Cl)=C1F SHSMZPYXZURMEE-UHFFFAOYSA-N 0.000 claims 2
- QRVGWOQDGHNNOJ-UHFFFAOYSA-N 2-[4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-1-piperazin-1-ylethanone Chemical compound C=12C=C(OC3CCN(CC(=O)N4CCNCC4)CC3)C(OC)=CC2=NC=NC=1NC1=CC=CC(Cl)=C1F QRVGWOQDGHNNOJ-UHFFFAOYSA-N 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 125000005236 alkanoylamino group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- DFJSJLGUIXFDJP-UHFFFAOYSA-N sapitinib Chemical compound C1CN(CC(=O)NC)CCC1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=CC(Cl)=C1F DFJSJLGUIXFDJP-UHFFFAOYSA-N 0.000 claims 2
- 150000003335 secondary amines Chemical class 0.000 claims 2
- TUJMSLXGODIOSJ-UHFFFAOYSA-N 2-[4-[4-(3-chloro-2,4-difluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-1-(4-methylpiperazin-1-yl)ethanone Chemical compound C=12C=C(OC3CCN(CC(=O)N4CCN(C)CC4)CC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1F TUJMSLXGODIOSJ-UHFFFAOYSA-N 0.000 claims 1
- OYVGKMHHOZESFV-UHFFFAOYSA-N 2-[4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-1-morpholin-4-ylethanone Chemical compound C=12C=C(OC3CCN(CC(=O)N4CCOCC4)CC3)C(OC)=CC2=NC=NC=1NC1=CC=CC(Cl)=C1F OYVGKMHHOZESFV-UHFFFAOYSA-N 0.000 claims 1
- QJKLDSLAYNMJPH-UHFFFAOYSA-N 2-[4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-1-morpholin-4-ylethanone Chemical compound C=12C=C(OC3CCN(CC(=O)N4CCOCC4)CC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 QJKLDSLAYNMJPH-UHFFFAOYSA-N 0.000 claims 1
- YAMOXVHULRXADY-UHFFFAOYSA-N 2-[4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-1-pyrrolidin-1-ylethanone Chemical compound C=12C=C(OC3CCN(CC(=O)N4CCCC4)CC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 YAMOXVHULRXADY-UHFFFAOYSA-N 0.000 claims 1
- DWKBIQXIOVLREL-UHFFFAOYSA-N 2-[4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-n,n-dimethylacetamide Chemical compound C=12C=C(OC3CCN(CC(=O)N(C)C)CC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 DWKBIQXIOVLREL-UHFFFAOYSA-N 0.000 claims 1
- UUHJZHSXOPNXJK-UHFFFAOYSA-N 2-[4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-n-methylacetamide Chemical compound C1CN(CC(=O)NC)CCC1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=C(F)C(Cl)=C1 UUHJZHSXOPNXJK-UHFFFAOYSA-N 0.000 claims 1
- BPJGLRNTMKLTFV-UHFFFAOYSA-N 2-[4-[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]oxypiperidin-1-yl]-1-morpholin-4-ylethanone Chemical compound C1=C(Cl)C(F)=CC=C1NC(C1=C2)=NC=NC1=CC=C2OC1CCN(CC(=O)N2CCOCC2)CC1 BPJGLRNTMKLTFV-UHFFFAOYSA-N 0.000 claims 1
- KFLQUVCHGBIZNL-UHFFFAOYSA-N 2-[4-[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]oxypiperidin-1-yl]-n,n-dimethylacetamide Chemical compound C1CN(CC(=O)N(C)C)CCC1OC1=CC=C(N=CN=C2NC=3C=C(Cl)C(F)=CC=3)C2=C1 KFLQUVCHGBIZNL-UHFFFAOYSA-N 0.000 claims 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
- AJGCCHYJVIYICA-UHFFFAOYSA-N 3-[4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-1-morpholin-4-ylpropan-1-one Chemical compound C=12C=C(OC3CCN(CCC(=O)N4CCOCC4)CC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 AJGCCHYJVIYICA-UHFFFAOYSA-N 0.000 claims 1
- VDDLIDPTQSBAAT-UHFFFAOYSA-N 4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n-(2-pyrrolidin-1-ylethyl)piperidine-1-carboxamide Chemical compound C=12C=C(OC3CCN(CC3)C(=O)NCCN3CCCC3)C(OC)=CC2=NC=NC=1NC1=CC=CC(Cl)=C1F VDDLIDPTQSBAAT-UHFFFAOYSA-N 0.000 claims 1
- LYTUHALVDRDFOK-UHFFFAOYSA-N 4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n-methylpiperidine-1-carboxamide Chemical compound C1CN(C(=O)NC)CCC1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=CC(Cl)=C1F LYTUHALVDRDFOK-UHFFFAOYSA-N 0.000 claims 1
- WMBRKFRXBSLUHE-UHFFFAOYSA-N 4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n,n-diethylpiperidine-1-carboxamide Chemical compound C1CN(C(=O)N(CC)CC)CCC1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=C(F)C(Cl)=C1 WMBRKFRXBSLUHE-UHFFFAOYSA-N 0.000 claims 1
- IQGVKORQJHVGOB-UHFFFAOYSA-N 4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n,n-dimethylpiperidine-1-carboxamide Chemical compound C=12C=C(OC3CCN(CC3)C(=O)N(C)C)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 IQGVKORQJHVGOB-UHFFFAOYSA-N 0.000 claims 1
- MLCJKARGBIMLJM-UHFFFAOYSA-N 4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n-ethylpiperidine-1-carboxamide Chemical compound C1CN(C(=O)NCC)CCC1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=C(F)C(Cl)=C1 MLCJKARGBIMLJM-UHFFFAOYSA-N 0.000 claims 1
- BDCBLXLWPRFFPU-UHFFFAOYSA-N 4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n-methylpiperidine-1-carboxamide Chemical compound C1CN(C(=O)NC)CCC1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=C(F)C(Cl)=C1 BDCBLXLWPRFFPU-UHFFFAOYSA-N 0.000 claims 1
- TYDXNUIFLUEDFR-UHFFFAOYSA-N 4-[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]oxy-n,n-dimethylpiperidine-1-carboxamide Chemical compound C1CN(C(=O)N(C)C)CCC1OC1=CC=C(N=CN=C2NC=3C=C(Cl)C(F)=CC=3)C2=C1 TYDXNUIFLUEDFR-UHFFFAOYSA-N 0.000 claims 1
- OPXXBONXLXHZNU-UHFFFAOYSA-N 4-[4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-1-morpholin-4-ylbutan-1-one Chemical compound C=12C=C(OC3CCN(CCCC(=O)N4CCOCC4)CC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 OPXXBONXLXHZNU-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- SNUHGTFGVZBUPD-UHFFFAOYSA-N [4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-morpholin-4-ylmethanone Chemical compound C=12C=C(OC3CCN(CC3)C(=O)N3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=CC(Cl)=C1F SNUHGTFGVZBUPD-UHFFFAOYSA-N 0.000 claims 1
- BHKSATWJMGPDRI-UHFFFAOYSA-N [4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-pyrrolidin-1-ylmethanone Chemical compound C=12C=C(OC3CCN(CC3)C(=O)N3CCCC3)C(OC)=CC2=NC=NC=1NC1=CC=CC(Cl)=C1F BHKSATWJMGPDRI-UHFFFAOYSA-N 0.000 claims 1
- HGQSWGUVSJUFJD-UHFFFAOYSA-N [4-[4-(3-chloro-4-fluoroanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxypiperidin-1-yl]-morpholin-4-ylmethanone Chemical compound C=12C=C(OC3CCN(CC3)C(=O)N3CCOCC3)C(OCCOC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 HGQSWGUVSJUFJD-UHFFFAOYSA-N 0.000 claims 1
- IWYSVFZTNXLAOF-UHFFFAOYSA-N [4-[4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl]oxypiperidin-1-yl]-morpholin-4-ylmethanone Chemical compound C=12C=C(OC3CCN(CC3)C(=O)N3CCOCC3)C(OCC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 IWYSVFZTNXLAOF-UHFFFAOYSA-N 0.000 claims 1
- XFVIYGALQWSYAD-UHFFFAOYSA-N [4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-(4-methylpiperazin-1-yl)methanone Chemical compound C=12C=C(OC3CCN(CC3)C(=O)N3CCN(C)CC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XFVIYGALQWSYAD-UHFFFAOYSA-N 0.000 claims 1
- SGPQZLAIXLGTBH-UHFFFAOYSA-N [4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-morpholin-4-ylmethanone Chemical compound C=12C=C(OC3CCN(CC3)C(=O)N3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 SGPQZLAIXLGTBH-UHFFFAOYSA-N 0.000 claims 1
- GCFQYHBVQUQWIX-UHFFFAOYSA-N [4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-piperidin-1-ylmethanone Chemical compound C=12C=C(OC3CCN(CC3)C(=O)N3CCCCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 GCFQYHBVQUQWIX-UHFFFAOYSA-N 0.000 claims 1
- AKGOXFWKPNRRRD-UHFFFAOYSA-N [4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-pyrrolidin-1-ylmethanone Chemical compound C=12C=C(OC3CCN(CC3)C(=O)N3CCCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 AKGOXFWKPNRRRD-UHFFFAOYSA-N 0.000 claims 1
- OTYKNBPRZBCEBA-UHFFFAOYSA-N [4-[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]oxypiperidin-1-yl]-morpholin-4-ylmethanone Chemical compound C1=C(Cl)C(F)=CC=C1NC(C1=C2)=NC=NC1=CC=C2OC1CCN(C(=O)N2CCOCC2)CC1 OTYKNBPRZBCEBA-UHFFFAOYSA-N 0.000 claims 1
- COUMVWRRFZOSEJ-UHFFFAOYSA-N [4-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-morpholin-4-ylmethanone Chemical compound C=12C=C(OC3CCN(CC3)C(=O)N3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 COUMVWRRFZOSEJ-UHFFFAOYSA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 125000005133 alkynyloxy group Chemical group 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 0 C*C(N(*)*)=O Chemical compound C*C(N(*)*)=O 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03292309 | 2003-09-19 | ||
| EP04291248 | 2004-05-14 | ||
| PCT/GB2004/003937 WO2005028469A1 (en) | 2003-09-19 | 2004-09-15 | Quinazoline derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007240846A Division JP2008037874A (ja) | 2003-09-19 | 2007-09-18 | キナゾリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007505875A JP2007505875A (ja) | 2007-03-15 |
| JP2007505875A5 true JP2007505875A5 (enExample) | 2007-07-05 |
| JP4036885B2 JP4036885B2 (ja) | 2008-01-23 |
Family
ID=34379392
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006526686A Expired - Fee Related JP4036885B2 (ja) | 2003-09-19 | 2004-09-15 | キナゾリン誘導体 |
| JP2007240846A Pending JP2008037874A (ja) | 2003-09-19 | 2007-09-18 | キナゾリン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007240846A Pending JP2008037874A (ja) | 2003-09-19 | 2007-09-18 | キナゾリン誘導体 |
Country Status (32)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
| US7569577B2 (en) | 2003-09-16 | 2009-08-04 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
| JP4036885B2 (ja) | 2003-09-19 | 2008-01-23 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
| DE602004004811T2 (de) * | 2003-09-19 | 2007-11-22 | Astrazeneca Ab | Chinazolinderivate |
| GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
| US20070043010A1 (en) * | 2003-09-25 | 2007-02-22 | Astrazeneca Uk Limited | Quinazoline derivatives |
| GB0326459D0 (en) | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
| ATE413389T1 (de) | 2004-02-03 | 2008-11-15 | Astrazeneca Ab | Chinazolinderivate |
| CN101124228B (zh) * | 2004-12-14 | 2011-06-15 | 阿斯利康(瑞典)有限公司 | 用作抗肿瘤药物的吡唑并嘧啶化合物 |
| EP1856095B1 (en) * | 2005-02-26 | 2011-08-24 | AstraZeneca AB | Quinazoline derivatives as tyrosine kinase inhibitors |
| CN101175733A (zh) * | 2005-05-12 | 2008-05-07 | 黄文林 | 一种酪氨酸激酶抑制剂、其制备方法及作为抗肿瘤药物的应用 |
| WO2007029251A2 (en) * | 2005-09-06 | 2007-03-15 | T.K. Signal Ltd. | Polyalkylene glycol derivatives of 4- (phenylamino)quinazolines useful as irreversible inhibitors of epidermal gr0wth fact0r receptor tyrosine kinase |
| JP2009518450A (ja) * | 2005-12-12 | 2009-05-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二環式複素環化合物、その化合物を含む薬剤、その使用及び製造方法 |
| EP1921070A1 (de) * | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
| EA200901041A1 (ru) | 2007-02-06 | 2010-02-26 | Бёрингер Ингельхайм Интернациональ Гмбх | Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения |
| RS52573B (sr) | 2008-02-07 | 2013-04-30 | Boehringer Ingelheim International Gmbh | Spirociklični heterocikli, lekovi koji sadrže navedeno jedinjenje, njihova primena i postupak za njihovu proizvodnju |
| WO2009138780A2 (en) * | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | Therapeutic treatment - 355 |
| WO2009138779A1 (en) * | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | Combination comprising 4- (3-chloro-2-fluoroanilino) -7-meth0xy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxyjquinazoline |
| BRPI0912170A2 (pt) * | 2008-05-13 | 2015-10-13 | Astrazeneca Ab | composto, forma a, processo para a preparação da mesma, composição farmacêutica, uso de um composto, e, método para tratar um câncer em um animal de sangue quente |
| CA2733153C (en) | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
| WO2010061208A2 (en) * | 2008-11-03 | 2010-06-03 | Astrazeneca Ab | Therapeutic treatment 555 |
| US8450482B2 (en) * | 2009-04-23 | 2013-05-28 | Astrazeneca Ab | Process for the preparation of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-([1-(N-methylcarbamoymethyl)piperidin-4-yl]oxy)quinazoline |
| CN102060875B (zh) * | 2009-11-18 | 2014-03-12 | 天津药物研究院 | 喹唑啉衍生物、制备方法和用途 |
| UA113280C2 (xx) | 2010-11-11 | 2017-01-10 | АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ | |
| CN103012367A (zh) * | 2011-09-22 | 2013-04-03 | 北大方正集团有限公司 | 一种喹啉衍生物 |
| CN103012368A (zh) * | 2011-09-22 | 2013-04-03 | 北大方正集团有限公司 | 喹啉衍生物 |
| TWI577671B (zh) | 2011-11-14 | 2017-04-11 | Sunshine Lake Pharma Co Ltd | Aminoquinazoline derivatives and salts thereof and methods of use thereof |
| KR20140096571A (ko) * | 2013-01-28 | 2014-08-06 | 한미약품 주식회사 | 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법 |
| EP3342770B1 (en) | 2013-03-06 | 2022-03-30 | AstraZeneca AB | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
| CN104513229A (zh) * | 2013-09-28 | 2015-04-15 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物及其制备方法 |
| JP6704422B2 (ja) | 2015-03-20 | 2020-06-03 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. | キナゾリン誘導体の塩およびその製造方法 |
| US10710968B2 (en) | 2016-01-13 | 2020-07-14 | Hadasit Medical Research Services And Development Ltd. | Radiolabeled erlotinib analogs and uses thereof |
| MX2022005388A (es) | 2019-11-06 | 2022-05-24 | Yuhan Corp | Compuestos de pirrolidina y piperidina. |
Family Cites Families (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3985749A (en) | 1975-12-22 | 1976-10-12 | Eastman Kodak Company | Process for preparation of 4-aminoquinazoline |
| JPS5538325A (en) | 1978-09-11 | 1980-03-17 | Sankyo Co Ltd | 4-anilinoquinazoline derivative and its preparation |
| US4335127A (en) | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
| US4332420A (en) | 1980-01-11 | 1982-06-01 | Coski William D | Reciprocably supported dual drive member and features thereof |
| GB2160201B (en) | 1984-06-14 | 1988-05-11 | Wyeth John & Brother Ltd | Quinazoline and cinnoline derivatives |
| KR910006138B1 (ko) | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
| IL89029A (en) | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them |
| US4921863A (en) | 1988-02-17 | 1990-05-01 | Eisai Co., Ltd. | Cyclic amine derivatives |
| CA1340821C (en) | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
| JPH0436885A (ja) * | 1990-05-31 | 1992-02-06 | Sharp Corp | 光学式文字読取装置 |
| US5252586A (en) | 1990-09-28 | 1993-10-12 | The Du Pont Merck Pharmaceutical Company | Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents |
| DE4105503A1 (de) | 1991-02-19 | 1992-08-20 | Jenapharm Gmbh | Ausgangsverbindungen zur herstellung von calcitriol sowie dessen abkoemmlingen, verfahren zur herstellung dieser ausgangsverbindungen sowie zwischenprodukte fuer dieses verfahren |
| US5721237A (en) | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
| US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| AU658646B2 (en) | 1991-05-10 | 1995-04-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| US5187168A (en) | 1991-10-24 | 1993-02-16 | American Home Products Corporation | Substituted quinazolines as angiotensin II antagonists |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| WO1993017682A1 (en) | 1992-03-04 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
| GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| BR9406724A (pt) | 1993-05-26 | 1996-02-06 | Syntex Inc | Novos ligantes de receptores 1-fenilalcanona 5-ht4 |
| US5395846A (en) | 1993-06-25 | 1995-03-07 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Amino Bi- and tri-carbocyclic aklane bis-aryl squalene synthase inhibitors |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| GB9314884D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Tricyclic derivatives |
| TW321649B (enExample) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| GB2295387A (en) | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US6046206A (en) | 1995-06-07 | 2000-04-04 | Cell Pathways, Inc. | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| CA2216169C (en) | 1996-01-31 | 2007-01-23 | Gist-Brocades B.V. | Use of compositions comprising stabilized biologically effective compounds |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| GB9607729D0 (en) | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
| US6004967A (en) | 1996-09-13 | 1999-12-21 | Sugen, Inc. | Psoriasis treatment with quinazoline compounds |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| US6225318B1 (en) | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
| GB9626589D0 (en) | 1996-12-20 | 1997-02-05 | Prolifix Ltd | Peptides |
| US5929080A (en) | 1997-05-06 | 1999-07-27 | American Cyanamid Company | Method of treating polycystic kidney disease |
| JP4245682B2 (ja) | 1997-12-25 | 2009-03-25 | 協和発酵キリン株式会社 | キノリン誘導体、イソキノリン誘導体、およびシンノリン誘導体、並びに抗炎症剤および抗アレルギー剤 |
| US6384223B1 (en) | 1998-07-30 | 2002-05-07 | American Home Products Corporation | Substituted quinazoline derivatives |
| US6297258B1 (en) | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| AU3281600A (en) | 1999-02-27 | 2000-09-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transsduction mediated by tyrosine kinases |
| US6080747A (en) | 1999-03-05 | 2000-06-27 | Hughes Institute | JAK-3 inhibitors for treating allergic disorders |
| DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| US6627651B1 (en) | 1999-05-07 | 2003-09-30 | Takeda Chemical Industries, Ltd. | Cyclic compounds and uses thereof |
| US6126917A (en) | 1999-06-01 | 2000-10-03 | Hadasit Medical Research Services And Development Ltd. | Epidermal growth factor receptor binding compounds for positron emission tomography |
| WO2000078735A1 (de) | 1999-06-21 | 2000-12-28 | Boehringer Ingelheim Pharma Kg | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| DE60040676D1 (de) | 1999-09-17 | 2008-12-11 | Millennium Pharm Inc | BENZAMIDE UND ÄHNLICHE INHIBITOREN VON FAKTOR Xa |
| WO2001021160A2 (en) | 1999-09-23 | 2001-03-29 | Axxima Pharmaceuticals Aktiengesellschaft | Carboxymide and aniline derivatives as selective inhibitors of pathogens |
| GB9925958D0 (en) | 1999-11-02 | 1999-12-29 | Bundred Nigel J | Therapeutic use |
| CA2401778C (en) | 2000-02-29 | 2010-12-21 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| US20030152572A1 (en) | 2000-04-06 | 2003-08-14 | Yoshimi Homma | Diagnostic and therapeutic agents for rheumatoid arthritis |
| US20040110743A1 (en) | 2000-05-19 | 2004-06-10 | Masaomi Miyamato | -Secretase inhibitors |
| GB0017635D0 (en) | 2000-07-18 | 2000-09-06 | Pharmacia & Upjohn Spa | Antitumor combined therapy |
| DE10042059A1 (de) | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| US6656946B2 (en) | 2000-08-26 | 2003-12-02 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
| US20020082270A1 (en) | 2000-08-26 | 2002-06-27 | Frank Himmelsbach | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
| DE10042061A1 (de) | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| US6617329B2 (en) | 2000-08-26 | 2003-09-09 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines and their use as medicaments |
| DE10042060A1 (de) | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10042058A1 (de) | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| US6653305B2 (en) | 2000-08-26 | 2003-11-25 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them |
| DE10042062A1 (de) | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Hertellung |
| US6740651B2 (en) | 2000-08-26 | 2004-05-25 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
| CN1543452A (zh) | 2000-09-01 | 2004-11-03 | Fmc | 1,4-二取代苯杀虫剂 |
| BR0113625A (pt) | 2000-09-08 | 2003-07-22 | Pharmacia Italia Spa | Exemestano como agente de quimioprevenção |
| AU2002213467A1 (en) | 2000-10-11 | 2002-04-22 | Chemocentryx, Inc. | Modulation of ccr4 function |
| US20030158196A1 (en) | 2002-02-16 | 2003-08-21 | Boehringer Ingelheim Pharma Gmbh Co. Kg | Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors |
| EP1339458B1 (en) * | 2000-11-22 | 2007-08-15 | Novartis AG | Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity |
| CA2431322A1 (en) | 2000-12-11 | 2002-06-20 | Eiji Nara | Medicinal compositions having improved absorbability |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| NZ516873A (en) | 2001-02-12 | 2003-11-28 | Warner Lambert Co | Compositions containing retinoids and erb inhibitors and their use in inhibiting retinoid skin damage |
| TWI309647B (enExample) | 2001-02-21 | 2009-05-11 | Mitsubishi Tanabe Pharma Corp | |
| US6562319B2 (en) | 2001-03-12 | 2003-05-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy |
| WO2002094790A1 (en) | 2001-05-23 | 2002-11-28 | Mitsubishi Pharma Corporation | Fused heterocyclic compound and medicinal use thereof |
| AU2002342051B2 (en) | 2001-10-12 | 2009-06-11 | Irm Llc | Kinase inhibitor scaffolds and methods for their preparation |
| JP2003246780A (ja) | 2001-12-17 | 2003-09-02 | Eisai Co Ltd | 含窒素芳香環化合物の製造方法 |
| DE10204462A1 (de) | 2002-02-05 | 2003-08-07 | Boehringer Ingelheim Pharma | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
| WO2003066602A1 (en) | 2002-02-06 | 2003-08-14 | Ube Industries, Ltd. | Process for producing 4-aminoquinazoline compound |
| TWI324597B (en) | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| AU2003226705B2 (en) * | 2002-03-30 | 2008-11-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 4-(N-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors |
| US20040044014A1 (en) | 2002-04-19 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
| US7312214B2 (en) | 2002-05-10 | 2007-12-25 | Bristol-Myers Squibb Company | 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors |
| EP1511769A2 (en) | 2002-05-15 | 2005-03-09 | Birgit Luber | Egf receptor antagonists in the treatment of gastric cancer |
| US20040038856A1 (en) | 2002-05-17 | 2004-02-26 | Sarvajit Chakravarty | Treatment of fibroproliferative disorders using TGF-beta inhibitors |
| WO2003101491A1 (en) | 2002-06-03 | 2003-12-11 | Mitsubishi Pharma Corporation | PREVENTIVES AND/OR REMEDIES FOR SUBJECTS WITH THE EXPRESSION OR ACTIVATION OF Her2 AND/OR EGFR |
| US7576074B2 (en) | 2002-07-15 | 2009-08-18 | Rice Kenneth D | Receptor-type kinase modulators and methods of use |
| CA2494367A1 (en) | 2002-07-25 | 2004-02-05 | Scios Inc. | Methods for improvement of lung function using tgf-.beta. inhibitors |
| AU2003247141A1 (en) | 2002-08-01 | 2004-02-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 4-anilido substituted quinazolines and use thereof as inhibitors of epidermal growth factor receptor kinases |
| AU2003257666A1 (en) | 2002-08-23 | 2004-03-11 | Kirin Beer Kabushiki Kaisha | COMPOUND HAVING TGFss INHIBITORY ACTIVITY AND MEDICINAL COMPOSITION CONTAINING THE SAME |
| JPWO2004060400A1 (ja) | 2003-01-06 | 2006-05-11 | 那波 宏之 | 上皮成長因子受容体を分子標的とする抗精神病薬 |
| DE10300097A1 (de) | 2003-01-07 | 2004-07-22 | Bayer Ag | Kupfer-Komplexe und ihre Verwendung |
| DE10300098A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Ag | Kupfer-Carben-Komplexe und ihre Verwendung |
| MXPA05008450A (es) | 2003-02-10 | 2005-10-18 | Vertex Pharma | Procesos para la preparacion de n-heteroaril-n-aril-aminas mediante reaccion de un ester de acido n-aril-carbamico con un halo-heteroarilo y procesos analogos. |
| CA2518716A1 (en) | 2003-03-11 | 2005-01-13 | Dana-Farber Cancer Institute | Inhibition of viral pathogenesis |
| AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| RU2431500C2 (ru) | 2003-06-09 | 2011-10-20 | Самуэль ВАКСАЛ | Способ ингибирования рецепторных тирозинкиназ с помощью внеклеточного антагониста и внутриклеточного антагониста |
| GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
| BRPI0413066A (pt) | 2003-07-29 | 2006-10-17 | Astrazeneca Ab | derivado de quinazolina, ou um sal farmaceuticamente aceitável, ou um éster farmaceuticamente aceitável do mesmo, da fórmula i, uso e processo para a preparação do mesmo, composto, composição farmacêutica, e, métodos para a produção de um efeito antiproliferativo em um animal de sangue quente, para a prevenção ou tratamento de um tumor, para prover um efeito inibitório de tirosina quinase de egfr seletivo, e para tratar um cáncer em um animal de sangue quente |
| JP2007502807A (ja) | 2003-08-18 | 2007-02-15 | ファイザー・プロダクツ・インク | Ｅｒｂｂ２抗がん剤の投与スケジュール |
| DE602004004811T2 (de) | 2003-09-19 | 2007-11-22 | Astrazeneca Ab | Chinazolinderivate |
| JP4036885B2 (ja) | 2003-09-19 | 2008-01-23 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
| US20070043010A1 (en) | 2003-09-25 | 2007-02-22 | Astrazeneca Uk Limited | Quinazoline derivatives |
| WO2005030140A2 (en) | 2003-09-26 | 2005-04-07 | Exelixis, Inc. | C-met modulators and methods of use |
| US20050096332A1 (en) * | 2003-10-30 | 2005-05-05 | Boehringer Ingelheim International Gmbh | Use of tyrosine kinase inhibitors for the treatment of inflammatory processes |
| JP5311673B2 (ja) | 2006-12-14 | 2013-10-09 | エグゼリクシス， インコーポレイテッド | Ｍｅｋ阻害剤の使用方法 |
-
2004
- 2004-09-15 JP JP2006526686A patent/JP4036885B2/ja not_active Expired - Fee Related
- 2004-09-15 NZ NZ545913A patent/NZ545913A/en not_active IP Right Cessation
- 2004-09-15 AT AT04768483T patent/ATE352550T1/de active
- 2004-09-15 ES ES04768483T patent/ES2279441T3/es not_active Expired - Lifetime
- 2004-09-15 WO PCT/GB2004/003937 patent/WO2005028469A1/en not_active Ceased
- 2004-09-15 CA CA2538752A patent/CA2538752C/en not_active Expired - Fee Related
- 2004-09-15 RU RU2006112845/04A patent/RU2370494C2/ru not_active IP Right Cessation
- 2004-09-15 DE DE602004004553T patent/DE602004004553T2/de not_active Expired - Lifetime
- 2004-09-15 EP EP04768483A patent/EP1667992B1/en not_active Expired - Lifetime
- 2004-09-15 BR BRPI0414532-1A patent/BRPI0414532B1/pt not_active IP Right Cessation
- 2004-09-15 PT PT04768483T patent/PT1667992E/pt unknown
- 2004-09-15 PL PL04768483T patent/PL1667992T3/pl unknown
- 2004-09-15 HR HR20070113T patent/HRP20070113T3/xx unknown
- 2004-09-15 AU AU2004274227A patent/AU2004274227B2/en not_active Ceased
- 2004-09-15 CN CN2004800339015A patent/CN1882569B/zh not_active Expired - Fee Related
- 2004-09-15 MX MXPA06003113A patent/MXPA06003113A/es active IP Right Grant
- 2004-09-15 DK DK04768483T patent/DK1667992T3/da active
- 2004-09-15 UA UAA200604367A patent/UA83252C2/uk unknown
- 2004-09-15 SI SI200430224T patent/SI1667992T1/sl unknown
- 2004-09-15 US US10/571,991 patent/US8318752B2/en not_active Expired - Fee Related
- 2004-09-16 MY MYPI20043767A patent/MY138851A/en unknown
- 2004-09-17 TW TW093128316A patent/TWI342879B/zh not_active IP Right Cessation
- 2004-09-17 UY UY28522A patent/UY28522A1/es not_active Application Discontinuation
- 2004-09-17 AR ARP040103357A patent/AR045762A1/es not_active Application Discontinuation
- 2004-09-18 SA SA4250296A patent/SA04250296B1/ar unknown
-
2006
- 2006-03-13 IL IL174284A patent/IL174284A/en active IP Right Grant
- 2006-03-17 ZA ZA2006/02264A patent/ZA200602264B/en unknown
- 2006-03-23 NO NO20061327A patent/NO333904B1/no not_active IP Right Cessation
- 2006-04-12 IS IS8412A patent/IS2545B/is unknown
- 2006-04-17 CO CO06036294A patent/CO5680435A2/es active IP Right Grant
- 2006-04-19 KR KR1020067007482A patent/KR101262442B1/ko not_active Expired - Fee Related
-
2007
- 2007-03-22 CY CY20071100399T patent/CY1106405T1/el unknown
- 2007-09-18 JP JP2007240846A patent/JP2008037874A/ja active Pending
-
2012
- 2012-09-10 US US13/607,999 patent/US20120329795A1/en not_active Abandoned