JP2006524487A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006524487A5 JP2006524487A5 JP2004571244A JP2004571244A JP2006524487A5 JP 2006524487 A5 JP2006524487 A5 JP 2006524487A5 JP 2004571244 A JP2004571244 A JP 2004571244A JP 2004571244 A JP2004571244 A JP 2004571244A JP 2006524487 A5 JP2006524487 A5 JP 2006524487A5
- Authority
- JP
- Japan
- Prior art keywords
- candidate compound
- compound
- metabolite
- candidate
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 97
- 238000000034 method Methods 0.000 claims 44
- 239000002207 metabolite Substances 0.000 claims 24
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 14
- 239000000651 prodrug Substances 0.000 claims 10
- 229940002612 prodrug Drugs 0.000 claims 10
- -1 amino acid phosphonoamidate Chemical class 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 7
- 230000036436 anti-hiv Effects 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 230000003834 intracellular effect Effects 0.000 claims 6
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 230000007062 hydrolysis Effects 0.000 claims 5
- 238000006460 hydrolysis reaction Methods 0.000 claims 5
- 108090000604 Hydrolases Proteins 0.000 claims 4
- 102000004157 Hydrolases Human genes 0.000 claims 4
- 125000002843 carboxylic acid group Chemical group 0.000 claims 4
- 210000003563 lymphoid tissue Anatomy 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 3
- 108010051152 Carboxylesterase Proteins 0.000 claims 2
- 102000013392 Carboxylesterase Human genes 0.000 claims 2
- 108010010369 HIV Protease Proteins 0.000 claims 2
- 108010058834 acylcarnitine hydrolase Proteins 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000000058 esterolytic effect Effects 0.000 claims 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 2
- 230000002688 persistence Effects 0.000 claims 2
- 125000004437 phosphorous atom Chemical group 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 108010002459 HIV Integrase Proteins 0.000 claims 1
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- VGKONPUVOVVNSU-UHFFFAOYSA-N naphthalen-1-yl acetate Chemical compound C1=CC=C2C(OC(=O)C)=CC=CC2=C1 VGKONPUVOVVNSU-UHFFFAOYSA-N 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37562202P | 2002-04-26 | 2002-04-26 | |
| US37583402P | 2002-04-26 | 2002-04-26 | |
| US37566502P | 2002-04-26 | 2002-04-26 | |
| US37577902P | 2002-04-26 | 2002-04-26 | |
| PCT/US2003/012943 WO2003090691A2 (en) | 2002-04-26 | 2003-04-25 | Method and compositions for identifying anti-hiv therapeutic compounds |
| PCT/US2003/012926 WO2003091264A2 (en) | 2002-04-26 | 2003-04-25 | Non nucleoside reverse transcriptase inhibitors |
| PCT/US2003/012901 WO2003090690A2 (en) | 2002-04-26 | 2003-04-25 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds and the compounds as such |
| PCT/EP2003/012423 WO2004096818A2 (en) | 2002-04-26 | 2003-11-06 | Method and compositions for identifying anti-hiv therapeutic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006524487A JP2006524487A (ja) | 2006-11-02 |
| JP2006524487A5 true JP2006524487A5 (https=) | 2006-12-28 |
Family
ID=29273807
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003587329A Expired - Lifetime JP4942915B2 (ja) | 2002-04-26 | 2003-04-25 | Hivプロテアーゼ阻害剤化合物のホスホネートアナログの細胞蓄積 |
| JP2003587330A Pending JP2006508634A (ja) | 2002-04-26 | 2003-04-25 | 抗hiv治療化合物を同定するための方法および組成物 |
| JP2003587822A Pending JP2005523922A (ja) | 2002-04-26 | 2003-04-25 | 非ヌクレオシド逆転写酵素阻害剤 |
| JP2004571244A Pending JP2006524487A (ja) | 2002-04-26 | 2003-11-06 | 抗hiv治療化合物を同定するための方法および組成物 |
| JP2009052719A Pending JP2009112319A (ja) | 2002-04-26 | 2009-03-05 | 抗hiv治療化合物を同定するための方法および組成物 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003587329A Expired - Lifetime JP4942915B2 (ja) | 2002-04-26 | 2003-04-25 | Hivプロテアーゼ阻害剤化合物のホスホネートアナログの細胞蓄積 |
| JP2003587330A Pending JP2006508634A (ja) | 2002-04-26 | 2003-04-25 | 抗hiv治療化合物を同定するための方法および組成物 |
| JP2003587822A Pending JP2005523922A (ja) | 2002-04-26 | 2003-04-25 | 非ヌクレオシド逆転写酵素阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009052719A Pending JP2009112319A (ja) | 2002-04-26 | 2009-03-05 | 抗hiv治療化合物を同定するための方法および組成物 |
Country Status (27)
| Country | Link |
|---|---|
| US (7) | US7649015B2 (https=) |
| EP (4) | EP1501841A2 (https=) |
| JP (5) | JP4942915B2 (https=) |
| KR (2) | KR100987815B1 (https=) |
| CN (4) | CN1313472C (https=) |
| AT (1) | ATE367394T1 (https=) |
| AU (4) | AU2003231765B9 (https=) |
| BR (2) | BR0309557A (https=) |
| CA (3) | CA2481285A1 (https=) |
| CY (1) | CY1108036T1 (https=) |
| DE (1) | DE60315023T2 (https=) |
| DK (1) | DK1509537T3 (https=) |
| EA (2) | EA200401437A1 (https=) |
| ES (1) | ES2290485T3 (https=) |
| HR (2) | HRP20041114A2 (https=) |
| IL (2) | IL164491A0 (https=) |
| IS (2) | IS7555A (https=) |
| MX (2) | MXPA04010527A (https=) |
| NO (2) | NO20045152L (https=) |
| NZ (1) | NZ535828A (https=) |
| PL (2) | PL374522A1 (https=) |
| PT (1) | PT1509537E (https=) |
| SI (1) | SI1509537T1 (https=) |
| TW (2) | TW200408645A (https=) |
| UA (1) | UA80819C2 (https=) |
| WO (4) | WO2003090690A2 (https=) |
| ZA (2) | ZA200409377B (https=) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003231765B9 (en) | 2002-04-26 | 2010-01-28 | Gilead Sciences, Inc. | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such |
| US20050239054A1 (en) * | 2002-04-26 | 2005-10-27 | Arimilli Murty N | Method and compositions for identifying anti-HIV therapeutic compounds |
| US7351738B2 (en) * | 2002-11-27 | 2008-04-01 | Elan Pharmaceuticals, Inc. | Substituted ureas and carbamates |
| MXPA05007016A (es) | 2003-01-14 | 2005-09-12 | Gilead Sciences Inc | Composiciones y metodos para terapia antiviral de combinacion. |
| MXPA05011296A (es) | 2003-04-25 | 2006-01-24 | Gilead Sciences Inc | Conjugados de fosfonato inhibidores de la cinasa. |
| US7470724B2 (en) * | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| WO2004096233A2 (en) * | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Nucleoside phosphonate conjugates |
| US7407965B2 (en) * | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| WO2005002626A2 (en) * | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| EP2359833A1 (en) * | 2003-04-25 | 2011-08-24 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
| WO2004096237A2 (en) * | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US7452901B2 (en) * | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| US7432261B2 (en) * | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| US20050261237A1 (en) * | 2003-04-25 | 2005-11-24 | Boojamra Constantine G | Nucleoside phosphonate analogs |
| CN101410120A (zh) * | 2003-04-25 | 2009-04-15 | 吉里德科学公司 | 抗炎的膦酸酯化合物 |
| US7273716B2 (en) | 2003-04-25 | 2007-09-25 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds with GS-7340 ester hydrolase |
| US20090247488A1 (en) * | 2003-04-25 | 2009-10-01 | Carina Cannizzaro | Anti-inflammatory phosphonate compounds |
| WO2004096287A2 (en) * | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| NZ542343A (en) * | 2003-04-25 | 2009-03-31 | Gilead Sciences Inc | Immunomodulator phosphonate conjugates |
| US7300924B2 (en) * | 2003-04-25 | 2007-11-27 | Gilead Sciences, Inc. | Anti-infective phosphonate analogs |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| WO2005044308A1 (en) * | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| US7427624B2 (en) | 2003-10-24 | 2008-09-23 | Gilead Sciences, Inc. | Purine nucleoside phosphorylase inhibitory phosphonate compounds |
| CA2548951A1 (en) * | 2003-12-22 | 2005-07-14 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
| US20070281907A1 (en) * | 2003-12-22 | 2007-12-06 | Watkins William J | Kinase Inhibitor Phosphonate Conjugates |
| US20050153990A1 (en) * | 2003-12-22 | 2005-07-14 | Watkins William J. | Phosphonate substituted kinase inhibitors |
| WO2005063751A1 (en) * | 2003-12-22 | 2005-07-14 | Gilead Sciences, Inc. | 4’-substituted carbovir-and abacavir-derivatives as well as related compounds with hiv and hcv antiviral activity |
| MXPA06007906A (es) * | 2004-01-12 | 2007-02-14 | Gilead Sciences Inc | Compuestos antivirales de fosfonato de pirimidilo y metodos de uso. |
| EP1742642B1 (en) * | 2004-04-14 | 2008-10-15 | Gilead Sciences, Inc. | Phosphonate analogs of hiv integrase inhibitor compounds |
| AU2011218664B2 (en) * | 2004-07-27 | 2014-08-21 | Gilead Sciences, Inc. | Antiviral compounds |
| ME03423B (me) * | 2004-07-27 | 2020-01-20 | Gilead Sciences Inc | Fosfonatni analozi jedinjenja hiv inhibitora |
| CN101084231B (zh) * | 2004-09-17 | 2011-08-24 | 埃迪尼克斯医药公司 | 作为hiv抑制剂的磷酸-吲哚 |
| DE602005011031D1 (en) | 2004-09-17 | 2008-12-24 | Idenix Pharmaceuticals Inc | Phosphoindole als hiv-inhibitoren |
| AU2005294123C1 (en) | 2004-10-07 | 2010-01-21 | Vitae Pharmaceuticals, Inc. | Diaminoalkane aspartic protease inhibitors |
| CN101094677A (zh) | 2004-11-15 | 2007-12-26 | 塞普泰尔公司 | 蛋白酪氨酸磷酸酶抑制剂及其使用方法 |
| WO2006066074A2 (en) | 2004-12-16 | 2006-06-22 | The Regents Of The University Of California | Lung-targeted drugs |
| RU2421459C2 (ru) | 2005-02-25 | 2011-06-20 | Тиботек Фармасьютикалз Лтд. | Синтез предшественника ингибитора протеазы |
| JP2008538354A (ja) * | 2005-04-08 | 2008-10-23 | キメリクス,インコーポレイテッド | ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法 |
| JP2008535862A (ja) * | 2005-04-08 | 2008-09-04 | キメリクス,インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
| AR053845A1 (es) | 2005-04-15 | 2007-05-23 | Tibotec Pharm Ltd | 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450 |
| TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
| AU2006276246B2 (en) * | 2005-07-25 | 2012-09-27 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis C virus replication |
| CA2616314A1 (en) * | 2005-07-27 | 2007-02-01 | Gilead Sciences, Inc. | Antiviral phosphonate conjugates for inhibition of hiv |
| ES2356776T3 (es) * | 2005-10-11 | 2011-04-13 | Intermune, Inc. | Compuestos y métodos para inhibir la replicación del virus de la hepatitis. |
| TWI411607B (zh) | 2005-11-14 | 2013-10-11 | Vitae Pharmaceuticals Inc | 天門冬胺酸蛋白酶抑制劑 |
| TWI432438B (zh) | 2005-11-28 | 2014-04-01 | Tibotec Pharm Ltd | 作為hiv蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物及衍生物 |
| TWI385173B (zh) | 2005-11-28 | 2013-02-11 | Tibotec Pharm Ltd | 作為hiv蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物 |
| ATE474560T1 (de) * | 2005-12-14 | 2010-08-15 | Cipla Ltd | Pharmazeutische kombination aus nucleotid und nucleosid-reverse-transkriptase-hemmern (wie tenofovir und lamivudin) in verschiedenen teilen der dosiereinheit |
| US20070167422A1 (en) * | 2006-01-18 | 2007-07-19 | Yu Kwok S | Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin |
| WO2007126812A2 (en) * | 2006-03-29 | 2007-11-08 | Gilead Sciences, Inc. | Process for preparation of hiv protease inhibitors |
| US20080070910A1 (en) * | 2006-07-24 | 2008-03-20 | Desai Manoj C | Therapeutic compounds and methods |
| CL2007002689A1 (es) | 2006-09-18 | 2008-04-18 | Vitae Pharmaceuticals Inc | Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras. |
| KR20090077813A (ko) | 2006-09-29 | 2009-07-15 | 아이데닉스 파마슈티칼스, 인코포레이티드 | Hiv 억제제로서의 거울상이성질체적으로 순수한 포스포인돌 |
| EP2121589A2 (en) * | 2006-12-18 | 2009-11-25 | University of Massachusetts | Crystal structures of hiv-1 protease inhibitors bound to hiv-1 protease |
| US7981929B2 (en) * | 2007-03-16 | 2011-07-19 | Sequoia Pharmaceuticals, Inc. | Benzofuran derived HIV protease inhibitors |
| CA2681718A1 (en) * | 2007-03-23 | 2008-10-02 | University Of Massachusetts | Hiv-1 protease inhibitors |
| SG174809A1 (en) * | 2007-05-03 | 2011-10-28 | Intermune Inc | Macrocyclic compounds useful as inhibitors of hepatitis c virus |
| WO2008151306A1 (en) * | 2007-06-05 | 2008-12-11 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Synthesis of cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity |
| CN101784532B (zh) | 2007-06-29 | 2014-10-22 | 韩国化学研究院 | Hiv逆转录酶抑制剂 |
| KR20100041798A (ko) | 2007-06-29 | 2010-04-22 | 한국화학연구원 | 신규 hiv 역전사효소 억제제 |
| US8067730B2 (en) | 2007-07-20 | 2011-11-29 | The George Washington University | Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry |
| US8901487B2 (en) * | 2007-07-20 | 2014-12-02 | George Washington University | Subcellular analysis by laser ablation electrospray ionization mass spectrometry |
| US7964843B2 (en) | 2008-07-18 | 2011-06-21 | The George Washington University | Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry |
| US20100285446A1 (en) * | 2007-07-20 | 2010-11-11 | Akos Vertes | Methods for Detecting Metabolic States by Laser Ablation Electrospray Ionization Mass Spectrometry |
| WO2009085797A1 (en) | 2007-12-21 | 2009-07-09 | Gilead Sciences, Inc. | Processes for preparing hiv reverse transcriptase inhibitors |
| EP2254582B1 (en) * | 2008-01-25 | 2016-01-20 | Chimerix, Inc. | Methods of treating viral infections |
| WO2009142842A2 (en) * | 2008-04-15 | 2009-11-26 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| PT2300013T (pt) | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| CN102088850A (zh) * | 2008-06-26 | 2011-06-08 | 生命医药公司 | 甲基2-((r)-(3-氯苯基)((r)-1-((s)-2-(甲氨基)-3((r)-四氢-2h-吡喃-3-基)丙基氨甲酰基)哌啶-3-基)甲氧基)氨基甲酸乙酯的盐 |
| UA103329C2 (ru) | 2008-07-08 | 2013-10-10 | Гилиад Сайенсиз, Инк. | Соли соединений-ингибиторов вич |
| KR20110075019A (ko) * | 2008-10-15 | 2011-07-05 | 인터뮨, 인크. | 치료용 항바이러스성 펩티드 |
| PT2376088T (pt) | 2008-12-23 | 2017-05-02 | Gilead Pharmasset Llc | Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída |
| KR20110098849A (ko) | 2008-12-23 | 2011-09-01 | 파마셋 인코포레이티드 | 뉴클레오시드 유사체 |
| SG194404A1 (en) | 2008-12-23 | 2013-11-29 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| AR075584A1 (es) * | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| EP2270021A1 (en) | 2009-06-18 | 2011-01-05 | Centre National de la Recherche Scientifique | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
| US20120232038A1 (en) * | 2009-06-25 | 2012-09-13 | Gilead Sciences, Inc. | Crystalline forms of (3r, 3as, 6ar) - hexahydrofuro [2,3-b] furan-3-yl (1s,2r) - (1-{4-[ (diethoxyphosphoryl) methoxy] pheny1}-3-hydroxy-4- [4-methoxy-n- (2-methylpropyl) benzenesul - fonamido] butan-2-yl) carbamate |
| US7924650B2 (en) * | 2009-06-30 | 2011-04-12 | Oracle America, Inc. | Dynamically controlled voltage regulator for a memory |
| SG177451A1 (en) * | 2009-07-02 | 2012-02-28 | Newgen Therapeutics Inc | Phosphorus containing quinazoline compounds and methods of use |
| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| AR077692A1 (es) | 2009-08-06 | 2011-09-14 | Vitae Pharmaceuticals Inc | Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo |
| DE102009041443A1 (de) * | 2009-09-16 | 2011-03-31 | Archimica Gmbh | Salze des 6-Chlor-4-(cyclopropylethinyl)-1,4-dihydro-4-(trifluormethyl)-2H-3,1-benzoxazin-2-ons und deren Synthese, Aufreinigung und Anwendung als Vorstufen für Efavirenz |
| MX2012003171A (es) * | 2009-09-28 | 2012-04-11 | Hoffmann La Roche | Novedosos inhibidores macrociclicos de la replicacion del virus de hepatitis c. |
| US20110082182A1 (en) * | 2009-10-01 | 2011-04-07 | Intermune, Inc. | Therapeutic antiviral peptides |
| WO2011053812A1 (en) * | 2009-10-30 | 2011-05-05 | Chimerix, Inc. | Methods of treating viral associated diseases |
| US9006218B2 (en) | 2010-02-12 | 2015-04-14 | Chimerix Inc. | Nucleoside phosphonate salts |
| UY33312A (es) | 2010-03-31 | 2011-10-31 | Pharmasset Inc | Fosforamidato de nucleosido de purina |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| PT2609923T (pt) | 2010-03-31 | 2017-08-30 | Gilead Pharmasset Llc | Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo |
| US9278135B2 (en) | 2010-04-26 | 2016-03-08 | Chimerix Inc. | Methods of treating retroviral infections and related dosage regimes |
| US8884027B2 (en) | 2010-10-22 | 2014-11-11 | University Of Rochester | Melampomagnolide B derivatives as antileukemic and cytotoxic agents |
| AU2011336632B2 (en) | 2010-11-30 | 2015-09-03 | Gilead Pharmasset Llc | Compounds |
| CN102127030B (zh) * | 2011-01-21 | 2013-05-22 | 天津大学 | 4-(取代-1,3-二炔基)-4-(三氟甲基)苯并-1,4-二氢噁嗪-2-酮类化合物及其制备方法和应用 |
| US9834518B2 (en) | 2011-05-04 | 2017-12-05 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| CA2835932C (en) | 2011-05-19 | 2020-03-24 | Gilead Sciences, Inc. | Processes and intermediates for preparing anti-hiv agents |
| US8829426B2 (en) | 2011-07-14 | 2014-09-09 | The George Washington University | Plume collimation for laser ablation electrospray ionization mass spectrometry |
| ES2467145T3 (es) * | 2011-07-18 | 2014-06-12 | Essilor International (Compagnie Générale d'Optique) | Máquina para revestir un artículo óptico con una composición de revestimiento antisuciedad y procedimiento para utilizar la máquina |
| EP4556010A3 (en) | 2011-11-30 | 2025-07-23 | Emory University | Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae |
| CA3085086C (en) | 2011-12-06 | 2023-08-08 | Delta Faucet Company | Ozone distribution in a faucet |
| US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| EA201892769A3 (ru) | 2013-03-15 | 2019-08-30 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Сложные диэфиры ациклических нуклеозидфосфонатов |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| RU2665135C2 (ru) | 2014-03-14 | 2018-08-28 | Олтек, Инк. | Композиции селеноорганических соединений и способы их применения |
| JPWO2016039403A1 (ja) * | 2014-09-11 | 2017-06-29 | 塩野義製薬株式会社 | 持続性hivプロテアーゼ阻害剤 |
| BR112017005111B1 (pt) | 2014-09-15 | 2023-02-14 | The Regents Of The University Of California | Compostos análogos de nucleotídeo acíclico, composição farmacêutica contendo tais compostos, e usos da composição no tratamento de uma infecção por papilomavírus |
| US9738664B2 (en) | 2014-10-29 | 2017-08-22 | Wisconsin Alumni Research Foundation | Boronic acid inhibitors of HIV protease |
| DK3236972T3 (en) | 2014-12-26 | 2021-10-04 | Univ Emory | Antivirale N4-hydroxycytidin-derivativer |
| WO2016187788A1 (en) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
| WO2017048956A1 (en) | 2015-09-15 | 2017-03-23 | The Regents Of The University Of California | Nucleotide analogs |
| WO2017048252A1 (en) | 2015-09-15 | 2017-03-23 | Alltech, Inc. | Compositions of selenoorganic compounds and methods of use thereof |
| EA201891066A1 (ru) | 2015-10-30 | 2018-10-31 | ЭнБиИ-ТЕРАПЬЮТИКС АГ | Антитела к ror1 |
| US10548910B2 (en) | 2015-11-17 | 2020-02-04 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors |
| CN108463437B (zh) | 2015-12-21 | 2022-07-08 | 德尔塔阀门公司 | 包括消毒装置的流体输送系统 |
| SG11201806120WA (en) | 2016-01-20 | 2018-08-30 | Scripps Research Inst | Ror1 antibody compositions and related methods |
| CN107709288A (zh) * | 2016-02-03 | 2018-02-16 | 四川海思科制药有限公司 | 一种磷酰胺衍生物及制备方法和用途 |
| CN106045874B (zh) * | 2016-05-20 | 2017-12-05 | 大连医科大学 | 二苯甲酮‐二酮酸类化合物,组合物及用途 |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| US10934312B2 (en) | 2016-12-02 | 2021-03-02 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as HIV integrase inhibitors |
| US11427613B2 (en) | 2017-03-16 | 2022-08-30 | Evolve Biologics Inc. | Method for purification of albumin |
| CN109305990B (zh) * | 2017-07-28 | 2021-02-26 | 四川海思科制药有限公司 | 一种磷酸衍生物及制备方法和用途 |
| CN109305989B (zh) * | 2017-07-28 | 2021-02-26 | 四川海思科制药有限公司 | 一种磷酰胺衍生物及制备方法和用途 |
| SI3661937T1 (sl) | 2017-08-01 | 2021-11-30 | Gilead Sciences, Inc. | Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb |
| EP3665193A1 (en) | 2017-08-07 | 2020-06-17 | NBE Therapeutics AG | Anthracycline-based antibody drug conjugates having high in vivo tolerability |
| JP6804790B1 (ja) | 2017-12-07 | 2020-12-23 | エモリー ユニバーシティー | N4−ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途 |
| US11542288B2 (en) * | 2020-06-01 | 2023-01-03 | University Of Massachusetts | Antiviral compounds |
| IL318465A (en) | 2022-07-21 | 2025-03-01 | Antiva Biosciences Inc | Compositions and dosage forms for the treatment of HPV infection and HPV-induced neoplasia |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE63869B1 (en) | 1986-11-06 | 1995-06-14 | Res Dev Foundation | Aerosols containing liposomes and method for their preparation |
| FR2611203B1 (fr) | 1987-02-20 | 1989-06-09 | Sturtz Georges | Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5631370A (en) | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
| DE4003574A1 (de) | 1990-02-07 | 1991-08-08 | Bayer Ag | Neue dipeptide, verfahren zu ihrer herstellung und ihre verwendung als renininhibitoren in arzneimitteln |
| ATE131825T1 (de) | 1990-06-13 | 1996-01-15 | Arnold Glazier | Phosphorylierte prodrugs |
| EP0465297B1 (en) | 1990-07-04 | 1996-01-31 | Merrell Dow Pharmaceuticals Inc. | 9-Purinyl phosphonic acid derivatives |
| US5177064A (en) | 1990-07-13 | 1993-01-05 | University Of Florida | Targeted drug delivery via phosphonate derivatives |
| DE4111730A1 (de) | 1991-04-10 | 1992-10-15 | Knoll Ag | Neue cytarabin-derivate, ihre herstellung und verwendung |
| EP0531597A1 (en) | 1991-09-12 | 1993-03-17 | Merrell Dow Pharmaceuticals Inc. | Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine |
| US5610294A (en) | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| GB9126144D0 (en) | 1991-12-10 | 1992-02-12 | British Bio Technology | Compounds |
| FR2692265B1 (fr) | 1992-05-25 | 1996-11-08 | Centre Nat Rech Scient | Composes biologiquement actifs de type phosphotriesters. |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| ATE199906T1 (de) | 1993-06-29 | 2001-04-15 | Mitsubishi Chem Corp | Phosphonat-nukleotid ester-derivate |
| WO1995002582A1 (en) | 1993-07-14 | 1995-01-26 | Ciba-Geigy Ag | Cyclic hydrazine compounds |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| US5854227A (en) | 1994-03-04 | 1998-12-29 | Hartmann; John F. | Therapeutic derivatives of diphosphonates |
| RU2157368C2 (ru) | 1994-09-26 | 2000-10-10 | Сионоги Энд Ко., Лтд. | Производные имидазола и фармацевтическая композиция на их основе |
| WO1996014314A2 (en) * | 1994-11-04 | 1996-05-17 | Gilead Sciences, Inc. | Thiepane compounds inhibiting and detecting hiv protease |
| US5705524A (en) * | 1994-11-04 | 1998-01-06 | Gilead Sciences, Inc. | Thiepane compounds |
| US5750493A (en) * | 1995-08-30 | 1998-05-12 | Raymond F. Schinazi | Method to improve the biological and antiviral activity of protease inhibitors |
| EP0852233A4 (en) | 1995-09-21 | 1999-09-15 | Nippon Shinyaku Co Ltd | CYCLOSPORIN PHOSPHATE DERIVATIVES AND MEDICINAL COMPOSITION |
| US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5874577A (en) | 1996-04-03 | 1999-02-23 | Medichem Research, Inc. | Method for the preparing 9-12-(Diethoxyphosphonomethoxy)ethyl!adenine and analogues thereof |
| CA2261619C (en) | 1996-07-26 | 2006-05-23 | Gilead Sciences, Inc. | Nucleotide analogs |
| US6194398B1 (en) | 1996-08-13 | 2001-02-27 | Mitsubishi Chemical Corporation | Phosphonate nucleotide compound |
| EP0948341A4 (en) | 1996-09-17 | 2003-05-21 | Supergen Inc | DERIVATIVES OF PHOSPHOLIPIDE MEDICINES |
| EE200000386A (et) * | 1997-12-24 | 2001-12-17 | Vertex Pharmaceuticals Incorporated | Aspartüülproteaasi inhibiitorite eelravimid |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| AU4125099A (en) | 1998-06-01 | 1999-12-20 | S & T Science And Technology Inc. | Antiviral phosphorus derivatives of 4'-thio-5-ethyl-2'-deoxyuridine |
| GB9815567D0 (en) * | 1998-07-18 | 1998-09-16 | Glaxo Group Ltd | Antiviral compound |
| TWI260322B (en) * | 1999-02-12 | 2006-08-21 | Vertex Pharma | Inhibitors of aspartyl protease |
| US6258831B1 (en) * | 1999-03-31 | 2001-07-10 | The Procter & Gamble Company | Viral treatment |
| AR031520A1 (es) * | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
| CA2381425A1 (en) | 1999-08-24 | 2001-03-01 | Cellgate, Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
| GB9920872D0 (en) * | 1999-09-04 | 1999-11-10 | Glaxo Group Ltd | Benzophenones as inhibitors of reverse transcriptase |
| IL131887A0 (en) | 1999-09-14 | 2001-03-19 | Dpharm Ltd | Phospholipid prodrugs of anti-proliferative drugs |
| DE60038038T2 (de) * | 1999-12-03 | 2009-02-12 | The Regents of The University of California at San Diego, La Jolla | Phosphonatverbindungen |
| WO2001046204A1 (en) | 1999-12-22 | 2001-06-28 | Merck Frosst Canada & Co. | Aromatic phosphonates as protein tyrosine phosphatase 1b (ptp-1b) inhibitors |
| WO2001064693A1 (fr) | 2000-02-29 | 2001-09-07 | Mitsubishi Pharma Corporation | Compose de nucleotide de phosphonate |
| IL153363A0 (en) | 2000-06-13 | 2003-07-06 | Shionogi & Co | Pharmaceutical compositions containing propenone derivatives |
| FR2810322B1 (fr) * | 2000-06-14 | 2006-11-10 | Pasteur Institut | PRODUCTION COMBINATOIRE D'ANALOGUES DE NUCLEOTIDES ET NUCLEOTIDES (XiTP) |
| UA72612C2 (en) * | 2000-07-06 | 2005-03-15 | Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells | |
| US6617310B2 (en) | 2000-07-19 | 2003-09-09 | Bristol-Myers Squibb Pharma Company | Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines |
| CZ304734B6 (cs) | 2000-07-21 | 2014-09-10 | Gilead Sciences, Inc. | Způsob přípravy 9-[2-(fosfonomethoxy)propyl]adeninu a 9-[2-(fosfonomethoxy)ethyl]adeninu |
| US6420586B1 (en) * | 2000-08-15 | 2002-07-16 | University Of Kansas | Amino acid-derived cyclic phosphonamides and methods of synthesizing the same |
| WO2002057425A2 (en) | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| GB0114286D0 (en) | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| ATE371026T1 (de) * | 2001-06-20 | 2007-09-15 | Nuevolution As | Eine methode zur synthese von matrizenabhängigen molekülen |
| KR20020097384A (ko) | 2001-06-20 | 2002-12-31 | 미쯔비시 도꾜 세이야꾸 가부시끼가이샤 | 기존의 약제에 내성변이를 가지는 바이러스에 유효한 약제 |
| WO2003028737A1 (en) | 2001-08-30 | 2003-04-10 | Mitsubishi Pharma Corporation | Anti-viral agents and in-vitro method for the identification of candidates able to inhibit binding of polymerase to epsilon |
| AU2002343556A1 (en) | 2001-12-07 | 2003-06-23 | Eli Lilly And Company | Use of phosphonate nucleotide analogue for treating hepatitis b virus infections |
| KR101016969B1 (ko) | 2001-12-21 | 2011-02-25 | 에이자이 아이엔씨. | 알콜 및 페놀의 수용성 포스포노옥시메틸 유도체를제조하는 방법 |
| JP4547911B2 (ja) | 2002-02-01 | 2010-09-22 | アリアド・ファーマシューティカルズ・インコーポレイテッド | リン含有化合物およびその用途 |
| EP1472230B1 (en) | 2002-02-08 | 2009-06-17 | Conforma Therapeutic Corporation | Ansamycins having improved pharmacological and biological properties |
| WO2003080078A1 (en) | 2002-03-18 | 2003-10-02 | Mitsubishi Pharma Corporation | Treatment of pre-core hepatitis b virus mutant infections |
| AU2003231765B9 (en) * | 2002-04-26 | 2010-01-28 | Gilead Sciences, Inc. | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such |
| US20050239054A1 (en) * | 2002-04-26 | 2005-10-27 | Arimilli Murty N | Method and compositions for identifying anti-HIV therapeutic compounds |
| EA012844B1 (ru) | 2003-02-19 | 2009-12-30 | Йельский Университет | Аналоги противовирусных нуклеозидов и способы лечения вирусных инфекций, в частности вич-инфекций |
| MXPA05011296A (es) | 2003-04-25 | 2006-01-24 | Gilead Sciences Inc | Conjugados de fosfonato inhibidores de la cinasa. |
-
2003
- 2003-04-25 AU AU2003231765A patent/AU2003231765B9/en not_active Expired
- 2003-04-25 HR HR20041114A patent/HRP20041114A2/hr not_active Application Discontinuation
- 2003-04-25 JP JP2003587329A patent/JP4942915B2/ja not_active Expired - Lifetime
- 2003-04-25 DK DK03747326T patent/DK1509537T3/da active
- 2003-04-25 IL IL16449103A patent/IL164491A0/xx unknown
- 2003-04-25 PL PL03374522A patent/PL374522A1/xx unknown
- 2003-04-25 CN CNB03814963XA patent/CN1313472C/zh not_active Expired - Lifetime
- 2003-04-25 AT AT03747326T patent/ATE367394T1/de active
- 2003-04-25 EP EP03747327A patent/EP1501841A2/en not_active Withdrawn
- 2003-04-25 KR KR1020047017227A patent/KR100987815B1/ko not_active Expired - Lifetime
- 2003-04-25 BR BR0309557-6A patent/BR0309557A/pt not_active IP Right Cessation
- 2003-04-25 CA CA002481285A patent/CA2481285A1/en not_active Abandoned
- 2003-04-25 US US10/423,496 patent/US7649015B2/en active Active
- 2003-04-25 US US10/511,183 patent/US20060115815A1/en not_active Abandoned
- 2003-04-25 JP JP2003587330A patent/JP2006508634A/ja active Pending
- 2003-04-25 EA EA200401437A patent/EA200401437A1/ru unknown
- 2003-04-25 US US10/424,186 patent/US20040121316A1/en not_active Abandoned
- 2003-04-25 EA EA200401436A patent/EA008775B1/ru not_active IP Right Cessation
- 2003-04-25 EP EP03747326A patent/EP1509537B9/en not_active Expired - Lifetime
- 2003-04-25 AU AU2003228707A patent/AU2003228707A1/en not_active Abandoned
- 2003-04-25 CN CNA2007100857467A patent/CN101074242A/zh active Pending
- 2003-04-25 MX MXPA04010527A patent/MXPA04010527A/es active IP Right Grant
- 2003-04-25 PL PL374968A patent/PL211979B1/pl unknown
- 2003-04-25 US US10/511,998 patent/US20070010489A1/en not_active Abandoned
- 2003-04-25 AU AU2003231766A patent/AU2003231766A1/en not_active Abandoned
- 2003-04-25 MX MXPA04010528A patent/MXPA04010528A/es not_active Application Discontinuation
- 2003-04-25 CN CNA2006101542031A patent/CN101041669A/zh active Pending
- 2003-04-25 UA UA20041109372A patent/UA80819C2/uk unknown
- 2003-04-25 WO PCT/US2003/012901 patent/WO2003090690A2/en not_active Ceased
- 2003-04-25 WO PCT/US2003/012926 patent/WO2003091264A2/en not_active Ceased
- 2003-04-25 US US10/424,130 patent/US7462608B2/en not_active Expired - Lifetime
- 2003-04-25 EP EP03726472A patent/EP1575486A4/en not_active Withdrawn
- 2003-04-25 TW TW092109755A patent/TW200408645A/zh unknown
- 2003-04-25 KR KR10-2004-7017134A patent/KR20040108756A/ko not_active Withdrawn
- 2003-04-25 CA CA002481449A patent/CA2481449A1/en not_active Abandoned
- 2003-04-25 CN CNA038124785A patent/CN1656109A/zh active Pending
- 2003-04-25 DE DE60315023T patent/DE60315023T2/de not_active Expired - Lifetime
- 2003-04-25 TW TW092109753A patent/TWI332956B/zh not_active IP Right Cessation
- 2003-04-25 HR HR20041113A patent/HRP20041113B1/xx not_active IP Right Cessation
- 2003-04-25 BR BR0309573-8A patent/BR0309573A/pt not_active IP Right Cessation
- 2003-04-25 SI SI200330953T patent/SI1509537T1/sl unknown
- 2003-04-25 US US10/511,182 patent/US20060128692A1/en not_active Abandoned
- 2003-04-25 JP JP2003587822A patent/JP2005523922A/ja active Pending
- 2003-04-25 WO PCT/US2003/012943 patent/WO2003090691A2/en not_active Ceased
- 2003-04-25 PT PT03747326T patent/PT1509537E/pt unknown
- 2003-04-25 NZ NZ535828A patent/NZ535828A/en not_active IP Right Cessation
- 2003-04-25 CA CA2481261A patent/CA2481261C/en not_active Expired - Lifetime
- 2003-04-25 ES ES03747326T patent/ES2290485T3/es not_active Expired - Lifetime
- 2003-11-06 EP EP03767521A patent/EP1620445A2/en not_active Withdrawn
- 2003-11-06 US US10/554,287 patent/US20070190523A1/en not_active Abandoned
- 2003-11-06 JP JP2004571244A patent/JP2006524487A/ja active Pending
- 2003-11-06 WO PCT/EP2003/012423 patent/WO2004096818A2/en not_active Ceased
- 2003-11-06 AU AU2003291998A patent/AU2003291998A1/en not_active Abandoned
-
2004
- 2004-10-11 IL IL164490A patent/IL164490A/en active IP Right Grant
- 2004-11-22 ZA ZA200409377A patent/ZA200409377B/en unknown
- 2004-11-22 ZA ZA2004/09376A patent/ZA200409376B/en unknown
- 2004-11-25 IS IS7555A patent/IS7555A/is unknown
- 2004-11-25 IS IS7556A patent/IS2714B/is unknown
- 2004-11-25 NO NO20045152A patent/NO20045152L/no not_active Application Discontinuation
- 2004-11-25 NO NO20045150A patent/NO336469B1/no not_active IP Right Cessation
-
2007
- 2007-10-15 CY CY20071101320T patent/CY1108036T1/el unknown
-
2009
- 2009-03-05 JP JP2009052719A patent/JP2009112319A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006524487A5 (https=) | ||
| JP2007515184A5 (https=) | ||
| Siddiqui et al. | The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: a structure− activity relationship | |
| Pickett et al. | Initiation of phospholipase A2 activity in human platelets by the calcium ion ionophore A23187 | |
| Chakraborti | Phospholipase A2 isoforms: a perspective | |
| Fraczek et al. | Toxicological and metabolic considerations for histone deacetylase inhibitors | |
| Chateau et al. | Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice | |
| Ray et al. | Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent | |
| GT199800113A (es) | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. | |
| Rhein et al. | Ebola virus entry into host cells: identifying therapeutic strategies | |
| Gobec et al. | Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall | |
| Al-Jafari et al. | Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: Phenserine | |
| Frankel et al. | Diminished efficiency of HIV-1 reverse transcriptase containing the K65R and M184V drug resistance mutations | |
| Garrard et al. | Inhibition of trypanothione reductase by substrate analogues | |
| Barry et al. | ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor | |
| Marchand et al. | Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir | |
| Gambero et al. | Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2 | |
| Sharma et al. | Recent advances towards identification of new drug targets for Mycobacterium tuberculosis | |
| CA2550157C (en) | Compositions and methods for modulating sirtuin activity | |
| PE68199A1 (es) | Composicion farmaceutica de residencia gastrica | |
| Ryan et al. | Synthesis, Structure− Activity Relationships, and the Effect of Polyethylene Glycol on Inhibitors of Phosphatidylinositol-Specific Phospholipase C from Bacillus cereus | |
| Rosowsky et al. | Synthesis and in vitro activity of long-chain 5 ‘-O-[(Alkoxycarbonyl) phosphinyl]-3 ‘-azido-3 ‘-deoxythymidines against wild-type and AZT-and foscarnet-resistant strains of HIV-1 | |
| Chu et al. | Anti-HIV Activity of (−)-(2 R, 4 R)-1-(2-Hydroxymethyl-1, 3-dioxolan-4-yl)-thymine against Drug-Resistant HIV-1 Mutants and Studies of Its Molecular Mechanism | |
| Fujikawa et al. | Extremely sensitive biomarker of acute organophosphorus insecticide exposure | |
| NO20043756L (no) | Testmidler for evaluering av farmakologisk effekt til medikamentet, og fremgangsmater og reagenser for screening av medikament som har god administreringseffekt og/eller lave bivirkninger |