|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4175122A
(en)
|
1975-04-15 |
1979-11-20 |
Burroughs Wellcome Co. |
Biologically active amides
|
|
US4223017A
(en)
|
1975-04-15 |
1980-09-16 |
Burroughs Wellcome Co. |
Biologically active amides
|
|
GB1560933A
(en)
|
1975-04-15 |
1980-02-13 |
Wellcome Found |
Biologically activy polypeptides
|
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
|
US4263428A
(en)
|
1978-03-24 |
1981-04-21 |
The Regents Of The University Of California |
Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
|
|
US4220653A
(en)
|
1979-01-24 |
1980-09-02 |
Vivino A Earl |
Administration of cimetidine to reduce appetite and facilitate weight loss in persons suffering from excessive weight
|
|
US4544546A
(en)
*
|
1980-04-21 |
1985-10-01 |
Abbott Laboratories |
Fluorescent nucleic acid stains
|
|
US4610794A
(en)
*
|
1980-10-14 |
1986-09-09 |
Shell Oil Company |
High current diversionary oil-boom
|
|
EP0052322B1
(de)
|
1980-11-10 |
1985-03-27 |
Gersonde, Klaus, Prof. Dr. |
Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens
|
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
|
SE430881B
(sv)
*
|
1981-02-20 |
1983-12-19 |
Lars Erik Trygg |
Flaskgripare
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
DE3374837D1
(en)
|
1982-02-17 |
1988-01-21 |
Ciba Geigy Ag |
Lipids in the aqueous phase
|
|
DE3218121A1
(de)
|
1982-05-14 |
1983-11-17 |
Leskovar, Peter, Dr.-Ing., 8000 München |
Arzneimittel zur tumorbehandlung
|
|
EP0102324A3
(de)
|
1982-07-29 |
1984-11-07 |
Ciba-Geigy Ag |
Lipide und Tenside in wässriger Phase
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
|
ATE159858T1
(de)
|
1983-09-26 |
1997-11-15 |
Ehrenfeld Udo |
Mittel und erzeugnis für die diagnose und therapie von tumoren sowie zur behandlung von schwächen der zelligen und humoralen immunabwehr
|
|
DE3474511D1
(en)
|
1983-11-01 |
1988-11-17 |
Terumo Corp |
Pharmaceutical composition containing urokinase
|
|
US4701441A
(en)
|
1985-02-11 |
1987-10-20 |
University Of Florida |
Methods and compositions for stimulation of appetite
|
|
US4698327A
(en)
|
1985-04-25 |
1987-10-06 |
Eli Lilly And Company |
Novel glycopeptide derivatives
|
|
CA1257199A
(en)
|
1986-05-20 |
1989-07-11 |
Paul Y. Wang |
Preparation containing bioactive macromolecular substance for multi-months release in vivo
|
|
HU196755B
(en)
|
1986-09-16 |
1989-01-30 |
Gyogyszerkutato Intezet |
Process for production of new substituated amilid derivatives and medical compositions containing them
|
|
IE63869B1
(en)
|
1986-11-06 |
1995-06-14 |
Res Dev Foundation |
Aerosols containing liposomes and method for their preparation
|
|
US5026685A
(en)
|
1988-07-15 |
1991-06-25 |
The Salk Institute For Biological Studies |
NPY peptide analogs
|
|
US5349052A
(en)
|
1988-10-20 |
1994-09-20 |
Royal Free Hospital School Of Medicine |
Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor
|
|
JP2989002B2
(ja)
|
1988-12-22 |
1999-12-13 |
キリン―アムジエン・インコーポレーテツド |
化学修飾顆粒球コロニー刺激因子
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
US6075181A
(en)
*
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
SE9002278L
(sv)
|
1990-06-28 |
1991-12-29 |
Perstorp Ab |
Anvaendning av inositoltrisfosfat foer framstaellning av ett laekemedel
|
|
IT1243390B
(it)
|
1990-11-22 |
1994-06-10 |
Vectorpharma Int |
Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
|
|
US5026665A
(en)
*
|
1990-12-24 |
1991-06-25 |
Motorola Inc. |
Semiconductor device electrode method
|
|
DK39892D0
(da)
|
1992-03-25 |
1992-03-25 |
Bernard Thorens |
Peptid
|
|
WO1994010220A1
(fr)
|
1992-10-28 |
1994-05-11 |
Kuraray Co., Ltd. |
Polyurethane et feuille en simili-cuir realisee a partir de celui-ci
|
|
JP2961045B2
(ja)
|
1993-02-24 |
1999-10-12 |
日清製粉株式会社 |
腸管粘膜増強促進剤
|
|
EP0692971A4
(en)
*
|
1993-03-29 |
1997-11-12 |
Univ Cincinnati |
PEPTID YY ANALOGS AND USES THEREFOR
|
|
AU7113594A
(en)
|
1993-06-21 |
1995-01-17 |
Enzon, Inc. |
Site specific synthesis of conjugated peptides
|
|
US6150141A
(en)
*
|
1993-09-10 |
2000-11-21 |
Trustees Of Boston University |
Intron-mediated recombinant techniques and reagents
|
|
US5880131A
(en)
|
1993-10-20 |
1999-03-09 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5965566A
(en)
|
1993-10-20 |
1999-10-12 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5545549A
(en)
|
1994-02-03 |
1996-08-13 |
Synaptic Pharmaceutical Corporation |
DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof
|
|
US5512549A
(en)
|
1994-10-18 |
1996-04-30 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
|
|
US5696093A
(en)
*
|
1994-10-28 |
1997-12-09 |
Crc For Biopharmaceutical Research Pty Limited |
Method of treating nasal congestion using neuropeptide Y Y2 agonist peptides
|
|
EP0791009A4
(en)
|
1994-11-07 |
2003-03-05 |
Merck & Co Inc |
Modified neuropeptide y receptors
|
|
EP0795562A4
(en)
|
1994-11-07 |
2000-08-09 |
Kyowa Hakko Kogyo Kk |
NEW OXYNTOMODULIN
|
|
US5574010A
(en)
|
1994-11-14 |
1996-11-12 |
The Regents Of The University Of California |
Treatment of pancreatic tumors with peptide YY and analogs thereof
|
|
US5602024A
(en)
|
1994-12-02 |
1997-02-11 |
Synaptic Pharmaceutical Corporation |
DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
|
|
US5989920A
(en)
|
1994-12-02 |
1999-11-23 |
Synaptic Pharmaceutical Corporation |
Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
|
|
US5907030A
(en)
|
1995-01-25 |
1999-05-25 |
University Of Southern California |
Method and compositions for lipidization of hydrophilic molecules
|
|
US5912227A
(en)
*
|
1995-01-27 |
1999-06-15 |
North Carolina State University |
Method of enhancing nutrient uptake
|
|
US5635503A
(en)
|
1995-06-07 |
1997-06-03 |
Bristol-Myers Squibb Company |
Dihydropyridine npy antagonists: piperazine derivatives
|
|
AU1328197A
(en)
|
1995-12-01 |
1997-06-19 |
Synaptic Pharmaceutical Corporation |
Aryl sulfonamide and sulfamide derivatives and uses thereof
|
|
PL189137B1
(pl)
|
1996-02-02 |
2005-06-30 |
Alza Corp |
Implantowane urządzenie do dostarczania substancji aktywnej
|
|
US5962270A
(en)
|
1996-02-06 |
1999-10-05 |
Bionebraska, Inc. |
Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
|
|
US5912229A
(en)
*
|
1996-03-01 |
1999-06-15 |
Novo Nordisk Als |
Use of a pharmaceutical composition comprising an appetite-suppressing peptide
|
|
US5965392A
(en)
|
1996-04-08 |
1999-10-12 |
Bayer Corporation |
Neuropeptide Y receptor Y5 and nucleic acid sequences
|
|
US5919901A
(en)
|
1996-04-08 |
1999-07-06 |
Bayer Corporation |
Neuropeptide Y receptor Y5 and nucleic acid sequences
|
|
US6254854B1
(en)
|
1996-05-24 |
2001-07-03 |
The Penn Research Foundation |
Porous particles for deep lung delivery
|
|
US6083692A
(en)
*
|
1996-06-03 |
2000-07-04 |
American Home Products Corporation |
Method of detecting the presence and measuring the quantity of biological polymers
|
|
US6355478B1
(en)
|
1996-06-17 |
2002-03-12 |
Eli Lilly And Company |
Rhesus monkey neuropeptide Y Y2 receptor
|
|
US6268343B1
(en)
|
1996-08-30 |
2001-07-31 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
US6458924B2
(en)
|
1996-08-30 |
2002-10-01 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
IL128332A0
(en)
*
|
1996-08-30 |
2000-01-31 |
Novo Nordisk As |
GLP-1 derivatives
|
|
UA65549C2
(uk)
*
|
1996-11-05 |
2004-04-15 |
Елі Ліллі Енд Компані |
Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
|
|
JP4798814B2
(ja)
*
|
1997-01-07 |
2011-10-19 |
アミリン・ファーマシューティカルズ，インコーポレイテッド |
食物摂取低減用のエキセンジンおよびそのアゴニストの使用
|
|
US6048900A
(en)
|
1998-02-13 |
2000-04-11 |
Bayer Corporation |
Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
|
|
US6001836A
(en)
|
1997-05-28 |
1999-12-14 |
Bristol-Myers Squibb Company |
Dihydropyridine NPY antagonists: cyanoguanidine derivatives
|
|
US5889016A
(en)
|
1997-06-26 |
1999-03-30 |
Bristol-Myers Squibb Company |
Dihydropyrimidone derivatives as NPY antagonists
|
|
US6266343B1
(en)
*
|
1997-07-22 |
2001-07-24 |
Nortel Networks Limited |
Telecommunications system
|
|
US6093692A
(en)
|
1997-09-25 |
2000-07-25 |
The University Of Southern California |
Method and compositions for lipidization of hydrophilic molecules
|
|
EP0920864A1
(en)
*
|
1997-12-03 |
1999-06-09 |
Pfizer Products Inc. |
Combination therapy including a specific beta-3 agonist and an anorectic agent
|
|
EP1520582A3
(en)
|
1998-02-02 |
2009-07-01 |
Trustees Of Tufts College |
Use of dipeptidylpetidase inhibitors to regulate glucose metabolism
|
|
FR2774674B1
(fr)
|
1998-02-10 |
2000-03-24 |
Atochem Elf Sa |
Procede de preparation d'une solution aqueuse de peroxyde d'hydrogene directement a partir d'hydrogene et d'oxygene et dispositif permettant sa mise en oeuvre
|
|
JP2002506792A
(ja)
|
1998-02-27 |
2002-03-05 |
ノボ ノルディスク アクティーゼルスカブ |
Ｎ末端修飾ｇｌｐ−１誘導体
|
|
US6046167A
(en)
|
1998-03-25 |
2000-04-04 |
University Of Cincinnati |
Peptide YY analogs
|
|
FR2777283B1
(fr)
*
|
1998-04-10 |
2000-11-24 |
Adir |
Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5993414A
(en)
|
1998-04-23 |
1999-11-30 |
Medtronic, Inc. |
Implantable device
|
|
DK1076644T3
(da)
|
1998-04-29 |
2004-08-30 |
Ortho Mcneil Pharm Inc |
N-Substituerede aminotetraliner som ligander for neutopeptid Y Y5-receptoren, der er nyttig til behandling af fedme og andre lidelser
|
|
DE69922676T2
(de)
|
1998-10-07 |
2005-12-15 |
Ortho-Mcneil Pharmaceutical, Inc. |
N-aralkylaminotetraline als neuropeptid-y-y5-rezeptorliganden
|
|
WO2000042026A1
(en)
|
1999-01-15 |
2000-07-20 |
Novo Nordisk A/S |
Non-peptide glp-1 agonists
|
|
US6737056B1
(en)
*
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US7396809B1
(en)
|
1999-02-10 |
2008-07-08 |
Curis, Inc. |
Methods and reagents for treating glucose metabolic disorders
|
|
US6407120B1
(en)
|
1999-02-18 |
2002-06-18 |
Pfizer Inc. |
Neuropeptide Y antagonists
|
|
EP1165519A1
(en)
|
1999-04-02 |
2002-01-02 |
Neurogen Corporation |
Aryl and heteroaryl fused aminoalkyl-imidazole derivatives and their use as antidiabetics
|
|
US6340683B1
(en)
|
1999-04-22 |
2002-01-22 |
Synaptic Pharmaceutical Corporation |
Selective NPY (Y5) antagonists (triazines)
|
|
US6218408B1
(en)
|
1999-06-30 |
2001-04-17 |
Synaptic Pharmaceutical Corporation |
Selective NPY (Y5) antagonists (bicyclics)
|
|
US7601691B2
(en)
|
1999-05-17 |
2009-10-13 |
Conjuchem Biotechnologies Inc. |
Anti-obesity agents
|
|
ATE372782T1
(de)
|
1999-06-21 |
2007-09-15 |
Lilly Co Eli |
Synergitische verwendung von thiazolidinedionen und glucagon-ähnlichem peptid-1 und dessen agonisten für die behandlung von nicht-insulin- abhängigen diabetes
|
|
US6225330B1
(en)
|
1999-06-30 |
2001-05-01 |
Synaptic Pharmaceutical Corporation |
Selective NPY (Y5) antagonists (tricyclics)
|
|
EP1076066A1
(en)
|
1999-07-12 |
2001-02-14 |
Zealand Pharmaceuticals A/S |
Peptides for lowering blood glucose levels
|
|
US6399631B1
(en)
|
1999-07-23 |
2002-06-04 |
Pfizer Inc. |
Carbazole neuropeptide Y5 antagonists
|
|
MXPA02000927A
(es)
|
1999-07-28 |
2003-07-14 |
Johnson & Johnson |
Amina y derivados de amida como ligandos para el receptor del neuropeptido y y5 utiles en el tratamiento de obesidad y otros trastornos.
|
|
CA2382528A1
(en)
*
|
1999-08-25 |
2001-03-01 |
Banyu Pharmaceutical Co., Ltd. |
Novel isoindole derivatives
|
|
AU6798000A
(en)
|
1999-08-26 |
2001-03-19 |
Viropharma Incorporated |
Compounds, compositions and methods for treating influenza
|
|
EP1206262A4
(en)
|
1999-08-26 |
2003-01-02 |
Bristol Myers Squibb Co |
Y NEUROPEPTID ANTAGONISTS: SPIROISOQUINOLINONE DERIVATIVES
|
|
JP2003510325A
(ja)
|
1999-09-30 |
2003-03-18 |
ニューロジェン・コーポレーション |
ある種のアルキレンジアミン−置換ピラゾロ［１，５−ａ］−１，５−ピリミジン及びピラゾロ［１，５−ａ］−１，３，５−トリアジン
|
|
EP1239871A1
(en)
|
1999-11-12 |
2002-09-18 |
Novo Nordisk A/S |
Use of glp-1 agonists for the inhibition of beta cell degeneration
|
|
US6436091B1
(en)
|
1999-11-16 |
2002-08-20 |
Microsolutions, Inc. |
Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
|
|
ES2311479T3
(es)
|
1999-11-26 |
2009-02-16 |
SHIONOGI & CO., LTD. |
Antagonistas de npy-y5.
|
|
WO2001066135A1
(en)
|
2000-03-08 |
2001-09-13 |
Novo Nordisk A/S |
Lowering serum lipids
|
|
IL142707A0
(en)
|
2000-04-27 |
2002-03-10 |
Pfizer Prod Inc |
Methods of treating obesity using a neurotensin receptor ligand
|
|
US6432960B2
(en)
|
2000-05-10 |
2002-08-13 |
Bristol-Myers Squibb Company |
Squarate derivatives of dihydropyridine NPY antagonists
|
|
US6444675B2
(en)
|
2000-05-10 |
2002-09-03 |
Bristol-Myers Squibb Company |
4-alkyl and 4-cycloalkyl derivatives of dihydropyridine NPY antagonists
|
|
US6391881B2
(en)
|
2000-05-19 |
2002-05-21 |
Bristol-Myers Squibb Company |
Thiourea derivatives of dihydropyridine NPY antagonists
|
|
WO2001089554A2
(en)
|
2000-05-19 |
2001-11-29 |
Bionebraska, Inc. |
Treatment of acute coronary syndrome with glp-1
|
|
PL365779A1
(en)
|
2000-07-06 |
2005-01-10 |
Metabasis Therapeutics, Inc. |
A combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes
|
|
US6586403B1
(en)
|
2000-07-20 |
2003-07-01 |
Salpep Biotechnology, Inc. |
Treating allergic reactions and inflammatory responses with tri-and dipeptides
|
|
US6900226B2
(en)
|
2000-09-06 |
2005-05-31 |
Hoffman-La Roche Inc. |
Neuropeptide Y antagonists
|
|
US20020156010A1
(en)
|
2000-11-20 |
2002-10-24 |
Lustig Robert H. |
Method of treating obesity in adult patients exhibiting primary insulin hypersecretion
|
|
PE20020574A1
(es)
*
|
2000-12-06 |
2002-07-02 |
Wyeth Corp |
Anticuerpos humanizados que reconocen el peptido amiloideo beta
|
|
CA2431800C
(en)
|
2000-12-14 |
2014-07-08 |
Amylin Pharmaceuticals, Inc. |
Peptide yy and peptide yy agonists for treatment of metabolic disorders
|
|
WO2002066479A1
(en)
|
2001-02-23 |
2002-08-29 |
Banyu Pharmaceutical Co.,Ltd. |
Novel isoindole derivatives
|
|
WO2002067918A1
(en)
|
2001-02-27 |
2002-09-06 |
Banyu Pharmaceutical Co., Ltd. |
Novel diallylmethylamine derivative
|
|
CA2454830C
(en)
|
2001-07-26 |
2010-02-02 |
Schering Corporation |
Substituted urea neuropeptide y y5 receptor antagonists
|
|
GB0121709D0
(en)
|
2001-09-07 |
2001-10-31 |
Imp College Innovations Ltd |
Food inhibition agent
|
|
BR0212985A
(pt)
|
2001-09-24 |
2005-08-30 |
Imp College Innovations Ltd |
Uso de pyy ou de um agonista do mesmo na preparação de medicamentos para tratamento de distúrbios associados com excesso de peso
|
|
US8058233B2
(en)
|
2002-01-10 |
2011-11-15 |
Oregon Health And Science University |
Modification of feeding behavior using PYY and GLP-1
|
|
US7166575B2
(en)
|
2002-12-17 |
2007-01-23 |
Nastech Pharmaceutical Company Inc. |
Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
|
|
GB0300571D0
(en)
|
2003-01-10 |
2003-02-12 |
Imp College Innovations Ltd |
Modification of feeding behaviour
|
|
CA2843439A1
(en)
|
2003-04-08 |
2004-10-21 |
Yeda Research And Development Co. Ltd |
Reversible pegylated drugs
|
|
CN1220702C
(zh)
|
2003-07-30 |
2005-09-28 |
北京中科亚光生物科技有限公司 |
促胰岛素分泌肽及其用途
|
|
AU2004266757A1
(en)
*
|
2003-08-21 |
2005-03-03 |
Novo Nordisk A/S |
Separation of polypeptides comprising a racemized amino acid
|
|
US20060205037A1
(en)
*
|
2003-08-28 |
2006-09-14 |
Homayoun Sadeghi |
Modified transferrin fusion proteins
|
|
WO2005035753A1
(ja)
*
|
2003-10-10 |
2005-04-21 |
Chugai Seiyaku Kabushiki Kaisha |
機能蛋白質を代替する二重特異性抗体
|
|
WO2005035761A1
(en)
|
2003-10-16 |
2005-04-21 |
Compugen Ltd. |
Splice variants of preproglucagon, glucagon-like peptide-1 and oxyntomodulin
|
|
BRPI0516572A
(pt)
*
|
2004-10-05 |
2008-09-16 |
Wyeth Corp |
métodos e composições para melhorar a produção de proteìnas recombinantes
|
|
GB0504857D0
(en)
|
2005-03-09 |
2005-04-13 |
Imp College Innovations Ltd |
Novel compounds and their effects on feeding behaviour
|
|
US8338368B2
(en)
|
2005-11-07 |
2012-12-25 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting physiological solubility and stability
|
|
WO2007100535A2
(en)
|
2006-02-22 |
2007-09-07 |
Merck & Co., Inc. |
Oxyntomodulin derivatives
|
|
BRPI0712383A2
(pt)
|
2006-06-07 |
2012-07-10 |
Human Genome Sciences Inc |
proteìnas de fusão da albumina
|
|
GB0613196D0
(en)
|
2006-07-03 |
2006-08-09 |
Imp Innovations Ltd |
Novel compounds and their effects on feeding behaviour
|
|
JP2010507387A
(ja)
*
|
2006-10-25 |
2010-03-11 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
新規のｓｉＲＮＡおよびその使用方法
|
|
TWI428346B
(zh)
|
2006-12-13 |
2014-03-01 |
Imp Innovations Ltd |
新穎化合物及其等對進食行為影響
|