JP2005511503A5 - 過剰体重を防止または治療するためのオキシントモジュリン - Google Patents
過剰体重を防止または治療するためのオキシントモジュリン Download PDFInfo
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- JP2005511503A5 JP2005511503A5 JP2003526432A JP2003526432A JP2005511503A5 JP 2005511503 A5 JP2005511503 A5 JP 2005511503A5 JP 2003526432 A JP2003526432 A JP 2003526432A JP 2003526432 A JP2003526432 A JP 2003526432A JP 2005511503 A5 JP2005511503 A5 JP 2005511503A5
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- oxyntomodulin
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- acid residues
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- 206010033307 Overweight Diseases 0.000 title claims 2
- 235000020825 overweight Nutrition 0.000 title claims 2
- 101800001388 Oxyntomodulin Proteins 0.000 claims description 16
- 102400000319 Oxyntomodulin Human genes 0.000 claims description 16
- PXZWGQLGAKCNKD-DPNMSELWSA-N MolPort-023-276-326 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 PXZWGQLGAKCNKD-DPNMSELWSA-N 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000004580 weight loss Effects 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 1
- 102000003743 Relaxin Human genes 0.000 claims 1
- 108090000103 Relaxin Proteins 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 230000000875 corresponding Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 150000002410 histidine derivatives Chemical class 0.000 claims 1
- 125000003372 histidine group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 101500013967 human Oxyntomodulin Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 235000018770 reduced food intake Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- SBMNPABNWKXNBJ-UHFFFAOYSA-N Serinyl-Lysine Chemical compound NCCCCC(C(O)=O)NC(=O)C(N)CO SBMNPABNWKXNBJ-UHFFFAOYSA-N 0.000 description 4
- HJCMDXDYPOUFDY-WHFBIAKZSA-N Ala-Gln Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O HJCMDXDYPOUFDY-WHFBIAKZSA-N 0.000 description 3
- NALWOULWGHTVDA-UWVGGRQHSA-N Asp-Tyr Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 NALWOULWGHTVDA-UWVGGRQHSA-N 0.000 description 3
- KRBMQYPTDYSENE-BQBZGAKWSA-N His-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CNC=N1 KRBMQYPTDYSENE-BQBZGAKWSA-N 0.000 description 3
- JMEWFDUAFKVAAT-UHFFFAOYSA-N Methionyl-Asparagine Chemical compound CSCCC(N)C(=O)NC(C(O)=O)CC(N)=O JMEWFDUAFKVAAT-UHFFFAOYSA-N 0.000 description 3
- IQHUITKNHOKGFC-MIMYLULJSA-N Thr-Phe Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 IQHUITKNHOKGFC-MIMYLULJSA-N 0.000 description 3
- 108010044940 alanylglutamine Proteins 0.000 description 3
- 108010068265 aspartyltyrosine Proteins 0.000 description 3
- 108010018006 histidylserine Proteins 0.000 description 3
- 108010080629 tryptophan-leucine Proteins 0.000 description 3
- IJYZHIOOBGIINM-WDSKDSINSA-N Arg-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCN=C(N)N IJYZHIOOBGIINM-WDSKDSINSA-N 0.000 description 2
- JSLGXODUIAFWCF-UHFFFAOYSA-N Arginyl-Asparagine Chemical compound NC(N)=NCCCC(N)C(=O)NC(CC(N)=O)C(O)=O JSLGXODUIAFWCF-UHFFFAOYSA-N 0.000 description 2
- YZQCXOFQZKCETR-UWVGGRQHSA-N Asp-Phe Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 YZQCXOFQZKCETR-UWVGGRQHSA-N 0.000 description 2
- JEFZIKRIDLHOIF-BYPYZUCNSA-N Gln-Gly Chemical compound NC(=O)CC[C@H](N)C(=O)NCC(O)=O JEFZIKRIDLHOIF-BYPYZUCNSA-N 0.000 description 2
- NFNVDJGXRFEYTK-YUMQZZPRSA-N Leu-Glu Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O NFNVDJGXRFEYTK-YUMQZZPRSA-N 0.000 description 2
- LYMVXFSTACVOLP-ZFWWWQNUSA-N Trp-Leu Chemical compound C1=CC=C2C(C[C@H]([NH3+])C(=O)N[C@@H](CC(C)C)C([O-])=O)=CNC2=C1 LYMVXFSTACVOLP-ZFWWWQNUSA-N 0.000 description 2
- XXDVDTMEVBYRPK-XPUUQOCRSA-N Val-Gln Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O XXDVDTMEVBYRPK-XPUUQOCRSA-N 0.000 description 2
- 108010069205 aspartyl-phenylalanine Proteins 0.000 description 2
- 108010078144 glutaminyl-glycine Proteins 0.000 description 2
- KXTAGESXNQEZKB-DZKIICNBSA-N (4S)-4-amino-5-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](C(C)C)C(O)=O)CC1=CC=CC=C1 KXTAGESXNQEZKB-DZKIICNBSA-N 0.000 description 1
- JQFZHHSQMKZLRU-IUCAKERBSA-N Arg-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCN=C(N)N JQFZHHSQMKZLRU-IUCAKERBSA-N 0.000 description 1
- QADCERNTBWTXFV-JSGCOSHPSA-N Arg-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CCCNC(N)=N)N)C(O)=O)=CNC2=C1 QADCERNTBWTXFV-JSGCOSHPSA-N 0.000 description 1
- MQLZLIYPFDIDMZ-UHFFFAOYSA-N Asparaginyl-Isoleucine Chemical compound CCC(C)C(C(O)=O)NC(=O)C(N)CC(N)=O MQLZLIYPFDIDMZ-UHFFFAOYSA-N 0.000 description 1
- QJMCHPGWFZZRID-UHFFFAOYSA-N Asparaginyl-Lysine Chemical compound NCCCCC(C(O)=O)NC(=O)C(N)CC(N)=O QJMCHPGWFZZRID-UHFFFAOYSA-N 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- LSPKYLAFTPBWIL-BYPYZUCNSA-N Glu-Gly Chemical compound OC(=O)CC[C@H](N)C(=O)NCC(O)=O LSPKYLAFTPBWIL-BYPYZUCNSA-N 0.000 description 1
- VYZAGTDAHUIRQA-WHFBIAKZSA-N L-alanyl-L-glutamic acid Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O VYZAGTDAHUIRQA-WHFBIAKZSA-N 0.000 description 1
- 241001417045 Lophius litulon Species 0.000 description 1
- GVUVRRPYYDHHGK-UHFFFAOYSA-N Prolyl-Threonine Chemical compound CC(O)C(C(O)=O)NC(=O)C1CCCN1 GVUVRRPYYDHHGK-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- LTFSLKWFMWZEBD-IMJSIDKUSA-N Ser-Asn Chemical compound OC[C@H](N)C(=O)N[C@H](C(O)=O)CC(N)=O LTFSLKWFMWZEBD-IMJSIDKUSA-N 0.000 description 1
- RZEQTVHJZCIUBT-UHFFFAOYSA-N Serinyl-Arginine Chemical compound OCC(N)C(=O)NC(C(O)=O)CCCNC(N)=N RZEQTVHJZCIUBT-UHFFFAOYSA-N 0.000 description 1
- HYLXOQURIOCKIH-VQVTYTSYSA-N Thr-Arg Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=N HYLXOQURIOCKIH-VQVTYTSYSA-N 0.000 description 1
- GXDLGHLJTHMDII-WISUUJSJSA-N Thr-Ser Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CO)C(O)=O GXDLGHLJTHMDII-WISUUJSJSA-N 0.000 description 1
- UQTNIFUCMBFWEJ-UHFFFAOYSA-N Threoninyl-Asparagine Chemical compound CC(O)C(N)C(=O)NC(C(O)=O)CC(N)=O UQTNIFUCMBFWEJ-UHFFFAOYSA-N 0.000 description 1
- YKRQRPFODDJQTC-UHFFFAOYSA-N Threoninyl-Lysine Chemical compound CC(O)C(N)C(=O)NC(C(O)=O)CCCCN YKRQRPFODDJQTC-UHFFFAOYSA-N 0.000 description 1
- AUEJLPRZGVVDNU-STQMWFEESA-N Tyr-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 AUEJLPRZGVVDNU-STQMWFEESA-N 0.000 description 1
- 108010062796 arginyllysine Proteins 0.000 description 1
- STKYPAFSDFAEPH-LURJTMIESA-N gly-val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)CN STKYPAFSDFAEPH-LURJTMIESA-N 0.000 description 1
- 108010051307 glycyl-glycyl-proline Proteins 0.000 description 1
- 108010089804 glycyl-threonine Proteins 0.000 description 1
- 108010037850 glycylvaline Proteins 0.000 description 1
- 108010051242 phenylalanylserine Proteins 0.000 description 1
- 108010078580 tyrosylleucine Proteins 0.000 description 1
Description
ＯＸＭ配列は、当業技術内でよく知られており、記録が残されている。本発明は、以下のＯＸＭヒト(human)配列（ラットおよびハムスターＯＸＭ配列と同じである）：
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Met Asn Thr Lys
Arg Asn Arg Asn Asn Ile Ala、
以下のＯＸＭアンコウ(angler fish)配列：
His Ser Glu Gly Thr Phe Ser Asn Asp Tyr
Ser Lys Tyr Leu Glu Asp Arg Lys Ala Gln
Glu Phe Val Arg Trp Leu Met Asn Asn Lys
Arg Ser Gly Val Ala Glu、
および、以下のウナギ(eel)ＯＸＭ配列：
His Ser Gln Gly Thr Phe Thr Asn Asp Tyr
Ser Lys Tyr Leu Glu Thr Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Met Asn Ser Lys
Arg Ser Gly Gly Pro Thr、
を特に含む、ここに列挙される全てのシーケンスに関する。
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr
Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Met Asn Thr Lys
Arg Asn Arg Asn Asn Ile Ala、
以下のＯＸＭアンコウ(angler fish)配列：
His Ser Glu Gly Thr Phe Ser Asn Asp Tyr
Ser Lys Tyr Leu Glu Asp Arg Lys Ala Gln
Glu Phe Val Arg Trp Leu Met Asn Asn Lys
Arg Ser Gly Val Ala Glu、
および、以下のウナギ(eel)ＯＸＭ配列：
His Ser Gln Gly Thr Phe Thr Asn Asp Tyr
Ser Lys Tyr Leu Glu Thr Arg Arg Ala Gln
Asp Phe Val Gln Trp Leu Met Asn Ser Lys
Arg Ser Gly Gly Pro Thr、
を特に含む、ここに列挙される全てのシーケンスに関する。
Claims (17)
- 哺乳動物の過剰体重の防止または治療における使用のための医薬の製造のためのオキシントモジュリンの使用。
- 前記過剰体重は、肥満であることを特徴とする、請求項１に記載の使用。
- 前記オキシントモジュリンは、ヒトオキシントモジュリンであることを特徴とする、請求項１または２に記載の使用。
- 前記オキシントモジュリンは、その類似体であり、この類似体は、１位にあるヒスチジン残基が、維持されているか、あるいは、正電荷を有する芳香族部分によってまたはヒスチジン誘導体によって置換されており、さらにこの類似体は、
（ｉ） いずれか１つまたは２２個までの複数の他のα−アミノ酸残基が、任意の他のα−アミノ酸残基、アミノ酸の修飾または異性形態、あるいは、その側鎖を介して結合された対応するまたは異なるアミノ酸、によって独立して置換されること、
（ｉｉ） １、２、３、４、または５個のアミノ酸残基が、ＯＸＭ配列から除去されること、および
（ｉｉｉ） ＯＸＭ配列のＣ末端が、さらなるアミノ酸残基または他の部分の付加により修飾されること、
のうちの少なくとも１つが行われていることを特徴とする、請求項１〜３のいずれか１つに記載の使用。 - 前記オキシントモジュリンは、塩の形態であるか、１つまたは複数の群に複合化されているか、化学的に修飾されているか、あるいは、金属の存在下に提供されることを特徴とする、請求項１〜４のいずれか１つに記載の使用。
- 前記医薬は、経口、非経口、粘膜、直腸、皮下、または経皮投与に適した形態であることを特徴とする、請求項１〜５のいずれか１つに記載の使用。
- 前記医薬は、吸入による投与、あるいは、口腔、舌下、または鼻腔投与に適した形態であることを特徴とする、請求項６記載の使用。
- 前記哺乳動物は、ヒトであることを特徴とする、請求項１〜７のいずれか１つに記載の使用。
- オキシントモジュリンを含む組成物を哺乳動物に投与することを含むことを特徴とする、哺乳動物の美容用体重減少のための方法。
- 前記オキシントモジュリンは、請求項３〜５のいずれか１つに記載されていることを特徴とする、請求項９記載の方法。
- 前記組成物は、請求項６または７に記載されていることを特徴とする、請求項９または１０に記載の方法。
- 前記哺乳動物は、ヒトであることを特徴とする、請求項９〜１１のいずれか１つに記載の方法。
- 前記体重減少は、減少された食物摂取の結果であることを特徴とする、請求項９〜１２のいずれか１つに記載の方法。
- 哺乳動物の過剰体重の防止または治療における使用のためのオキシントモジュリン。
- 前記オキシントモジュリンは、請求項３〜５のいずれか１つに記載されていることを特徴とする、請求項１４記載のオキシントモジュリン。
- 前記組成物は、請求項６または７に記載されていることを特徴とする、請求項１４または１５に記載のオキシントモジュリン。
- 前記哺乳動物は、ヒトであることを特徴とする、請求項１４〜１７のいずれか１つに記載のオキシントモジュリン。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0121709.0 | 2001-09-07 | ||
| GBGB0121709.0A GB0121709D0 (en) | 2001-09-07 | 2001-09-07 | Food inhibition agent |
| PCT/GB2002/004082 WO2003022304A1 (en) | 2001-09-07 | 2002-09-09 | Oxynthomodulin for preventing or treating excess weight |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009114118A Division JP5792925B2 (ja) | 2001-09-07 | 2009-05-11 | 過剰体重を防止または治療するためのオキシンソモジュリン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005511503A JP2005511503A (ja) | 2005-04-28 |
| JP2005511503A5 true JP2005511503A5 (ja) | 2006-01-05 |
| JP4980554B2 JP4980554B2 (ja) | 2012-07-18 |
Family
ID=9921723
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003526432A Expired - Fee Related JP4980554B2 (ja) | 2001-09-07 | 2002-09-09 | 過剰体重を防止または治療するためのオキシントモジュリン |
| JP2009114118A Expired - Fee Related JP5792925B2 (ja) | 2001-09-07 | 2009-05-11 | 過剰体重を防止または治療するためのオキシンソモジュリン |
| JP2013098484A Pending JP2013151562A (ja) | 2001-09-07 | 2013-05-08 | 過剰体重を防止または治療するためのオキシンソモジュリン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009114118A Expired - Fee Related JP5792925B2 (ja) | 2001-09-07 | 2009-05-11 | 過剰体重を防止または治療するためのオキシンソモジュリン |
| JP2013098484A Pending JP2013151562A (ja) | 2001-09-07 | 2013-05-08 | 過剰体重を防止または治療するためのオキシンソモジュリン |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7666835B2 (ja) |
| EP (2) | EP1427437B1 (ja) |
| JP (3) | JP4980554B2 (ja) |
| KR (2) | KR100925017B1 (ja) |
| CN (2) | CN101057968B (ja) |
| AU (1) | AU2002324155B2 (ja) |
| BR (1) | BR0212374A (ja) |
| CA (1) | CA2459862C (ja) |
| DK (1) | DK1427437T3 (ja) |
| ES (1) | ES2399741T3 (ja) |
| GB (1) | GB0121709D0 (ja) |
| HK (1) | HK1066471A1 (ja) |
| HU (1) | HUP0501116A3 (ja) |
| IL (2) | IL160713A0 (ja) |
| MX (1) | MXPA04002142A (ja) |
| NZ (1) | NZ531609A (ja) |
| PL (1) | PL367274A1 (ja) |
| RU (1) | RU2351359C2 (ja) |
| WO (1) | WO2003022304A1 (ja) |
| ZA (1) | ZA200401804B (ja) |
Families Citing this family (167)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| GB0121709D0 (en) * | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
| MXPA04002751A (es) | 2001-09-24 | 2005-09-08 | Univ Oregon Health & Science | Modificacion del comportamiento de alimentacion. |
| US8058233B2 (en) * | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| DE60318938T2 (de) | 2002-03-20 | 2009-01-22 | Mannkind Corp., Valencia | Inhalationsgerät |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| GB0300571D0 (en) * | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
| WO2005035761A1 (en) * | 2003-10-16 | 2005-04-21 | Compugen Ltd. | Splice variants of preproglucagon, glucagon-like peptide-1 and oxyntomodulin |
| JP4865565B2 (ja) | 2003-12-09 | 2012-02-01 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アゴニストを用いた食物選択の制御 |
| BRPI0507594A (pt) | 2004-02-11 | 2007-07-03 | Amylin Pharmaceuticals Inc | polipetìdeos hìbridos com propriedades selecionáveis |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| EP2316446A1 (en) | 2004-06-11 | 2011-05-04 | Novo Nordisk A/S | Counteracting drug-induced obesity using GLP-1 agonists |
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2002
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- 2002-09-09 DK DK02758573.6T patent/DK1427437T3/da active
- 2002-09-09 US US10/488,341 patent/US7666835B2/en not_active Expired - Fee Related
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- 2002-09-09 MX MXPA04002142A patent/MXPA04002142A/es active IP Right Grant
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- 2002-09-09 PL PL02367274A patent/PL367274A1/xx unknown
- 2002-09-09 ES ES02758573T patent/ES2399741T3/es not_active Expired - Lifetime
- 2002-09-09 EP EP02758573A patent/EP1427437B1/en not_active Revoked
- 2002-09-09 IL IL16071302A patent/IL160713A0/xx unknown
- 2002-09-09 EP EP10186109A patent/EP2343082A1/en not_active Withdrawn
- 2002-09-09 BR BR0212374-6A patent/BR0212374A/pt not_active IP Right Cessation
- 2002-09-09 KR KR1020047003458A patent/KR100925017B1/ko not_active IP Right Cessation
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- 2002-09-09 KR KR1020097015843A patent/KR20090089918A/ko not_active Application Discontinuation
- 2002-09-09 RU RU2004110726/15A patent/RU2351359C2/ru not_active IP Right Cessation
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- 2010-01-29 US US12/696,493 patent/US20110034374A1/en not_active Abandoned
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