JP2006500393A5 - - Google Patents
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- JP2006500393A5 JP2006500393A5 JP2004534697A JP2004534697A JP2006500393A5 JP 2006500393 A5 JP2006500393 A5 JP 2006500393A5 JP 2004534697 A JP2004534697 A JP 2004534697A JP 2004534697 A JP2004534697 A JP 2004534697A JP 2006500393 A5 JP2006500393 A5 JP 2006500393A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- hydroxy
- methyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 hydroxy, carboxy Chemical group 0.000 claims 352
- 125000000217 alkyl group Chemical group 0.000 claims 239
- 125000001072 heteroaryl group Chemical group 0.000 claims 55
- 125000003545 alkoxy group Chemical group 0.000 claims 51
- 125000003118 aryl group Chemical group 0.000 claims 51
- 125000001424 substituent group Chemical group 0.000 claims 45
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 38
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 32
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 32
- 125000004093 cyano group Chemical group *C#N 0.000 claims 31
- 229910052736 halogen Inorganic materials 0.000 claims 30
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 28
- 150000002367 halogens Chemical class 0.000 claims 28
- 229910052739 hydrogen Inorganic materials 0.000 claims 28
- 239000001257 hydrogen Substances 0.000 claims 28
- 125000000753 cycloalkyl group Chemical group 0.000 claims 27
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 24
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 22
- 125000004452 carbocyclyl group Chemical group 0.000 claims 21
- 150000002431 hydrogen Chemical class 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- 229910052757 nitrogen Inorganic materials 0.000 claims 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000003342 alkenyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 125000001153 fluoro group Chemical group F* 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 8
- 208000002193 Pain Diseases 0.000 claims 8
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 8
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 8
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 8
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 7
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 5
- 125000006509 3,4-difluorobenzyl group Chemical group [H]C1=C(F)C(F)=C([H])C(=C1[H])C([H])([H])* 0.000 claims 5
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 239000011737 fluorine Chemical group 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 5
- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 208000019901 Anxiety disease Diseases 0.000 claims 4
- 208000020925 Bipolar disease Diseases 0.000 claims 4
- 208000000094 Chronic Pain Diseases 0.000 claims 4
- 206010011224 Cough Diseases 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 4
- 208000030814 Eating disease Diseases 0.000 claims 4
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 4
- 206010020772 Hypertension Diseases 0.000 claims 4
- 206010026749 Mania Diseases 0.000 claims 4
- 208000019695 Migraine disease Diseases 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 4
- 208000028017 Psychotic disease Diseases 0.000 claims 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 4
- 206010046543 Urinary incontinence Diseases 0.000 claims 4
- 208000005298 acute pain Diseases 0.000 claims 4
- 230000001919 adrenal effect Effects 0.000 claims 4
- 230000036506 anxiety Effects 0.000 claims 4
- 206010003119 arrhythmia Diseases 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- 208000028683 bipolar I disease Diseases 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 235000014632 disordered eating Nutrition 0.000 claims 4
- 230000004064 dysfunction Effects 0.000 claims 4
- 206010015037 epilepsy Diseases 0.000 claims 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 4
- 206010027599 migraine Diseases 0.000 claims 4
- 230000036651 mood Effects 0.000 claims 4
- 208000004296 neuralgia Diseases 0.000 claims 4
- 208000021722 neuropathic pain Diseases 0.000 claims 4
- 235000020824 obesity Nutrition 0.000 claims 4
- 201000000980 schizophrenia Diseases 0.000 claims 4
- 208000011117 substance-related disease Diseases 0.000 claims 4
- 125000004605 1,2,3,4-tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 3
- 125000006507 2,4-difluorobenzyl group Chemical group [H]C1=C(F)C([H])=C(F)C(=C1[H])C([H])([H])* 0.000 claims 3
- ZYHQGITXIJDDKC-UHFFFAOYSA-N 2-[2-(2-aminophenyl)ethyl]aniline Chemical group NC1=CC=CC=C1CCC1=CC=CC=C1N ZYHQGITXIJDDKC-UHFFFAOYSA-N 0.000 claims 3
- 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000002927 2-methoxybenzyl group Chemical group [H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000006479 2-pyridyl methyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000006494 2-trifluoromethyl benzyl group Chemical group [H]C1=C([H])C([H])=C(C(=C1[H])C([H])([H])*)C(F)(F)F 0.000 claims 3
- 125000005806 3,4,5-trimethoxybenzyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])* 0.000 claims 3
- 125000006512 3,4-dichlorobenzyl group Chemical group [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C([H])([H])* 0.000 claims 3
- 125000002774 3,4-dimethoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000006279 3-bromobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(Br)=C1[H])C([H])([H])* 0.000 claims 3
- 125000006284 3-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(F)=C1[H])C([H])([H])* 0.000 claims 3
- 125000006482 3-iodobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(I)=C1[H])C([H])([H])* 0.000 claims 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000006495 3-trifluoromethyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])*)C(F)(F)F 0.000 claims 3
- 125000006281 4-bromobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Br)C([H])([H])* 0.000 claims 3
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims 3
- WNWVKZTYMQWFHE-UHFFFAOYSA-N 4-ethylmorpholine Chemical group [CH2]CN1CCOCC1 WNWVKZTYMQWFHE-UHFFFAOYSA-N 0.000 claims 3
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims 3
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 125000000173 4-trifluoromethoxy benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)C([H])([H])* 0.000 claims 3
- 125000001318 4-trifluoromethylbenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])*)C(F)(F)F 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 230000007370 cognitive improvement Effects 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 230000006993 memory improvement Effects 0.000 claims 3
- 125000005322 morpholin-1-yl group Chemical group 0.000 claims 3
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 claims 3
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 3
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 3
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 230000006641 stabilisation Effects 0.000 claims 3
- 238000011105 stabilization Methods 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 2
- 125000006280 2-bromobenzyl group Chemical group [H]C1=C([H])C(Br)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000003852 3-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])* 0.000 claims 2
- 125000006497 3-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000006180 3-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 206010013654 Drug abuse Diseases 0.000 claims 2
- DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 2
- 108010020615 nociceptin receptor Proteins 0.000 claims 2
- 201000009032 substance abuse Diseases 0.000 claims 2
- 231100000736 substance abuse Toxicity 0.000 claims 2
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- OYGRPMXMTBVAQE-MUUNZHRXSA-N 1-(4-fluorophenyl)-3-[(2r)-2-hydroxy-3-(3-hydroxypropylamino)propyl]-8-[(8-methylnaphthalen-1-yl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C=12C(C)=CC=CC2=CC=CC=1CN(CC1)CCC1(C(N(C[C@H](O)CNCCCO)C1)=O)N1C1=CC=C(F)C=C1 OYGRPMXMTBVAQE-MUUNZHRXSA-N 0.000 claims 1
- IMGQPABKFUXCTN-GDLZYMKVSA-N 1-(4-fluorophenyl)-3-[(2r)-2-hydroxy-3-[3-(methylamino)propylamino]propyl]-8-[(8-methylnaphthalen-1-yl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C1CN(CC=2C3=C(C)C=CC=C3C=CC=2)CCC21C(=O)N(C[C@H](O)CNCCCNC)CN2C1=CC=C(F)C=C1 IMGQPABKFUXCTN-GDLZYMKVSA-N 0.000 claims 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000001847 2-phenylcyclopropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C1([H])* 0.000 claims 1
- AWYSBTQCCOWYQC-HHHXNRCGSA-N 3-[(2r)-3-(dimethylamino)-2-hydroxypropyl]-1-(4-fluorophenyl)-8-[(8-methylnaphthalen-1-yl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C1CN(CC=2C3=C(C)C=CC=C3C=CC=2)CCC21C(=O)N(C[C@H](O)CN(C)C)CN2C1=CC=C(F)C=C1 AWYSBTQCCOWYQC-HHHXNRCGSA-N 0.000 claims 1
- HWQFSZPVJZOLNP-SSEXGKCCSA-N 3-[(2r)-3-[3-(dimethylamino)propylamino]-2-hydroxypropyl]-1-(4-fluorophenyl)-8-[(8-methylnaphthalen-1-yl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C1CN(CC=2C3=C(C)C=CC=C3C=CC=2)CCC21C(=O)N(C[C@H](O)CNCCCN(C)C)CN2C1=CC=C(F)C=C1 HWQFSZPVJZOLNP-SSEXGKCCSA-N 0.000 claims 1
- ALXBWOVLKSYZNY-RUZDIDTESA-N 3-[(2r)-3-amino-2-hydroxypropyl]-1-(4-fluorophenyl)-8-[(8-methylnaphthalen-1-yl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C=12C(C)=CC=CC2=CC=CC=1CN(CC1)CCC1(C(N(C[C@H](O)CN)C1)=O)N1C1=CC=C(F)C=C1 ALXBWOVLKSYZNY-RUZDIDTESA-N 0.000 claims 1
- NNFWJRYNXMYWJE-JOCHJYFZSA-N 3-[(2r)-3-amino-2-hydroxypropyl]-8-cyclooctyl-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C1CN(C2CCCCCCC2)CCC21C(=O)N(C[C@H](O)CN)CN2C1=CC=C(F)C=C1 NNFWJRYNXMYWJE-JOCHJYFZSA-N 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000005141 aryl amino sulfonyl group Chemical group 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000000068 chlorophenyl group Chemical group 0.000 claims 1
- 230000003930 cognitive ability Effects 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 claims 1
- 210000002816 gill Anatomy 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- XMVJITFPVVRMHC-UHFFFAOYSA-N roxarsone Chemical compound OC1=CC=C([As](O)(O)=O)C=C1[N+]([O-])=O XMVJITFPVVRMHC-UHFFFAOYSA-N 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 0 *C1C2C1CCC2 Chemical compound *C1C2C1CCC2 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40913402P | 2002-09-09 | 2002-09-09 | |
| US60/409,134 | 2002-09-09 | ||
| PCT/US2003/027956 WO2004022558A2 (en) | 2002-09-09 | 2003-09-05 | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006500393A JP2006500393A (ja) | 2006-01-05 |
| JP2006500393A5 true JP2006500393A5 (enExample) | 2006-10-26 |
| JP4712384B2 JP4712384B2 (ja) | 2011-06-29 |
Family
ID=31978719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004534697A Expired - Fee Related JP4712384B2 (ja) | 2002-09-09 | 2003-09-05 | Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7081463B2 (enExample) |
| EP (1) | EP1601674B1 (enExample) |
| JP (1) | JP4712384B2 (enExample) |
| KR (1) | KR20050043935A (enExample) |
| CN (1) | CN100402529C (enExample) |
| AR (1) | AR041205A1 (enExample) |
| AU (1) | AU2003268512A1 (enExample) |
| BR (1) | BR0306309A (enExample) |
| CA (1) | CA2498275C (enExample) |
| CL (1) | CL2003001814A1 (enExample) |
| EA (1) | EA009369B1 (enExample) |
| MX (1) | MXPA05002622A (enExample) |
| NO (1) | NO20051743L (enExample) |
| NZ (1) | NZ538307A (enExample) |
| PL (1) | PL377047A1 (enExample) |
| RS (1) | RS20050208A (enExample) |
| TW (1) | TWI296627B (enExample) |
| WO (1) | WO2004022558A2 (enExample) |
| ZA (1) | ZA200502836B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05002622A (es) | 2002-09-09 | 2005-09-08 | Johnson & Johnson | Derivados de 1,3,8,-triazaespiro [4.5]decan-4-ona sustituidos con hidroxialquilo utiles para el tratamiento de desordenes mediados por el receptor opioide huerfano. |
| US20080287478A1 (en) * | 2003-05-23 | 2008-11-20 | Lars Bo Laurenborg Hansen | Nociceptin Analogues and Uses Thereof |
| AR046756A1 (es) * | 2003-12-12 | 2005-12-21 | Solvay Pharm Gmbh | Derivados de hidronopol como agonistas de receptores orl-1 humanos. |
| US20060178390A1 (en) * | 2004-08-02 | 2006-08-10 | Alfonzo Jordan | 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
| ATE488519T1 (de) * | 2005-09-28 | 2010-12-15 | Hoffmann La Roche | Indol-3-ylcarbonylazaspiroderivate als vasopressinrezeptorantagonisten |
| TW200819457A (en) | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
| CN101622254B (zh) * | 2006-11-28 | 2013-05-29 | 詹森药业有限公司 | 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐 |
| EP2101769B1 (en) * | 2006-11-28 | 2012-10-24 | Janssen Pharmaceutica, N.V. | Methods for the treatment of alcohol abuse, addiction and dependency |
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- 2003-09-05 KR KR1020057003938A patent/KR20050043935A/ko not_active Ceased
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- 2003-09-05 EA EA200500331A patent/EA009369B1/ru not_active IP Right Cessation
- 2003-09-05 RS YUP-2005/0208A patent/RS20050208A/sr unknown
- 2003-09-05 AU AU2003268512A patent/AU2003268512A1/en not_active Abandoned
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- 2003-09-05 PL PL377047A patent/PL377047A1/pl not_active Application Discontinuation
- 2003-09-05 JP JP2004534697A patent/JP4712384B2/ja not_active Expired - Fee Related
- 2003-09-05 WO PCT/US2003/027956 patent/WO2004022558A2/en not_active Ceased
- 2003-09-05 EP EP03749479A patent/EP1601674B1/en not_active Expired - Lifetime
- 2003-09-05 NZ NZ538307A patent/NZ538307A/en unknown
- 2003-09-08 AR ARP030103248A patent/AR041205A1/es unknown
- 2003-09-08 TW TW092124686A patent/TWI296627B/zh not_active IP Right Cessation
- 2003-09-09 CL CL200301814A patent/CL2003001814A1/es unknown
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