CN100402529C - 用于治疗orl-1受体介导疾病的羟基烷基取代的1,3,8-三氮杂螺[4,5]癸-4-酮衍生物 - Google Patents
用于治疗orl-1受体介导疾病的羟基烷基取代的1,3,8-三氮杂螺[4,5]癸-4-酮衍生物 Download PDFInfo
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- CN100402529C CN100402529C CNB038249901A CN03824990A CN100402529C CN 100402529 C CN100402529 C CN 100402529C CN B038249901 A CNB038249901 A CN B038249901A CN 03824990 A CN03824990 A CN 03824990A CN 100402529 C CN100402529 C CN 100402529C
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Addiction (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40913402P | 2002-09-09 | 2002-09-09 | |
| US60/409,134 | 2002-09-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1694883A CN1694883A (zh) | 2005-11-09 |
| CN100402529C true CN100402529C (zh) | 2008-07-16 |
Family
ID=31978719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB038249901A Expired - Fee Related CN100402529C (zh) | 2002-09-09 | 2003-09-05 | 用于治疗orl-1受体介导疾病的羟基烷基取代的1,3,8-三氮杂螺[4,5]癸-4-酮衍生物 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7081463B2 (enExample) |
| EP (1) | EP1601674B1 (enExample) |
| JP (1) | JP4712384B2 (enExample) |
| KR (1) | KR20050043935A (enExample) |
| CN (1) | CN100402529C (enExample) |
| AR (1) | AR041205A1 (enExample) |
| AU (1) | AU2003268512A1 (enExample) |
| BR (1) | BR0306309A (enExample) |
| CA (1) | CA2498275C (enExample) |
| CL (1) | CL2003001814A1 (enExample) |
| EA (1) | EA009369B1 (enExample) |
| MX (1) | MXPA05002622A (enExample) |
| NO (1) | NO20051743L (enExample) |
| NZ (1) | NZ538307A (enExample) |
| PL (1) | PL377047A1 (enExample) |
| RS (1) | RS20050208A (enExample) |
| TW (1) | TWI296627B (enExample) |
| WO (1) | WO2004022558A2 (enExample) |
| ZA (1) | ZA200502836B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20050043935A (ko) * | 2002-09-09 | 2005-05-11 | 얀센 파마슈티카 엔.브이. | Orl-1 수용체 매개 장애의 치료에 유용한 하이드록시 알킬 치환된 1,3,8-트리아자스피로[4.5]데칸-4-온 유도체 |
| NZ544282A (en) * | 2003-05-23 | 2009-07-31 | Zealand Pharma As | Triaza-spiro compounds as nociceptin analogues and uses thereof |
| AR046756A1 (es) | 2003-12-12 | 2005-12-21 | Solvay Pharm Gmbh | Derivados de hidronopol como agonistas de receptores orl-1 humanos. |
| US20060178390A1 (en) * | 2004-08-02 | 2006-08-10 | Alfonzo Jordan | 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
| BRPI0616618A2 (pt) * | 2005-09-28 | 2011-06-28 | Hoffmann La Roche | derivados de indol-3-il-carbonil-azaespiro como antagonistas de receptor de vasopressina |
| TW200819457A (en) | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
| KR20090083954A (ko) * | 2006-11-28 | 2009-08-04 | 얀센 파마슈티카 엔.브이. | 3-(3-아미노-2-(r)-하이드록시프로필)-1-(4-플루오로페닐)-8-(8-메틸나프탈렌-1-일메틸)-1,3,8-트리아자-스피로[4.5]데칸-4-온의 염 |
| KR20090087042A (ko) * | 2006-11-28 | 2009-08-14 | 얀센 파마슈티카 엔.브이. | 알콜 남용, 중독 및 의존증 치료방법 |
| CA2683598C (en) * | 2007-04-09 | 2015-11-17 | Janssen Pharmaceutica Nv | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
| US20100076003A1 (en) * | 2008-09-19 | 2010-03-25 | Kathleen Battista | 5-oxazolidin-2-one substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful as orl-1 receptor modulators |
| UA107943C2 (xx) * | 2009-11-16 | 2015-03-10 | Lilly Co Eli | Сполуки спіропіперидину як антагоністи рецептора orl-1 |
| WO2014100719A2 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US9611257B2 (en) | 2012-12-21 | 2017-04-04 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| EP2935240A1 (en) | 2012-12-21 | 2015-10-28 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2014100734A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US8940726B2 (en) | 2012-12-21 | 2015-01-27 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環(4.5)癸烷衍生物 |
| CA2953572A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| KR102043337B1 (ko) | 2014-08-28 | 2019-11-11 | 아셰뉴론 에스아 | 글리코시다제 저해제 |
| US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
| EP3383390A4 (en) * | 2015-12-02 | 2019-11-20 | Astraea Therapeutics, LLC | PIPERIDINYL-nociceptin RECEPTOR COMPOUNDS |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| MA43677A (fr) | 2016-02-25 | 2018-11-28 | Asceneuron Sa | Inhibiteurs de glycosidases |
| MA43680A (fr) | 2016-02-25 | 2018-11-28 | Asceneuron Sa | Inhibiteurs de glycosidases |
| KR102800480B1 (ko) | 2016-02-25 | 2025-04-25 | 아셰뉴론 에스아 | 피페라진 유도체의 산 부가 염 |
| EP3672959A1 (en) | 2017-08-24 | 2020-07-01 | Asceneuron SA | Linear glycosidase inhibitors |
| HUE067314T2 (hu) | 2017-09-22 | 2024-10-28 | Jubilant Epipad LLC | Heterociklusos vegyületek mint PAD gátlók |
| KR102782563B1 (ko) | 2017-10-18 | 2025-03-14 | 주빌런트 에피파드 엘엘씨 | Pad 억제제로서의 이미다조-피리딘 화합물 |
| KR20200085836A (ko) | 2017-11-06 | 2020-07-15 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체 |
| BR112020010322A2 (pt) | 2017-11-24 | 2020-11-17 | Jubilant Episcribe Llc | composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer |
| SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
| US11795165B2 (en) | 2018-08-22 | 2023-10-24 | Asceneuron Sa | Tetrahydro-benzoazepine glycosidase inhibitors |
| SG11202101651RA (en) | 2018-08-22 | 2021-03-30 | Asceneuron S A | Succinate and fumarate acid addition salts of piperazine derivatives useful as glycosidase inhibitors |
| WO2020039029A1 (en) * | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Spiro compounds as glycosidase inhibitors |
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2003
- 2003-09-05 KR KR1020057003938A patent/KR20050043935A/ko not_active Ceased
- 2003-09-05 CA CA2498275A patent/CA2498275C/en not_active Expired - Fee Related
- 2003-09-05 RS YUP-2005/0208A patent/RS20050208A/sr unknown
- 2003-09-05 NZ NZ538307A patent/NZ538307A/en unknown
- 2003-09-05 US US10/656,934 patent/US7081463B2/en not_active Expired - Lifetime
- 2003-09-05 EA EA200500331A patent/EA009369B1/ru not_active IP Right Cessation
- 2003-09-05 AU AU2003268512A patent/AU2003268512A1/en not_active Abandoned
- 2003-09-05 MX MXPA05002622A patent/MXPA05002622A/es active IP Right Grant
- 2003-09-05 JP JP2004534697A patent/JP4712384B2/ja not_active Expired - Fee Related
- 2003-09-05 WO PCT/US2003/027956 patent/WO2004022558A2/en not_active Ceased
- 2003-09-05 CN CNB038249901A patent/CN100402529C/zh not_active Expired - Fee Related
- 2003-09-05 BR BR0306309-7A patent/BR0306309A/pt not_active IP Right Cessation
- 2003-09-05 EP EP03749479A patent/EP1601674B1/en not_active Expired - Lifetime
- 2003-09-05 PL PL377047A patent/PL377047A1/pl not_active Application Discontinuation
- 2003-09-08 TW TW092124686A patent/TWI296627B/zh not_active IP Right Cessation
- 2003-09-08 AR ARP030103248A patent/AR041205A1/es unknown
- 2003-09-09 CL CL200301814A patent/CL2003001814A1/es unknown
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2005
- 2005-04-07 ZA ZA200502836A patent/ZA200502836B/en unknown
- 2005-04-08 NO NO20051743A patent/NO20051743L/no not_active Application Discontinuation
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2008
- 2008-12-03 US US12/327,437 patent/US8778956B2/en not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1601674A2 (en) | 2005-12-07 |
| TWI296627B (en) | 2008-05-11 |
| WO2004022558A2 (en) | 2004-03-18 |
| WO2004022558A3 (en) | 2004-05-21 |
| PL377047A1 (pl) | 2006-01-23 |
| JP2006500393A (ja) | 2006-01-05 |
| AR041205A1 (es) | 2005-05-11 |
| KR20050043935A (ko) | 2005-05-11 |
| US20040142955A1 (en) | 2004-07-22 |
| ZA200502836B (en) | 2006-06-28 |
| CL2003001814A1 (es) | 2005-02-11 |
| EP1601674B1 (en) | 2012-08-08 |
| US20060030577A1 (en) | 2006-02-09 |
| EA009369B1 (ru) | 2007-12-28 |
| RS20050208A (sr) | 2007-08-03 |
| NZ538307A (en) | 2008-04-30 |
| US20090124614A1 (en) | 2009-05-14 |
| US7081463B2 (en) | 2006-07-25 |
| CA2498275A1 (en) | 2004-03-18 |
| BR0306309A (pt) | 2004-10-19 |
| CA2498275C (en) | 2011-07-12 |
| US7582649B2 (en) | 2009-09-01 |
| JP4712384B2 (ja) | 2011-06-29 |
| US8778956B2 (en) | 2014-07-15 |
| NO20051743L (no) | 2005-05-18 |
| TW200418857A (en) | 2004-10-01 |
| CN1694883A (zh) | 2005-11-09 |
| MXPA05002622A (es) | 2005-09-08 |
| EA200500331A1 (ru) | 2005-08-25 |
| AU2003268512A1 (en) | 2004-03-29 |
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