EA200500331A1 - Производные гидроксизамещенного 1,3,8-триазинспиро[4,5]декан-4-она, полезные для лечения расстройств, опосредованных orl-рецептором - Google Patents

Производные гидроксизамещенного 1,3,8-триазинспиро[4,5]декан-4-она, полезные для лечения расстройств, опосредованных orl-рецептором

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Publication number
EA200500331A1
EA200500331A1 EA200500331A EA200500331A EA200500331A1 EA 200500331 A1 EA200500331 A1 EA 200500331A1 EA 200500331 A EA200500331 A EA 200500331A EA 200500331 A EA200500331 A EA 200500331A EA 200500331 A1 EA200500331 A1 EA 200500331A1
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disorder
disorders
orl
decan
treatment
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EA200500331A
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English (en)
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EA009369B1 (ru
Inventor
Кэтлин Баттиста
Жилль Биньян
Питер Дж. Коннолли
Аллен Б. Рейтц
Тина Морган Росс
Малколм Скотт
Стивен А. Миддлтон
Майкл Орсини
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Янссен Фармацевтика, Н. В.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31978719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200500331(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика, Н. В. filed Critical Янссен Фармацевтика, Н. В.
Publication of EA200500331A1 publication Critical patent/EA200500331A1/ru
Publication of EA009369B1 publication Critical patent/EA009369B1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение относится к новым гидроксиалкилзамещенным производным 1,3,8-триазаспиро[4.5]декан-4-она общей формулы (I), где все переменные определены в описании, полезным для лечения расстройств и состояний, проводимых ORL-1 рецептором, сопряженным с G-белком. Точнее, соединения данного изобретения применимы для лечения таких расстройств и состояний, как состояние страха, депрессия, состояние панического страха, маниакальный синдром, слабоумие, биполярное расстройство, токсикомания, невропатическая боль, острая боль, хроническая боль, мигрень, астма, кашель, психоз, шизофрения, эпилепсия, гипертензия, ожирение, расстройство аппетита, одержимость, диабет, сердечная аритмия, синдром воспаленной толстой кишки, болезнь Крона, недержание мочи, расстройства надпочечников, дефицит внимания (ADD), расстройство, характеризующееся дефицитом внимания в сочетании с гиперактивностью (ADHD), болезнь Альцгеймера, а также для улучшения познавательной способности или памяти и стабилизации настроения.Отчет о международном поиске был опубликован 2004.05.21.
EA200500331A 2002-09-09 2003-09-05 Производные гидроксизамещенного 1,3,8-триазинспиро[4,5]декан-4-она, полезные для лечения расстройств, опосредованных orl-рецептором EA009369B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40913402P 2002-09-09 2002-09-09
PCT/US2003/027956 WO2004022558A2 (en) 2002-09-09 2003-09-05 Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders

Publications (2)

Publication Number Publication Date
EA200500331A1 true EA200500331A1 (ru) 2005-08-25
EA009369B1 EA009369B1 (ru) 2007-12-28

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ID=31978719

Family Applications (1)

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EA200500331A EA009369B1 (ru) 2002-09-09 2003-09-05 Производные гидроксизамещенного 1,3,8-триазинспиро[4,5]декан-4-она, полезные для лечения расстройств, опосредованных orl-рецептором

Country Status (19)

Country Link
US (3) US7081463B2 (ru)
EP (1) EP1601674B1 (ru)
JP (1) JP4712384B2 (ru)
KR (1) KR20050043935A (ru)
CN (1) CN100402529C (ru)
AR (1) AR041205A1 (ru)
AU (1) AU2003268512A1 (ru)
BR (1) BR0306309A (ru)
CA (1) CA2498275C (ru)
CL (1) CL2003001814A1 (ru)
EA (1) EA009369B1 (ru)
MX (1) MXPA05002622A (ru)
NO (1) NO20051743L (ru)
NZ (1) NZ538307A (ru)
PL (1) PL377047A1 (ru)
RS (1) RS20050208A (ru)
TW (1) TWI296627B (ru)
WO (1) WO2004022558A2 (ru)
ZA (1) ZA200502836B (ru)

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TWI296627B (en) 2008-05-11
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