JP2014523420A5 - - Google Patents
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- Publication number
- JP2014523420A5 JP2014523420A5 JP2014516016A JP2014516016A JP2014523420A5 JP 2014523420 A5 JP2014523420 A5 JP 2014523420A5 JP 2014516016 A JP2014516016 A JP 2014516016A JP 2014516016 A JP2014516016 A JP 2014516016A JP 2014523420 A5 JP2014523420 A5 JP 2014523420A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- oxo
- azaspiro
- oxa
- imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161498104P | 2011-06-17 | 2011-06-17 | |
| US61/498,104 | 2011-06-17 | ||
| PCT/US2012/042607 WO2012174342A1 (en) | 2011-06-17 | 2012-06-15 | Trpv4 antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014523420A JP2014523420A (ja) | 2014-09-11 |
| JP2014523420A5 true JP2014523420A5 (enExample) | 2015-07-16 |
| JP5969016B2 JP5969016B2 (ja) | 2016-08-10 |
Family
ID=47357483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014516016A Expired - Fee Related JP5969016B2 (ja) | 2011-06-17 | 2012-06-15 | Ｔｒｐｖ４拮抗薬 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9487507B2 (enExample) |
| EP (1) | EP2720546B1 (enExample) |
| JP (1) | JP5969016B2 (enExample) |
| ES (1) | ES2571409T3 (enExample) |
| WO (1) | WO2012174342A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8927585B2 (en) | 2011-06-17 | 2015-01-06 | Glaxosmithkline Intellectual Property (No.2) Limited | TRPV4 antagonists |
| JO3154B1 (ar) * | 2011-06-17 | 2017-09-20 | Glaxosmithkline Llc | عوامل مضادة لـ trpv4 |
| US9499533B2 (en) | 2012-03-27 | 2016-11-22 | Shionogi & Co., Ltd. | Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity |
| WO2015046193A1 (ja) | 2013-09-25 | 2015-04-02 | 塩野義製薬株式会社 | Ｔｒｐｖ４阻害活性を有する芳香族複素環式アミン誘導体 |
| CN106103416B (zh) | 2014-03-14 | 2021-03-02 | 拉夸里亚创药株式会社 | 作为trpm8拮抗剂的氮杂螺衍生物 |
| ES2813108T3 (es) * | 2016-05-19 | 2021-03-22 | Glaxosmithkline Ip No 2 Ltd | Antagonista de TRPV4 |
| US10968209B2 (en) | 2016-05-19 | 2021-04-06 | Glaxosmithkline Intellectual Property (No.2) Limited | TRPV4 antagonist |
| WO2018185701A1 (en) * | 2017-04-06 | 2018-10-11 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists as antitussive agents |
| JP7692219B2 (ja) | 2020-04-30 | 2025-06-13 | ラクオリア創薬株式会社 | Ｔｒｐｖ４拮抗薬としてのピリミジン－４（３ｈ）－オン誘導体 |
| CN111704613B (zh) * | 2020-06-23 | 2021-07-06 | 中国人民解放军军事科学院军事医学研究院 | 咪唑类衍生物及其作为trpv4抑制剂的用途 |
| EP4183415A4 (en) | 2020-07-16 | 2024-07-17 | RaQualia Pharma Inc. | Trpv4 inhibitor as therapeutic drug for eye disease |
| EP4551572A1 (en) | 2022-07-08 | 2025-05-14 | Actio Biosciences, Inc. | Therapeutic compounds and methods |
| WO2024217452A1 (zh) * | 2023-04-18 | 2024-10-24 | 河北乌图药业有限公司 | 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用 |
| WO2024217429A1 (zh) * | 2023-04-18 | 2024-10-24 | 河北乌图药业有限公司 | 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE482945T1 (de) * | 1998-05-26 | 2010-10-15 | Chugai Pharmaceutical Co Ltd | Heterozyklische indolderivate und mono- oder diazaindol-derivate |
| CA2531619A1 (en) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| TW200819457A (en) * | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
| JP2010517966A (ja) * | 2007-02-01 | 2010-05-27 | グラクソ グループ リミテッド | 摂食障害の処置のための１−オキサ−３−アザスピロ（４．５）デカン−２−オンおよび１−オキサ−３，８−ジアザスピロ（４．５）デカン−２−オン誘導体 |
| US20090042897A1 (en) * | 2007-02-01 | 2009-02-12 | Glaxo Group Limited | Chemical Compounds |
| GB0707934D0 (en) * | 2007-04-24 | 2007-05-30 | Glaxo Group Ltd | Chemical compounds |
| MX2010001486A (es) * | 2007-08-09 | 2010-03-01 | Abbott Lab | Derivados de tetrahidropiridin carboxamida como antagonistas de trpvl. |
| TW200944520A (en) * | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
| US8450484B2 (en) * | 2008-07-25 | 2013-05-28 | GlaxoSmithKline, LLC | TRPV4 antagonists |
| JP2012006837A (ja) * | 2008-09-30 | 2012-01-12 | Mochida Pharmaceut Co Ltd | ２−インドールアクリルアミド類縁体 |
| US8927585B2 (en) | 2011-06-17 | 2015-01-06 | Glaxosmithkline Intellectual Property (No.2) Limited | TRPV4 antagonists |
| JO3154B1 (ar) | 2011-06-17 | 2017-09-20 | Glaxosmithkline Llc | عوامل مضادة لـ trpv4 |
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2012
- 2012-06-15 US US14/125,370 patent/US9487507B2/en not_active Expired - Fee Related
- 2012-06-15 ES ES12800913T patent/ES2571409T3/es active Active
- 2012-06-15 EP EP12800913.1A patent/EP2720546B1/en active Active
- 2012-06-15 WO PCT/US2012/042607 patent/WO2012174342A1/en not_active Ceased
- 2012-06-15 JP JP2014516016A patent/JP5969016B2/ja not_active Expired - Fee Related