JP2009518309A5 - - Google Patents
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- Publication number
- JP2009518309A5 JP2009518309A5 JP2008543538A JP2008543538A JP2009518309A5 JP 2009518309 A5 JP2009518309 A5 JP 2009518309A5 JP 2008543538 A JP2008543538 A JP 2008543538A JP 2008543538 A JP2008543538 A JP 2008543538A JP 2009518309 A5 JP2009518309 A5 JP 2009518309A5
- Authority
- JP
- Japan
- Prior art keywords
- difluoro
- oxo
- carboxylic acid
- dihydroquinoline
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74223405P | 2005-12-05 | 2005-12-05 | |
| US60/742,234 | 2005-12-05 | ||
| US78927206P | 2006-04-04 | 2006-04-04 | |
| US60/789,272 | 2006-04-04 | ||
| PCT/US2006/046262 WO2007067489A1 (en) | 2005-12-05 | 2006-12-04 | Quinolone m1 receptor positive allosteric modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009518309A JP2009518309A (ja) | 2009-05-07 |
| JP2009518309A5 true JP2009518309A5 (enExample) | 2010-01-21 |
| JP5192389B2 JP5192389B2 (ja) | 2013-05-08 |
Family
ID=37963841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543538A Expired - Fee Related JP5192389B2 (ja) | 2005-12-05 | 2006-12-04 | キノロンｍ１レセプター陽性アロステリックモジュレータ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8389545B2 (enExample) |
| EP (1) | EP1963271B1 (enExample) |
| JP (1) | JP5192389B2 (enExample) |
| AT (1) | ATE475650T1 (enExample) |
| AU (1) | AU2006322045A1 (enExample) |
| CA (1) | CA2631917A1 (enExample) |
| DE (1) | DE602006015851D1 (enExample) |
| TW (1) | TW200840814A (enExample) |
| WO (2) | WO2007067489A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2037739B1 (en) | 2006-06-28 | 2011-10-26 | Merck Sharp & Dohme Corp. | Benzyl-substituted quinolone m1 receptor positive allosteric modulators |
| AU2009206580A1 (en) * | 2008-01-25 | 2009-07-30 | Merck Sharp & Dohme Corp. | Quinolizidinone M1 receptor positive allosteric modulators |
| WO2009102588A1 (en) * | 2008-02-15 | 2009-08-20 | Merck & Co., Inc. | Fused pyridone m1 receptor positive allosteric modulators |
| EP2268280B1 (en) * | 2008-03-21 | 2013-04-24 | Merck Sharp & Dohme Corp. | Quinolizidinone M1 receptor positive allosteric modulators |
| CA2722577A1 (en) | 2008-05-01 | 2009-11-05 | Merck Sharp & Dohme Corp. | 4-oxo-1,4-dihydroquinoline m1 receptor positive allosteric modulators |
| JP2011530602A (ja) * | 2008-08-12 | 2011-12-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｎ−ヘテロ環式ｍ１受容体ポジティブアロステリックモジュレーター |
| WO2010042347A1 (en) | 2008-10-06 | 2010-04-15 | Merck Sharp & Dohme Corp. | Quinolizidinone m1 receptor positive allosteric modulators |
| AU2009307892A1 (en) * | 2008-10-23 | 2010-04-29 | Merck Sharp & Dohme Corp. | Fused heterocyclic M1 receptor positive allosteric modulators |
| AU2010216263A1 (en) * | 2009-02-23 | 2011-07-14 | Merck Sharp & Dohme Corp. | Pyrazolo [4,3-c] cinnolin-3-one M1 receptor positive allosteric modulators |
| EP2421366B1 (en) * | 2009-04-20 | 2013-08-28 | Merck Sharp & Dohme Corp. | Heterocyclic fused cinnoline m1 receptor positive allosteric modulators |
| US8426438B2 (en) * | 2009-10-01 | 2013-04-23 | Merck Sharp & Dohme Corp. | Heterocyclic-fused pyrazolo[4,3-c]pyridin-3-one M1 receptor positive allosteric modulators |
| WO2011062853A1 (en) * | 2009-11-20 | 2011-05-26 | Merck Sharp & Dohme Corp. | Quinolizidinone carboxamide m1 receptor positive allosteric modulators |
| ES2575154T3 (es) * | 2009-12-17 | 2016-06-24 | Merck Sharp & Dohme Corp. | Moduladores alostéricos positivos del receptor M1 de quinolina amida |
| US8507494B2 (en) | 2010-04-30 | 2013-08-13 | Merck Sharp & Dohme Corp. | Heterocyclic quinolizine derived M1 receptor positive allosteric modulators |
| EP2582676B1 (en) * | 2010-06-15 | 2016-12-14 | Merck Sharp & Dohme Corp. | Tetrahydroquinoline amide m1 receptor positive allosteric modulators |
| EP2582241B1 (en) | 2010-06-15 | 2016-04-06 | Merck Sharp & Dohme Corp. | Heterocyclic fused phenanthrolinone m1 receptor positive allosteric modulators |
| EP2588104B1 (en) | 2010-07-01 | 2014-12-10 | Merck Sharp & Dohme Corp. | Isoindolone m1 receptor positive allosteric modulators |
| EP2709621B1 (en) | 2011-05-17 | 2016-11-02 | Merck Sharp & Dohme Corp. | N-linked quinolineamide m1 receptor positive allosteric modulators |
| EP2709624B1 (en) | 2011-05-17 | 2016-04-27 | Merck Sharp & Dohme Corp. | N-methyl tetrahydroquinoline m1 receptor positive allosteric modulators |
| EP2709451B1 (en) | 2011-05-17 | 2015-12-30 | Merck Sharp & Dohme Corp. | N-linked lactam m1 receptor positive allosteric modulators |
| US9586964B2 (en) | 2011-10-28 | 2017-03-07 | Vanderbilt University | Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1 |
| WO2013071201A1 (en) | 2011-11-11 | 2013-05-16 | Vanderbilt University | Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
| US9029563B2 (en) | 2012-01-06 | 2015-05-12 | Vanderbilt University | Substituted 1-benzylindolin-2-one analogs as positive allosteric modulators of muscarinic acetylcholine M1 receptors |
| WO2013106795A1 (en) * | 2012-01-12 | 2013-07-18 | Vanderbilt University | Substituted 4-(1h~pyrazol-4.yl)benzyl analogues as positive allosteric modulators of machr m1 receptors |
| EP2821401B1 (en) | 2012-03-02 | 2020-09-09 | Takeda Pharmaceutical Company Limited | Dihydroquinolinone compounds as modulators of the muscarininc m1 receptor |
| EP2921480B1 (en) | 2012-11-19 | 2017-10-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| MA43913B1 (fr) | 2015-06-08 | 2019-05-31 | Suven Life Sciences Ltd | Modulateurs allostériques positifs du récepteur m1 muscarinique |
| UY36714A (es) * | 2015-06-09 | 2016-12-30 | Bayer Pharma Akttiengesellschaft | Moduladores alostéricos positivos del receptor muscarínico m2 |
| PT3347349T (pt) | 2015-09-10 | 2019-10-30 | Suven Life Sciences Ltd | Derivados de fluoroindole como moduladores alostéricos positivos para recetor m1 muscarínico |
| WO2017155816A1 (en) * | 2016-03-09 | 2017-09-14 | Merck Sharp & Dohme Corp. | Quinazoline compounds useful as m1 receptor positive allosteric modulators |
| US11523858B2 (en) | 2017-08-11 | 2022-12-13 | Bradley D. Vilims | System and method for RF ablation with generated images of ablated tissue lesions |
| CN111018778B (zh) * | 2019-12-30 | 2020-11-06 | 杭州师范大学 | 一种喹诺酮类衍生物及其制备方法和应用 |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1175836A (en) * | 1977-09-20 | 1984-10-09 | Marcel Pesson | Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives |
| JPS5845426B2 (ja) * | 1978-09-29 | 1983-10-08 | 杏林製薬株式会社 | 置換キノリンカルボン酸誘導体 |
| US4914110A (en) * | 1984-05-11 | 1990-04-03 | Societe De Conseils De Recherches Et D'applications Scientifiques | Quinoline derivatives, their preparation and therapeutic compositions containing the same |
| US4623650A (en) * | 1984-12-06 | 1986-11-18 | Pfizer Inc. | Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
| JPS61218584A (ja) | 1985-03-23 | 1986-09-29 | Hokuriku Seiyaku Co Ltd | キノリン−３−カルボン酸誘導体 |
| JP2831000B2 (ja) * | 1988-03-03 | 1998-12-02 | 大日本製薬株式会社 | （２−アミノベンゾイル）酢酸エステル誘導体 |
| FR2674247B1 (fr) | 1991-03-19 | 1993-07-16 | Bouchara Sa | Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant. |
| FR2675144B1 (fr) * | 1991-04-10 | 1995-06-16 | Bouchara Sa | Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant. |
| TW301607B (enExample) * | 1993-03-09 | 1997-04-01 | Takeda Pharm Industry Co Ltd | |
| AU2407997A (en) * | 1996-04-30 | 1997-11-19 | Takeda Chemical Industries Ltd. | Combined use of gnrh agonist and antagonist |
| JP2000103707A (ja) * | 1998-09-28 | 2000-04-11 | Permachem Asia Ltd | 工業用殺菌剤 |
| US6583153B2 (en) * | 2000-12-12 | 2003-06-24 | Ortho-Mcneil Pharmaceutical, Inc. | 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone |
| DE10108271A1 (de) * | 2001-02-21 | 2002-08-22 | Schering Ag | Chinolin-, Isochinolin- und Phthalazinderivate als Antagonisten des Gonadotropin freisetzenden Hormons |
| SE0101256D0 (sv) | 2001-04-06 | 2001-04-06 | A & Science Invest Ab | Treatment of low back pain |
| EP1503759B1 (en) * | 2002-05-14 | 2008-12-17 | The Regents Of The University Of California | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| US7488739B2 (en) * | 2003-07-24 | 2009-02-10 | Astellas Pharma Inc. | Quinolone derivative or salt thereof |
| US7498341B2 (en) * | 2004-01-31 | 2009-03-03 | Sanofi Aventis Deutschland Gmbh | Heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments |
| ATE482208T1 (de) | 2004-03-10 | 2010-10-15 | Us Of America Represented By T | Chinolin-4-one als inhibitoren der retroviralen integrase zur behandlung von hiv, aids und aids- related complex (arc) |
| US7897607B2 (en) * | 2004-04-07 | 2011-03-01 | Takeda Pharmaceutical Company Limited | Cyclic compounds |
| JP2006117555A (ja) | 2004-10-20 | 2006-05-11 | Kyorin Pharmaceut Co Ltd | １−トリフルオロメチル−４−キノロンカルボン酸誘導体 |
| JP4858683B2 (ja) | 2005-01-20 | 2012-01-18 | アステラス製薬株式会社 | キノロン誘導体又はその塩の製造法 |
| JP2008094720A (ja) | 2005-01-20 | 2008-04-24 | Astellas Pharma Inc | キノロン誘導体のプロドラッグ又はその塩 |
| JP4853824B2 (ja) | 2005-01-20 | 2012-01-11 | アステラス製薬株式会社 | キノロン誘導体を有効成分とする医薬組成物 |
-
2006
- 2006-12-04 US US11/920,717 patent/US8389545B2/en active Active
- 2006-12-04 DE DE602006015851T patent/DE602006015851D1/de active Active
- 2006-12-04 JP JP2008543538A patent/JP5192389B2/ja not_active Expired - Fee Related
- 2006-12-04 AT AT06838942T patent/ATE475650T1/de not_active IP Right Cessation
- 2006-12-04 AU AU2006322045A patent/AU2006322045A1/en not_active Abandoned
- 2006-12-04 WO PCT/US2006/046262 patent/WO2007067489A1/en not_active Ceased
- 2006-12-04 WO PCT/US2006/046332 patent/WO2007100366A2/en not_active Ceased
- 2006-12-04 EP EP06838942A patent/EP1963271B1/en not_active Ceased
- 2006-12-04 CA CA002631917A patent/CA2631917A1/en not_active Abandoned
-
2007
- 2007-04-04 TW TW096112153A patent/TW200840814A/zh unknown