JP2006149365A5 - - Google Patents

Info

Publication number

JP2006149365A5

JP2006149365A5 JP2005146848A JP2005146848A JP2006149365A5 JP 2006149365 A5 JP2006149365 A5 JP 2006149365A5 JP 2005146848 A JP2005146848 A JP 2005146848A JP 2005146848 A JP2005146848 A JP 2005146848A JP 2006149365 A5 JP2006149365 A5 JP 2006149365A5

Authority

JP

Japan

Prior art keywords

seq

amino acids

sequence

polypeptide

protein

Prior art date

2005-05-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001413 amino acids Chemical class 0.000 claims 50
• 229920001184 polypeptide Polymers 0.000 claims 32
• 102000004196 processed proteins & peptides Human genes 0.000 claims 32
• 108090000765 processed proteins & peptides Proteins 0.000 claims 32
• 102000018368 Triggering Receptor Expressed on Myeloid Cells-1 Human genes 0.000 claims 18
• 108010066451 Triggering Receptor Expressed on Myeloid Cells-1 Proteins 0.000 claims 18
• 239000005557 antagonist Substances 0.000 claims 16
• 238000001212 derivatisation Methods 0.000 claims 12
• 230000000903 blocking effect Effects 0.000 claims 10
• 239000003446 ligand Substances 0.000 claims 8
• 125000006239 protecting group Chemical group 0.000 claims 8
• 102000004169 proteins and genes Human genes 0.000 claims 8
• 108090000623 proteins and genes Proteins 0.000 claims 8
• 230000021736 acetylation Effects 0.000 claims 7
• 238000006640 acetylation reaction Methods 0.000 claims 7
• 230000009435 amidation Effects 0.000 claims 7
• 238000007112 amidation reaction Methods 0.000 claims 7
• 230000013595 glycosylation Effects 0.000 claims 7
• 238000006206 glycosylation reaction Methods 0.000 claims 7
• 230000006320 pegylation Effects 0.000 claims 7
• 230000026731 phosphorylation Effects 0.000 claims 7
• 238000006366 phosphorylation reaction Methods 0.000 claims 7
• 230000001413 cellular effect Effects 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 206010040047 Sepsis Diseases 0.000 claims 3
• 206010040070 Septic Shock Diseases 0.000 claims 3
• 230000004048 modification Effects 0.000 claims 3
• 238000012986 modification Methods 0.000 claims 3
• 230000036303 septic shock Effects 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1