PL1817337T3 - Peptydy terapeutyczne zawierające sekwencje z CDR2 lub CDR3 z TREM-1 oraz ich zastosowania do hamowania posocznicy - Google Patents
Peptydy terapeutyczne zawierające sekwencje z CDR2 lub CDR3 z TREM-1 oraz ich zastosowania do hamowania posocznicyInfo
- Publication number
- PL1817337T3 PL1817337T3 PL05752687T PL05752687T PL1817337T3 PL 1817337 T3 PL1817337 T3 PL 1817337T3 PL 05752687 T PL05752687 T PL 05752687T PL 05752687 T PL05752687 T PL 05752687T PL 1817337 T3 PL1817337 T3 PL 1817337T3
- Authority
- PL
- Poland
- Prior art keywords
- trem
- cdr2
- cdr3
- sequences derived
- therapeutic peptides
- Prior art date
Links
- 206010040047 Sepsis Diseases 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 102000018368 Triggering Receptor Expressed on Myeloid Cells-1 Human genes 0.000 abstract 1
- 108010066451 Triggering Receptor Expressed on Myeloid Cells-1 Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0426146.7A GB0426146D0 (en) | 2004-11-29 | 2004-11-29 | Therapeutic peptides and method |
| PCT/EP2005/052338 WO2006056492A1 (en) | 2004-11-29 | 2005-05-20 | Therapeutic peptides comprising sequences derived from cdr2 or cdr3 of trem-1 and uses thereof to inhibit sepsis |
| EP05752687A EP1817337B1 (en) | 2004-11-29 | 2005-05-20 | Therapeutic peptides comprising sequences derived from cdr2 or cdr3 of trem-1 and uses thereof to inhibit sepsis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1817337T3 true PL1817337T3 (pl) | 2011-10-31 |
Family
ID=33561499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05752687T PL1817337T3 (pl) | 2004-11-29 | 2005-05-20 | Peptydy terapeutyczne zawierające sekwencje z CDR2 lub CDR3 z TREM-1 oraz ich zastosowania do hamowania posocznicy |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8013116B2 (pl) |
| EP (1) | EP1817337B1 (pl) |
| JP (3) | JP4951213B2 (pl) |
| CN (1) | CN1817901A (pl) |
| AT (1) | ATE496942T1 (pl) |
| BR (1) | BRPI0518675A2 (pl) |
| DE (1) | DE602005026157D1 (pl) |
| ES (1) | ES2360184T3 (pl) |
| GB (2) | GB0426146D0 (pl) |
| IL (1) | IL183165A (pl) |
| PL (1) | PL1817337T3 (pl) |
| TW (1) | TWI356062B (pl) |
| WO (1) | WO2006056492A1 (pl) |
| ZA (1) | ZA200703782B (pl) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060084082A1 (en) | 1997-03-07 | 2006-04-20 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
| GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| JP2010516678A (ja) * | 2007-01-16 | 2010-05-20 | ワイス エルエルシー | Ｔｒｅｍ−１による炎症治療、検出およびモニタリング |
| CA2681828A1 (en) | 2007-03-28 | 2008-10-09 | Universidad De Barcelona | Cd6 products for the treatment of sepsis |
| GR1007327B (el) * | 2007-08-08 | 2011-06-27 | Ευαγγελος Γιαμαρελλος-Μπουρμπουλης | Ο διαλυτος υποδοχεας ενεργοποιησης των μυελοκυτταρων (strem-1) ως δεικτης αποτελεσματικοτητας της θεραπειας του πεπτικου ελκους |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US12419839B2 (en) | 2009-10-09 | 2025-09-23 | Signablok, Inc. | Methods and compositions for targeted delivery of protein fragments |
| PT2555789T (pt) * | 2010-04-08 | 2020-07-14 | Inst Nat Sante Rech Med | Péptidos inibidores derivados do transcrito 1 tipo-trem (tlt-1) e seus usos |
| CN102517287B (zh) * | 2012-01-10 | 2013-09-11 | 广西大学 | 抑制水牛TREM1基因表达的shRNA、慢病毒表达载体及其构建方法和应用 |
| US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
| LT2814844T (lt) | 2012-02-15 | 2017-10-25 | Novo Nordisk A/S | Antikūnai, kurie jungiasi ir blokuoja ekspresuotą ant mieloidinių ląstelių inicijuojantį receptorių 1 (trem-1) |
| SI2814842T1 (sl) | 2012-02-15 | 2018-10-30 | Novo Nordisk A/S | Protitelesa, ki vežejo peptidoglikal prepoznan protein 1 |
| CN115927242A (zh) | 2012-05-11 | 2023-04-07 | 珍白斯凯尔有限公司 | 具有抗炎活性的肽及其在制备抗炎组合物中的应用 |
| EP2875826B1 (en) | 2012-05-11 | 2017-08-23 | KAEL-GemVax Co.,Ltd | Composition for preventing or treating sepsis |
| JP6272853B2 (ja) | 2012-07-11 | 2018-01-31 | ジェムバックス アンド カエル カンパニー，リミティド | 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物 |
| PL2892920T3 (pl) | 2012-09-07 | 2020-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Peptydy hamujące pochodzące z receptora aktywującego wykazującego ekspresję na podobnym do trem transkrypcie 1 (tlt-1) komórek szpikowych-1 (trem-1) i ich zastosowania |
| KR102258864B1 (ko) | 2013-04-19 | 2021-06-01 | 주식회사 젬백스앤카엘 | 허혈성 손상 치료 및 예방용 조성물 |
| CA2912557A1 (en) | 2013-06-07 | 2014-12-11 | Gemvax & Kael Co., Ltd. | Biological markers useful in cancer immunotherapy |
| TWI539960B (zh) | 2013-06-21 | 2016-07-01 | 凱爾傑姆維克斯有限公司 | 激素分泌調節劑、包括其的組成物以及其用途 |
| ES2773296T3 (es) | 2013-10-23 | 2020-07-10 | Gemvax & Kael Co Ltd | Composición para tratar y prevenir la hiperplasia prostática benigna |
| KR102494803B1 (ko) | 2013-11-22 | 2023-02-06 | 주식회사 젬백스앤카엘 | 혈관 신생 억제 활성을 가지는 펩티드 및 이를 포함하는 조성물 |
| CN105939723B (zh) | 2013-12-17 | 2020-02-28 | 珍白斯凯尔有限公司 | 前列腺癌治疗用组合物 |
| KR102373603B1 (ko) | 2014-04-11 | 2022-03-14 | 주식회사 젬백스앤카엘 | 섬유증 억제 활성을 가지는 펩티드 및 이를 포함하는 조성물 |
| EP3138399B1 (en) | 2014-04-30 | 2023-09-06 | Gemvax & Kael Co., Ltd. | Composition for organ, tissue, or cell transplantation, kit, and transplantation method |
| WO2016009086A1 (en) | 2014-07-17 | 2016-01-21 | Novo Nordisk A/S | Site directed mutagenesis of trem-1 antibodies for decreasing viscosity |
| KR102413243B1 (ko) | 2014-12-23 | 2022-06-27 | 주식회사 젬백스앤카엘 | 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물 |
| KR102636129B1 (ko) | 2015-02-27 | 2024-02-14 | 주식회사 젬백스앤카엘 | 청력 손상 방어용 펩타이드 및 이를 포함하는 조성물 |
| US11015179B2 (en) | 2015-07-02 | 2021-05-25 | Gemvax & Kael Co., Ltd. | Peptide having anti-viral effect and composition containing same |
| US11213598B2 (en) | 2015-11-12 | 2022-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Labeled probe and methods of use |
| WO2017152102A2 (en) | 2016-03-04 | 2017-09-08 | Alector Llc | Anti-trem1 antibodies and methods of use thereof |
| KR20180123512A (ko) | 2016-04-07 | 2018-11-16 | 주식회사 젬백스앤카엘 | 텔로머라제 활성 증가 및 텔로미어 연장 효능을 가지는 펩티드 및 이를 포함하는 조성물 |
| US20190240194A1 (en) | 2016-08-31 | 2019-08-08 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| WO2019195126A1 (en) | 2018-04-02 | 2019-10-10 | Bristol-Myers Squibb Company | Anti-trem-1 antibodies and uses thereof |
| EP3836951A1 (en) | 2018-08-13 | 2021-06-23 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| US20220218652A1 (en) * | 2018-09-05 | 2022-07-14 | The General Hospital Corporation | Methods of treating cytokine release syndrome |
| SG11202106117SA (en) | 2018-12-10 | 2021-07-29 | Massachusetts Gen Hospital | Cromolyn esters and uses thereof |
| CN110734470B (zh) * | 2019-11-18 | 2021-04-16 | 浙江省农业科学院 | 一种降血脂的蚕蛹蛋白肽hpp及其应用 |
| US12458622B2 (en) | 2020-04-06 | 2025-11-04 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
| CN113687081A (zh) * | 2021-05-19 | 2021-11-23 | 大汉生物科技(广东)有限公司 | 髓系细胞触发受体2在制备脓毒症相关功能产品中的应用 |
| CN120093892B (zh) * | 2025-05-12 | 2025-07-25 | 中国人民解放军陆军军医大学 | Lp17在制备预防/治疗自闭症的干预药物中的应用 |
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2005
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- 2005-05-20 ES ES05752687T patent/ES2360184T3/es not_active Expired - Lifetime
- 2005-05-20 GB GB0709406A patent/GB2433936B/en not_active Expired - Fee Related
- 2005-05-20 WO PCT/EP2005/052338 patent/WO2006056492A1/en not_active Ceased
- 2005-05-20 PL PL05752687T patent/PL1817337T3/pl unknown
- 2005-05-20 EP EP05752687A patent/EP1817337B1/en not_active Expired - Lifetime
- 2005-05-20 BR BRPI0518675-7A patent/BRPI0518675A2/pt not_active Application Discontinuation
- 2005-05-20 DE DE602005026157T patent/DE602005026157D1/de not_active Expired - Lifetime
- 2005-05-20 TW TW094116511A patent/TWI356062B/zh not_active IP Right Cessation
- 2005-05-20 AT AT05752687T patent/ATE496942T1/de not_active IP Right Cessation
- 2005-11-21 CN CNA200510104693XA patent/CN1817901A/zh active Pending
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2007
- 2007-05-10 ZA ZA200703782A patent/ZA200703782B/xx unknown
- 2007-05-14 IL IL183165A patent/IL183165A/en active IP Right Grant
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2009
- 2009-02-02 US US12/320,707 patent/US8013116B2/en not_active Expired - Fee Related
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2011
- 2011-07-12 US US13/181,323 patent/US9273111B2/en not_active Expired - Fee Related
- 2011-11-30 JP JP2011261103A patent/JP5599382B2/ja not_active Expired - Fee Related
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2014
- 2014-06-17 JP JP2014124403A patent/JP2015006180A/ja active Pending
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| GB0709406D0 (en) | 2007-06-27 |
| JP5599382B2 (ja) | 2014-10-01 |
| DE602005026157D1 (de) | 2011-03-10 |
| US8013116B2 (en) | 2011-09-06 |
| US20200254058A1 (en) | 2020-08-13 |
| ES2360184T3 (es) | 2011-06-01 |
| GB0426146D0 (en) | 2004-12-29 |
| ZA200703782B (en) | 2010-07-28 |
| IL183165A (en) | 2014-07-31 |
| ATE496942T1 (de) | 2011-02-15 |
| CN1817901A (zh) | 2006-08-16 |
| BRPI0518675A2 (pt) | 2008-12-02 |
| EP1817337A1 (en) | 2007-08-15 |
| GB2433936B (en) | 2010-06-23 |
| US20120015867A1 (en) | 2012-01-19 |
| US9273111B2 (en) | 2016-03-01 |
| US20090253632A1 (en) | 2009-10-08 |
| EP1817337B1 (en) | 2011-01-26 |
| JP2006149365A (ja) | 2006-06-15 |
| JP4951213B2 (ja) | 2012-06-13 |
| TWI356062B (en) | 2012-01-11 |
| TW200616657A (en) | 2006-06-01 |
| WO2006056492A1 (en) | 2006-06-01 |
| US20160193288A1 (en) | 2016-07-07 |
| JP2012082206A (ja) | 2012-04-26 |
| JP2015006180A (ja) | 2015-01-15 |
| US10603357B2 (en) | 2020-03-31 |
| GB2433936A (en) | 2007-07-11 |
| IL183165A0 (en) | 2007-09-20 |
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