JP2005511508A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005511508A5 JP2005511508A5 JP2003528536A JP2003528536A JP2005511508A5 JP 2005511508 A5 JP2005511508 A5 JP 2005511508A5 JP 2003528536 A JP2003528536 A JP 2003528536A JP 2003528536 A JP2003528536 A JP 2003528536A JP 2005511508 A5 JP2005511508 A5 JP 2005511508A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- formula
- aryl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 59
- 150000001875 compounds Chemical class 0.000 claims 49
- 125000003118 aryl group Chemical group 0.000 claims 31
- 229910052739 hydrogen Inorganic materials 0.000 claims 30
- 239000001257 hydrogen Substances 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 29
- 239000012453 solvate Substances 0.000 claims 29
- 229910052736 halogen Inorganic materials 0.000 claims 18
- 150000002367 halogens Chemical class 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 18
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 8
- 125000006239 protecting group Chemical group 0.000 claims 8
- -1 4-((R) -2- {6- [2- (2,6-dichlorobenzyloxy) -ethoxy] -hexylamino} -1-hydroxyethyl) -2-hydroxymethyl-phenol α-phenylcinnamic acid salt Chemical class 0.000 claims 5
- 230000001225 therapeutic effect Effects 0.000 claims 5
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 239000004615 ingredient Substances 0.000 claims 3
- DAFYYTQWSAWIGS-DEOSSOPVSA-N vilanterol Chemical compound C1=C(O)C(CO)=CC([C@@H](O)CNCCCCCCOCCOCC=2C(=CC=CC=2Cl)Cl)=C1 DAFYYTQWSAWIGS-DEOSSOPVSA-N 0.000 claims 3
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- YJTKZCDBKVTVBY-UHFFFAOYSA-N 1,3-Diphenylbenzene Chemical group C1=CC=CC=C1C1=CC=CC(C=2C=CC=CC=2)=C1 YJTKZCDBKVTVBY-UHFFFAOYSA-N 0.000 claims 1
- HYJZGLOLVOHGRY-LJAQVGFWSA-N 1-[3-[2-[5-[[(2r)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino]pentoxy]ethoxymethyl]phenyl]-3-phenylurea Chemical compound C1=C(O)C(CO)=CC([C@@H](O)CNCCCCCOCCOCC=2C=C(NC(=O)NC=3C=CC=CC=3)C=CC=2)=C1 HYJZGLOLVOHGRY-LJAQVGFWSA-N 0.000 claims 1
- PYIBXZPZFHXOST-PMERELPUSA-N 1-[3-[2-[6-[[(2r)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino]hexoxy]ethoxymethyl]phenyl]-3-phenylurea Chemical compound C1=C(O)C(CO)=CC([C@@H](O)CNCCCCCCOCCOCC=2C=C(NC(=O)NC=3C=CC=CC=3)C=CC=2)=C1 PYIBXZPZFHXOST-PMERELPUSA-N 0.000 claims 1
- ZXQRIBVIRUROHJ-DEOSSOPVSA-N 4-[(1r)-1-hydroxy-2-[6-[2-[(3-hydroxyphenyl)methoxy]ethoxy]hexylamino]ethyl]-2-(hydroxymethyl)phenol Chemical compound C1=C(O)C(CO)=CC([C@@H](O)CNCCCCCCOCCOCC=2C=C(O)C=CC=2)=C1 ZXQRIBVIRUROHJ-DEOSSOPVSA-N 0.000 claims 1
- YGPLZKHGYBRUPZ-SANMLTNESA-N 4-[(1r)-2-[6-[2-[(3,5-dimethylphenyl)methoxy]ethoxy]hexylamino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol Chemical compound CC1=CC(C)=CC(COCCOCCCCCCNC[C@H](O)C=2C=C(CO)C(O)=CC=2)=C1 YGPLZKHGYBRUPZ-SANMLTNESA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- RVKZZBUDWBBMCG-JMBOZCNDSA-N OCC(C=C([C@H](CNCCCCCCOCCOCC(C(Cl)=CC=C1)=C1Cl)O)C=C1)=C1O.O[C@@H](C(O)=O)C1=CC=CC=C1 Chemical compound OCC(C=C([C@H](CNCCCCCCOCCOCC(C(Cl)=CC=C1)=C1Cl)O)C=C1)=C1O.O[C@@H](C(O)=O)C1=CC=CC=C1 RVKZZBUDWBBMCG-JMBOZCNDSA-N 0.000 claims 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
- YTHPOCWIEYYGCI-XIFFEERXSA-N [4-[(1r)-2-[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexylamino]-1-hydroxyethyl]-2-(hydroxymethyl)phenyl] naphthalene-1-carboxylate Chemical compound C([C@H](O)C=1C=C(C(=CC=1)OC(=O)C=1C2=CC=CC=C2C=CC=1)CO)NCCCCCCOCCOCC1=C(Cl)C=CC=C1Cl YTHPOCWIEYYGCI-XIFFEERXSA-N 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 230000002152 alkylating effect Effects 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 238000007796 conventional method Methods 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- NHADDZMCASKINP-HTRCEHHLSA-N decarboxydihydrocitrinin Natural products C1=C(O)C(C)=C2[C@H](C)[C@@H](C)OCC2=C1O NHADDZMCASKINP-HTRCEHHLSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- JDUWVWHYHBGVGT-DHUJRADRSA-N n-[3-[[3-[2-[6-[[(2r)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino]hexoxy]ethoxymethyl]phenyl]carbamoylamino]phenyl]pyridine-3-carboxamide Chemical compound C1=C(O)C(CO)=CC([C@@H](O)CNCCCCCCOCCOCC=2C=C(NC(=O)NC=3C=C(NC(=O)C=4C=NC=CC=4)C=CC=3)C=CC=2)=C1 JDUWVWHYHBGVGT-DHUJRADRSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- 230000035479 physiological effects, processes and functions Effects 0.000 claims 1
- 230000035790 physiological processes and functions Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0122201A GB0122201D0 (en) | 2001-09-14 | 2001-09-14 | Medicinal compounds |
| GB0126997A GB0126997D0 (en) | 2001-11-09 | 2001-11-09 | Medicinal Compounds |
| PCT/GB2002/004140 WO2003024439A1 (en) | 2001-09-14 | 2002-09-11 | Phenethanolamine derivatives for treatment of respiratory diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005511508A JP2005511508A (ja) | 2005-04-28 |
| JP2005511508A5 true JP2005511508A5 (enExample) | 2005-12-22 |
| JP4191034B2 JP4191034B2 (ja) | 2008-12-03 |
Family
ID=26246542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528536A Expired - Lifetime JP4191034B2 (ja) | 2001-09-14 | 2002-09-11 | 呼吸器疾患の治療のためのフェネタノールアミン誘導体 |
Country Status (31)
| Country | Link |
|---|---|
| US (6) | US7361787B2 (enExample) |
| EP (2) | EP1425001B1 (enExample) |
| JP (1) | JP4191034B2 (enExample) |
| KR (2) | KR100912324B1 (enExample) |
| CN (3) | CN1585633B (enExample) |
| AR (2) | AR036874A1 (enExample) |
| AT (1) | ATE417606T1 (enExample) |
| AU (1) | AU2002326026B2 (enExample) |
| BE (1) | BE2014C026I2 (enExample) |
| BR (1) | BRPI0212455B8 (enExample) |
| CA (1) | CA2458534C (enExample) |
| CO (1) | CO5560552A2 (enExample) |
| CY (3) | CY1109422T1 (enExample) |
| DE (1) | DE60230425D1 (enExample) |
| DK (2) | DK1425001T3 (enExample) |
| ES (2) | ES2316599T3 (enExample) |
| FR (1) | FR14C0028I2 (enExample) |
| HU (2) | HU228508B1 (enExample) |
| IL (2) | IL160595A0 (enExample) |
| LT (1) | LTC1425001I2 (enExample) |
| LU (1) | LU92439I2 (enExample) |
| MX (1) | MXPA04002405A (enExample) |
| MY (1) | MY129422A (enExample) |
| NO (2) | NO333813B1 (enExample) |
| NZ (1) | NZ531651A (enExample) |
| PL (2) | PL211953B1 (enExample) |
| PT (2) | PT1425001E (enExample) |
| RU (2) | RU2312854C2 (enExample) |
| SI (2) | SI2042168T1 (enExample) |
| TW (1) | TWI299661B (enExample) |
| WO (1) | WO2003024439A1 (enExample) |
Families Citing this family (169)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6759398B2 (en) * | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
| MXPA04002405A (es) * | 2001-09-14 | 2004-05-31 | Glaxo Group Limetd | Derivados de fenetanolamina para tratamiento de enfermedades respiratorias. |
| EP1487417A4 (en) | 2001-09-17 | 2010-03-17 | Glaxo Group Ltd | DRY POWDER DRUG FORMULATIONS |
| TWI249515B (en) * | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| JP2005527618A (ja) | 2002-05-28 | 2005-09-15 | セラヴァンス インコーポレーテッド | アルコキシアリールβ２アドレナリン作動性レセプターアゴニスト |
| GB0220730D0 (en) * | 2002-09-06 | 2002-10-16 | Glaxo Group Ltd | Medicinal compounds |
| BR0315720A (pt) * | 2002-10-28 | 2005-09-06 | Glaxo Group Ltd | Composto, método para a profilaxia ou tratamento de uma condição clìnica em um mamìmefero, formulação farmacêutica, combinação, uso de um composto, processo para a preparação de um composto, e, intermediário |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| GB0303396D0 (en) * | 2003-02-14 | 2003-03-19 | Glaxo Group Ltd | Medicinal compounds |
| EP1622875B1 (en) | 2003-05-08 | 2009-12-02 | Theravance, Inc. | Crystalline forms of an arylaniline beta-2 adrenergic receptor agonist |
| TW200510277A (en) | 2003-05-27 | 2005-03-16 | Theravance Inc | Crystalline form of β2-adrenergic receptor agonist |
| US7067541B2 (en) | 2003-06-04 | 2006-06-27 | Pfizer Inc | 2-amino-pyridine derivatives useful for the treatment of diseases |
| BRPI0410660A (pt) * | 2003-06-04 | 2006-06-20 | Pfizer | derivados de 2-amino-piridina como agonistas de adrenoreceptor ß2 |
| GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| TW200526547A (en) | 2003-09-22 | 2005-08-16 | Theravance Inc | Amino-substituted ethylamino β2 adrenergic receptor agonists |
| GB0329182D0 (en) * | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Chemical compounds |
| TW200531692A (en) | 2004-01-12 | 2005-10-01 | Theravance Inc | Aryl aniline derivatives as β2 adrenergic receptor agonists |
| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| TWI341836B (en) | 2004-03-11 | 2011-05-11 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| RU2006146042A (ru) | 2004-06-03 | 2008-07-20 | Тереванс | Диаминные агонисты 2-адренергических рецепторов |
| TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| EP1778638A1 (en) | 2004-07-21 | 2007-05-02 | Theravance, Inc. | Diaryl ether beta2 adrenergic receptor agonists |
| GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| WO2006023460A2 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| EP1786762A2 (en) * | 2004-09-10 | 2007-05-23 | Theravance, Inc. | Amidine substituted aryl aniline compounds |
| GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| US7579335B2 (en) | 2005-01-10 | 2009-08-25 | Glaxo Group Limited | Androstane 17α-carbonate derivatives for use in the treatment of allergic and inflammatory conditions |
| TWI389690B (zh) | 2005-03-25 | 2013-03-21 | Glaxo Group Ltd | 新穎化合物（一） |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
| US7994211B2 (en) | 2005-08-08 | 2011-08-09 | Argenta Discovery Limited | Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses |
| TW200738658A (en) | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| GB0520794D0 (en) * | 2005-10-12 | 2005-11-23 | Innovata Biomed Ltd | Inhaler |
| JP5006330B2 (ja) | 2005-10-21 | 2012-08-22 | ノバルティス アーゲー | Ｉｌ１３に対するヒト抗体および治療的使用 |
| TW200730498A (en) | 2005-12-20 | 2007-08-16 | Glaxo Group Ltd | Compounds |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| TW200745067A (en) | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| CA2649509A1 (en) | 2006-04-20 | 2007-11-01 | Glaxo Group Limited | Novel compounds |
| WO2007121920A2 (en) | 2006-04-21 | 2007-11-01 | Novartis Ag | Purine derivatives for use as adenosin a2a receptor agonists |
| GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
| TW200817006A (en) | 2006-06-23 | 2008-04-16 | Smithkline Beecham Corp | IL-8 receptor antagonist |
| US8003663B2 (en) | 2006-08-01 | 2011-08-23 | Glaxo Group Limited | Pyrazolo[3,4-b]pyridine compounds, and their use as PDE4 inhibitors |
| TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| DK2104535T3 (da) | 2007-01-10 | 2011-04-04 | Irm Llc | Forbindelser og sammensætninger som kanalaktiverende proteaseinhibitorer |
| GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| CA2677485A1 (en) | 2007-02-09 | 2008-08-14 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| CN101687851B (zh) | 2007-05-07 | 2013-02-27 | 诺瓦提斯公司 | 有机化合物 |
| EA017919B1 (ru) | 2007-12-10 | 2013-04-30 | Новартис Аг | Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов |
| CN101910153B (zh) | 2008-01-11 | 2014-01-22 | 诺华股份有限公司 | 作为激酶抑制剂的嘧啶类 |
| EP2096105A1 (en) * | 2008-02-28 | 2009-09-02 | Laboratorios Almirall, S.A. | Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor |
| JP5791500B2 (ja) | 2008-05-23 | 2015-10-07 | パンミラ ファーマシューティカルズ，エルエルシー． | ５−リポキシゲナーゼ活性化タンパク質阻害剤 |
| JP5502858B2 (ja) | 2008-06-05 | 2014-05-28 | グラクソ グループ リミテッド | Ｐｉ３キナーゼの阻害剤として有用な４−カルボキサミドインダゾール誘導体 |
| EA201001848A1 (ru) | 2008-06-10 | 2011-08-30 | Новартис Аг | Производные пиразина в качестве блокаторов эпителиальных натриевых каналов |
| WO2009154557A1 (en) | 2008-06-18 | 2009-12-23 | Astrazeneca Ab | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
| US8236786B2 (en) | 2008-08-07 | 2012-08-07 | Pulmagen Therapeutics (Inflammation) Limited | Respiratory disease treatment |
| SI2379507T1 (sl) | 2008-12-30 | 2014-02-28 | Pulmagen Therapeutics (Inflammation) Limited | Spojine sulfonamida za zdravljenje respiratornih motenj |
| WO2010094643A1 (en) | 2009-02-17 | 2010-08-26 | Glaxo Group Limited | Quinoline derivatives and their uses for rhinitis and urticaria |
| ES2994042T3 (en) * | 2009-02-26 | 2025-01-16 | Glaxo Group Ltd | Pharmaceutical formulations comprising 4-{(1 r)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol |
| WO2010097114A1 (en) * | 2009-02-26 | 2010-09-02 | Glaxo Group Limited | Novel combination of therapeutic agents |
| WO2010102958A1 (en) | 2009-03-09 | 2010-09-16 | Glaxo Group Limited | 4-oxadiazol-2 -yl- indazoles as inhibitors of p13 kinases |
| WO2010102968A1 (en) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
| US20120058984A1 (en) | 2009-03-17 | 2012-03-08 | Catherine Mary Alder | Pyrimidine derivatives used as itk inhibitors |
| AU2010226604A1 (en) | 2009-03-19 | 2011-10-13 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of BTB and CNC homology 1, basic leucine zipper transcription factor 1 (Bach 1) gene expression using short interfering nucleic acid (siNA) sequence listing |
| JP2012520685A (ja) | 2009-03-19 | 2012-09-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いたＧＡＴＡ結合タンパク質３（ＧＡＴＡ３）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| US20120016011A1 (en) | 2009-03-19 | 2012-01-19 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| JP2012520686A (ja) | 2009-03-19 | 2012-09-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いたシグナル伝達性転写因子６（ＳＴＡＴ６）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| WO2010111464A1 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2010111490A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE THYMIC STROMAL LYMPHOPOIETIN (TSLP) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP2411019A2 (en) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| CA2756069A1 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of the intercellular adhesion molecule 1 (icam-1)gene expression using short interfering nucleic acid (sina) |
| US20120004281A1 (en) | 2009-03-27 | 2012-01-05 | Merck Sharp & Dohme Corp | RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| US8399436B2 (en) | 2009-04-24 | 2013-03-19 | Glaxo Group Limited | N-pyrazolyl carboxamides as CRAC channel inhibitors |
| EP2421834A1 (en) | 2009-04-24 | 2012-02-29 | Glaxo Group Limited | Pyrazole and triazole carboxamides as crac channel inhibitors |
| CA2759476C (en) | 2009-04-30 | 2018-10-09 | Julie Nicole Hamblin | Novel compounds |
| WO2010150014A1 (en) | 2009-06-24 | 2010-12-29 | Pulmagen Therapeutics (Inflammation) Limited | 5r- 5 -deuterated glitazones for respiratory disease treatment |
| PL2453894T3 (pl) | 2009-07-15 | 2016-04-29 | Theravance Biopharma R&D Ip Llc | Postać krystaliczna wolnej zasady związku bifenylowego |
| JP2013508414A (ja) | 2009-10-22 | 2013-03-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症および他の慢性疾患の治療のための組成物 |
| GB0918924D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Azaindole derivatives |
| GB0918923D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminothiazole derivatives |
| GB0918922D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminopyridine derivatives |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| GB0921075D0 (en) * | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
| EP2507223A1 (en) | 2009-12-03 | 2012-10-10 | Glaxo Group Limited | Benzpyrazole derivatives as inhibitors of p13 kinases |
| EP2507226A1 (en) | 2009-12-03 | 2012-10-10 | Glaxo Group Limited | Novel compounds |
| WO2011067366A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Indazole derivatives as pi 3 - kinase inhibitors |
| WO2011084316A2 (en) | 2009-12-16 | 2011-07-14 | 3M Innovative Properties Company | Formulations and methods for controlling mdi particle size delivery |
| WO2011098746A1 (en) | 2010-02-09 | 2011-08-18 | Pulmagen Therapeutics (Inflammation) Limited | Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone |
| GB201002224D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
| GB201002243D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
| WO2011110575A1 (en) | 2010-03-11 | 2011-09-15 | Glaxo Group Limited | Derivatives of 2-[2-(benzo- or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| GB201007203D0 (en) | 2010-04-29 | 2010-06-16 | Glaxo Group Ltd | Novel compounds |
| KR101004750B1 (ko) * | 2010-08-16 | 2011-01-04 | 주식회사 행림종합 건축사사무소 | 피막보호형 보강 단열패널 및 이를 이용한 노출형 외단열방수공법 |
| AU2014268195B2 (en) * | 2010-08-31 | 2015-11-12 | Glaxo Group Limited | Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same |
| ES2546422T5 (es) | 2010-08-31 | 2023-01-20 | Glaxosmithkline Ip Dev Ltd | Productos medicinales de inhalación de polvo seco que presentan propiedades de control de la humedad y procedimientos de administración de los mismos |
| ES2548036T3 (es) | 2010-09-08 | 2015-10-13 | Glaxosmithkline Intellectual Property Development Limited | Polimorfos y sales de N-[5-[4-(5-{[(2R,6S)-2,6-dimetil-4-morfolinil]metil}-1,3-oxazol-2-il)-1H-indazol-6-il]-2-(metiloxi)-3-piridinil]metanosulfonamida |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| WO2012035055A1 (en) | 2010-09-17 | 2012-03-22 | Glaxo Group Limited | Novel compounds |
| US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| ES2532213T3 (es) | 2010-10-21 | 2015-03-25 | Glaxo Group Limited | Compuestos de pirazol que actúan contra afecciones alérgicas, inmunitarias e inflamatorias |
| JP2013544794A (ja) | 2010-10-21 | 2013-12-19 | グラクソ グループ リミテッド | アレルギー性障害、炎症性障害及び免疫障害に作用するピラゾール化合物 |
| GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
| KR20140012989A (ko) | 2011-02-17 | 2014-02-04 | 시플라 리미티드 | 글리코피롤레이트 및 베타2-효능제의 조합 |
| SG192795A1 (en) | 2011-02-25 | 2013-09-30 | Irm Llc | Compounds and compositions as trk inhibitors |
| GB201104153D0 (en) | 2011-03-11 | 2011-04-27 | Glaxo Group Ltd | Novel compounds |
| US20140005188A1 (en) | 2011-03-11 | 2014-01-02 | Glaxo Group Limited | Pyrido[3,4-b]pyrazine derivatives as syk inhibitors |
| RU2013153202A (ru) | 2011-06-08 | 2015-07-20 | Глаксо Груп Лимитед | Композиции для ингалятора сухого порошка, содержащие умеклидиний |
| UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
| WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| US9056867B2 (en) | 2011-09-16 | 2015-06-16 | Novartis Ag | N-substituted heterocyclyl carboxamides |
| CN103946221B (zh) | 2011-09-16 | 2016-08-03 | 诺华股份有限公司 | 用于治疗囊性纤维化的杂环化合物 |
| WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
| WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| GB201116641D0 (en) | 2011-09-27 | 2011-11-09 | Glaxo Group Ltd | Novel compounds |
| US8809340B2 (en) | 2012-03-19 | 2014-08-19 | Novartis Ag | Crystalline form |
| JP6267685B2 (ja) | 2012-04-13 | 2018-01-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | 集合粒子 |
| GB201207406D0 (en) | 2012-04-27 | 2012-06-13 | Glaxo Group Ltd | Novel compounds |
| CN104379559B (zh) | 2012-04-27 | 2016-11-09 | 葛兰素集团有限公司 | 化合物 |
| EA036153B1 (ru) | 2012-07-05 | 2020-10-06 | Арвен Айлак Санайи Ве Тиджарет А.С. | Фармацевтическая композиция для ингаляции, упакованная дозированная форма, капсула, способ лечения обструктивных заболеваний дыхательных путей и фармацевтический набор |
| WO2014041565A2 (en) * | 2012-09-13 | 2014-03-20 | Laurus Labs Private Limited | An improved process for the preparation of vilanterol and intermediates thereof |
| GB201222679D0 (en) | 2012-12-17 | 2013-01-30 | Glaxo Group Ltd | Pharmaceutical combination products |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| RS57075B1 (sr) | 2013-03-15 | 2018-06-29 | Verona Pharma Plc | Kombinacija leka |
| AU2014336250A1 (en) | 2013-10-17 | 2016-04-14 | Glaxosmithkline Intellectual Property Development Limited | PI3K inhibitor for treatment of respiratory disease |
| JP6475707B2 (ja) | 2013-10-17 | 2019-02-27 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | 呼吸器疾患の治療のためのｐｉ３ｋ阻害剤 |
| CN104744270A (zh) * | 2013-12-26 | 2015-07-01 | 成都伊诺达博医药科技有限公司 | 长效β2受体激动剂维兰特罗的合成新方法 |
| CN104744271B (zh) * | 2013-12-26 | 2016-08-31 | 成都伊诺达博医药科技有限公司 | 一种合成维兰特罗的新工艺 |
| BR112016024533A8 (pt) | 2014-04-24 | 2021-03-30 | Novartis Ag | derivados de amino pirazina como inibidores de fosfatidilinositol 3-cinase ou sal, seu uso, e composição e combinação farmacêuticas |
| WO2015162461A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| KR20160145780A (ko) | 2014-04-24 | 2016-12-20 | 노파르티스 아게 | 포스파티딜이노시톨 3-키나제 억제제로서의 아미노 피리딘 유도체 |
| US20170100385A1 (en) | 2014-05-12 | 2017-04-13 | Glaxosmithkline Intellectual Property (No. 2) Limited | Pharmaceutical compositions comprising danirixin for treating infectious diseases |
| ES2775606T3 (es) | 2014-05-28 | 2020-07-27 | Glaxosmithkline Ip Dev Ltd | Furoato de fluticasona en el tratamiento de la EPOC |
| TR201407010A2 (tr) | 2014-06-16 | 2015-12-21 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Vilanterol formülasyonları. |
| MA39288A (fr) | 2014-06-16 | 2015-12-23 | Arven Ilac Sanayi Ve Ticaret As | Formulations pharmaceutiques comprenant du vilanterol |
| EP2957553A1 (en) | 2014-06-16 | 2015-12-23 | Arven Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical formulations of vilanterol |
| EP2957552B1 (en) | 2014-06-16 | 2020-01-22 | Arven Ilac Sanayi Ve Ticaret A.S. | Vilanterol formulations |
| WO2016005443A1 (en) | 2014-07-09 | 2016-01-14 | Arven Ilac Sanayi Ve Ticaret A.S. | A process for the preparation of formulations for inhalation |
| WO2016005447A1 (en) | 2014-07-09 | 2016-01-14 | Arven Ilac Sanayi Ve Ticaret A.S. | A process for preparing the inhalation formulations |
| US20170143626A1 (en) | 2014-07-09 | 2017-05-25 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | A PROCESS FOR THE PREPARATION of DRY POWDER FORMULATIONS |
| WO2017001907A1 (en) | 2015-06-29 | 2017-01-05 | Teva Pharmaceuticals International Gmbh | Biocatalytic processes for the preparation of vilanterol |
| GB201602527D0 (en) | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| CN107188813B (zh) * | 2016-03-14 | 2019-04-26 | 益方生物科技（上海）有限公司 | 苯乙醇胺衍生物及其制备方法和用途 |
| EP3497100A1 (en) | 2016-08-08 | 2019-06-19 | GlaxoSmithKline Intellectual Property Development Limited | Chemical compounds |
| GB201706102D0 (en) | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| PT110209B (pt) * | 2017-07-19 | 2021-05-17 | Hovione Farm Sa | Formas polimórficas de trifenatato de vilanterol e processos para a preparação das mesmas. |
| GB201712081D0 (en) | 2017-07-27 | 2017-09-13 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| EP3766866B1 (en) | 2018-03-14 | 2023-10-25 | Asahi Kasei Kabushiki Kaisha | Method for producing sulfonic-acid-group-containing monomer |
| IT201800004492A1 (it) * | 2018-04-13 | 2019-10-13 | Procedimento per la sintesi di beta-amminoalcoli otticamente attivi | |
| US11484531B2 (en) | 2018-08-30 | 2022-11-01 | Theravance Biopharma R&D Ip, Llc | Methods for treating chronic obstructive pulmonary disease |
| FR3085834B1 (fr) | 2018-09-14 | 2022-04-29 | Euroteknika | Systeme d'implants dentaire |
| CN109574861A (zh) * | 2019-01-22 | 2019-04-05 | 安徽德信佳生物医药有限公司 | 一种维兰特罗三苯乙酸盐的结晶方法 |
| CN111807973B (zh) * | 2019-04-10 | 2021-04-30 | 上海谷森医药有限公司 | 维兰特罗及其盐的制备方法 |
| WO2020237151A1 (en) | 2019-05-23 | 2020-11-26 | Huang Cai Gu | Inhalable formulation of a solution containing vilanterol trifenatate and umeclidinium bromide |
| BR112021024668A2 (pt) | 2019-06-10 | 2022-05-31 | Novartis Ag | Derivado de piridina e pirazina para o tratamento de fc, dpoc e bronquiectasia |
| KR20220052934A (ko) | 2019-08-28 | 2022-04-28 | 노파르티스 아게 | 치환 1,3-페닐 헤테로아릴 유도체 및 질환 치료에서의 이의 용도 |
| US11083693B1 (en) | 2020-01-20 | 2021-08-10 | Cai Gu Huang | Liposome formulation of vilanterol trifenatate |
| PL4188905T3 (pl) * | 2020-07-27 | 2024-12-02 | Inke, S.A. | Sposób oczyszczania trifenatanu wilanterolu |
| WO2023118833A1 (en) | 2021-12-22 | 2023-06-29 | Hovione Scientia Limited | Process to prepare vilanterol trifenatate |
| CN115286491B (zh) * | 2022-08-31 | 2023-09-15 | 山东省药学科学院 | 一种2-[2-(6-溴己氧基)乙氧基甲基]-1,3-二氯苯的制备方法 |
| CN117679423A (zh) | 2022-09-05 | 2024-03-12 | 立生医药(苏州)有限公司 | 预防或治疗呼吸系统疾病的吸入用药物组合物 |
| CN115745945B (zh) * | 2022-11-15 | 2024-06-11 | 奥锐特药业股份有限公司 | 一锅法制备维兰特罗中间体的方法 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2140800A (en) * | 1937-04-26 | 1938-12-20 | Metallurg De Hoboken Soc Gen | Treatment of substances containing tantalum and/or niobium |
| US2918408A (en) | 1957-04-08 | 1959-12-22 | Lakeside Lab Inc | Anti-spasmodic compositions specific for treating spasm of the colon |
| DE2140800C3 (de) | 1971-08-14 | 1980-10-16 | Industriewerk Schaeffler Ohg, 8522 Herzogenaurach | Loswalze für Streckwerke von Spinnmaschinen |
| US3994974A (en) | 1972-02-05 | 1976-11-30 | Yamanouchi Pharmaceutical Co., Ltd. | α-Aminomethylbenzyl alcohol derivatives |
| CY1308A (en) | 1979-12-06 | 1985-12-06 | Glaxo Group Ltd | Device for dispensing medicaments |
| EP0069715B1 (en) | 1981-07-08 | 1986-11-05 | Aktiebolaget Draco | Powder inhalator |
| AT396333B (de) | 1982-10-08 | 1993-08-25 | Glaxo Group Ltd | Vorrichtung zur verabreichung von medikamenten an patienten, einrichtung mit mehreren solchen vorrichtungen und traeger mit medikamentbehaeltern hiefuer |
| GB2169265B (en) | 1982-10-08 | 1987-08-12 | Glaxo Group Ltd | Pack for medicament |
| ZW6584A1 (en) | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
| DE3571808D1 (en) | 1984-04-17 | 1989-08-31 | Glaxo Group Ltd | Ethanolamine compounds |
| US4853381A (en) * | 1984-04-17 | 1989-08-01 | Glaxo Group Limited | Ethanolamine compounds |
| FR2562889B1 (fr) | 1984-04-17 | 1988-10-28 | Glaxo Group Ltd | Composes de phenethanolamine. procede pour leur preparation et compositions pharmaceutiques les comprenant |
| GB8426200D0 (en) * | 1984-10-17 | 1984-11-21 | Glaxo Holdings Ltd | Chemical compounds |
| IL75794A (en) | 1984-07-13 | 1989-01-31 | Glaxo Group Ltd | 2-hydroxy-5-(1-hydroxy-2-(aralkyloxyalkylamino)ethyl)aniline derivatives,their preparation and pharmaceutical compositions containing them |
| DK163640C (da) | 1985-07-30 | 1992-08-17 | Glaxo Group Ltd | Apparat til administrering af medikamenter |
| GB8525483D0 (en) | 1985-10-16 | 1985-11-20 | Glaxo Group Ltd | Chemical compounds |
| EP0223410A3 (en) | 1985-10-16 | 1987-11-19 | Glaxo Group Limited | Ethanolamine derivatives |
| FR2588474B1 (fr) | 1985-10-16 | 1987-11-27 | Cird | Compositions synergetiques anti-inflammatoires a base d'un corticosteroide et d'un beta agoniste |
| EP0220054A3 (en) | 1985-10-16 | 1987-12-02 | Glaxo Group Limited | Ethanolamine derivatives |
| JPS6485964A (en) * | 1987-03-12 | 1989-03-30 | Glaxo Group Ltd | Compound |
| GB8718940D0 (en) | 1987-08-11 | 1987-09-16 | Glaxo Group Ltd | Chemical compounds |
| GB8821179D0 (en) * | 1988-09-09 | 1988-10-12 | Glaxo Group Ltd | Chemical compounds |
| JPH0228141A (ja) | 1987-11-13 | 1990-01-30 | Glaxo Group Ltd | フェネタノールアミン誘導体 |
| GB2230523A (en) | 1989-04-14 | 1990-10-24 | Glaxo Group Ltd | 1-(3-Bromoisoxazol-5-yl)-2-aminoethanol derivatives |
| GB8909273D0 (en) * | 1989-04-24 | 1989-06-07 | Glaxo Group Ltd | Chemical compounds |
| US5290815A (en) * | 1989-09-07 | 1994-03-01 | Glaxo Group Limited | Treatment of inflammation and allergy |
| IL95590A (en) | 1989-09-08 | 1996-06-18 | Glaxo Group Ltd | Medicinal preparations containing Salmetrol and Pluticasone Propionate |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| DE4028398A1 (de) * | 1990-09-07 | 1992-03-12 | Thomae Gmbh Dr K | Phenylethanolamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| WO1993019749A1 (en) * | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
| GB9222700D0 (en) | 1992-10-29 | 1992-12-09 | Smithkline Beecham Plc | Chemical compounds |
| TW263495B (enExample) * | 1992-12-23 | 1995-11-21 | Celltech Ltd | |
| GB9313574D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Medicaments |
| GB9323429D0 (en) | 1993-11-12 | 1994-01-05 | Wellcome Found | Therapy |
| AU1533495A (en) | 1994-01-12 | 1995-08-01 | Byk Nederland Bv | Phenyl ethanol amine ethers and uses thereof as beta-adreno-receptor agonists |
| US5998428A (en) | 1995-05-31 | 1999-12-07 | Smithkline Beecham Corporation | Compounds and methods for treating PDE IV-related diseases |
| EP0947498B1 (en) | 1996-12-02 | 2004-09-15 | Chisso Corporation | Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same |
| WO1999016766A1 (en) | 1997-10-01 | 1999-04-08 | Kyowa Hakko Kogyo Co., Ltd. | Benzodioxole derivatives |
| SI1070056T1 (en) | 1998-03-14 | 2004-12-31 | Altana Pharma Ag | Phthalazinone pde iii/iv inhibitors |
| AR035987A1 (es) | 1999-03-01 | 2004-08-04 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de la pde 4 para la manufactura de un medicamento y el medicamento para tratar asma inducida por ejercicio |
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| SI1212089T1 (sl) | 1999-08-21 | 2006-08-31 | Altana Pharma Ag | Sinergisticna kombinacija roflumilasta in salmeterola |
| GB0103630D0 (en) | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
| WO2002070490A1 (en) | 2001-03-08 | 2002-09-12 | Glaxo Group Limited | Agonists of beta-adrenoceptors |
| MXPA04002405A (es) | 2001-09-14 | 2004-05-31 | Glaxo Group Limetd | Derivados de fenetanolamina para tratamiento de enfermedades respiratorias. |
| GB0303396D0 (en) | 2003-02-14 | 2003-03-19 | Glaxo Group Ltd | Medicinal compounds |
| US7351787B2 (en) * | 2004-03-05 | 2008-04-01 | Bioartificial Gel Technologies, Inc. | Process for the preparation of activated polyethylene glycols |
-
2002
- 2002-09-11 MX MXPA04002405A patent/MXPA04002405A/es active IP Right Grant
- 2002-09-11 ES ES02760407T patent/ES2316599T3/es not_active Expired - Lifetime
- 2002-09-11 DE DE60230425T patent/DE60230425D1/de not_active Expired - Lifetime
- 2002-09-11 PL PL370276A patent/PL211953B1/pl not_active IP Right Cessation
- 2002-09-11 PT PT02760407T patent/PT1425001E/pt unknown
- 2002-09-11 ES ES08170993.3T patent/ES2438985T3/es not_active Expired - Lifetime
- 2002-09-11 AT AT02760407T patent/ATE417606T1/de active
- 2002-09-11 BR BRPI0212455A patent/BRPI0212455B8/pt not_active IP Right Cessation
- 2002-09-11 NZ NZ531651A patent/NZ531651A/en not_active IP Right Cessation
- 2002-09-11 AU AU2002326026A patent/AU2002326026B2/en active Active
- 2002-09-11 CN CN02822325XA patent/CN1585633B/zh not_active Expired - Lifetime
- 2002-09-11 SI SI200231039T patent/SI2042168T1/sl unknown
- 2002-09-11 IL IL16059502A patent/IL160595A0/xx unknown
- 2002-09-11 KR KR1020047003795A patent/KR100912324B1/ko not_active Expired - Lifetime
- 2002-09-11 KR KR1020097010537A patent/KR20090057477A/ko not_active Ceased
- 2002-09-11 WO PCT/GB2002/004140 patent/WO2003024439A1/en not_active Ceased
- 2002-09-11 US US10/489,569 patent/US7361787B2/en not_active Ceased
- 2002-09-11 HU HU0401619A patent/HU228508B1/hu active Protection Beyond IP Right Term
- 2002-09-11 PT PT81709933T patent/PT2042168E/pt unknown
- 2002-09-11 JP JP2003528536A patent/JP4191034B2/ja not_active Expired - Lifetime
- 2002-09-11 CA CA2458534A patent/CA2458534C/en not_active Expired - Lifetime
- 2002-09-11 EP EP02760407A patent/EP1425001B1/en not_active Expired - Lifetime
- 2002-09-11 EP EP08170993.3A patent/EP2042168B1/en not_active Expired - Lifetime
- 2002-09-11 CN CN201310042387.2A patent/CN103288793B/zh not_active Expired - Lifetime
- 2002-09-11 RU RU2004106555/04A patent/RU2312854C2/ru active Protection Beyond IP Right Term
- 2002-09-11 CN CN200910208840.6A patent/CN101701006B/zh not_active Expired - Lifetime
- 2002-09-11 PL PL393155A patent/PL393155A1/pl not_active Application Discontinuation
- 2002-09-11 SI SI200230795T patent/SI1425001T1/sl unknown
- 2002-09-11 US US13/719,797 patent/USRE44874E1/en not_active Expired - Lifetime
- 2002-09-11 DK DK02760407T patent/DK1425001T3/da active
- 2002-09-11 DK DK08170993.3T patent/DK2042168T3/da active
- 2002-09-12 TW TW091120875A patent/TWI299661B/zh active
- 2002-09-12 MY MYPI20023401A patent/MY129422A/en unknown
- 2002-09-13 AR ARP020103476A patent/AR036874A1/es active IP Right Grant
-
2004
- 2004-02-26 IL IL160595A patent/IL160595A/en active Protection Beyond IP Right Term
- 2004-03-10 CO CO04021965A patent/CO5560552A2/es active IP Right Grant
- 2004-03-11 NO NO20041041A patent/NO333813B1/no not_active IP Right Cessation
-
2006
- 2006-12-04 US US11/566,346 patent/US7439393B2/en not_active Expired - Lifetime
-
2007
- 2007-06-28 RU RU2007124187/04A patent/RU2007124187A/ru not_active Application Discontinuation
-
2008
- 2008-09-16 US US12/211,322 patent/US7776895B2/en not_active Expired - Lifetime
-
2009
- 2009-02-25 CY CY20091100211T patent/CY1109422T1/el unknown
-
2010
- 2010-07-14 US US12/836,025 patent/US7982067B2/en not_active Expired - Lifetime
-
2011
- 2011-06-21 US US13/165,037 patent/US8198483B2/en not_active Expired - Fee Related
-
2013
- 2013-06-27 AR ARP130102285 patent/AR091595A2/es not_active Application Discontinuation
- 2013-12-16 CY CY20131101131T patent/CY1114728T1/el unknown
-
2014
- 2014-04-02 FR FR14C0028C patent/FR14C0028I2/fr active Active
- 2014-04-03 NO NO2014007C patent/NO2014007I1/no not_active IP Right Cessation
- 2014-04-11 LT LTPA2014019C patent/LTC1425001I2/lt unknown
- 2014-04-24 HU HUS1400025C patent/HUS1400025I1/hu unknown
- 2014-04-25 BE BE2014C026C patent/BE2014C026I2/fr unknown
- 2014-04-28 CY CY2014019C patent/CY2014019I2/el unknown
- 2014-04-30 LU LU92439C patent/LU92439I2/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005511508A5 (enExample) | ||
| RU2312854C2 (ru) | Производные фенэтаноламина для лечения респираторных заболеваний | |
| JP2007509852A5 (enExample) | ||
| DE60133584T2 (de) | 4-arylpiperidine als opioidrezeptorbindende agenzien | |
| JP2005523920A5 (enExample) | ||
| JP2006506373A5 (enExample) | ||
| RU2004112780A (ru) | Производные и промежуточные соединения n-адамантилметила в качестве фармацевтических композиций и способы их получения | |
| DE602005002930T2 (de) | Sulfonamidderivate zur behandlung von krankheiten | |
| ZA200500133B (en) | 1H-1,2,4-triazole-3-carboxamide derivatives as ca nnabinoid- CB, receptor ligands. | |
| RU2008111991A (ru) | Органические соединения | |
| JP2005519083A5 (enExample) | ||
| JP2011063620A (ja) | ピペリジンおよびピペラジン誘導体 | |
| EP1302463A1 (en) | Medicine comprising dicyanopyridine derivative | |
| RU2011121876A (ru) | Пиразолопиримидиновые соединения-ингибиторы jak и способы | |
| KR20150114480A (ko) | Hbv 감염에 대한 항바이러스 물질 | |
| CA2467752A1 (en) | Piperidin-2-one derivative compounds and pharmaceutical composition comprising the same as active ingredient | |
| JPH08176145A (ja) | アロイル−ピペリジン誘導体 | |
| AU2004263491A1 (en) | 4,5-dihydro-imidazole as P2X7 ion channel blockers | |
| ZA200306037B (en) | Derivatives of N-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same. | |
| JPH0331715B2 (enExample) | ||
| JP2007505931A5 (enExample) | ||
| RU2010113358A (ru) | Гуанидинсодержащие соединения, применимые в качестве антагонистов мускариновых рецепторов | |
| JPH0276854A (ja) | ピリジニウム誘導体 | |
| JP2008508247A5 (enExample) | ||
| EP1572625A1 (en) | Arylene-carboxylic acid (2-amino-phenyl)-amide derivatives as pharmaceutical agents |