JP2007509103A5 - - Google Patents
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- Publication number
- JP2007509103A5 JP2007509103A5 JP2006536054A JP2006536054A JP2007509103A5 JP 2007509103 A5 JP2007509103 A5 JP 2007509103A5 JP 2006536054 A JP2006536054 A JP 2006536054A JP 2006536054 A JP2006536054 A JP 2006536054A JP 2007509103 A5 JP2007509103 A5 JP 2007509103A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound
- hydrogen
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 22
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 15
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000001475 halogen functional group Chemical group 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
- 239000000048 adrenergic agonist Substances 0.000 claims 2
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 1
- ICHJLRZMVDJZKN-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[1-hydroxy-2-[2-[4-(2-phenylmethoxyethoxy)phenyl]ethylamino]ethyl]pyridin-3-ol Chemical compound C1=C(O)C(CO)=NC(C(O)CNCCC=2C=CC(OCCOCC=3C=CC=CC=3)=CC=2)=C1 ICHJLRZMVDJZKN-UHFFFAOYSA-N 0.000 claims 1
- GJSBYVWPVHUVJP-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[1-hydroxy-2-[2-[4-(4-phenylbutoxy)phenyl]ethylamino]ethyl]pyridin-3-ol Chemical compound C1=C(O)C(CO)=NC(C(O)CNCCC=2C=CC(OCCCCC=3C=CC=CC=3)=CC=2)=C1 GJSBYVWPVHUVJP-UHFFFAOYSA-N 0.000 claims 1
- OWCJNTCMXLPNRA-VWLOTQADSA-N 2-fluoro-4-[(1r)-1-hydroxy-2-[2-[4-(2-phenylmethoxyethoxy)phenyl]ethylamino]ethyl]phenol Chemical compound C([C@H](O)C=1C=C(F)C(O)=CC=1)NCCC(C=C1)=CC=C1OCCOCC1=CC=CC=C1 OWCJNTCMXLPNRA-VWLOTQADSA-N 0.000 claims 1
- XONXUOQCMYRGLW-SANMLTNESA-N 2-fluoro-4-[(1r)-1-hydroxy-2-[2-[4-(4-phenylbutoxy)phenyl]ethylamino]ethyl]phenol Chemical compound C([C@H](O)C=1C=C(F)C(O)=CC=1)NCCC(C=C1)=CC=C1OCCCCC1=CC=CC=C1 XONXUOQCMYRGLW-SANMLTNESA-N 0.000 claims 1
- NEBLIVRWSKMOSR-SANMLTNESA-N 3-[2-[4-[2-[[(2r)-2-hydroxy-2-[4-hydroxy-3-(methanesulfonamido)phenyl]ethyl]amino]ethyl]phenoxy]ethoxymethyl]benzamide Chemical compound C1=C(O)C(NS(=O)(=O)C)=CC([C@@H](O)CNCCC=2C=CC(OCCOCC=3C=C(C=CC=3)C(N)=O)=CC=2)=C1 NEBLIVRWSKMOSR-SANMLTNESA-N 0.000 claims 1
- NFLJCBQMWFDRDJ-UHFFFAOYSA-N 3-[2-[4-[2-[[2-hydroxy-2-[5-hydroxy-6-(hydroxymethyl)pyridin-2-yl]ethyl]amino]ethyl]phenoxy]ethoxymethyl]benzamide Chemical compound NC(=O)C1=CC=CC(COCCOC=2C=CC(CCNCC(O)C=3N=C(CO)C(O)=CC=3)=CC=2)=C1 NFLJCBQMWFDRDJ-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 230000002152 alkylating effect Effects 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 238000003795 desorption Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- BVWGFLBWNSWVPH-SANMLTNESA-N n-[2-hydroxy-5-[(1r)-1-hydroxy-2-[2-[4-(2-phenylmethoxyethoxy)phenyl]ethylamino]ethyl]phenyl]methanesulfonamide Chemical compound C1=C(O)C(NS(=O)(=O)C)=CC([C@@H](O)CNCCC=2C=CC(OCCOCC=3C=CC=CC=3)=CC=2)=C1 BVWGFLBWNSWVPH-SANMLTNESA-N 0.000 claims 1
- FYOWHEIXDUQBPT-MHZLTWQESA-N n-[2-hydroxy-5-[(1r)-1-hydroxy-2-[2-[4-(4-phenylbutoxy)phenyl]ethylamino]ethyl]phenyl]methanesulfonamide Chemical compound C1=C(O)C(NS(=O)(=O)C)=CC([C@@H](O)CNCCC=2C=CC(OCCCCC=3C=CC=CC=3)=CC=2)=C1 FYOWHEIXDUQBPT-MHZLTWQESA-N 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0324654.3A GB0324654D0 (en) | 2003-10-22 | 2003-10-22 | Medicinal compounds |
| PCT/EP2004/011952 WO2005040103A1 (en) | 2003-10-22 | 2004-10-20 | Medicinal compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007509103A JP2007509103A (ja) | 2007-04-12 |
| JP2007509103A5 true JP2007509103A5 (enExample) | 2007-10-11 |
Family
ID=29595615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006536054A Pending JP2007509103A (ja) | 2003-10-22 | 2004-10-20 | 医薬化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090105309A1 (enExample) |
| EP (1) | EP1675823B1 (enExample) |
| JP (1) | JP2007509103A (enExample) |
| AT (1) | ATE402141T1 (enExample) |
| DE (1) | DE602004015316D1 (enExample) |
| ES (1) | ES2309571T3 (enExample) |
| GB (1) | GB0324654D0 (enExample) |
| WO (1) | WO2005040103A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
| KR20080036632A (ko) | 2005-08-08 | 2008-04-28 | 아젠터 디스커버리 리미티드 | 바이시클로[2.2.1]헵트-7-일아민 유도체 및 이들의 용도 |
| TW200738658A (en) | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| CA2625664C (en) | 2005-10-21 | 2016-01-05 | Novartis Ag | Human antibodies against il13 and therapeutic uses |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| TW200745067A (en) | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2007121920A2 (en) | 2006-04-21 | 2007-11-01 | Novartis Ag | Purine derivatives for use as adenosin a2a receptor agonists |
| ES2302447B1 (es) * | 2006-10-20 | 2009-06-12 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
| TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| WO2009087224A1 (en) | 2008-01-11 | 2009-07-16 | Novartis Ag | Pyrimidines as kinase inhibitors |
| EP2303873A4 (en) | 2008-06-18 | 2012-01-04 | Astrazeneca Ab | BENZOXAZINE DERIVATIVES AS A BETA2 ADRENORE RECEPTOR AGONIST FOR THE TREATMENT OF RESPIRATORY DISEASES |
| US8236786B2 (en) | 2008-08-07 | 2012-08-07 | Pulmagen Therapeutics (Inflammation) Limited | Respiratory disease treatment |
| US8362064B2 (en) | 2008-12-30 | 2013-01-29 | Pulmagen Theraputics (Inflammation) Limited | Sulfonamide compounds for the treatment of respiratory disorders |
| WO2010150014A1 (en) | 2009-06-24 | 2010-12-29 | Pulmagen Therapeutics (Inflammation) Limited | 5r- 5 -deuterated glitazones for respiratory disease treatment |
| GB0918923D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminothiazole derivatives |
| GB0918924D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Azaindole derivatives |
| GB0918922D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminopyridine derivatives |
| WO2011098746A1 (en) | 2010-02-09 | 2011-08-18 | Pulmagen Therapeutics (Inflammation) Limited | Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone |
| GB201002243D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
| GB201002224D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| JP5959541B2 (ja) | 2011-02-25 | 2016-08-02 | ノバルティス アーゲー | Ｔｒｋ阻害剤としてのピラゾロ［１，５−ａ］ピリジン |
| EP2578570A1 (en) | 2011-10-07 | 2013-04-10 | Almirall, S.A. | Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis. |
| EP2641900A1 (en) | 2012-03-20 | 2013-09-25 | Almirall, S.A. | Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR8007911A (pt) * | 1979-12-06 | 1981-06-16 | Glaxo Group Ltd | Inalador aperfeicoado |
| ZA824902B (en) * | 1981-07-11 | 1983-04-27 | Beecham Group Plc | Secondary amines |
| WO1984000956A1 (en) * | 1982-08-27 | 1984-03-15 | Beecham Group Plc | Secondary arylethanolamines |
| US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| ZW6584A1 (en) * | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
| ZA862665B (en) * | 1985-04-16 | 1986-11-26 | Hoffmann La Roche | Phenethanolamine derivatives |
| ATE41655T1 (de) * | 1985-04-16 | 1989-04-15 | Hoffmann La Roche | Phenaethanolaminderivate. |
| DK163640C (da) * | 1985-07-30 | 1992-08-17 | Glaxo Group Ltd | Apparat til administrering af medikamenter |
| DE3621775A1 (de) * | 1986-03-13 | 1988-01-07 | Thomae Gmbh Dr K | Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| CZ283425B6 (cs) * | 1992-04-02 | 1998-04-15 | Smithkline Beecham Corporation | Fenylové deriváty a farmaceutické prostředky s jejich obsahem |
| US5860645A (en) * | 1995-10-20 | 1999-01-19 | Canon Kabushiki Kaisha | Sheet supplying apparatus |
| DOP2003000587A (es) * | 2002-02-27 | 2003-08-30 | Pfizer Prod Inc | AGONISTAS DEL RECEPTOR ß3-ADRENERGICO |
| ES2298511T3 (es) * | 2002-04-25 | 2008-05-16 | Glaxo Group Limited | Derivados de fenetanolamina. |
-
2003
- 2003-10-22 GB GBGB0324654.3A patent/GB0324654D0/en not_active Ceased
-
2004
- 2004-10-20 WO PCT/EP2004/011952 patent/WO2005040103A1/en not_active Ceased
- 2004-10-20 DE DE602004015316T patent/DE602004015316D1/de not_active Expired - Fee Related
- 2004-10-20 ES ES04790747T patent/ES2309571T3/es not_active Expired - Lifetime
- 2004-10-20 US US10/595,432 patent/US20090105309A1/en not_active Abandoned
- 2004-10-20 AT AT04790747T patent/ATE402141T1/de not_active IP Right Cessation
- 2004-10-20 EP EP04790747A patent/EP1675823B1/en not_active Expired - Lifetime
- 2004-10-20 JP JP2006536054A patent/JP2007509103A/ja active Pending
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