JP2005507400A5 - - Google Patents
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- JP2005507400A5 JP2005507400A5 JP2003537607A JP2003537607A JP2005507400A5 JP 2005507400 A5 JP2005507400 A5 JP 2005507400A5 JP 2003537607 A JP2003537607 A JP 2003537607A JP 2003537607 A JP2003537607 A JP 2003537607A JP 2005507400 A5 JP2005507400 A5 JP 2005507400A5
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- JP
- Japan
- Prior art keywords
- composition
- dosage form
- gabapentin
- composition according
- stomach
- Prior art date
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- 239000000203 mixture Substances 0.000 claims 46
- 239000002552 dosage form Substances 0.000 claims 25
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapen Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 13
- 229960002870 gabapentin Drugs 0.000 claims 13
- 210000002784 Stomach Anatomy 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 210000001198 Duodenum Anatomy 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 235000012054 meals Nutrition 0.000 claims 2
- 210000000813 small intestine Anatomy 0.000 claims 2
- VUKAUDKDFVSVFT-UHFFFAOYSA-N 2-[6-[4,5-bis(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol Chemical compound COC1C(OC)C(OC2C(C(O)C(OC)C(CO)O2)O)C(COC)OC1OC1C(COCC(C)O)OC(OC)C(OCC(C)O)C1OCC(C)O VUKAUDKDFVSVFT-UHFFFAOYSA-N 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N 3-hydroxy-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- 206010015037 Epilepsy Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010027599 Migraine Diseases 0.000 claims 1
- 208000008085 Migraine Disorders Diseases 0.000 claims 1
- 208000004296 Neuralgia Diseases 0.000 claims 1
- 229940005483 OPIOID ANALGESICS Drugs 0.000 claims 1
- 206010037175 Psychiatric disease Diseases 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000002921 anti-spasmodic Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229960004502 levodopa Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 201000009457 movement disease Diseases 0.000 claims 1
- 230000003364 opioid Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000002035 prolonged Effects 0.000 claims 1
- 230000000069 prophylaxis Effects 0.000 claims 1
- 239000007939 sustained release tablet Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 claims 1
Claims (23)
- 神経障害性疼痛を処置するための薬学的組成物であって、該組成物は、胃に留まる投薬形態にて、治療的有効量のガバペンチンまたはその薬学的に受容可能な塩を含む、組成物。
- 請求項1に記載の組成物であって、前記投薬形態は、1日に1回投与され得る、組成物。
- 請求項2に記載の組成物であって、前記投薬形態は、食事と共に投与され得る、組成物。
- 請求項1に記載の組成物であって、前記投薬形態は、1日に2回投与され得る、組成物。
- 請求項4に記載の組成物であって、前記投薬形態は、食事と共に投与され得る、組成物。
- 請求項1に記載の組成物であって、該組成物は、鎮痙薬、三環系抗鬱薬、オピオイド、およびレボドパからなる群より選択される、1種類以上の治療剤をさらに含む、組成物。
- 請求項1に記載の組成物であって、前記投薬形態は、1日に1回または1日に2回投与され得、1日投薬量中のガバペンチンの総量は、約100〜4800mgである、組成物。
- 請求項7に記載の組成物であって、前記1日投薬量中のガバペンチンの総量は、約300〜3600mgである、組成物。
- 請求項8に記載の組成物であって、前記1日投薬量中のガバペンチンの総量は、約900〜2400mgである、組成物。
- 請求項1に記載の組成物であって、前記投薬形態は、胃、十二指腸、および小腸へガバペンチンを放出するための長期放出性経口薬物の投薬形態である、組成物。
- 請求項10に記載の組成物であって、前記投薬形態は、該投薬形態が少なくとも5時間の期間にわたって投与された場合に、前記ガバペンチンの少なくとも40重量%が、少なくとも1時間にわたって該投薬形態中に留まるように処方される、組成物。
- 請求項11に記載の組成物であって、前記投薬形態は、該投薬形態が約5〜12時間の期間にわたって送達された場合に、前記ガバペンチンの少なくとも80重量%が送達されるように処方される、組成物。
- 請求項11に記載の組成物であって、前記投薬形態は、栄養補給様式での該投薬形態の留まりを促進するような程度まで膨潤し得る、少なくとも1つの親水性ポリマーを含む、組成物。
- 請求項13に記載の組成物であって、前記ポリマーは、ポリエチレンオキシド、アルキル置換セルロース物質、およびこれらの組み合わせからなる群より選択される、組成物。
- 請求項11に記載の組成物であって、前記投薬形態は、気体発生剤をさらに含む、組成物。
- 請求項15に記載の組成物であって、前記ガバペンチンは、前記気体発生剤とともに膜サシェ中に含まれる、組成物。
- 請求項1に記載の組成物であって、前記投薬形態は、接着性錠剤である、組成物。
- 請求項1に記載の組成物であって、前記投薬形態は、前記哺乳動物の胃、十二指腸および小腸におけるガバペンチンの長期放出を可能にする、フィルムコーティング投薬形態またはカプセル剤投薬形態である、組成物。
- 請求項1に記載の組成物であって、前記投薬形態は、ポリ(エチレンオキシド)およびヒドロキシプロピルメチルセルロースから構成されるマトリクスを有する、膨潤可能な徐放性錠剤である、組成物。
- 癲癇を処置するための薬学的組成物であって、該組成物は、胃に留まる投薬形態にて、治療的有効量のガバペンチンまたはその薬学的に受容可能な塩を含む、組成物。
- 精神医学的障害を処置するための薬学的組成物であって、該組成物は、胃に留まる投薬形態にて、治療的有効量のガバペンチンまたはその薬学的に受容可能な塩を含む、組成物。
- 運動障害を処置するための薬学的組成物であって、該組成物は、胃に留まる投薬形態にて、治療的有効量のガバペンチンまたはその薬学的に受容可能な塩を含む、組成物。
- 片頭痛の予防処置のための薬学的組成物であって、該組成物は、胃に留まる投薬形態にて、治療的有効量のガバペンチンまたはその薬学的に受容可能な塩を含む、組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33524801P | 2001-10-25 | 2001-10-25 | |
US60/335,248 | 2001-10-25 | ||
PCT/IB2002/005440 WO2003035040A1 (en) | 2001-10-25 | 2002-10-25 | Methods of treatment using a gastric retained gabapentin dosage |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010179064A Division JP2010254713A (ja) | 2001-10-25 | 2010-08-09 | 胃に留まるガバペンチン投薬を使用する処置方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2005507400A JP2005507400A (ja) | 2005-03-17 |
JP2005507400A5 true JP2005507400A5 (ja) | 2006-01-05 |
JP5421511B2 JP5421511B2 (ja) | 2014-02-19 |
Family
ID=23310919
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003537607A Expired - Fee Related JP5421511B2 (ja) | 2001-10-25 | 2002-10-25 | 胃に留まるガバペンチン投薬を使用する処置方法 |
JP2010179064A Pending JP2010254713A (ja) | 2001-10-25 | 2010-08-09 | 胃に留まるガバペンチン投薬を使用する処置方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010179064A Pending JP2010254713A (ja) | 2001-10-25 | 2010-08-09 | 胃に留まるガバペンチン投薬を使用する処置方法 |
Country Status (9)
Country | Link |
---|---|
US (10) | US7438927B2 (ja) |
EP (2) | EP2266539A3 (ja) |
JP (2) | JP5421511B2 (ja) |
AU (1) | AU2002348828B2 (ja) |
CA (1) | CA2464322C (ja) |
DK (1) | DK1439825T4 (ja) |
MX (1) | MXPA04003946A (ja) |
TW (1) | TWI312285B (ja) |
WO (1) | WO2003035040A1 (ja) |
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-
2002
- 2002-10-24 TW TW091124777A patent/TWI312285B/zh not_active IP Right Cessation
- 2002-10-25 EP EP10179051A patent/EP2266539A3/en not_active Withdrawn
- 2002-10-25 CA CA2464322A patent/CA2464322C/en not_active Expired - Lifetime
- 2002-10-25 MX MXPA04003946A patent/MXPA04003946A/es active IP Right Grant
- 2002-10-25 AU AU2002348828A patent/AU2002348828B2/en not_active Ceased
- 2002-10-25 EP EP02781665.1A patent/EP1439825B2/en not_active Expired - Lifetime
- 2002-10-25 WO PCT/IB2002/005440 patent/WO2003035040A1/en active Application Filing
- 2002-10-25 JP JP2003537607A patent/JP5421511B2/ja not_active Expired - Fee Related
- 2002-10-25 DK DK02781665.1T patent/DK1439825T4/en active
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2003
- 2003-01-22 US US10/280,309 patent/US7438927B2/en not_active Expired - Lifetime
-
2008
- 2008-09-26 US US12/239,591 patent/US7731989B2/en not_active Expired - Fee Related
-
2010
- 2010-03-29 US US12/749,101 patent/US8252332B2/en not_active Expired - Lifetime
- 2010-08-09 JP JP2010179064A patent/JP2010254713A/ja active Pending
-
2011
- 2011-05-19 US US13/111,575 patent/US8192756B2/en not_active Expired - Lifetime
- 2011-11-21 US US13/301,644 patent/US8231905B2/en not_active Expired - Lifetime
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2012
- 2012-02-14 US US13/396,441 patent/US8409613B2/en not_active Expired - Fee Related
- 2012-07-19 US US13/553,622 patent/US8333991B2/en not_active Expired - Lifetime
- 2012-07-27 US US13/560,938 patent/US8333992B2/en not_active Expired - Lifetime
-
2013
- 2013-04-01 US US13/854,433 patent/US8580303B2/en not_active Expired - Fee Related
- 2013-11-08 US US14/075,965 patent/US20140072623A1/en not_active Abandoned
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