JP2005501873A - アミン誘導体 - Google Patents
アミン誘導体 Download PDFInfo
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- JP2005501873A JP2005501873A JP2003524319A JP2003524319A JP2005501873A JP 2005501873 A JP2005501873 A JP 2005501873A JP 2003524319 A JP2003524319 A JP 2003524319A JP 2003524319 A JP2003524319 A JP 2003524319A JP 2005501873 A JP2005501873 A JP 2005501873A
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- Prior art keywords
- branched
- linear
- hydroxy
- hydrogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 Cc1cc2c(*)cc(*)c(C)c2c(*)c1* Chemical compound Cc1cc2c(*)cc(*)c(C)c2c(*)c1* 0.000 description 8
- HSUVVEOSEDYFSO-UHFFFAOYSA-N Nc1c(cc(cc2)O)c2ccc1Cl Chemical compound Nc1c(cc(cc2)O)c2ccc1Cl HSUVVEOSEDYFSO-UHFFFAOYSA-N 0.000 description 2
- PHWJSJHLLGLMRS-RCCKNPSSSA-N C=CCOc(ccc1ccc2)cc1c2/N=C/c1ccccc1 Chemical compound C=CCOc(ccc1ccc2)cc1c2/N=C/c1ccccc1 PHWJSJHLLGLMRS-RCCKNPSSSA-N 0.000 description 1
- NIGGDBPJPZJICI-UHFFFAOYSA-N C=CCOc1ccc(cccc2N)c2c1 Chemical compound C=CCOc1ccc(cccc2N)c2c1 NIGGDBPJPZJICI-UHFFFAOYSA-N 0.000 description 1
- HFGKNKCAZMAPBD-UHFFFAOYSA-N CC(Oc(ccc1c(cc2Cl)Cl)cc1c2NC(Oc1ccccc1)=O)=O Chemical compound CC(Oc(ccc1c(cc2Cl)Cl)cc1c2NC(Oc1ccccc1)=O)=O HFGKNKCAZMAPBD-UHFFFAOYSA-N 0.000 description 1
- OAPDPORYXWQVJE-UHFFFAOYSA-N CCCc(cc1)ccc1N Chemical compound CCCc(cc1)ccc1N OAPDPORYXWQVJE-UHFFFAOYSA-N 0.000 description 1
- QNNBTCARDUSZHJ-UHFFFAOYSA-N CCCc(cc1)ccc1NC(Nc(c(Cl)c1)c(cc(cc2)O)c2c1Cl)=O Chemical compound CCCc(cc1)ccc1NC(Nc(c(Cl)c1)c(cc(cc2)O)c2c1Cl)=O QNNBTCARDUSZHJ-UHFFFAOYSA-N 0.000 description 1
- XAOXEHQAXPDTLD-UHFFFAOYSA-N CCNc(ccc1ccc2Cl)cc1c2N Chemical compound CCNc(ccc1ccc2Cl)cc1c2N XAOXEHQAXPDTLD-UHFFFAOYSA-N 0.000 description 1
- VZDNXXPBYLGWOS-UHFFFAOYSA-N COC(c1cc(N)ccc1)=O Chemical compound COC(c1cc(N)ccc1)=O VZDNXXPBYLGWOS-UHFFFAOYSA-N 0.000 description 1
- FMLZSQJZMUGXER-UHFFFAOYSA-N COC(c1cccc(NC(Nc2cccc(cc3)c2cc3O)=O)c1)=O Chemical compound COC(c1cccc(NC(Nc2cccc(cc3)c2cc3O)=O)c1)=O FMLZSQJZMUGXER-UHFFFAOYSA-N 0.000 description 1
- YBYKNEWXBWMVMZ-UHFFFAOYSA-N Cc(c(c1c2)ccc2O)cc(Cl)c1N Chemical compound Cc(c(c1c2)ccc2O)cc(Cl)c1N YBYKNEWXBWMVMZ-UHFFFAOYSA-N 0.000 description 1
- QRTQKHOBYIQCQO-UHFFFAOYSA-N Cc(c(c1c2)ccc2O)ccc1N Chemical compound Cc(c(c1c2)ccc2O)ccc1N QRTQKHOBYIQCQO-UHFFFAOYSA-N 0.000 description 1
- KVHHMYZBFBSVDI-UHFFFAOYSA-N Nc(c1c2)cccc1ccc2O Chemical compound Nc(c1c2)cccc1ccc2O KVHHMYZBFBSVDI-UHFFFAOYSA-N 0.000 description 1
- MUNOBADFTHUUFG-UHFFFAOYSA-N Nc1cccc(-c2ccccc2)c1 Chemical compound Nc1cccc(-c2ccccc2)c1 MUNOBADFTHUUFG-UHFFFAOYSA-N 0.000 description 1
- YQKWJRJWZYRHJA-LDADJPATSA-N Oc(ccc1ccc2)cc1c2/N=C/c1ccccc1 Chemical compound Oc(ccc1ccc2)cc1c2/N=C/c1ccccc1 YQKWJRJWZYRHJA-LDADJPATSA-N 0.000 description 1
- XQQVNNCIURLIDB-UHFFFAOYSA-N Oc1ccc(ccc(Cl)c2NC(Nc3cc(-c4ccccc4)ccc3)=O)c2c1 Chemical compound Oc1ccc(ccc(Cl)c2NC(Nc3cc(-c4ccccc4)ccc3)=O)c2c1 XQQVNNCIURLIDB-UHFFFAOYSA-N 0.000 description 1
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
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- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
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- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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- C—CHEMISTRY; METALLURGY
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Applications Claiming Priority (3)
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JP2001232503A JP2003055209A (ja) | 2001-07-31 | 2001-07-31 | フェニルナフチル尿素誘導体 |
JP2001392310 | 2001-12-25 | ||
PCT/EP2002/008493 WO2003014064A1 (en) | 2001-07-31 | 2002-07-31 | Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists |
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JP2005501873A true JP2005501873A (ja) | 2005-01-20 |
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JP2003524319A Withdrawn JP2005501873A (ja) | 2001-07-31 | 2002-07-31 | アミン誘導体 |
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-
2002
- 2002-07-31 EP EP02758413A patent/EP1414788A1/en not_active Withdrawn
- 2002-07-31 WO PCT/EP2002/008493 patent/WO2003014064A1/en not_active Application Discontinuation
- 2002-07-31 US US10/485,481 patent/US20040259875A1/en not_active Abandoned
- 2002-07-31 JP JP2003524319A patent/JP2005501873A/ja not_active Withdrawn
- 2002-07-31 AU AU2002325381A patent/AU2002325381A1/en not_active Abandoned
- 2002-07-31 CA CA002455754A patent/CA2455754A1/en not_active Abandoned
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JP2007501246A (ja) * | 2003-02-11 | 2007-01-25 | アボット・ラボラトリーズ | バニロイド受容体サブタイプ1(vr1)受容体を阻害する縮合アザ二環式化合物 |
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Also Published As
Publication number | Publication date |
---|---|
EP1414788A1 (en) | 2004-05-06 |
CA2455754A1 (en) | 2003-02-20 |
AU2002325381A1 (en) | 2003-02-24 |
WO2003014064A1 (en) | 2003-02-20 |
WO2003014064A8 (en) | 2003-11-27 |
US20040259875A1 (en) | 2004-12-23 |
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