JP2004502752A5 - - Google Patents
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- Publication number
- JP2004502752A5 JP2004502752A5 JP2002509074A JP2002509074A JP2004502752A5 JP 2004502752 A5 JP2004502752 A5 JP 2004502752A5 JP 2002509074 A JP2002509074 A JP 2002509074A JP 2002509074 A JP2002509074 A JP 2002509074A JP 2004502752 A5 JP2004502752 A5 JP 2004502752A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- compound according
- pharmaceutically acceptable
- minocycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229960004023 minocycline Drugs 0.000 description 8
- -1 minocycline compound Chemical class 0.000 description 8
- 208000035143 Bacterial infection Diseases 0.000 description 5
- 125000003282 alkyl amino group Chemical group 0.000 description 5
- 208000022362 bacterial infectious disease Diseases 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000000651 prodrug Substances 0.000 description 4
- 229940002612 prodrug Drugs 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000004098 Tetracycline Substances 0.000 description 3
- 229960002180 tetracycline Drugs 0.000 description 3
- 229930101283 tetracycline Natural products 0.000 description 3
- 235000019364 tetracycline Nutrition 0.000 description 3
- 150000003522 tetracyclines Chemical class 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000004663 dialkyl amino group Chemical group 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical class C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 125000004894 pentylamino group Chemical group C(CCCC)N* 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21665900P | 2000-07-07 | 2000-07-07 | |
| US60/216,659 | 2000-07-07 | ||
| US27562101P | 2001-03-13 | 2001-03-13 | |
| US60/275,621 | 2001-03-13 | ||
| PCT/US2001/020721 WO2002004406A2 (en) | 2000-07-07 | 2001-06-29 | 9-substituted minocycline compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008157219A Division JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502752A JP2004502752A (ja) | 2004-01-29 |
| JP2004502752A5 true JP2004502752A5 (enrdf_load_stackoverflow) | 2008-08-07 |
| JP4925549B2 JP4925549B2 (ja) | 2012-04-25 |
Family
ID=26911221
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002509074A Expired - Lifetime JP4925549B2 (ja) | 2000-07-07 | 2001-06-29 | ９−置換ミノサイクリン化合物 |
| JP2008157219A Expired - Lifetime JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
| JP2012034839A Pending JP2012107045A (ja) | 2000-07-07 | 2012-02-21 | ９−置換ミノサイクリン化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008157219A Expired - Lifetime JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
| JP2012034839A Pending JP2012107045A (ja) | 2000-07-07 | 2012-02-21 | ９−置換ミノサイクリン化合物 |
Country Status (24)
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US20020123637A1 (en) * | 1998-01-23 | 2002-09-05 | Stuart B. Levy | Pharmaceutically active compounds and methods of use thereof |
| CA2383364C (en) * | 1999-09-14 | 2009-11-17 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| AU3105801A (en) * | 2000-01-24 | 2001-07-31 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| JP2004505012A (ja) * | 2000-03-31 | 2004-02-19 | トラスティーズ・オブ・タフツ・カレッジ | ７−および９−カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール−アミノ置換テトラサイクリン化合物 |
| US6642270B2 (en) * | 2000-05-15 | 2003-11-04 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
| WO2001098236A2 (en) * | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| EP3461808A1 (en) * | 2000-07-07 | 2019-04-03 | Trustees of Tufts College | 9-substituted minocycline compounds |
| CZ20032780A3 (cs) * | 2001-03-13 | 2004-01-14 | Paratek Pharmaceuticals, Inc. | 7,9- Substituované tetracyklinové sloučeniny |
| EP1241160A1 (en) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
| AU2002250331A1 (en) * | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| JP2005504722A (ja) | 2001-03-14 | 2005-02-17 | パラテック ファーマシューティカルズ インコーポレイテッド | 相乗的抗真菌薬剤としての置換テトラサイクリン化合物 |
| US8088820B2 (en) | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| EP2327409A1 (en) | 2001-07-13 | 2011-06-01 | Paratek Pharmaceuticals, Inc. | Tetracycline compound having target therapeutic activities |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| AU2002365120A1 (en) | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
| AU2003235759A1 (en) * | 2002-01-08 | 2003-07-24 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| EP2316450A1 (en) * | 2002-03-08 | 2011-05-04 | Paratek Pharmaceuticals, Inc. | Amino-methyl substituted tetracycline compounds |
| AU2003218242A1 (en) * | 2002-03-21 | 2003-10-08 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| IL164180A0 (en) * | 2002-03-21 | 2005-12-18 | Paratek Pharm Innc | Substituted tetracycline compounds |
| CA2492273C (en) * | 2002-07-12 | 2013-02-05 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
| WO2004038001A2 (en) * | 2002-10-24 | 2004-05-06 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| JP4686189B2 (ja) | 2002-10-24 | 2011-05-18 | パラテック ファーマシューティカルズ インコーポレイテッド | Ｒｎａを調節するための置換テトラサイクリン化合物の使用方法 |
| WO2004091513A2 (en) * | 2003-04-10 | 2004-10-28 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| EP2298322A3 (en) * | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20050137174A1 (en) * | 2003-07-09 | 2005-06-23 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| US8691258B2 (en) * | 2003-12-12 | 2014-04-08 | Medtronic, Inc. | Anti-infective medical device |
| JP5010284B2 (ja) | 2004-01-15 | 2012-08-29 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の芳香族ａ環誘導体 |
| PT1753713T (pt) | 2004-05-21 | 2016-11-08 | Harvard College | Síntese de tetraciclinas e seus análogos |
| TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
| CA2585248A1 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US7858601B2 (en) | 2004-10-25 | 2010-12-28 | Paratek Pharmaceuticals, Inc. | 4-substituted tetracyclines and methods of use thereof |
| US8088755B2 (en) * | 2005-02-04 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
| AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
| AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
| AU2006272698B2 (en) * | 2005-07-21 | 2012-11-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
| RU2008121238A (ru) * | 2005-12-22 | 2010-01-27 | Вайет (Us) | Способы лечения инфекций желудочно-кишечного тракта с применением тайгециклина |
| EP1965770A2 (en) * | 2005-12-22 | 2008-09-10 | Wyeth a Corporation of the State of Delaware | Oral formulations comprising tigecycline |
| EP1991236A2 (en) * | 2006-01-24 | 2008-11-19 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| AU2007235279B2 (en) * | 2006-04-07 | 2012-12-06 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| JP2009543544A (ja) | 2006-05-15 | 2009-12-10 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法 |
| WO2008127361A2 (en) * | 2006-10-11 | 2008-10-23 | President And Fellows Of Harvard College | Synthesis of enone intermediate |
| WO2008045507A2 (en) | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of bacillus anthracis infections |
| IL270446B2 (en) * | 2006-12-21 | 2023-10-01 | Paratek Pharm Innc | A tetracycline compound, a pharmaceutical composition comprising the tetracycline compound, and the tetracycline compound of the pharmaceutical composition for treating a tetracycline responsive state |
| CA2892739A1 (en) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| WO2008127722A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| EP2216323A3 (en) * | 2007-04-27 | 2010-12-29 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| EA201070048A1 (ru) * | 2007-07-06 | 2010-10-29 | Паратек Фармасьютикалс, Инк. | Способы синтеза замещённых соединений тетрациклина (варианты) |
| MX2010005519A (es) | 2007-11-29 | 2010-06-11 | Actelion Pharmaceuticals Ltd | Derivados de acido fosfonico y su uso como antagonista del receptor p2 y12. |
| RU2010140682A (ru) | 2008-03-05 | 2012-04-10 | Пэрэтек Фамэсьютикэлс, Инк. (US) | Способ лечения пациента от инфекции, фармацевтическая композиция (варианты) и лекарственное средство |
| PT2271348T (pt) * | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| WO2009128913A1 (en) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| TWI585071B (zh) * | 2008-05-19 | 2017-06-01 | 派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| PL2682387T3 (pl) * | 2008-08-08 | 2016-03-31 | Tetraphase Pharmaceuticals Inc | C7-fluoro podstawione związki tetracyklinowe |
| JP5443720B2 (ja) * | 2008-09-05 | 2014-03-19 | 住友化学株式会社 | 組成物、光学フィルム及びその製造方法、光学部材ならびに表示装置 |
| CN101759598B (zh) * | 2008-09-12 | 2011-11-09 | 山东轩竹医药科技有限公司 | 具有氨基烷基脒的四环素化合物 |
| CN101684083B (zh) * | 2008-09-16 | 2011-10-05 | 山东轩竹医药科技有限公司 | 胍基烷酰胺基取代的四环素衍生物 |
| CN101684080B (zh) * | 2008-09-16 | 2011-12-14 | 山东轩竹医药科技有限公司 | 含有甲酰肼基的四环素化合物 |
| CN101759599B (zh) * | 2008-09-17 | 2012-05-30 | 山东轩竹医药科技有限公司 | 具有氨基肟基的四环素类化合物 |
| US20100190755A1 (en) * | 2008-09-19 | 2010-07-29 | Paul Abato | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment |
| EP2424834B1 (en) | 2009-04-30 | 2018-07-11 | President and Fellows of Harvard College | Synthesis of tetracyclines and intermediates thereof |
| US9315451B2 (en) | 2009-05-08 | 2016-04-19 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| PT2470500T (pt) | 2009-08-28 | 2018-01-09 | Tetraphase Pharmaceuticals Inc | Compostos de tetraciclina |
| LT2738156T (lt) * | 2011-07-26 | 2018-05-25 | Kbp Biosciences Usa Inc. | 9-aminometilu pakeisti tetraciklino junginiai |
| JP2015525766A (ja) * | 2012-07-13 | 2015-09-07 | パラテック ファーマシューティカルズ インコーポレイテッド | 神経変性障害を治療するためのテトラサイクリン化合物 |
| LT2890673T (lt) | 2012-08-31 | 2019-04-10 | Tetraphase Pharmaceuticals, Inc. | Tetraciklino junginiai |
| EP2969004A4 (en) | 2013-03-15 | 2016-09-21 | Melinta Therapeutics Inc | METHOD FOR THE TREATMENT OF INFECTIONS IN OVERWEIGHT AND ADIPOSIVE PATIENTS USING ANTIBIOTICS |
| TW201615218A (zh) * | 2014-10-24 | 2016-05-01 | 朗齊生物醫學股份有限公司 | 心血管疾病藥物臨床新應用 |
| JP6826582B2 (ja) | 2015-03-24 | 2021-02-03 | パラテック ファーマシューティカルズ，インコーポレイテッド | 生物兵器防衛のためのミノサイクリン化合物 |
| AU2017238644B2 (en) * | 2016-03-24 | 2022-12-15 | Paratek Pharmaceuticals, Inc. | Methods for treating and preventing C. difficile infection |
| HRP20240605T1 (hr) | 2016-10-19 | 2024-07-19 | Tetraphase Pharmaceuticals, Inc. | Kristalni oblici eravaciklina |
| JP7545803B2 (ja) | 2016-11-01 | 2024-09-05 | パラテック ファーマシューティカルズ，インコーポレイテッド | ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用 |
| MA53564A (fr) | 2018-09-04 | 2021-07-14 | Paratek Pharm Innc | Procédés de traitement d'infections mycobactériennes à l'aide de composés de tétracycline |
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-
2001
- 2001-06-29 EP EP18187132.8A patent/EP3461808A1/en not_active Withdrawn
- 2001-06-29 ES ES10182900T patent/ES2701599T3/es not_active Expired - Lifetime
- 2001-06-29 DE DE60122341T patent/DE60122341T2/de not_active Expired - Lifetime
- 2001-06-29 EP EP06007501A patent/EP1679305B1/en not_active Expired - Lifetime
- 2001-06-29 AT AT01965828T patent/ATE336481T1/de active
- 2001-06-29 DK DK01965828T patent/DK1301467T3/da active
- 2001-06-29 CZ CZ20090877A patent/CZ303702B6/cs not_active IP Right Cessation
- 2001-06-29 PT PT01965828T patent/PT1301467E/pt unknown
- 2001-06-29 AT AT06007501T patent/ATE544745T1/de active
- 2001-06-29 HU HU0301169A patent/HU229577B1/hu unknown
- 2001-06-29 CZ CZ2003344A patent/CZ2003344A3/cs unknown
- 2001-06-29 KR KR1020057025319A patent/KR100699390B1/ko not_active Expired - Fee Related
- 2001-06-29 WO PCT/US2001/020721 patent/WO2002004406A2/en active Application Filing
- 2001-06-29 EA EA201000496A patent/EA201000496A1/ru unknown
- 2001-06-29 EP EP01965828A patent/EP1301467B1/en not_active Expired - Lifetime
- 2001-06-29 AU AU8638801A patent/AU8638801A/xx active Pending
- 2001-06-29 KR KR1020037000160A patent/KR100674047B1/ko not_active Expired - Lifetime
- 2001-06-29 BR BRPI0112269A patent/BRPI0112269B8/pt not_active IP Right Cessation
- 2001-06-29 HR HR20030091A patent/HRP20030091B1/xx not_active IP Right Cessation
- 2001-06-29 CN CNB01815087XA patent/CN100473644C/zh not_active Expired - Lifetime
- 2001-06-29 JP JP2002509074A patent/JP4925549B2/ja not_active Expired - Lifetime
- 2001-06-29 US US09/895,857 patent/US6846939B2/en not_active Expired - Lifetime
- 2001-06-29 SI SI200130646T patent/SI1301467T1/sl unknown
- 2001-06-29 CN CN2005100530441A patent/CN1690047B/zh not_active Expired - Fee Related
- 2001-06-29 DK DK06007501.7T patent/DK1679305T3/da active
- 2001-06-29 EA EA200300135A patent/EA009175B1/ru not_active IP Right Cessation
- 2001-06-29 IL IL15363901A patent/IL153639A0/xx unknown
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- 2001-06-29 EP EP10182900.0A patent/EP2308832B8/en not_active Expired - Lifetime
- 2001-06-29 MX MXPA03000055A patent/MXPA03000055A/es active IP Right Grant
- 2001-06-29 AU AU2001286388A patent/AU2001286388B2/en not_active Expired
- 2001-06-29 CA CA2415178A patent/CA2415178C/en not_active Expired - Lifetime
- 2001-06-29 ES ES01965828T patent/ES2271070T3/es not_active Expired - Lifetime
- 2001-07-06 TW TW090116602A patent/TWI299038B/zh not_active IP Right Cessation
- 2001-07-06 TW TW093140806A patent/TWI305528B/zh not_active IP Right Cessation
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2003
- 2003-01-28 ZA ZA2003/00749A patent/ZA200300749B/en unknown
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2004
- 2004-05-04 US US10/839,023 patent/US8048867B2/en not_active Expired - Fee Related
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2005
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2006
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- 2006-10-13 CY CY20061101475T patent/CY1107524T1/el unknown
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2008
- 2008-06-16 JP JP2008157219A patent/JP5037436B2/ja not_active Expired - Lifetime
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2009
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- 2009-05-11 AU AU2009201857A patent/AU2009201857B9/en not_active Ceased
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2012
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