JP2003521888A5 - - Google Patents
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- Publication number
- JP2003521888A5 JP2003521888A5 JP2001512892A JP2001512892A JP2003521888A5 JP 2003521888 A5 JP2003521888 A5 JP 2003521888A5 JP 2001512892 A JP2001512892 A JP 2001512892A JP 2001512892 A JP2001512892 A JP 2001512892A JP 2003521888 A5 JP2003521888 A5 JP 2003521888A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polynucleotide
- bacterial cell
- amino acid
- modified bacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001580 bacterial effect Effects 0.000 description 29
- 229920001184 polypeptide Polymers 0.000 description 29
- 108090000765 processed proteins & peptides Proteins 0.000 description 29
- 102000004196 processed proteins & peptides Human genes 0.000 description 29
- 238000000034 method Methods 0.000 description 25
- 102000040430 polynucleotide Human genes 0.000 description 19
- 108091033319 polynucleotide Proteins 0.000 description 19
- 239000002157 polynucleotide Substances 0.000 description 19
- 150000001413 amino acids Chemical class 0.000 description 12
- 239000002773 nucleotide Substances 0.000 description 12
- 125000003729 nucleotide group Chemical group 0.000 description 12
- 238000012217 deletion Methods 0.000 description 11
- 230000037430 deletion Effects 0.000 description 11
- 101150053253 pgi gene Proteins 0.000 description 11
- 102000039446 nucleic acids Human genes 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 9
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 150000008575 L-amino acids Chemical class 0.000 description 8
- 235000001014 amino acid Nutrition 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 230000004075 alteration Effects 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 238000006467 substitution reaction Methods 0.000 description 5
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 4
- 241000186226 Corynebacterium glutamicum Species 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 102000004195 Isomerases Human genes 0.000 description 2
- 108090000769 Isomerases Proteins 0.000 description 2
- 235000019766 L-Lysine Nutrition 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- VFRROHXSMXFLSN-SLPGGIOYSA-N aldehydo-D-glucose 6-phosphate Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O VFRROHXSMXFLSN-SLPGGIOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 230000006801 homologous recombination Effects 0.000 description 2
- 238000002744 homologous recombination Methods 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 108020001657 6-phosphogluconate dehydrogenase Proteins 0.000 description 1
- 102000004567 6-phosphogluconate dehydrogenase Human genes 0.000 description 1
- 102100031126 6-phosphogluconolactonase Human genes 0.000 description 1
- 108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 description 1
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 1
- 101710104378 Putative malate oxidoreductase [NAD] Proteins 0.000 description 1
- 101000693619 Starmerella bombicola Lactone esterase Proteins 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000002414 glycolytic effect Effects 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000004108 pentose phosphate pathway Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14521799P | 1999-07-23 | 1999-07-23 | |
| US60/145,217 | 1999-07-23 | ||
| US15001799P | 1999-08-20 | 1999-08-20 | |
| US60/150,017 | 1999-08-20 | ||
| PCT/US2000/019914 WO2001007626A2 (en) | 1999-07-23 | 2000-07-21 | Methods for producing l-amino acids by increasing cellular nadph |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010268851A Division JP2011041582A (ja) | 1999-07-23 | 2010-12-01 | 細胞性ｎａｄｐｈの増加によるｌ−アミノ酸の生成方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003521888A JP2003521888A (ja) | 2003-07-22 |
| JP2003521888A5 true JP2003521888A5 (https=) | 2007-09-20 |
| JP4841093B2 JP4841093B2 (ja) | 2011-12-21 |
Family
ID=26842765
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512892A Expired - Lifetime JP4841093B2 (ja) | 1999-07-23 | 2000-07-21 | 細胞性ｎａｄｐｈの増加によるｌ−アミノ酸の生成方法 |
| JP2010268851A Withdrawn JP2011041582A (ja) | 1999-07-23 | 2010-12-01 | 細胞性ｎａｄｐｈの増加によるｌ−アミノ酸の生成方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010268851A Withdrawn JP2011041582A (ja) | 1999-07-23 | 2010-12-01 | 細胞性ｎａｄｐｈの増加によるｌ−アミノ酸の生成方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6465238B1 (https=) |
| EP (1) | EP1208205B1 (https=) |
| JP (2) | JP4841093B2 (https=) |
| KR (1) | KR100575403B1 (https=) |
| CN (1) | CN1372597A (https=) |
| AT (1) | ATE340857T1 (https=) |
| AU (1) | AU6362200A (https=) |
| BR (1) | BR0012712B1 (https=) |
| CA (1) | CA2377693C (https=) |
| DE (1) | DE60030988T2 (https=) |
| DK (1) | DK1208205T3 (https=) |
| ES (1) | ES2272303T3 (https=) |
| MX (1) | MXPA02000729A (https=) |
| NZ (1) | NZ517295A (https=) |
| PT (1) | PT1208205E (https=) |
| WO (1) | WO2001007626A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2377693C (en) * | 1999-07-23 | 2016-11-08 | Archer-Daniels-Midland Company | Methods for producing l-amino acids |
| US6830903B1 (en) | 1999-07-23 | 2004-12-14 | Archer-Daniels-Midland Company | Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene |
| US6586214B1 (en) * | 1999-09-15 | 2003-07-01 | Degussa Ag | Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene) |
| MXPA01011643A (es) * | 2000-03-20 | 2003-02-27 | Degussa | Proceso para la preparacion fermentativa de l-aminoacidos con amplificacion del gen gnd. |
| DE10112992A1 (de) * | 2001-03-17 | 2002-09-26 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| US7160711B2 (en) * | 2001-08-06 | 2007-01-09 | Degussa Ag | Coryneform bacteria which produce chemical compounds I |
| DE10220574A1 (de) * | 2002-05-08 | 2003-11-20 | Degussa | Verfahren zur Herstellung von Aminosäuren mit coryneformen Bakterien unter Verwendung von Phosphoglucose-Isomerasen aus coryneformen Bakterien |
| AU2004299729A1 (en) | 2003-12-18 | 2005-06-30 | Basf Aktiengesellschaft | Methods for the preparation of lysine by fermentation of corynebacterium glutamicum |
| EP1704241A2 (en) * | 2003-12-18 | 2006-09-27 | Basf Aktiengesellschaft | Methods for the preparation of a fine chemical by fermentation |
| BRPI0417773A (pt) * | 2003-12-18 | 2007-03-20 | Basf Ag | métodos para aumentar o fluxo metabólico através da via de pentose fosfato em um microorganismo e para produzir uma substáncia quìmica fina, e, microorganismo recombinante |
| RU2288264C2 (ru) * | 2004-02-12 | 2006-11-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Бактерия, принадлежащая к роду escherichia - продуцент l-треонина и способ получения l-треонина |
| US20050191684A1 (en) * | 2004-02-25 | 2005-09-01 | Zimenkov Danila V. | Method for producing L-amino acids |
| WO2005080583A2 (en) * | 2004-02-25 | 2005-09-01 | Ajinomoto Co., Inc. | Method for producing l-amino acids |
| RU2004105179A (ru) * | 2004-02-25 | 2005-08-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | 6-фосфоглюконолактоназа из escherichia coli, фрагмент днк, бактерия, принадлежащая к роду escherichia, -продуцент l-аминокислоты, и способ получения l-аминокислоты |
| JP4780783B2 (ja) * | 2004-02-27 | 2011-09-28 | 協和発酵バイオ株式会社 | アミノ酸の製造法 |
| KR100563226B1 (ko) * | 2004-08-10 | 2006-03-21 | 한국생산기술연구원 | 연료전지용 분리판 |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| MX2007007834A (es) * | 2004-12-22 | 2007-09-04 | Michigan Biotech Inst | Microorganismos recombinantes para la produccion incrementada de acidos organicos. |
| DE102005013676A1 (de) | 2005-03-24 | 2006-09-28 | Degussa Ag | Allele des zwf-Gens aus coryneformen Bakterien |
| DE102005023829A1 (de) | 2005-05-24 | 2006-11-30 | Degussa Ag | Allele des opcA-Gens aus coryneformen Bakterien |
| DE102005048818A1 (de) | 2005-10-10 | 2007-04-12 | Degussa Ag | Mikrobiologische Herstellung von 3-Hydroxypropionsäure |
| KR100873168B1 (ko) * | 2007-03-07 | 2008-12-10 | 전북대학교산학협력단 | ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신 |
| EP2615164A1 (en) | 2007-11-10 | 2013-07-17 | Joule Unlimited Technologies, Inc. | Hyperphotosynthetic organisms |
| CN103189513A (zh) * | 2010-03-31 | 2013-07-03 | 纳幕尔杜邦公司 | 上调磷酸戊糖途径以提高转基因微生物中受关注的非天然产物的产量 |
| US9181568B2 (en) | 2012-04-23 | 2015-11-10 | Exxonmobil Research And Engineering Company | Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases |
| KR101429814B1 (ko) * | 2012-10-05 | 2014-08-12 | 상지대학교산학협력단 | Ｇｄｈ 활성 조절을 통해 ｌ-쓰레오닌 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-쓰레오닌 생산 방법 |
| CN106559997B (zh) | 2014-05-12 | 2021-04-09 | 代谢探索者公司 | 基于nadph依赖型丙酮醇还原酶和改进的nadph供给用于生产1,2-丙二醇的新微生物和方法 |
| KR102384227B1 (ko) | 2015-05-18 | 2022-04-07 | 삼성전자주식회사 | Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법 |
| CN112725253B (zh) * | 2020-12-30 | 2023-01-06 | 宁夏伊品生物科技股份有限公司 | 一种改造基因bbd29_14900的重组菌株及其构建方法与应用 |
| CN113930465A (zh) * | 2021-10-21 | 2022-01-14 | 呼伦贝尔东北阜丰生物科技有限公司 | 一种苏氨酸发酵代谢调控工艺 |
| CN113774096A (zh) * | 2021-10-21 | 2021-12-10 | 呼伦贝尔东北阜丰生物科技有限公司 | 一种苏氨酸生产提取工艺的优化方法 |
| CN114181288B (zh) * | 2022-02-17 | 2022-05-03 | 北京中科伊品生物科技有限公司 | 制备l-缬氨酸的方法及其所用的基因与该基因编码的蛋白质 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS594988B2 (ja) * | 1976-02-03 | 1984-02-02 | 日石三菱株式会社 | グリコ−スイソメラ−ゼの製法 |
| ATE184917T1 (de) | 1992-11-05 | 1999-10-15 | Xyrofin Oy | Rekombinante methode und wirt zur herstellung von xylitol |
| EP0672161B1 (en) | 1992-11-05 | 1999-09-22 | Xyrofin Oy | Recombinant method and host for manufacture of xylitol |
| SK283058B6 (sk) | 1993-10-28 | 2003-02-04 | Ajinomoto Co., Inc. | Spôsob produkcie cieľovej látky použitím mikroorganizmov |
| ES2191710T3 (es) | 1994-08-19 | 2003-09-16 | Ajinomoto Kk | Procedimiento para producir l-lisina y acido l-glutamico por fermentacion. |
| JPH09224662A (ja) * | 1996-02-23 | 1997-09-02 | Mitsubishi Chem Corp | ６−ホスホグルコン酸デヒドロゲナーゼおよびそれをコードするｄｎａ |
| JPH09224661A (ja) * | 1996-02-23 | 1997-09-02 | Mitsubishi Chem Corp | グルコース−６−リン酸デヒドロゲナーゼおよびそれをコードするｄｎａ |
| EP1004663B1 (en) * | 1997-07-18 | 2007-02-07 | Ajinomoto Co., Inc. | Process and microorganism for producing purine nucleosides via fermentation |
| FR2772788B1 (fr) | 1997-12-19 | 2000-11-17 | Roquette Freres | Procede pour accroitre la production de certains polyols par une souche osmotolerante |
| CA2377693C (en) * | 1999-07-23 | 2016-11-08 | Archer-Daniels-Midland Company | Methods for producing l-amino acids |
| US6586214B1 (en) * | 1999-09-15 | 2003-07-01 | Degussa Ag | Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene) |
-
2000
- 2000-07-21 CA CA2377693A patent/CA2377693C/en not_active Expired - Fee Related
- 2000-07-21 EP EP00950529A patent/EP1208205B1/en not_active Expired - Lifetime
- 2000-07-21 BR BRPI0012712-4A patent/BR0012712B1/pt not_active IP Right Cessation
- 2000-07-21 AT AT00950529T patent/ATE340857T1/de not_active IP Right Cessation
- 2000-07-21 ES ES00950529T patent/ES2272303T3/es not_active Expired - Lifetime
- 2000-07-21 CN CN00810748A patent/CN1372597A/zh active Pending
- 2000-07-21 KR KR1020027000925A patent/KR100575403B1/ko not_active Expired - Lifetime
- 2000-07-21 WO PCT/US2000/019914 patent/WO2001007626A2/en not_active Ceased
- 2000-07-21 JP JP2001512892A patent/JP4841093B2/ja not_active Expired - Lifetime
- 2000-07-21 DE DE60030988T patent/DE60030988T2/de not_active Expired - Lifetime
- 2000-07-21 DK DK00950529T patent/DK1208205T3/da active
- 2000-07-21 MX MXPA02000729A patent/MXPA02000729A/es active IP Right Grant
- 2000-07-21 US US09/621,451 patent/US6465238B1/en not_active Expired - Lifetime
- 2000-07-21 PT PT00950529T patent/PT1208205E/pt unknown
- 2000-07-21 AU AU63622/00A patent/AU6362200A/en not_active Abandoned
- 2000-07-21 NZ NZ517295A patent/NZ517295A/en not_active IP Right Cessation
-
2002
- 2002-08-20 US US10/223,355 patent/US6680190B2/en not_active Expired - Lifetime
-
2010
- 2010-12-01 JP JP2010268851A patent/JP2011041582A/ja not_active Withdrawn
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