ATE340857T1 - Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph - Google Patents
Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadphInfo
- Publication number
- ATE340857T1 ATE340857T1 AT00950529T AT00950529T ATE340857T1 AT E340857 T1 ATE340857 T1 AT E340857T1 AT 00950529 T AT00950529 T AT 00950529T AT 00950529 T AT00950529 T AT 00950529T AT E340857 T1 ATE340857 T1 AT E340857T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acids
- producing
- bacterial cells
- increasing cellular
- nadph
- Prior art date
Links
- 150000008575 L-amino acids Chemical class 0.000 title abstract 3
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 title abstract 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 title abstract 2
- 230000001413 cellular effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 abstract 4
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14521799P | 1999-07-23 | 1999-07-23 | |
| US15001799P | 1999-08-20 | 1999-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE340857T1 true ATE340857T1 (de) | 2006-10-15 |
Family
ID=26842765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00950529T ATE340857T1 (de) | 1999-07-23 | 2000-07-21 | Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6465238B1 (https=) |
| EP (1) | EP1208205B1 (https=) |
| JP (2) | JP4841093B2 (https=) |
| KR (1) | KR100575403B1 (https=) |
| CN (1) | CN1372597A (https=) |
| AT (1) | ATE340857T1 (https=) |
| AU (1) | AU6362200A (https=) |
| BR (1) | BR0012712B1 (https=) |
| CA (1) | CA2377693C (https=) |
| DE (1) | DE60030988T2 (https=) |
| DK (1) | DK1208205T3 (https=) |
| ES (1) | ES2272303T3 (https=) |
| MX (1) | MXPA02000729A (https=) |
| NZ (1) | NZ517295A (https=) |
| PT (1) | PT1208205E (https=) |
| WO (1) | WO2001007626A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2377693C (en) * | 1999-07-23 | 2016-11-08 | Archer-Daniels-Midland Company | Methods for producing l-amino acids |
| US6830903B1 (en) | 1999-07-23 | 2004-12-14 | Archer-Daniels-Midland Company | Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene |
| US6586214B1 (en) * | 1999-09-15 | 2003-07-01 | Degussa Ag | Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene) |
| MXPA01011643A (es) * | 2000-03-20 | 2003-02-27 | Degussa | Proceso para la preparacion fermentativa de l-aminoacidos con amplificacion del gen gnd. |
| DE10112992A1 (de) * | 2001-03-17 | 2002-09-26 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| US7160711B2 (en) * | 2001-08-06 | 2007-01-09 | Degussa Ag | Coryneform bacteria which produce chemical compounds I |
| DE10220574A1 (de) * | 2002-05-08 | 2003-11-20 | Degussa | Verfahren zur Herstellung von Aminosäuren mit coryneformen Bakterien unter Verwendung von Phosphoglucose-Isomerasen aus coryneformen Bakterien |
| AU2004299729A1 (en) | 2003-12-18 | 2005-06-30 | Basf Aktiengesellschaft | Methods for the preparation of lysine by fermentation of corynebacterium glutamicum |
| EP1704241A2 (en) * | 2003-12-18 | 2006-09-27 | Basf Aktiengesellschaft | Methods for the preparation of a fine chemical by fermentation |
| BRPI0417773A (pt) * | 2003-12-18 | 2007-03-20 | Basf Ag | métodos para aumentar o fluxo metabólico através da via de pentose fosfato em um microorganismo e para produzir uma substáncia quìmica fina, e, microorganismo recombinante |
| RU2288264C2 (ru) * | 2004-02-12 | 2006-11-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Бактерия, принадлежащая к роду escherichia - продуцент l-треонина и способ получения l-треонина |
| US20050191684A1 (en) * | 2004-02-25 | 2005-09-01 | Zimenkov Danila V. | Method for producing L-amino acids |
| WO2005080583A2 (en) * | 2004-02-25 | 2005-09-01 | Ajinomoto Co., Inc. | Method for producing l-amino acids |
| RU2004105179A (ru) * | 2004-02-25 | 2005-08-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | 6-фосфоглюконолактоназа из escherichia coli, фрагмент днк, бактерия, принадлежащая к роду escherichia, -продуцент l-аминокислоты, и способ получения l-аминокислоты |
| JP4780783B2 (ja) * | 2004-02-27 | 2011-09-28 | 協和発酵バイオ株式会社 | アミノ酸の製造法 |
| KR100563226B1 (ko) * | 2004-08-10 | 2006-03-21 | 한국생산기술연구원 | 연료전지용 분리판 |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| MX2007007834A (es) * | 2004-12-22 | 2007-09-04 | Michigan Biotech Inst | Microorganismos recombinantes para la produccion incrementada de acidos organicos. |
| DE102005013676A1 (de) | 2005-03-24 | 2006-09-28 | Degussa Ag | Allele des zwf-Gens aus coryneformen Bakterien |
| DE102005023829A1 (de) | 2005-05-24 | 2006-11-30 | Degussa Ag | Allele des opcA-Gens aus coryneformen Bakterien |
| DE102005048818A1 (de) | 2005-10-10 | 2007-04-12 | Degussa Ag | Mikrobiologische Herstellung von 3-Hydroxypropionsäure |
| KR100873168B1 (ko) * | 2007-03-07 | 2008-12-10 | 전북대학교산학협력단 | ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신 |
| EP2615164A1 (en) | 2007-11-10 | 2013-07-17 | Joule Unlimited Technologies, Inc. | Hyperphotosynthetic organisms |
| CN103189513A (zh) * | 2010-03-31 | 2013-07-03 | 纳幕尔杜邦公司 | 上调磷酸戊糖途径以提高转基因微生物中受关注的非天然产物的产量 |
| US9181568B2 (en) | 2012-04-23 | 2015-11-10 | Exxonmobil Research And Engineering Company | Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases |
| KR101429814B1 (ko) * | 2012-10-05 | 2014-08-12 | 상지대학교산학협력단 | Ｇｄｈ 활성 조절을 통해 ｌ-쓰레오닌 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-쓰레오닌 생산 방법 |
| CN106559997B (zh) | 2014-05-12 | 2021-04-09 | 代谢探索者公司 | 基于nadph依赖型丙酮醇还原酶和改进的nadph供给用于生产1,2-丙二醇的新微生物和方法 |
| KR102384227B1 (ko) | 2015-05-18 | 2022-04-07 | 삼성전자주식회사 | Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법 |
| CN112725253B (zh) * | 2020-12-30 | 2023-01-06 | 宁夏伊品生物科技股份有限公司 | 一种改造基因bbd29_14900的重组菌株及其构建方法与应用 |
| CN113930465A (zh) * | 2021-10-21 | 2022-01-14 | 呼伦贝尔东北阜丰生物科技有限公司 | 一种苏氨酸发酵代谢调控工艺 |
| CN113774096A (zh) * | 2021-10-21 | 2021-12-10 | 呼伦贝尔东北阜丰生物科技有限公司 | 一种苏氨酸生产提取工艺的优化方法 |
| CN114181288B (zh) * | 2022-02-17 | 2022-05-03 | 北京中科伊品生物科技有限公司 | 制备l-缬氨酸的方法及其所用的基因与该基因编码的蛋白质 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS594988B2 (ja) * | 1976-02-03 | 1984-02-02 | 日石三菱株式会社 | グリコ−スイソメラ−ゼの製法 |
| ATE184917T1 (de) | 1992-11-05 | 1999-10-15 | Xyrofin Oy | Rekombinante methode und wirt zur herstellung von xylitol |
| EP0672161B1 (en) | 1992-11-05 | 1999-09-22 | Xyrofin Oy | Recombinant method and host for manufacture of xylitol |
| SK283058B6 (sk) | 1993-10-28 | 2003-02-04 | Ajinomoto Co., Inc. | Spôsob produkcie cieľovej látky použitím mikroorganizmov |
| ES2191710T3 (es) | 1994-08-19 | 2003-09-16 | Ajinomoto Kk | Procedimiento para producir l-lisina y acido l-glutamico por fermentacion. |
| JPH09224662A (ja) * | 1996-02-23 | 1997-09-02 | Mitsubishi Chem Corp | ６−ホスホグルコン酸デヒドロゲナーゼおよびそれをコードするｄｎａ |
| JPH09224661A (ja) * | 1996-02-23 | 1997-09-02 | Mitsubishi Chem Corp | グルコース−６−リン酸デヒドロゲナーゼおよびそれをコードするｄｎａ |
| EP1004663B1 (en) * | 1997-07-18 | 2007-02-07 | Ajinomoto Co., Inc. | Process and microorganism for producing purine nucleosides via fermentation |
| FR2772788B1 (fr) | 1997-12-19 | 2000-11-17 | Roquette Freres | Procede pour accroitre la production de certains polyols par une souche osmotolerante |
| CA2377693C (en) * | 1999-07-23 | 2016-11-08 | Archer-Daniels-Midland Company | Methods for producing l-amino acids |
| US6586214B1 (en) * | 1999-09-15 | 2003-07-01 | Degussa Ag | Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene) |
-
2000
- 2000-07-21 CA CA2377693A patent/CA2377693C/en not_active Expired - Fee Related
- 2000-07-21 EP EP00950529A patent/EP1208205B1/en not_active Expired - Lifetime
- 2000-07-21 BR BRPI0012712-4A patent/BR0012712B1/pt not_active IP Right Cessation
- 2000-07-21 AT AT00950529T patent/ATE340857T1/de not_active IP Right Cessation
- 2000-07-21 ES ES00950529T patent/ES2272303T3/es not_active Expired - Lifetime
- 2000-07-21 CN CN00810748A patent/CN1372597A/zh active Pending
- 2000-07-21 KR KR1020027000925A patent/KR100575403B1/ko not_active Expired - Lifetime
- 2000-07-21 WO PCT/US2000/019914 patent/WO2001007626A2/en not_active Ceased
- 2000-07-21 JP JP2001512892A patent/JP4841093B2/ja not_active Expired - Lifetime
- 2000-07-21 DE DE60030988T patent/DE60030988T2/de not_active Expired - Lifetime
- 2000-07-21 DK DK00950529T patent/DK1208205T3/da active
- 2000-07-21 MX MXPA02000729A patent/MXPA02000729A/es active IP Right Grant
- 2000-07-21 US US09/621,451 patent/US6465238B1/en not_active Expired - Lifetime
- 2000-07-21 PT PT00950529T patent/PT1208205E/pt unknown
- 2000-07-21 AU AU63622/00A patent/AU6362200A/en not_active Abandoned
- 2000-07-21 NZ NZ517295A patent/NZ517295A/en not_active IP Right Cessation
-
2002
- 2002-08-20 US US10/223,355 patent/US6680190B2/en not_active Expired - Lifetime
-
2010
- 2010-12-01 JP JP2010268851A patent/JP2011041582A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001007626A2 (en) | 2001-02-01 |
| EP1208205A2 (en) | 2002-05-29 |
| MXPA02000729A (es) | 2002-08-20 |
| BR0012712A (pt) | 2002-04-09 |
| US6465238B1 (en) | 2002-10-15 |
| KR100575403B1 (ko) | 2006-05-03 |
| US20030017557A1 (en) | 2003-01-23 |
| AU6362200A (en) | 2001-02-13 |
| JP4841093B2 (ja) | 2011-12-21 |
| ES2272303T3 (es) | 2007-05-01 |
| CA2377693C (en) | 2016-11-08 |
| EP1208205B1 (en) | 2006-09-27 |
| CN1372597A (zh) | 2002-10-02 |
| NZ517295A (en) | 2004-04-30 |
| WO2001007626A3 (en) | 2001-05-31 |
| US6680190B2 (en) | 2004-01-20 |
| JP2011041582A (ja) | 2011-03-03 |
| JP2003521888A (ja) | 2003-07-22 |
| KR20020048928A (ko) | 2002-06-24 |
| BR0012712B1 (pt) | 2011-12-13 |
| CA2377693A1 (en) | 2001-02-01 |
| DE60030988T2 (de) | 2007-01-04 |
| PT1208205E (pt) | 2006-12-29 |
| DE60030988D1 (de) | 2006-11-09 |
| DK1208205T3 (da) | 2007-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |