JP2003511450A5 - - Google Patents
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- Publication number
- JP2003511450A5 JP2003511450A5 JP2001530327A JP2001530327A JP2003511450A5 JP 2003511450 A5 JP2003511450 A5 JP 2003511450A5 JP 2001530327 A JP2001530327 A JP 2001530327A JP 2001530327 A JP2001530327 A JP 2001530327A JP 2003511450 A5 JP2003511450 A5 JP 2003511450A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- imidazo
- butyl
- amine
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920006395 saturated elastomer Polymers 0.000 description 18
- 150000001875 compounds Chemical class 0.000 description 12
- 150000002527 isonitriles Chemical class 0.000 description 11
- 238000006467 substitution reaction Methods 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 8
- 125000001072 heteroaryl group Chemical group 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- -1 7-methyl-2-pyridin-3-yl-imidazo [1,2-a] pyridin-3-yl Chemical group 0.000 description 4
- 208000024827 Alzheimer disease Diseases 0.000 description 4
- 206010003210 Arteriosclerosis Diseases 0.000 description 4
- 206010008120 Cerebral ischaemia Diseases 0.000 description 4
- 208000023105 Huntington disease Diseases 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 4
- 206010065390 Inflammatory pain Diseases 0.000 description 4
- 201000009906 Meningitis Diseases 0.000 description 4
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 4
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 4
- 208000018737 Parkinson disease Diseases 0.000 description 4
- 206010040070 Septic Shock Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 208000011775 arteriosclerosis disease Diseases 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 201000006417 multiple sclerosis Diseases 0.000 description 4
- 230000036303 septic shock Effects 0.000 description 4
- 201000006474 Brain Ischemia Diseases 0.000 description 3
- 208000019695 Migraine disease Diseases 0.000 description 3
- 150000003927 aminopyridines Chemical class 0.000 description 3
- 206010008118 cerebral infarction Diseases 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010027599 migraine Diseases 0.000 description 3
- LNTHINXYEPSOKT-UHFFFAOYSA-N n-tert-butyl-2,5,7-trimethylimidazo[1,2-a]pyridin-3-amine Chemical compound C1=C(C)C=C(C)N2C(NC(C)(C)C)=C(C)N=C21 LNTHINXYEPSOKT-UHFFFAOYSA-N 0.000 description 3
- PILXZSKVZNJVJB-UHFFFAOYSA-N n-tert-butyl-2,7-dimethylimidazo[1,2-a]pyridin-3-amine Chemical compound C1=C(C)C=CN2C(NC(C)(C)C)=C(C)N=C21 PILXZSKVZNJVJB-UHFFFAOYSA-N 0.000 description 3
- KUPJGEBCLOKTAI-UHFFFAOYSA-N n-tert-butyl-2-cyclohexyl-5,7-dimethylimidazo[1,2-a]pyridin-3-amine Chemical compound N1=C2C=C(C)C=C(C)N2C(NC(C)(C)C)=C1C1CCCCC1 KUPJGEBCLOKTAI-UHFFFAOYSA-N 0.000 description 3
- AVUXSWKQTDMSKC-UHFFFAOYSA-N n-tert-butyl-2-cyclohexyl-7-methylimidazo[1,2-a]pyridin-3-amine Chemical compound N1=C2C=C(C)C=CN2C(NC(C)(C)C)=C1C1CCCCC1 AVUXSWKQTDMSKC-UHFFFAOYSA-N 0.000 description 3
- YZGFPSZQJDPTGW-UHFFFAOYSA-N n-tert-butyl-7-methylimidazo[1,2-a]pyridin-3-amine Chemical class C1=C(C)C=CN2C(NC(C)(C)C)=CN=C21 YZGFPSZQJDPTGW-UHFFFAOYSA-N 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- NNGDTFNYWWYMKI-UHFFFAOYSA-N 3-[3-(tert-butylamino)-5,7-dimethylimidazo[1,2-a]pyridin-2-yl]phenol Chemical compound N1=C2C=C(C)C=C(C)N2C(NC(C)(C)C)=C1C1=CC=CC(O)=C1 NNGDTFNYWWYMKI-UHFFFAOYSA-N 0.000 description 2
- UQMMDAXQSRVVDM-UHFFFAOYSA-N 3-[3-(tert-butylamino)-7-methylimidazo[1,2-a]pyridin-2-yl]phenol Chemical compound N1=C2C=C(C)C=CN2C(NC(C)(C)C)=C1C1=CC=CC(O)=C1 UQMMDAXQSRVVDM-UHFFFAOYSA-N 0.000 description 2
- DXGSPAYUJRCIKT-UHFFFAOYSA-N 5-[3-(tert-butylamino)-5,7-dimethylimidazo[1,2-a]pyridin-2-yl]furan-2-carboxylic acid Chemical compound N1=C2C=C(C)C=C(C)N2C(NC(C)(C)C)=C1C1=CC=C(C(O)=O)O1 DXGSPAYUJRCIKT-UHFFFAOYSA-N 0.000 description 2
- RCQFFBBGAATMLI-UHFFFAOYSA-N 5-[3-(tert-butylamino)-7-methylimidazo[1,2-a]pyridin-2-yl]thiophene-2-carboxylic acid Chemical compound N1=C2C=C(C)C=CN2C(NC(C)(C)C)=C1C1=CC=C(C(O)=O)S1 RCQFFBBGAATMLI-UHFFFAOYSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- XBIJCAKRLAMAPN-UHFFFAOYSA-N [5-[3-(tert-butylamino)-7-methylimidazo[1,2-a]pyridin-2-yl]furan-2-yl]methanol Chemical compound N1=C2C=C(C)C=CN2C(NC(C)(C)C)=C1C1=CC=C(CO)O1 XBIJCAKRLAMAPN-UHFFFAOYSA-N 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- DUUHRRDRKOEUSK-UHFFFAOYSA-N n-tert-butyl-2-(furan-2-yl)-5,7-dimethylimidazo[1,2-a]pyridin-3-amine Chemical compound N1=C2C=C(C)C=C(C)N2C(NC(C)(C)C)=C1C1=CC=CO1 DUUHRRDRKOEUSK-UHFFFAOYSA-N 0.000 description 2
- GAOXLBQDTVDEJH-UHFFFAOYSA-N n-tert-butyl-2-(furan-2-yl)-7-methylimidazo[1,2-a]pyridin-3-amine Chemical compound N1=C2C=C(C)C=CN2C(NC(C)(C)C)=C1C1=CC=CO1 GAOXLBQDTVDEJH-UHFFFAOYSA-N 0.000 description 2
- LYCYZJPXXHLUGQ-UHFFFAOYSA-N n-tert-butyl-2-[5-(1,3-dioxolan-2-yl)furan-2-yl]-7-methylimidazo[1,2-a]pyridin-3-amine Chemical compound N1=C2C=C(C)C=CN2C(NC(C)(C)C)=C1C(O1)=CC=C1C1OCCO1 LYCYZJPXXHLUGQ-UHFFFAOYSA-N 0.000 description 2
- MMWRUWSLSMDDMI-UHFFFAOYSA-N n-tert-butyl-7-methyl-2-naphthalen-1-ylimidazo[1,2-a]pyridin-3-amine Chemical compound C1=CC=C2C(C3=C(NC(C)(C)C)N4C=CC(=CC4=N3)C)=CC=CC2=C1 MMWRUWSLSMDDMI-UHFFFAOYSA-N 0.000 description 2
- XKXCEJQFBQELLH-UHFFFAOYSA-N n-tert-butyl-7-methyl-2-phenylimidazo[1,2-a]pyridin-3-amine Chemical compound N1=C2C=C(C)C=CN2C(NC(C)(C)C)=C1C1=CC=CC=C1 XKXCEJQFBQELLH-UHFFFAOYSA-N 0.000 description 2
- KLJVZHQAYPDCRK-UHFFFAOYSA-N n-tert-butyl-7-methyl-2-pyridin-2-ylimidazo[1,2-a]pyridin-3-amine Chemical compound N1=C2C=C(C)C=CN2C(NC(C)(C)C)=C1C1=CC=CC=N1 KLJVZHQAYPDCRK-UHFFFAOYSA-N 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000008673 Persea americana Nutrition 0.000 description 1
- 240000002426 Persea americana var. drymifolia Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- PBAYDYUZOSNJGU-UHFFFAOYSA-N chelidonic acid Natural products OC(=O)C1=CC(=O)C=C(C(O)=O)O1 PBAYDYUZOSNJGU-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- MKBVTTATIPGGJD-UHFFFAOYSA-N n-tert-butyl-7-methyl-2-pyridin-3-ylimidazo[1,2-a]pyridin-3-amine Chemical compound N1=C2C=C(C)C=CN2C(NC(C)(C)C)=C1C1=CC=CN=C1 MKBVTTATIPGGJD-UHFFFAOYSA-N 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000010490 three component reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19948434.1 | 1999-10-08 | ||
| DE19948434A DE19948434A1 (de) | 1999-10-08 | 1999-10-08 | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
| PCT/EP2000/009791 WO2001027109A2 (de) | 1999-10-08 | 2000-10-06 | Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amin-derivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003511450A JP2003511450A (ja) | 2003-03-25 |
| JP2003511450A5 true JP2003511450A5 (https=) | 2007-09-27 |
Family
ID=7924888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001530327A Pending JP2003511450A (ja) | 1999-10-08 | 2000-10-06 | ｔ−ブチル−（７−メチル−イミダゾ［１，２−ａ］ピリジン−３−イル）−アミン誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6703404B2 (https=) |
| EP (1) | EP1218378B1 (https=) |
| JP (1) | JP2003511450A (https=) |
| KR (1) | KR100793619B1 (https=) |
| CN (1) | CN1208336C (https=) |
| AR (2) | AR025960A1 (https=) |
| AT (1) | ATE238304T1 (https=) |
| AU (2) | AU7419900A (https=) |
| BR (1) | BR0014827A (https=) |
| CA (1) | CA2386804A1 (https=) |
| CO (2) | CO5210861A1 (https=) |
| CZ (1) | CZ20021241A3 (https=) |
| DE (2) | DE19948434A1 (https=) |
| DK (1) | DK1218378T3 (https=) |
| ES (1) | ES2198355T3 (https=) |
| HK (1) | HK1047749B (https=) |
| HU (1) | HUP0203545A3 (https=) |
| IL (3) | IL148997A0 (https=) |
| MX (1) | MXPA02003546A (https=) |
| NO (1) | NO20021564L (https=) |
| NZ (1) | NZ518438A (https=) |
| PE (2) | PE20010632A1 (https=) |
| PL (1) | PL355109A1 (https=) |
| PT (1) | PT1218378E (https=) |
| RU (1) | RU2002110281A (https=) |
| SK (1) | SK4622002A3 (https=) |
| WO (2) | WO2001027119A2 (https=) |
| ZA (2) | ZA200203579B (https=) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083966A (en) | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
| CN1585639A (zh) | 1998-09-21 | 2005-02-23 | 佛罗里达大学研究基金会 | 抗疟疾制剂 |
| WO2001076694A1 (en) | 2000-04-10 | 2001-10-18 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| DE10043845A1 (de) * | 2000-09-06 | 2002-03-14 | Gruenenthal Gmbh | Verfahren zur Messung der Aktivität der NO-Synthase |
| DE10050663A1 (de) * | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
| AU2002224927A1 (en) * | 2000-12-13 | 2002-06-24 | Basf Aktiengesellschaft | Use of substituted imidazoazines, novel imidazoazines, methods for the production thereof, and agents containing these compounds |
| DE10117183A1 (de) * | 2001-04-05 | 2002-10-10 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel |
| DE10117184A1 (de) * | 2001-04-05 | 2002-10-17 | Gruenenthal Gmbh | Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen |
| DE10132726A1 (de) | 2001-07-05 | 2003-02-27 | Gruenenthal Gmbh | Verwendung von substituierten gamma-Lactonverbindungen als Arzneimittel |
| DK1483247T3 (da) | 2002-03-13 | 2009-08-17 | Euro Celtique Sa | Arylsubstituerede pyrimidiner og anvendelsen deraf |
| CA2482991A1 (en) | 2002-04-19 | 2003-10-30 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines method of making and method of use thereof |
| US20050197435A1 (en) * | 2002-06-14 | 2005-09-08 | Dotson Darin L. | Polymer additive compositions for bimolecular nucleation in thermoplastics |
| US7312341B2 (en) | 2002-09-09 | 2007-12-25 | Cgi Pharmaceuticals, Inc. | 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof |
| DE10246890A1 (de) | 2002-10-08 | 2004-04-22 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-alpyridin-3-yl-methylamine |
| AU2003290333A1 (en) * | 2002-12-24 | 2004-07-22 | Biofocus Plc | Compound libraries of imidazo(1,5-a)pyridin-3-yl derivatives and related heterobicycles for targetting compounds capable of binding to g-protein coupled receptors |
| WO2004072081A1 (en) | 2003-02-10 | 2004-08-26 | Cellular Genomics, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity |
| US7405295B2 (en) | 2003-06-04 | 2008-07-29 | Cgi Pharmaceuticals, Inc. | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
| US7393848B2 (en) | 2003-06-30 | 2008-07-01 | Cgi Pharmaceuticals, Inc. | Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds |
| US7259164B2 (en) | 2003-08-11 | 2007-08-21 | Cgi Pharmaceuticals, Inc. | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity |
| WO2005034949A1 (en) | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| DE102004021716A1 (de) * | 2004-04-30 | 2005-12-01 | Grünenthal GmbH | Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen |
| DE102004044884A1 (de) | 2004-09-14 | 2006-05-24 | Grünenthal GmbH | Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen |
| US7820654B2 (en) | 2004-09-23 | 2010-10-26 | Dr. Reddy's Laboratories Ltd. | Pyrimidine compounds, process for their preparation and compositions containing them |
| TR201910900T4 (tr) | 2005-04-04 | 2019-08-21 | Univ Florida | Desferritiyokin polieter analogları. |
| DE102005016547A1 (de) * | 2005-04-08 | 2006-10-12 | Grünenthal GmbH | Substituierte 5,6,7,8-Tetrahydro-imidazo(1,2-a)pyridin-2-ylamin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| WO2007024294A2 (en) | 2005-05-03 | 2007-03-01 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| EP1902056A2 (en) | 2005-05-20 | 2008-03-26 | Array Biopharma, Inc. | Raf inhibitor compounds and methods of use thereof |
| US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| EP1910385B1 (en) | 2005-08-04 | 2013-07-24 | Sirtris Pharmaceuticals, Inc. | Benzothiazoles and thiazolopyridines as sirtuin modulators |
| US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US7855289B2 (en) | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US7709468B2 (en) | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
| SI2495016T1 (sl) | 2005-12-23 | 2020-04-30 | Ariad Pharmaceuticals, Inc. | Biciklične heteroarilne spojine |
| DE102006011574A1 (de) | 2006-03-10 | 2007-10-31 | Grünenthal GmbH | Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln |
| ES2422890T3 (es) | 2006-03-17 | 2013-09-16 | Ambit Biosciences Corporation | Compuestos de imidazolotiazol para el tratamiento de enfermedades proliferativas |
| WO2008115433A1 (en) | 2007-03-15 | 2008-09-25 | University Of Florida | Desferrithiocin polyether analogues |
| WO2008134553A1 (en) * | 2007-04-26 | 2008-11-06 | Xenon Pharmaceuticals Inc. | Methods of using bicyclic compounds in treating sodium channel-mediated diseases |
| GB0708188D0 (en) * | 2007-04-27 | 2007-06-06 | Merck Sharp & Dohme | Therapeutic compounds |
| CL2008001821A1 (es) | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de imidazo[2,1-b]-tiazol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de diabetes, sindrome metabolico, resistencia a la insulina, entre otras. |
| TW200916472A (en) | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
| DE102007040336A1 (de) * | 2007-08-27 | 2009-03-05 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Neue Inhibitoren der 5-Lipoxygenase und deren Verwendungen |
| CA2696776C (en) | 2007-09-19 | 2015-12-15 | Ambit Biosciences Corporation | Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
| JP5496915B2 (ja) | 2008-02-13 | 2014-05-21 | シージーアイ ファーマシューティカルズ，インコーポレーテッド | ６−アリール−イミダゾ［１，２−ａ］ピラジン誘導体、その製造方法、及びその使用方法 |
| RS52561B (sr) * | 2008-04-15 | 2013-04-30 | Eisai R&D Management Co., Ltd. | Jedinjenje 3-fenilpirazolo[5,1-b]tiazol |
| WO2010032195A1 (en) | 2008-09-16 | 2010-03-25 | Csir | Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors |
| EA021293B1 (ru) | 2008-12-08 | 2015-05-29 | Джилид Коннектикут, Инк. | ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| CN102307474B (zh) | 2008-12-08 | 2015-04-01 | 吉利德康涅狄格股份有限公司 | 咪唑并吡嗪syk抑制剂 |
| EP2376502B1 (en) | 2008-12-19 | 2015-06-17 | GlaxoSmithKline LLC | Thiazolopyridine sirtuin modulating compounds |
| AR078521A1 (es) * | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
| CN103168039B (zh) | 2010-03-11 | 2016-08-03 | 吉利德康涅狄格公司 | 咪唑并吡啶类syk抑制剂 |
| EP3620161A1 (en) | 2011-12-16 | 2020-03-11 | University of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
| BR112014026651A8 (pt) | 2012-04-26 | 2018-01-16 | Bristol Myers Squibb Co | derivados de imidazotiadiazol e de imidazopiridazina como inibidores do receptor ativado por proteases 4 (par4) para o tratamento de agregação plaquetária |
| WO2013163244A1 (en) | 2012-04-26 | 2013-10-31 | Bristol-Myers Squibb Company | Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| LT2841437T (lt) | 2012-04-26 | 2017-09-11 | Bristol-Myers Squibb Company | Imidazotiadiazolo ir imidazopirazino dariniai, kaip proteazės aktyvuotų receptorių 4 (par4) inhibitoriai, skirti trombocitų agregacijos gydymui |
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- 1999-10-08 DE DE19948434A patent/DE19948434A1/de not_active Withdrawn
-
2000
- 2000-09-18 AU AU74199/00A patent/AU7419900A/en not_active Abandoned
- 2000-09-18 WO PCT/EP2000/009098 patent/WO2001027119A2/de not_active Ceased
- 2000-09-18 IL IL14899700A patent/IL148997A0/xx not_active IP Right Cessation
- 2000-10-02 CO CO00074640A patent/CO5210861A1/es not_active Application Discontinuation
- 2000-10-05 AR ARP000105251A patent/AR025960A1/es not_active Application Discontinuation
- 2000-10-05 AR ARP000105250A patent/AR025959A1/es not_active Application Discontinuation
- 2000-10-06 BR BR0014827-0A patent/BR0014827A/pt not_active IP Right Cessation
- 2000-10-06 PL PL00355109A patent/PL355109A1/xx not_active IP Right Cessation
- 2000-10-06 ES ES00969439T patent/ES2198355T3/es not_active Expired - Lifetime
- 2000-10-06 DK DK00969439T patent/DK1218378T3/da active
- 2000-10-06 AU AU79153/00A patent/AU780526B2/en not_active Ceased
- 2000-10-06 CN CNB008167079A patent/CN1208336C/zh not_active Expired - Fee Related
- 2000-10-06 HU HU0203545A patent/HUP0203545A3/hu unknown
- 2000-10-06 JP JP2001530327A patent/JP2003511450A/ja active Pending
- 2000-10-06 CA CA002386804A patent/CA2386804A1/en not_active Abandoned
- 2000-10-06 NZ NZ518438A patent/NZ518438A/en not_active IP Right Cessation
- 2000-10-06 CO CO00076179A patent/CO5251429A1/es not_active Application Discontinuation
- 2000-10-06 KR KR1020027004518A patent/KR100793619B1/ko not_active Expired - Fee Related
- 2000-10-06 AT AT00969439T patent/ATE238304T1/de active
- 2000-10-06 DE DE50001911T patent/DE50001911D1/de not_active Expired - Lifetime
- 2000-10-06 CZ CZ20021241A patent/CZ20021241A3/cs unknown
- 2000-10-06 MX MXPA02003546A patent/MXPA02003546A/es active IP Right Grant
- 2000-10-06 RU RU2002110281/04A patent/RU2002110281A/ru not_active Application Discontinuation
- 2000-10-06 EP EP00969439A patent/EP1218378B1/de not_active Expired - Lifetime
- 2000-10-06 IL IL14899900A patent/IL148999A0/xx active IP Right Grant
- 2000-10-06 HK HK02109385.2A patent/HK1047749B/zh not_active IP Right Cessation
- 2000-10-06 PE PE2000001063A patent/PE20010632A1/es not_active Application Discontinuation
- 2000-10-06 WO PCT/EP2000/009791 patent/WO2001027109A2/de not_active Ceased
- 2000-10-06 SK SK462-2002A patent/SK4622002A3/sk unknown
- 2000-10-06 PT PT00969439T patent/PT1218378E/pt unknown
- 2000-10-06 PE PE2000001062A patent/PE20010706A1/es not_active Application Discontinuation
-
2002
- 2002-04-03 NO NO20021564A patent/NO20021564L/no not_active Application Discontinuation
- 2002-04-04 IL IL148999A patent/IL148999A/en not_active IP Right Cessation
- 2002-04-08 US US10/117,339 patent/US6703404B2/en not_active Expired - Fee Related
- 2002-05-06 ZA ZA200203579A patent/ZA200203579B/xx unknown
- 2002-05-06 ZA ZA200203581A patent/ZA200203581B/xx unknown
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