JP2003300959A5 - - Google Patents
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- JP2003300959A5 JP2003300959A5 JP2003021750A JP2003021750A JP2003300959A5 JP 2003300959 A5 JP2003300959 A5 JP 2003300959A5 JP 2003021750 A JP2003021750 A JP 2003021750A JP 2003021750 A JP2003021750 A JP 2003021750A JP 2003300959 A5 JP2003300959 A5 JP 2003300959A5
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- JP
- Japan
- Prior art keywords
- group
- atom
- dihydro
- phenyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 biphenylyl group Chemical group 0.000 claims 406
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 126
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 125
- 229910052757 nitrogen Inorganic materials 0.000 claims 114
- 125000000217 alkyl group Chemical group 0.000 claims 91
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 73
- 150000001875 compounds Chemical class 0.000 claims 69
- 229910052799 carbon Inorganic materials 0.000 claims 59
- 125000003277 amino group Chemical group 0.000 claims 58
- 125000004076 pyridyl group Chemical group 0.000 claims 57
- 150000001721 carbon Chemical group 0.000 claims 54
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 48
- 229910052801 chlorine Inorganic materials 0.000 claims 45
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 44
- 229910052731 fluorine Inorganic materials 0.000 claims 44
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 43
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 43
- 125000004432 carbon atom Chemical group C* 0.000 claims 41
- 125000001153 fluoro group Chemical group F* 0.000 claims 41
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 41
- 125000001424 substituent group Chemical group 0.000 claims 39
- 125000001309 chloro group Chemical group Cl* 0.000 claims 38
- 125000004093 cyano group Chemical group *C#N 0.000 claims 37
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 32
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 32
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 31
- 125000004663 dialkyl amino group Chemical group 0.000 claims 31
- 125000000623 heterocyclic group Chemical group 0.000 claims 31
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 31
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 30
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 30
- 125000001072 heteroaryl group Chemical group 0.000 claims 30
- 125000006239 protecting group Chemical group 0.000 claims 30
- 125000003545 alkoxy group Chemical group 0.000 claims 28
- 125000006598 aminocarbonylamino group Chemical group 0.000 claims 28
- 150000003839 salts Chemical class 0.000 claims 28
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 27
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 25
- 125000002252 acyl group Chemical group 0.000 claims 25
- 125000005331 diazinyl group Chemical group N1=NC(=CC=C1)* 0.000 claims 25
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 24
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 24
- 125000003282 alkyl amino group Chemical class 0.000 claims 24
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 24
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 23
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 22
- 229910052760 oxygen Inorganic materials 0.000 claims 21
- 239000001301 oxygen Substances 0.000 claims 21
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 20
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 20
- 229910052717 sulfur Inorganic materials 0.000 claims 19
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 claims 18
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims 18
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 17
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 16
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 16
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 15
- 125000001624 naphthyl group Chemical group 0.000 claims 14
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 13
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000002071 phenylalkoxy group Chemical group 0.000 claims 12
- 238000002360 preparation method Methods 0.000 claims 12
- 125000004434 sulfur atom Chemical group 0.000 claims 12
- 238000006243 chemical reaction Methods 0.000 claims 11
- 125000002541 furyl group Chemical group 0.000 claims 11
- 125000002883 imidazolyl group Chemical group 0.000 claims 11
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 11
- 125000004548 quinolin-3-yl group Chemical group N1=CC(=CC2=CC=CC=C12)* 0.000 claims 11
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 10
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 10
- 125000004949 alkyl amino carbonyl amino group Chemical group 0.000 claims 10
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 10
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 10
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 10
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 10
- 239000002243 precursor Substances 0.000 claims 10
- 238000006467 substitution reaction Methods 0.000 claims 10
- 239000011593 sulfur Substances 0.000 claims 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 9
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 claims 9
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 9
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 9
- 125000003884 phenylalkyl group Chemical group 0.000 claims 9
- 125000000168 pyrrolyl group Chemical group 0.000 claims 9
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 9
- 125000000335 thiazolyl group Chemical group 0.000 claims 9
- 125000006546 (C4-C10) cycloalkyl group Chemical group 0.000 claims 8
- 125000001589 carboacyl group Chemical group 0.000 claims 8
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 8
- 125000000524 functional group Chemical group 0.000 claims 8
- 125000001544 thienyl group Chemical group 0.000 claims 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 7
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 7
- 125000002723 alicyclic group Chemical group 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 7
- 125000000842 isoxazolyl group Chemical group 0.000 claims 7
- 125000004430 oxygen atom Chemical group O* 0.000 claims 7
- 229920006395 saturated elastomer Polymers 0.000 claims 7
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 6
- 125000005605 benzo group Chemical group 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 6
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 6
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 5
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 5
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 5
- 239000000460 chlorine Chemical group 0.000 claims 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 5
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 5
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 5
- 239000011737 fluorine Substances 0.000 claims 5
- 125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 claims 5
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 5
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 4
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims 4
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 4
- 125000004744 butyloxycarbonyl group Chemical group 0.000 claims 4
- 150000001735 carboxylic acids Chemical class 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims 4
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 3
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 3
- 125000005079 alkoxycarbonylmethyl group Chemical group 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 3
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 3
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 125000003831 tetrazolyl group Chemical group 0.000 claims 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 2
- OXHNLMTVIGZXSG-UHFFFAOYSA-N 1-Methylpyrrole Chemical group CN1C=CC=C1 OXHNLMTVIGZXSG-UHFFFAOYSA-N 0.000 claims 2
- MCTWTZJPVLRJOU-UHFFFAOYSA-N 1-methyl-1H-imidazole Chemical group CN1C=CN=C1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims 2
- 125000003435 aroyl group Chemical group 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 claims 2
- 239000012948 isocyanate Substances 0.000 claims 2
- 150000002513 isocyanates Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 2
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- OFJBYLCQNJHFMI-UHFFFAOYSA-N 2,5-dihydro-1,2-oxazole Chemical group C1ONC=C1 OFJBYLCQNJHFMI-UHFFFAOYSA-N 0.000 claims 1
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 238000012286 ELISA Assay Methods 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical group [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 125000006267 biphenyl group Chemical group 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 125000000837 carbohydrate group Chemical group 0.000 claims 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004984 dialkylaminoalkoxy group Chemical group 0.000 claims 1
- 125000002474 dimethylaminoethoxy group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])O* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 239000002858 neurotransmitter agent Substances 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 150000003335 secondary amines Chemical class 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000024883 vasodilation Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19636623A DE19636623A1 (de) | 1996-09-10 | 1996-09-10 | Abgewandelte Aminosäuren, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE19636623.2 | 1996-09-10 | ||
| DE19720011A DE19720011A1 (de) | 1997-05-14 | 1997-05-14 | Abgewandelte Aminosäuren, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Hetstellung |
| DE19720011.7 | 1997-05-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51322798A Division JP3483893B2 (ja) | 1996-09-10 | 1997-09-08 | 修飾アミノ酸、これらの化合物を含む薬物及びそれらの調製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003300959A JP2003300959A (ja) | 2003-10-21 |
| JP2003300959A5 true JP2003300959A5 (enExample) | 2005-06-16 |
Family
ID=26029200
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51322798A Expired - Fee Related JP3483893B2 (ja) | 1996-09-10 | 1997-09-08 | 修飾アミノ酸、これらの化合物を含む薬物及びそれらの調製方法 |
| JP2003021750A Pending JP2003300959A (ja) | 1996-09-10 | 2003-01-30 | 修飾アミノ酸、これらの化合物を含む薬物及びそれらの調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51322798A Expired - Fee Related JP3483893B2 (ja) | 1996-09-10 | 1997-09-08 | 修飾アミノ酸、これらの化合物を含む薬物及びそれらの調製方法 |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6344449B1 (enExample) |
| EP (2) | EP0927192B1 (enExample) |
| JP (2) | JP3483893B2 (enExample) |
| CN (1) | CN1129605C (enExample) |
| AR (1) | AR009742A1 (enExample) |
| AT (2) | ATE402187T1 (enExample) |
| AU (1) | AU721035C (enExample) |
| BG (1) | BG64214B1 (enExample) |
| BR (1) | BR9712023A (enExample) |
| CA (1) | CA2262818A1 (enExample) |
| CO (1) | CO4910127A1 (enExample) |
| CZ (1) | CZ82399A3 (enExample) |
| DE (2) | DE59711622D1 (enExample) |
| DK (1) | DK0927192T3 (enExample) |
| EA (1) | EA004037B1 (enExample) |
| EE (1) | EE04375B1 (enExample) |
| ES (2) | ES2221691T3 (enExample) |
| HR (1) | HRP970481B1 (enExample) |
| ID (1) | ID21045A (enExample) |
| IL (1) | IL128118A0 (enExample) |
| MY (1) | MY140677A (enExample) |
| NO (1) | NO991130L (enExample) |
| NZ (1) | NZ334543A (enExample) |
| PE (1) | PE109698A1 (enExample) |
| PT (1) | PT927192E (enExample) |
| RS (1) | RS49791B (enExample) |
| SA (1) | SA97180668B1 (enExample) |
| SK (1) | SK285631B6 (enExample) |
| TR (1) | TR199900537T2 (enExample) |
| TW (2) | TW498076B (enExample) |
| UY (1) | UY24704A1 (enExample) |
| WO (1) | WO1998011128A1 (enExample) |
Families Citing this family (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025372A (en) * | 1997-04-04 | 2000-02-15 | Merck & Co., Inc. | Somatostatin agonists |
| GB9819860D0 (en) | 1998-09-12 | 1998-11-04 | Zeneca Ltd | Chemical compounds |
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| WO2018200977A1 (en) | 2017-04-28 | 2018-11-01 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| WO2019046167A1 (en) | 2017-08-30 | 2019-03-07 | Acadia Pharmaceuticals Inc. | PIMAVANSERIN FORMULATIONS |
| CR20210373A (es) | 2019-01-08 | 2021-08-19 | H Lundbeck As | Tratamiento agudo y tratamiento rápido de la cefalea usando anticuerpos anti-cgrp |
| GEAP202515803A (en) | 2019-05-02 | 2025-06-10 | H Lundbeck As | Treatment of headache using anti-cgrp antibodies |
| KR20210124867A (ko) | 2020-04-06 | 2021-10-15 | 하. 룬드벡 아크티에셀스카브 | 항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료 |
| JP2024509165A (ja) | 2021-03-02 | 2024-02-29 | シージーアールピー ダイアグノスティクス ゲーエムベーハー | 片頭痛の治療及び／又は発生の低減 |
| WO2023026205A1 (en) | 2021-08-24 | 2023-03-02 | Cgrp Diagnostics Gmbh | Preventative treatment of migraine |
| CN120187434A (zh) | 2022-11-11 | 2025-06-20 | 勃林格殷格翰国际有限公司 | 用于治疗脓毒症的奥塞吉泮 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873342A (en) * | 1985-04-16 | 1989-10-10 | Suntory Limited | Dipeptide derivative and synthesis and use thereof |
| CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
| EP0298135A1 (en) * | 1987-03-30 | 1989-01-11 | Shosuke Okamoto | Phenylalanine derivative and proteinase inhibitor |
| US4873253A (en) * | 1987-03-30 | 1989-10-10 | Shosuke Okamoto | Phenylalanine derivative and proteinase inhibitor |
| US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| JP2668003B2 (ja) * | 1992-06-12 | 1997-10-27 | ファイザー インク． | ヒトの心臓キマーゼを含むアンギオテンシンｉキマーゼに関する阻害剤 |
| CA2166075A1 (en) * | 1993-06-30 | 1995-01-12 | Yoshiharu Ikeda | Novel dipiperidine derivative |
| DE69433747D1 (de) * | 1994-08-16 | 2004-06-03 | Human Genome Sciences Inc | Calcitoninrezeptor |
| US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
| FR2729855A1 (fr) * | 1995-01-26 | 1996-08-02 | Oreal | Utilisation d'un antagoniste de cgrp dans une composition cosmetique, pharmaceutique ou dermatologique et composition obtenue |
-
1997
- 1997-09-08 DE DE59711622T patent/DE59711622D1/de not_active Expired - Lifetime
- 1997-09-08 CZ CZ99823A patent/CZ82399A3/cs unknown
- 1997-09-08 IL IL12811897A patent/IL128118A0/xx unknown
- 1997-09-08 US US09/254,281 patent/US6344449B1/en not_active Expired - Lifetime
- 1997-09-08 CA CA002262818A patent/CA2262818A1/en not_active Abandoned
- 1997-09-08 AU AU41196/97A patent/AU721035C/en not_active Ceased
- 1997-09-08 PT PT97938928T patent/PT927192E/pt unknown
- 1997-09-08 SK SK297-99A patent/SK285631B6/sk unknown
- 1997-09-08 DK DK97938928T patent/DK0927192T3/da active
- 1997-09-08 DE DE59712953T patent/DE59712953D1/de not_active Expired - Lifetime
- 1997-09-08 EP EP97938928A patent/EP0927192B1/de not_active Expired - Lifetime
- 1997-09-08 TR TR1999/00537T patent/TR199900537T2/xx unknown
- 1997-09-08 NZ NZ334543A patent/NZ334543A/en unknown
- 1997-09-08 CN CN97197772A patent/CN1129605C/zh not_active Expired - Fee Related
- 1997-09-08 JP JP51322798A patent/JP3483893B2/ja not_active Expired - Fee Related
- 1997-09-08 AT AT04003959T patent/ATE402187T1/de not_active IP Right Cessation
- 1997-09-08 AT AT97938928T patent/ATE266673T1/de not_active IP Right Cessation
- 1997-09-08 BR BR9712023-5A patent/BR9712023A/pt not_active Application Discontinuation
- 1997-09-08 EA EA199900278A patent/EA004037B1/ru not_active IP Right Cessation
- 1997-09-08 ES ES97938928T patent/ES2221691T3/es not_active Expired - Lifetime
- 1997-09-08 ID IDW990071A patent/ID21045A/id unknown
- 1997-09-08 WO PCT/EP1997/004862 patent/WO1998011128A1/de not_active Ceased
- 1997-09-08 EE EEP199900115A patent/EE04375B1/xx not_active IP Right Cessation
- 1997-09-08 ES ES04003959T patent/ES2314305T3/es not_active Expired - Lifetime
- 1997-09-08 EP EP04003959A patent/EP1440976B1/de not_active Expired - Lifetime
- 1997-09-09 MY MYPI97004176A patent/MY140677A/en unknown
- 1997-09-09 HR HR970481A patent/HRP970481B1/xx not_active IP Right Cessation
- 1997-09-09 RS YUP-372/97A patent/RS49791B/sr unknown
- 1997-09-09 PE PE1997000801A patent/PE109698A1/es not_active Application Discontinuation
- 1997-09-10 TW TW089125839A patent/TW498076B/zh not_active IP Right Cessation
- 1997-09-10 UY UY24704A patent/UY24704A1/es not_active IP Right Cessation
- 1997-09-10 AR ARP970104149A patent/AR009742A1/es unknown
- 1997-09-10 TW TW086113120A patent/TW477792B/zh not_active IP Right Cessation
- 1997-09-10 CO CO97052652A patent/CO4910127A1/es unknown
- 1997-12-01 SA SA97180668A patent/SA97180668B1/ar unknown
-
1999
- 1999-03-09 NO NO991130A patent/NO991130L/no not_active Application Discontinuation
- 1999-03-15 BG BG103250A patent/BG64214B1/bg unknown
-
2001
- 2001-02-21 US US09/789,391 patent/US20010036946A1/en not_active Abandoned
-
2003
- 2003-01-30 JP JP2003021750A patent/JP2003300959A/ja active Pending
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