JP2002505574A - ポリアルキレンオキシド修飾された単鎖ポリペプチド - Google Patents

ポリアルキレンオキシド修飾された単鎖ポリペプチド

Info

Publication number
JP2002505574A
JP2002505574A JP54734798A JP54734798A JP2002505574A JP 2002505574 A JP2002505574 A JP 2002505574A JP 54734798 A JP54734798 A JP 54734798A JP 54734798 A JP54734798 A JP 54734798A JP 2002505574 A JP2002505574 A JP 2002505574A
Authority
JP
Japan
Prior art keywords
antigen
polypeptide
binding
chain
polyalkylene oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP54734798A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002505574A5 (enExample
Inventor
ホワイトロウ，マーク
ジー．エル． ショアー，ロバート
アール． フィルプラ，デイビッド
エス． リー，リーシン
Original Assignee
エンゾン，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エンゾン，インコーポレイテッド filed Critical エンゾン，インコーポレイテッド
Publication of JP2002505574A publication Critical patent/JP2002505574A/ja
Publication of JP2002505574A5 publication Critical patent/JP2002505574A5/ja
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP54734798A 1997-04-30 1998-04-30 ポリアルキレンオキシド修飾された単鎖ポリペプチド Pending JP2002505574A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US4444997P 1997-04-30 1997-04-30
US5047297P 1997-06-23 1997-06-23
US6307497P 1997-10-27 1997-10-27
US6734197P 1997-12-02 1997-12-02
US60/063,074 1997-12-02
US60/067,341 1997-12-02
US60/044,449 1997-12-02
US60/050,472 1997-12-02
PCT/US1998/008654 WO1998048837A1 (en) 1997-04-30 1998-04-30 Polyalkylene oxide-modified single chain polypeptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008008563A Division JP2008115193A (ja) 1997-04-30 2008-01-17 ポリアルキレンオキシド修飾された単鎖ポリペプチド

Publications (2)

Publication Number Publication Date
JP2002505574A true JP2002505574A (ja) 2002-02-19
JP2002505574A5 JP2002505574A5 (enExample) 2005-12-02

Family

ID=27488916

Family Applications (4)

Application Number Title Priority Date Filing Date
JP54734798A Pending JP2002505574A (ja) 1997-04-30 1998-04-30 ポリアルキレンオキシド修飾された単鎖ポリペプチド
JP54735198A Expired - Lifetime JP4187277B2 (ja) 1997-04-30 1998-04-30 グリコシル化し得る抗原結合単鎖タンパク質、それらの生成および使用
JP2008008563A Withdrawn JP2008115193A (ja) 1997-04-30 2008-01-17 ポリアルキレンオキシド修飾された単鎖ポリペプチド
JP2009281051A Withdrawn JP2010051331A (ja) 1997-04-30 2009-12-10 ポリアルキレンオキシド修飾された単鎖ポリペプチド

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP54735198A Expired - Lifetime JP4187277B2 (ja) 1997-04-30 1998-04-30 グリコシル化し得る抗原結合単鎖タンパク質、それらの生成および使用
JP2008008563A Withdrawn JP2008115193A (ja) 1997-04-30 2008-01-17 ポリアルキレンオキシド修飾された単鎖ポリペプチド
JP2009281051A Withdrawn JP2010051331A (ja) 1997-04-30 2009-12-10 ポリアルキレンオキシド修飾された単鎖ポリペプチド

Country Status (6)

Country Link
US (8) US6323322B1 (enExample)
EP (2) EP0981548A4 (enExample)
JP (4) JP2002505574A (enExample)
AU (2) AU7266698A (enExample)
CA (2) CA2288992C (enExample)
WO (2) WO1998048837A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007516195A (ja) * 2003-06-30 2007-06-21 ドマンティス リミテッド ポリペプチド

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