|
US6228879B1
(en)
|
1997-10-16 |
2001-05-08 |
The Children's Medical Center |
Methods and compositions for inhibition of angiogenesis
|
|
US6429221B1
(en)
|
1994-12-30 |
2002-08-06 |
Celgene Corporation |
Substituted imides
|
|
DE69740140D1
(de)
*
|
1996-07-24 |
2011-04-14 |
Celgene Corp |
Substituierte 2-(2,6-Dioxopiperidin-3-yl)-phthalimide und Oxoisoindoline und Verfahren zur Verringerung der TNF-Alpha-Stufen
|
|
HU228769B1
(en)
*
|
1996-07-24 |
2013-05-28 |
Celgene Corp |
Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
|
|
US5635517B1
(en)
|
1996-07-24 |
1999-06-29 |
Celgene Corp |
Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
|
|
DE19703763C1
(de)
*
|
1997-02-01 |
1998-10-01 |
Gruenenthal Gmbh |
Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione
|
|
AU752958B2
(en)
*
|
1997-11-18 |
2002-10-03 |
Celgene Corporation |
Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and their use to reduce TNFalpha levels
|
|
US5955476A
(en)
*
|
1997-11-18 |
1999-09-21 |
Celgene Corporation |
Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
|
|
TR200101500T2
(tr)
*
|
1998-03-16 |
2002-06-21 |
Celgene Corporation |
2-(2,6-dioksopiperidin-3-il)izoindolin türevleri, bunların hazırlanması ve enflamatuarn sitokinlerin inhibitörleri olarak kullanımı.
|
|
WO2000055134A1
(en)
|
1999-03-18 |
2000-09-21 |
Celgene Corporation |
Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels
|
|
DE19917195B4
(de)
*
|
1999-04-16 |
2006-09-28 |
Immatics Biotechnologies Gmbh |
Peptid zur Auslösung einer Immunreaktion gegen Tumorzellen, diese enthaltende pharmzeutische Zusammensetzungen, dessen Verwendungen, dafür codierende Nukleinsäure und diese Nukleinsäure enthaltender Expressionsvektor
|
|
US7629360B2
(en)
|
1999-05-07 |
2009-12-08 |
Celgene Corporation |
Methods for the treatment of cachexia and graft v. host disease
|
|
US7182953B2
(en)
*
|
1999-12-15 |
2007-02-27 |
Celgene Corporation |
Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders
|
|
US6458810B1
(en)
|
2000-11-14 |
2002-10-01 |
George Muller |
Pharmaceutically active isoindoline derivatives
|
|
CA2430669C
(en)
*
|
2000-11-30 |
2011-06-14 |
The Children's Medical Center Corporation |
Synthesis of 3-amino-thalidomide and its enantiomers
|
|
PL362979A1
(en)
*
|
2000-12-11 |
2004-11-02 |
Takeda Chemical Industries, Ltd. |
Medicinal compositions improved in solublity in water
|
|
US7091353B2
(en)
|
2000-12-27 |
2006-08-15 |
Celgene Corporation |
Isoindole-imide compounds, compositions, and uses thereof
|
|
US20030045552A1
(en)
*
|
2000-12-27 |
2003-03-06 |
Robarge Michael J. |
Isoindole-imide compounds, compositions, and uses thereof
|
|
JP4361273B2
(ja)
*
|
2001-02-27 |
2009-11-11 |
アメリカ合衆国 |
潜在的な血管形成阻害剤としてのサリドマイド類似体
|
|
DE60231989D1
(de)
*
|
2001-08-06 |
2009-05-28 |
Childrens Medical Center |
Antiangiogenese wirkung von stickstoffsubstituierten thalidomid-analoga
|
|
US7498171B2
(en)
|
2002-04-12 |
2009-03-03 |
Anthrogenesis Corporation |
Modulation of stem and progenitor cell differentiation, assays, and uses thereof
|
|
USRE48890E1
(en)
|
2002-05-17 |
2022-01-11 |
Celgene Corporation |
Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
|
|
US7968569B2
(en)
|
2002-05-17 |
2011-06-28 |
Celgene Corporation |
Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
|
US7393862B2
(en)
|
2002-05-17 |
2008-07-01 |
Celgene Corporation |
Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
|
|
US7323479B2
(en)
|
2002-05-17 |
2008-01-29 |
Celgene Corporation |
Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
|
|
DK1505973T3
(da)
|
2002-05-17 |
2010-05-31 |
Celgene Corp |
Kombinationer til behandling af multipelt myelom
|
|
EP1900369A1
(en)
|
2002-10-15 |
2008-03-19 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes
|
|
US8404716B2
(en)
|
2002-10-15 |
2013-03-26 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
|
US7189740B2
(en)
|
2002-10-15 |
2007-03-13 |
Celgene Corporation |
Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
|
|
US8404717B2
(en)
|
2002-10-15 |
2013-03-26 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes using lenalidomide
|
|
US11116782B2
(en)
|
2002-10-15 |
2021-09-14 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
|
FR2845994B1
(fr)
*
|
2002-10-18 |
2006-05-19 |
Servier Lab |
Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
KR20050057672A
(ko)
*
|
2002-10-24 |
2005-06-16 |
셀진 코포레이션 |
통증의 치료, 변형 및 관리를 위한 면역조절 화합물을포함하는 조성물 및 이의 사용 방법
|
|
CA2504024A1
(en)
*
|
2002-10-31 |
2004-05-21 |
Celgene Corporation |
Composition for the treatment of macular degeneration
|
|
US7563810B2
(en)
|
2002-11-06 |
2009-07-21 |
Celgene Corporation |
Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
|
|
CH696542A5
(de)
*
|
2003-07-09 |
2007-07-31 |
Siegfried Ltd |
Verfahren zur Herstellung von substituierten 2,6-Dioxopiperidin-3-yl-Verbindungen.
|
|
UA83504C2
(en)
|
2003-09-04 |
2008-07-25 |
Селджин Корпорейшн |
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
|
CA2808646C
(en)
|
2003-09-17 |
2016-08-23 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Thalidomide analogs as tnf-alpha modulators
|
|
US8952895B2
(en)
|
2011-06-03 |
2015-02-10 |
Apple Inc. |
Motion-based device operations
|
|
US7612096B2
(en)
|
2003-10-23 |
2009-11-03 |
Celgene Corporation |
Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
|
|
US20050100529A1
(en)
*
|
2003-11-06 |
2005-05-12 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
|
|
AU2005226649B2
(en)
|
2004-03-22 |
2010-04-29 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of skin diseases or disorders
|
|
WO2005112928A1
(en)
*
|
2004-05-05 |
2005-12-01 |
Celgene Corporation |
Method of using and compositions comprising immunomodulatory compounds for the treatment and management of myeloproliferative diseases
|
|
NZ554068A
(en)
*
|
2004-09-03 |
2009-07-31 |
Celgene Corp |
Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindo-lines
|
|
PL1907373T3
(pl)
|
2005-06-30 |
2013-05-31 |
Celgene Corp |
Sposób wytwarzania związków 4-amino-2-(2,6-diokso-piperydyn-3-ylo)izoindolino-1,3-dionu
|
|
WO2007009062A2
(en)
|
2005-07-13 |
2007-01-18 |
Anthrogenesis Corporation |
Treatment of leg ulcers using placenta derived collagen biofabric
|
|
CA2822094C
(en)
|
2005-08-31 |
2015-10-27 |
Celgene Corporation |
Isoindole-imide compounds and compositions comprising and methods of using the same
|
|
PL1928492T3
(pl)
|
2005-09-01 |
2011-09-30 |
Celgene Corp |
Immunologiczne zastosowania związków immunomodulujących do szczepionki i przeciwzakaźnego leczenia choroby
|
|
US20070066512A1
(en)
|
2005-09-12 |
2007-03-22 |
Dominique Verhelle |
Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
|
|
CN1939922B
(zh)
*
|
2005-09-27 |
2010-10-13 |
天津和美生物技术有限公司 |
可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物
|
|
US9598669B2
(en)
|
2005-12-29 |
2017-03-21 |
Anthrogenesis Corporation |
Composition for collecting placental stem cells and methods of using the composition
|
|
CA2646316C
(en)
|
2006-03-15 |
2016-05-24 |
Theralogics, Inc. |
Methods of treating muscular wasting diseases using nf-kb activation inhibitors
|
|
WO2007136640A2
(en)
*
|
2006-05-16 |
2007-11-29 |
Celgene Corporation |
Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
|
|
CL2007002218A1
(es)
|
2006-08-03 |
2008-03-14 |
Celgene Corp Soc Organizada Ba |
Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa.
|
|
WO2008021391A1
(en)
|
2006-08-15 |
2008-02-21 |
Anthrogenesis Corporation |
Umbilical cord biomaterial for medical use
|
|
US8877780B2
(en)
|
2006-08-30 |
2014-11-04 |
Celgene Corporation |
5-substituted isoindoline compounds
|
|
AU2007290407A1
(en)
*
|
2006-08-30 |
2008-03-06 |
Celgene Corporation |
5-substituted isoindoline compounds
|
|
HUE035389T2
(en)
|
2006-09-26 |
2018-05-02 |
Celgene Corp |
5-substituted quinazolinone derivatives as anticancer agents
|
|
EP1923053A1
(en)
|
2006-09-27 |
2008-05-21 |
Novartis AG |
Pharmaceutical compositions comprising nilotinib or its salt
|
|
US8071135B2
(en)
|
2006-10-04 |
2011-12-06 |
Anthrogenesis Corporation |
Placental tissue compositions
|
|
AU2007318210B2
(en)
|
2006-10-06 |
2014-02-20 |
Celularity Inc. |
Native (telopeptide) placental collagen compositions
|
|
AU2008305581C1
(en)
|
2007-09-26 |
2014-12-11 |
Celgene Corporation |
6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same
|
|
EP2203176B1
(en)
|
2007-09-28 |
2014-11-26 |
Anthrogenesis Corporation |
Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
|
|
US20090088393A1
(en)
*
|
2007-09-28 |
2009-04-02 |
Zomanex, Llc |
Methods and formulations for converting intravenous and injectable drugs into oral dosage forms
|
|
CN101909609A
(zh)
*
|
2007-11-08 |
2010-12-08 |
细胞基因公司 |
免疫调节化合物在治疗与内皮功能障碍有关的紊乱中的用途
|
|
CA2710196A1
(en)
|
2007-12-20 |
2009-07-09 |
Celgene Corporation |
Use of micro-rna as a biomarker of immunomodulatory drug activity
|
|
KR20100124710A
(ko)
*
|
2008-03-11 |
2010-11-29 |
닥터 레디스 레보러터리즈 리미티드 |
레날리도미드의 제조
|
|
CN101531653B
(zh)
*
|
2008-03-13 |
2014-07-09 |
峡江和美药业有限公司 |
3-(4-氨基-1-氧代-1,3-二氢异吲哚-2-基)哌啶-2,6-二酮及其衍生物的盐或盐的多晶型物及其制备和应用
|
|
US20110060010A1
(en)
*
|
2008-03-13 |
2011-03-10 |
Tianjin Hemay Bio-Tech Co., Ltd |
Salts of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)piperidine-2,6-dione and derivatives thereof, or polymorphs of salts, process for preparing same and use thereof
|
|
US20090298882A1
(en)
*
|
2008-05-13 |
2009-12-03 |
Muller George W |
Thioxoisoindoline compounds and compositions comprising and methods of using the same
|
|
CA2957226C
(en)
|
2008-10-29 |
2018-08-14 |
Celgene Corporation |
Isoindoline compounds for use in the treatment of cancer
|
|
US9045453B2
(en)
|
2008-11-14 |
2015-06-02 |
Concert Pharmaceuticals, Inc. |
Substituted dioxopiperidinyl phthalimide derivatives
|
|
DE102008057285A1
(de)
|
2008-11-14 |
2010-05-20 |
Ratiopharm Gmbh |
3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidindion in Form einer festen Lösung
|
|
DE102008057284A1
(de)
|
2008-11-14 |
2010-05-20 |
Ratiopharm Gmbh |
Tabletten enthaltend Lenalidomid und Adhäsionsverstärker
|
|
DE102008057335A1
(de)
|
2008-11-14 |
2010-05-20 |
Ratiopharm Gmbh |
Amorphes Lenalidomid
|
|
MX2011005112A
(es)
*
|
2008-11-14 |
2011-06-16 |
Concert Pharmaceuticals Inc |
Derivados de dioxopiperidinil-ftalimida sustituida.
|
|
EP2396312A1
(en)
|
2009-02-11 |
2011-12-21 |
Celgene Corporation |
Isotopologues of lenalidomide
|
|
CA3110964A1
(en)
|
2009-03-25 |
2010-09-30 |
Xiaokui Zhang |
Preventing a symptom of graft-versus-host disease using human placenta-derived intermediate natural killer cells
|
|
EP3351240B1
(en)
|
2009-05-19 |
2019-04-10 |
Celgene Corporation |
Formulations of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
|
|
US20120134969A1
(en)
|
2009-05-25 |
2012-05-31 |
Hiroshi Handa |
Pharmaceutical composition containing nuclear factor involved in proliferation and differentiation of central neuronal cells
|
|
CN101580501B
(zh)
*
|
2009-06-01 |
2011-03-09 |
南京卡文迪许生物工程技术有限公司 |
3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
|
|
EP2493872A1
(en)
|
2009-09-03 |
2012-09-05 |
Ranbaxy Laboratories Limited |
Process for the preparation of lenalidomide
|
|
WO2011050962A1
(en)
*
|
2009-10-29 |
2011-05-05 |
Ratiopharm Gmbh |
Acid addition salts of lenalidomide
|
|
CN102127054B
(zh)
*
|
2009-11-02 |
2013-04-03 |
南京卡文迪许生物工程技术有限公司 |
3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
|
|
CN101696205B
(zh)
|
2009-11-02 |
2011-10-19 |
南京卡文迪许生物工程技术有限公司 |
3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
|
|
WO2011069608A1
(en)
*
|
2009-12-09 |
2011-06-16 |
Ratiopharm Gmbh |
S-lenalidomide, polymorphic forms thereof and blend comprising s- und r-lenalidomide
|
|
AU2010333767A1
(en)
|
2009-12-22 |
2012-07-05 |
Celgene Corporation |
(Methylsulfonyl) ethyl benzene isoindoline derivatives and their therapeutical uses
|
|
MX337566B
(es)
|
2010-01-05 |
2016-03-10 |
Celgene Corp |
Combinación de un compuesto inmunomodulador y una artemisinina o un derivado de ésta para tratar cáncer.
|
|
SG183257A1
(en)
|
2010-02-11 |
2012-09-27 |
Celgene Corp |
Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
|
|
WO2011127019A2
(en)
|
2010-04-07 |
2011-10-13 |
Celgene Corporation |
Methods for treating respiratory viral infection
|
|
WO2012078492A1
(en)
|
2010-12-06 |
2012-06-14 |
Celgene Corporation |
A combination therapy with lenalidomide and a cdk inhibitor for treating multiple myeloma
|
|
ES2673114T3
(es)
|
2011-01-10 |
2018-06-19 |
Celgene Corporation |
Derivados de fenetilsulfona isoindolina como inhibidores de PDE 4 y/o citoquinas
|
|
RU2611007C2
(ru)
|
2011-03-11 |
2017-02-17 |
Селджин Корпорейшн |
Твердые формы 3-(5-амино-2-метил-4-оксо-4н-хиназолин-3-ил)пиперидин-2, 6-диона и их фармацевтические композиции и применение
|
|
EP2699091B1
(en)
|
2011-03-28 |
2017-06-21 |
DeuteRx, LLC |
2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
|
|
EP2699909A1
(en)
|
2011-04-18 |
2014-02-26 |
Celgene Corporation |
Biomarkers for the treatment of multiple myeloma
|
|
WO2012149299A2
(en)
|
2011-04-29 |
2012-11-01 |
Celgene Corporaiton |
Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
|
|
WO2012177678A2
(en)
|
2011-06-22 |
2012-12-27 |
Celgene Corporation |
Isotopologues of pomalidomide
|
|
CA2848493A1
(en)
|
2011-09-14 |
2013-03-21 |
Celgene Corporation |
Formulations of cyclopropanecarboxylic acid {2-[(1s)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1h-isoindol-4-yl}-amide
|
|
US8927725B2
(en)
|
2011-12-02 |
2015-01-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Thio compounds
|
|
AU2012362562B2
(en)
|
2011-12-27 |
2017-11-02 |
Amgen (Europe) GmbH |
Formulations of (+)-2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-4-acetyl aminoisoindoline-1,3-dione
|
|
US9085551B2
(en)
*
|
2012-02-21 |
2015-07-21 |
Celgene Corporation |
Solid forms of 3-(4-nitro-1-oxisoindolin-2-yl)piperidine-2,6-dione
|
|
US20150174235A1
(en)
|
2012-06-06 |
2015-06-25 |
Bionor Immuno As |
Vaccine
|
|
ES2872967T3
(es)
|
2012-06-29 |
2021-11-03 |
Celgene Corp |
Métodos para determinar la eficacia de fármacos usando IKZF3 (AIOLOS)
|
|
LT2882737T
(lt)
|
2012-08-09 |
2019-04-25 |
Celgene Corporation |
(s)-3-(4-((4-morfolinometil)benzil)oksi)-1-oksoizoindolin-2-il)piperidin-2,6-diono hidrochlorido kieta forma
|
|
US9587281B2
(en)
|
2012-08-14 |
2017-03-07 |
Celgene Corporation |
Cereblon isoforms and their use as biomarkers for therapeutic treatment
|
|
EP2922838B1
(en)
|
2012-10-22 |
2018-03-14 |
Concert Pharmaceuticals Inc. |
Solid forms of {s-3-(4-amino-1-oxo-isoindolin-2-yl)(piperidine-3,4,4,5,5-d5)-2,6-dione} .
|
|
AU2013204922B2
(en)
|
2012-12-20 |
2015-05-14 |
Celgene Corporation |
Chimeric antigen receptors
|
|
FR2999915B1
(fr)
*
|
2012-12-21 |
2017-08-11 |
Oreal |
Utilisation de derives de l'acide imidocarboxylique en tant qu'agent apaisant
|
|
FR2999914B1
(fr)
*
|
2012-12-21 |
2015-08-07 |
Oreal |
Utilisation de derives de l'acide imidocarboxylique pour traiter les alterations de la peau liees a l'age ou au photovieillissement
|
|
WO2014110322A2
(en)
|
2013-01-11 |
2014-07-17 |
Concert Pharmaceuticals, Inc. |
Substituted dioxopiperidinyl phthalimide derivatives
|
|
AU2014205043B2
(en)
|
2013-01-14 |
2018-10-04 |
Deuterx, Llc |
3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
|
|
EP3622960A1
(en)
|
2013-02-05 |
2020-03-18 |
Celularity, Inc. |
Natural killer cells from placenta
|
|
EP2764866A1
(en)
|
2013-02-07 |
2014-08-13 |
IP Gesellschaft für Management mbH |
Inhibitors of nedd8-activating enzyme
|
|
EP2970372B1
(en)
|
2013-03-15 |
2020-09-30 |
Celgene Corporation |
Modified t lymphocytes
|
|
CN104072476B
(zh)
*
|
2013-03-27 |
2018-08-21 |
江苏豪森药业集团有限公司 |
泊马度胺晶型及其制备方法和用途
|
|
CA2908954C
(en)
|
2013-04-17 |
2021-08-03 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer
|
|
EP2815749A1
(en)
*
|
2013-06-20 |
2014-12-24 |
IP Gesellschaft für Management mbH |
Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
|
|
WO2015007337A1
(en)
|
2013-07-19 |
2015-01-22 |
Bionor Immuno As |
Method for the vaccination against hiv
|
|
CN103497174B
(zh)
*
|
2013-07-29 |
2015-10-28 |
杭州派臣医药科技有限公司 |
泊利度胺的制备和精制方法
|
|
CN104557857A
(zh)
*
|
2013-10-29 |
2015-04-29 |
上海医药工业研究院 |
一种泊利度胺的纯化方法
|
|
CN104557858B
(zh)
*
|
2013-10-29 |
2018-06-01 |
上海医药工业研究院 |
一种泊利度胺的制备方法
|
|
EP3076973B1
(en)
|
2013-12-03 |
2020-04-29 |
Acetylon Pharmaceuticals, Inc. |
Combinations of histone deacetylase inhibitors and immunomodulatory drugs
|
|
CN104016967A
(zh)
*
|
2014-04-04 |
2014-09-03 |
南京工业大学 |
一种泊利度胺的合成方法
|
|
EP4649963A3
(en)
*
|
2014-04-14 |
2026-05-13 |
Arvinas Operations, Inc. |
Imide-based modulators of proteolysis and associated methods of use
|
|
US20180228907A1
(en)
|
2014-04-14 |
2018-08-16 |
Arvinas, Inc. |
Cereblon ligands and bifunctional compounds comprising the same
|
|
ES2843973T3
(es)
|
2014-06-27 |
2021-07-21 |
Celgene Corp |
Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3
|
|
CN105348257A
(zh)
*
|
2014-08-20 |
2016-02-24 |
河北菲尼斯生物技术有限公司 |
泊马度胺的制备方法
|
|
AU2015305449B2
(en)
|
2014-08-22 |
2021-05-06 |
Celgene Corporation |
Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
|
|
CN105440013B
(zh)
*
|
2014-08-29 |
2018-10-09 |
杭州和泽医药科技有限公司 |
一种泊马度胺的制备方法
|
|
NZ731789A
(en)
*
|
2014-10-30 |
2019-04-26 |
Kangpu Biopharmaceuticals Ltd |
Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof
|
|
US10471156B2
(en)
|
2014-12-19 |
2019-11-12 |
Synthon B.V. |
Pharmaceutical composition comprising amorphous lenalidomide
|
|
US10507204B2
(en)
|
2014-12-19 |
2019-12-17 |
Synthon B.V. |
Pharmaceutical composition comprising amorphous lenalidomide
|
|
CN104447689B
(zh)
*
|
2014-12-22 |
2016-07-20 |
上海迈柏医药科技有限公司 |
来那度胺的晶型及其制备方法
|
|
JP6817962B2
(ja)
|
2015-01-20 |
2021-01-20 |
アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． |
ターゲティングされたアンドロゲン受容体分解のための化合物および方法
|
|
US12312316B2
(en)
|
2015-01-20 |
2025-05-27 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
|
AU2016266942B2
(en)
*
|
2015-05-22 |
2018-10-18 |
Biotheryx, Inc. |
Compounds targeting proteins, compositions, methods, and uses thereof
|
|
WO2016197114A1
(en)
|
2015-06-05 |
2016-12-08 |
Arvinas, Inc. |
Tank-binding kinase-1 protacs and associated methods of use
|
|
SI3313818T1
(sl)
|
2015-06-26 |
2024-03-29 |
Celgene Corporation |
Postopki zdravljenja Kaposijevega sarkoma ali s KSHV povzročenega limfoma, z uporabo imunomodulatornih spojin in uporabe biomarkerjev
|
|
EP3337476A4
(en)
|
2015-08-19 |
2019-09-04 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of bromodomain-containing proteins
|
|
EP3393457A1
(en)
|
2015-12-22 |
2018-10-31 |
Synthon B.V. |
Pharmaceutical composition comprising amorphous lenalidomide and an antioxidant
|
|
US10830762B2
(en)
|
2015-12-28 |
2020-11-10 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases
|
|
US20170281784A1
(en)
|
2016-04-05 |
2017-10-05 |
Arvinas, Inc. |
Protein-protein interaction inducing technology
|
|
WO2017201069A1
(en)
|
2016-05-18 |
2017-11-23 |
Biotheryx, Inc. |
Oxoindoline derivatives as protein function modulators
|
|
SI3526202T1
(sl)
|
2016-10-11 |
2025-04-30 |
Arvinas Operations, Inc. |
Spojine in postopki za ciljno razgradnjo androgenskih receptorjev
|
|
MX2019005007A
(es)
|
2016-11-01 |
2019-07-18 |
Arvinas Inc |
Protac dirigidos a la proteína tau y métodos asociados de uso.
|
|
IL266842B
(en)
|
2016-12-01 |
2022-09-01 |
Arvinas Operations Inc |
History of tetrahydronaphthalene and tetrahydroisoquinoline as estrogen receptor antagonists
|
|
JP2019536460A
(ja)
|
2016-12-03 |
2019-12-19 |
ジュノー セラピューティクス インコーポレイテッド |
Ｃａｒ−ｔ細胞の調節方法
|
|
KR20220028178A
(ko)
|
2016-12-16 |
2022-03-08 |
강푸 바이오파마슈티칼즈 리미티드 |
조성물, 이의 적용 및 치료 방법
|
|
IL325835A
(en)
|
2016-12-23 |
2026-03-01 |
Univ Yale |
Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
|
|
CN110753693A
(zh)
|
2016-12-23 |
2020-02-04 |
阿尔维纳斯运营股份有限公司 |
Egfr蛋白水解靶向嵌合分子和相关使用方法
|
|
US11173211B2
(en)
|
2016-12-23 |
2021-11-16 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
|
|
US10806737B2
(en)
|
2016-12-23 |
2020-10-20 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
|
|
US11191741B2
(en)
|
2016-12-24 |
2021-12-07 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
|
|
IL300417A
(en)
|
2017-01-26 |
2023-04-01 |
Arvinas Operations Inc |
Bifunctional benzothiophene compounds, preparations containing them and their use in therapy
|
|
IL319363A
(en)
|
2017-01-31 |
2025-05-01 |
Arvinas Operations Inc |
Cervalon ligands and bifunctional compounds containing them
|
|
JP6773915B2
(ja)
|
2017-02-13 |
2020-10-21 |
カング バイオファーマシューティカルズ リミテッド |
前立腺癌を治療する組み合わせ、薬物組成物および治療方法
|
|
PL3618842T3
(pl)
|
2017-05-01 |
2024-02-19 |
Juno Therapeutics, Inc. |
Kombinacja terapii komórkowej i związku immunomodulującego
|
|
US10093647B1
(en)
|
2017-05-26 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione dihydrate, compositions and methods of use thereof
|
|
IL327498A
(en)
|
2017-06-02 |
2026-05-01 |
Juno Therapeutics Inc |
Articles of manufacture and methods for treatment using adoptive cell therapy
|
|
CN111050545A
(zh)
|
2017-06-29 |
2020-04-21 |
朱诺治疗学股份有限公司 |
评估与免疫疗法相关的毒性的小鼠模型
|
|
TWI793151B
(zh)
*
|
2017-08-23 |
2023-02-21 |
瑞士商諾華公司 |
3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
|
|
US10093649B1
(en)
|
2017-09-22 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate, compositions and methods of use thereof
|
|
US10093648B1
(en)
|
2017-09-22 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate, compositions and methods of use thereof
|
|
WO2019067792A1
(en)
|
2017-09-28 |
2019-04-04 |
Celularity, Inc. |
TUMOR CONTROL WITH INTERMEDIATE NATURAL KILLER CELLS DERIVED FROM HUMAN PLACENTA (PINK) IN COMBINATION WITH ANTIBODY
|
|
WO2019089858A2
(en)
|
2017-11-01 |
2019-05-09 |
Juno Therapeutics, Inc. |
Methods of assessing or monitoring a response to a cell therapy
|
|
MA49911A
(fr)
|
2017-11-01 |
2020-06-24 |
Juno Therapeutics Inc |
Anticorps et récepteurs antigéniques chimériques spécifiques de l'antigene de maturation des lymphocytes b
|
|
US11065231B2
(en)
|
2017-11-17 |
2021-07-20 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
|
|
EP3724225A1
(en)
|
2017-12-15 |
2020-10-21 |
Juno Therapeutics, Inc. |
Anti-cct5 binding molecules and methods of use thereof
|
|
EP3505158A1
(en)
|
2017-12-27 |
2019-07-03 |
KRKA, d.d., Novo mesto |
Pharmaceutical composition of lenalidomide pharmaceutically acceptable acid addition salt
|
|
WO2019138424A1
(en)
|
2018-01-11 |
2019-07-18 |
Natco Pharma Limited |
Stable pharmaceutical compositions comprising lenalidomide
|
|
JP2021512153A
(ja)
|
2018-01-26 |
2021-05-13 |
イエール ユニバーシティ |
タンパク質分解のイミド系モジュレーターおよび使用方法
|
|
BR112020017053A2
(pt)
|
2018-02-21 |
2020-12-15 |
Celgene Corporation |
Anticorpos que se ligam ao bcma e usos dos mesmos
|
|
EP3545949A1
(en)
|
2018-03-29 |
2019-10-02 |
Midas Pharma GmbH |
Oral dosage forms comprising pomalidomide crystalline form a
|
|
BR112020020307A2
(pt)
|
2018-04-04 |
2021-01-12 |
Arvinas Operations, Inc. |
Moduladores de proteólise e métodos de uso associados
|
|
JP7581052B2
(ja)
|
2018-04-13 |
2024-11-12 |
サムヤン ホールディングス コーポレイション |
レナリドミドの経口用コーティング錠剤組成物
|
|
KR102286500B1
(ko)
|
2018-04-13 |
2021-08-05 |
주식회사 삼양홀딩스 |
레날리도마이드를 포함하는 경구용 고형제제의 제조방법
|
|
KR102286497B1
(ko)
|
2018-04-13 |
2021-08-05 |
주식회사 삼양홀딩스 |
다양한 용량의 레날리도마이드의 경구용 정제 조성물
|
|
KR102259798B1
(ko)
|
2018-04-13 |
2021-06-02 |
주식회사 삼양홀딩스 |
붕해가 개선된 레날리도마이드의 경구용 정제 조성물
|
|
WO2019199134A1
(ko)
|
2018-04-13 |
2019-10-17 |
주식회사 삼양바이오팜 |
레날리도마이드를 포함하는 약제학적 조성물
|
|
US11707452B2
(en)
|
2018-08-20 |
2023-07-25 |
Arvinas Operations, Inc. |
Modulators of alpha-synuclein proteolysis and associated methods of use
|
|
CN113573719A
(zh)
|
2018-11-08 |
2021-10-29 |
朱诺治疗学股份有限公司 |
治疗和t细胞调节的方法和组合
|
|
BR112021009420A2
(pt)
|
2018-11-16 |
2021-11-23 |
Juno Therapeutics Inc |
Métodos de dosagem de células t manipuladas para o tratamento de malignidades de células b
|
|
EP4427810A3
(en)
|
2018-11-30 |
2024-12-04 |
Juno Therapeutics, Inc. |
Methods for treatment using adoptive cell therapy
|
|
WO2020118098A1
(en)
*
|
2018-12-05 |
2020-06-11 |
Vividion Therapeutics, Inc. |
Substituted isoindolinones as modulators of cereblon-mediated neo-substrate recruitment
|
|
EA202192103A1
(ru)
|
2019-01-29 |
2021-12-15 |
Джуно Терапьютикс, Инк. |
Антитела и химерные антигенные рецепторы, специфичные к орфанному рецептору типа рецеторной тирозинкиназы 1 (ror1)
|
|
US20230248696A1
(en)
*
|
2019-05-03 |
2023-08-10 |
Dynamic Biologics Inc. |
Lenalidomide prodrugs, polymeric conjugates, and formulations thereof, and their uses for the treatment of multiple myeloma
|
|
CN110343063A
(zh)
*
|
2019-08-09 |
2019-10-18 |
新乡双鹭药业有限公司 |
一种泊马度胺合成中杂质的制备方法
|
|
WO2021041348A1
(en)
|
2019-08-26 |
2021-03-04 |
Arvinas Operations, Inc. |
Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders
|
|
WO2021061644A1
(en)
*
|
2019-09-23 |
2021-04-01 |
Accutar Biotechnology Inc. |
Novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof
|
|
EP4034114A4
(en)
|
2019-09-23 |
2023-07-26 |
Accutar Biotechnology Inc. |
Novel ureas having androgen receptor degradation activity and uses thereof
|
|
MX2022004526A
(es)
|
2019-10-17 |
2022-07-21 |
Arvinas Operations Inc |
Moléculas bifuncionales que contienen una porción de unión a la ligasa de ubiquitina e3 unida a una porción de direccionamiento a bcl6.
|
|
JP7629459B2
(ja)
|
2019-11-19 |
2025-02-13 |
ブリストル－マイヤーズ スクイブ カンパニー |
Ｈｅｌｉｏｓタンパク質の阻害剤として有用な化合物
|
|
JP7871189B2
(ja)
*
|
2019-12-17 |
2026-06-08 |
オリオニス バイオサイエンシズ，インコーポレイテッド |
タンパク質の動員および／または分解を調節する化合物
|
|
WO2021127443A1
(en)
|
2019-12-19 |
2021-06-24 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
|
TW202140441A
(zh)
|
2020-03-23 |
2021-11-01 |
美商必治妥美雅史谷比公司 |
經取代之側氧基異吲哚啉化合物
|
|
BR112022020897A2
(pt)
|
2020-04-15 |
2022-11-29 |
Tecnimede Sociedade Tecnico Medicinal Sa |
Forma de dosagem oral sólida compreendendo pomalidomida.
|
|
CN115996918A
(zh)
|
2020-05-09 |
2023-04-21 |
阿尔维纳斯运营股份有限公司 |
制造双官能团化合物的方法、双官能团化合物的超纯形式以及包括所述双官能团化合物的剂型
|
|
WO2022047145A1
(en)
|
2020-08-28 |
2022-03-03 |
Arvinas Operations, Inc. |
Rapidly accelerating fibrosarcoma protein degrading compounds and associated methods of use
|
|
AU2021342287A1
(en)
|
2020-09-14 |
2023-04-13 |
Arvinas Operations, Inc. |
Crystalline forms of a compound for the targeted degradation of estrogen receptor
|
|
CN117242060B
(zh)
|
2021-01-13 |
2026-07-17 |
蒙特罗莎治疗股份有限公司 |
异吲哚啉酮化合物
|
|
PE20231941A1
(es)
|
2021-04-06 |
2023-12-05 |
Bristol Myers Squibb Co |
Compuestos de oxoisoindolina sustituidos con piridinilo
|
|
CN118388454A
(zh)
|
2021-04-16 |
2024-07-26 |
阿尔维纳斯运营股份有限公司 |
Bcl6蛋白水解的调节剂和其相关使用方法
|
|
WO2023126531A1
(en)
|
2021-12-31 |
2023-07-06 |
A Fine House S.A. |
Lenalidomide oral solution
|
|
US20250073220A1
(en)
|
2021-12-31 |
2025-03-06 |
A Fine House S.A. |
Oral solution comprising lenalidomide
|
|
JP2025521543A
(ja)
|
2022-06-22 |
2025-07-10 |
ジュノー セラピューティクス インコーポレイテッド |
Ｃｄ１９標的ｃａｒ ｔ細胞のセカンドライン治療のための処置方法
|
|
EP4584258A1
(en)
|
2022-09-07 |
2025-07-16 |
Arvinas Operations, Inc. |
Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use
|
|
US20260166082A1
(en)
|
2022-11-02 |
2026-06-18 |
Celgene Corporation |
Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy
|
|
PE20260006A1
(es)
|
2023-01-26 |
2026-01-06 |
Arvinas Operations Inc |
Protacs degradadores de kras basados en cereblon y usos relacionados con los mismos
|
|
AU2024392985A1
(en)
|
2023-12-08 |
2026-06-04 |
Arvinas Operations, Inc. |
Use of androgen receptor degrader for the treatment of spinal and bulbar muscular atrophy
|
|
WO2026006247A1
(en)
*
|
2024-06-26 |
2026-01-02 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
2-(piperidin-3-yl)isoindole-1,3-dione analogs and uses thereof
|
|
WO2026149422A1
(zh)
*
|
2025-01-08 |
2026-07-16 |
上海惠康济民生物医药技术有限公司 |
含吗啉基的异吲哚啉化合物的晶型及其制备方法和应用
|