JP2000512138A5 - - Google Patents

Download PDF

Info

Publication number
JP2000512138A5
JP2000512138A5 JP1998500807A JP50080798A JP2000512138A5 JP 2000512138 A5 JP2000512138 A5 JP 2000512138A5 JP 1998500807 A JP1998500807 A JP 1998500807A JP 50080798 A JP50080798 A JP 50080798A JP 2000512138 A5 JP2000512138 A5 JP 2000512138A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998500807A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000512138A (ja
JP4278712B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/009620 external-priority patent/WO1997046707A2/en
Publication of JP2000512138A publication Critical patent/JP2000512138A/ja
Publication of JP2000512138A5 publication Critical patent/JP2000512138A5/ja
Application granted granted Critical
Publication of JP4278712B2 publication Critical patent/JP4278712B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP50080798A 1996-06-04 1997-06-04 Dna増幅を蛍光でモニタリングするためのシステムと方法 Expired - Lifetime JP4278712B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65899396A 1996-06-04 1996-06-04
US08/658,993 1996-06-04
PCT/US1997/009620 WO1997046707A2 (en) 1996-06-04 1997-06-04 System and method for monitoring for dna amplification by fluorescence

Publications (3)

Publication Number Publication Date
JP2000512138A JP2000512138A (ja) 2000-09-19
JP2000512138A5 true JP2000512138A5 (cg-RX-API-DMAC10.html) 2005-02-10
JP4278712B2 JP4278712B2 (ja) 2009-06-17

Family

ID=24643601

Family Applications (2)

Application Number Title Priority Date Filing Date
JP50087498A Expired - Lifetime JP4281877B2 (ja) 1996-06-04 1997-06-04 生物学的プロセスを実行し且つモニタリングするためのシステムと方法
JP50080798A Expired - Lifetime JP4278712B2 (ja) 1996-06-04 1997-06-04 Dna増幅を蛍光でモニタリングするためのシステムと方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP50087498A Expired - Lifetime JP4281877B2 (ja) 1996-06-04 1997-06-04 生物学的プロセスを実行し且つモニタリングするためのシステムと方法

Country Status (11)

Country Link
EP (7) EP1442794B1 (cg-RX-API-DMAC10.html)
JP (2) JP4281877B2 (cg-RX-API-DMAC10.html)
AT (5) ATE390491T1 (cg-RX-API-DMAC10.html)
AU (2) AU727296B2 (cg-RX-API-DMAC10.html)
CA (2) CA2256612C (cg-RX-API-DMAC10.html)
DE (5) DE69740030D1 (cg-RX-API-DMAC10.html)
DK (1) DK2298931T3 (cg-RX-API-DMAC10.html)
ES (6) ES2304573T3 (cg-RX-API-DMAC10.html)
NZ (2) NZ333135A (cg-RX-API-DMAC10.html)
PT (1) PT2298931E (cg-RX-API-DMAC10.html)
WO (2) WO1997046707A2 (cg-RX-API-DMAC10.html)

Families Citing this family (244)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2282623C (en) * 1997-02-28 2007-05-22 Cepheid Heat exchanging, optically interrogated chemical reaction assembly
DE19811730A1 (de) * 1998-03-18 1999-09-23 November Ag Molekulare Medizin Verfahren und Vorrichtung zum Identifizieren einer Markierung
EP1614473A3 (en) 1998-05-01 2007-03-14 Gen-Probe Incorporated Multiple ring assembly for providing specimen to reaction receptacles within an automated analyzer
AU759974B2 (en) 1998-05-16 2003-05-01 Applied Biosystems, Llc Instrument for monitoring polymerase chain reaction of DNA
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US6140054A (en) * 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
DE19850593A1 (de) * 1998-11-03 2000-05-04 Biochip Technologies Gmbh Verfahren zum Nachweis von Hybridisierungsereignissen bei DNA
US6303305B1 (en) 1999-03-30 2001-10-16 Roche Diagnostics, Gmbh Method for quantification of an analyte
US6387621B1 (en) 1999-04-27 2002-05-14 University Of Utah Research Foundation Automated analysis of real-time nucleic acid amplification
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7387891B2 (en) 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US7423750B2 (en) 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US7708945B1 (en) 1999-08-13 2010-05-04 Bayer Technology Services Gmbh Device and method for determining multiple analytes
DE19946296A1 (de) * 1999-09-28 2001-03-29 Roche Diagnostics Gmbh Multiplex-PCR zum Nachweis von EHEC-Infektionen
DE60039062D1 (de) * 1999-11-12 2008-07-10 Du Pont Fluorimeter mit lichtquelle mit geringer wärmeerzeugung
US6691041B2 (en) 2000-03-31 2004-02-10 Roche Molecular Systems, Inc. Method for the efficiency-corrected real-time quantification of nucleic acids
DE10045521A1 (de) * 2000-03-31 2001-10-04 Roche Diagnostics Gmbh Nukleinsäureamplifikationen
US6783934B1 (en) 2000-05-01 2004-08-31 Cepheid, Inc. Methods for quantitative analysis of nucleic acid amplification reaction
CA2412275C (en) * 2000-06-28 2009-12-08 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6563581B1 (en) 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
EP1360324A2 (en) 2000-08-31 2003-11-12 Mayo Foundation For Medical Education And Research Detection of varicella-zoster virus
DE10044373A1 (de) 2000-09-08 2002-03-21 Roche Diagnostics Gmbh Neues Reagenz zur Markierung von Nukleinsäuren
ATE465272T1 (de) 2001-01-31 2010-05-15 Mayo Foundation Nachweis von herpex-simplex-virus
WO2002089844A1 (en) 2001-05-07 2002-11-14 Mayo Foundation For Medical Education And Research Legionella detection with fluorescent resonance energy transfer
US7226732B2 (en) * 2001-07-16 2007-06-05 Cepheid Methods, apparatus, and computer programs for verifying the integrity of a probe
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US7373253B2 (en) 2002-02-12 2008-05-13 Idaho Technology Multi-test analysis of real-time nucleic acid amplification
US6593093B1 (en) 2002-02-20 2003-07-15 Mayo Foundation For Medical Education And Research Detection of group a Streptococcus
US7785776B2 (en) 2002-05-13 2010-08-31 Idaho Technology, Inc. Genotyping by amplicon melting curve analysis
ES2543587T3 (es) 2002-05-17 2015-08-20 Life Technologies Corporation Instrumento óptico que incluye una fuente de excitación
AUPS267802A0 (en) * 2002-05-30 2002-06-20 Bio-Molecular Holdings Pty Limited Improved dna amplification apparatus and method
CA2433473A1 (en) * 2002-07-23 2004-01-23 F. Hoffmann-La Roche Ag Fluorescent hybridization probes with reduced background
US7074598B2 (en) 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US7365176B2 (en) 2002-09-26 2008-04-29 Mayo Foundation For Medical Education And Research Detection of Epstein-Barr virus
US7074599B2 (en) 2002-09-27 2006-07-11 Mayo Foundation For Medical Education And Research Detection of mecA-containing Staphylococcus spp.
US9850381B2 (en) * 2002-10-23 2017-12-26 University Of Utah Research Foundation Amplicon melting analysis with saturation dyes
AU2003286573B2 (en) 2002-10-23 2009-09-10 Idaho Technology, Inc. Amplicon melting analysis with saturation dyes
WO2004044243A1 (ja) * 2002-11-13 2004-05-27 Hitachi High-Technologies Corporation 核酸の増幅方法及びその装置
CN105349657A (zh) 2002-12-06 2016-02-24 霍夫曼-拉罗奇有限公司 病原生物的多种分析检测
US7718361B2 (en) 2002-12-06 2010-05-18 Roche Molecular Systems, Inc. Quantitative test for bacterial pathogens
GB2399776A (en) * 2003-03-24 2004-09-29 Pa Knowledge Ltd Cyclical heating and cooling device and associated methods
US8137616B2 (en) 2003-04-04 2012-03-20 Roche Molecular Systems, Inc. System for multi color real time PCR
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
US7788039B2 (en) 2003-09-25 2010-08-31 Roche Molecular Systems, Inc. Quantitation of nucleic acids using growth curves
CA2494571C (en) 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
CA2548205C (en) 2003-12-03 2017-06-27 Abbott Laboratories Double stranded linear nucleic acid probe and uses thereof
WO2005086679A2 (en) 2004-03-05 2005-09-22 Medical College Of Ohio Methods and compositions for assessing nucleic acids and alleles
JP2005295877A (ja) * 2004-04-09 2005-10-27 Taiyo Yuden Co Ltd 核酸分析方法、分析装置及び分析用ディスク
EP1745157A4 (en) 2004-04-12 2008-06-11 Ohio Med College METHOD AND COMPOSITIONS FOR TESTING ANALYTES
US9657347B2 (en) 2004-04-20 2017-05-23 University of Utah Research Foundation and BioFire Defense, LLC Nucleic acid melting analysis with saturation dyes
JP4820756B2 (ja) 2004-08-05 2011-11-24 ユニバーサル・バイオ・リサーチ株式会社 反応容器、反応容器液導入装置、液導入反応測定装置、および液導入装置
DE502004007951D1 (de) * 2004-08-18 2008-10-09 Roche Diagnostics Gmbh Verfahren zur Messung einer Nukleinsäureamplifikation in Real Time beinhaltend die Positionierung eines Reaktionsgefässes relativ zu einer Detektionseinheit
GB0419325D0 (en) * 2004-09-01 2004-09-29 Perkinelmer Ltd A method of analysing a sample including fluorescent labels and apparatus therefor
EP1634965B1 (en) 2004-09-09 2010-01-20 Roche Diagnostics GmbH Real time PCR with the addition of pyrophosphatase
DE102004043909A1 (de) * 2004-09-10 2006-03-30 Kendro Laboratory Products Gmbh Erwärmungsvorrichtung für Proben auf dem Gebiet der Life-Science
WO2006038643A1 (ja) 2004-10-06 2006-04-13 Universal Bio Research Co., Ltd. 反応容器、および反応制御装置
US20060094028A1 (en) * 2004-11-04 2006-05-04 Welch Allyn, Inc. Rapid diagnostic assay
ATE357653T1 (de) 2005-01-18 2007-04-15 Hoffmann La Roche Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken
ES2285578T3 (es) 2005-01-18 2007-11-16 F. Hoffmann-La Roche Ag Visualizacion de señales de fluorescencia utilizando telecentricidad.
US7897337B2 (en) * 2005-03-10 2011-03-01 Gen-Probe Incorporated Method for performing multi-formatted assays
EP1909108B1 (en) * 2005-03-10 2019-05-29 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifiying analytes
EP1700922B1 (en) 2005-03-10 2016-08-24 Roche Diagnostics GmbH 3-Substituted 5-Nitroindole derivatives and labeled oligonucleotide probes containing them
US7759469B2 (en) 2005-03-10 2010-07-20 Roche Diagnostics Operations, Inc. Labeling reagent
US7680604B2 (en) 2005-03-11 2010-03-16 Roche Molecular Systems, Inc. PCR elbow determination by rotational transform after zero slope alignment
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US20070048877A1 (en) * 2005-08-26 2007-03-01 Karl Skold Method and device for preparing a biological sample for biological analyses
US9017964B2 (en) 2005-08-26 2015-04-28 Denator Aktiebolag Preparing biological samples for analysis
US7569367B2 (en) 2005-09-07 2009-08-04 Roche Diagnostics Operations, Inc. Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy
US7991561B2 (en) 2005-09-29 2011-08-02 Roche Molecular Systems, Inc. Ct determination by cluster analysis with variable cluster endpoint
US7991558B2 (en) 2005-09-29 2011-08-02 Roche Molecular Systems, Inc. Systems and methods for determining real-time PCR cycle thresholds using cluster analysis
US7781165B2 (en) 2005-10-19 2010-08-24 Roche Diagnostics Operations, Inc. Benzimidazolium compounds and salts of benzimidazolium compounds for nucleic acid amplification
US7875425B2 (en) 2005-11-09 2011-01-25 Applied Biosystems, Llc Methods for monitoring polymerase chain reactions
GB0522972D0 (en) * 2005-11-11 2005-12-21 Integrated Design Ltd Thermal cycler
ES2332139T3 (es) 2005-11-23 2010-01-27 F. Hoffmann-La Roche Ag Polinucleotidos con mimetico de fosfato.
US7680868B2 (en) 2005-12-20 2010-03-16 Roche Molecular Systems, Inc. PCR elbow determination by use of a double sigmoid function curve fit with the Levenburg-Marquardt algorithm and normalization
US7991562B2 (en) 2005-12-20 2011-08-02 Roche Molecular Systems, Inc. PCR elbow determination using curvature analysis of a double sigmoid
US7844403B2 (en) * 2005-12-20 2010-11-30 Roche Molecular Systems, Inc. Temperature step correction with double sigmoid Levenberg-Marquardt and robust linear regression
US7668663B2 (en) 2005-12-20 2010-02-23 Roche Molecular Systems, Inc. Levenberg-Marquardt outlier spike removal method
US7981606B2 (en) 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
WO2007096182A1 (en) 2006-02-27 2007-08-30 Roche Diagnostics Gmbh Pcr hot start by magnesium sequestration
EP2002013A4 (en) 2006-04-04 2010-05-05 Labonnet Ltd ASSESSMENT OF REACTION KINETICS COMPATIBILITY BETWEEN POLYMERASE CHAIN REACTIONS
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
US8119352B2 (en) 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US8535888B2 (en) 2006-12-29 2013-09-17 Mayo Foundation For Medical Education And Research Compositions and methods for detecting methicillin-resistant S. aureus
EP1956097A1 (en) 2007-02-06 2008-08-13 bioMerieux B.V. Method for discriminating single nucleotide polymorphisms (SNPs)
JP5381100B2 (ja) * 2007-02-22 2014-01-08 東洋紡株式会社 核酸増幅装置
JP4458133B2 (ja) * 2007-02-27 2010-04-28 ソニー株式会社 核酸増幅装置
US9475051B2 (en) 2007-02-27 2016-10-25 Sony Corporation Nucleic acid amplifier
JP5191041B2 (ja) 2007-04-05 2013-04-24 エフ.ホフマン−ラ ロシュ アーゲー 急速ワンステップrt−pcr
WO2008126827A1 (ja) 2007-04-06 2008-10-23 Universal Bio Research Co., Ltd. 温度制御装置および温度制御方法
WO2008136318A1 (ja) * 2007-04-26 2008-11-13 Toyo Boseki Kabushiki Kaisha 核酸増幅方法およびそれに用いる容器
CN101802163A (zh) 2007-05-23 2010-08-11 信诚医疗有限公司 反应液用容器,使用这种容器的反应促进装置,及其方法
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US8386184B2 (en) 2007-08-28 2013-02-26 Becton, Dickinson And Company Systems and methods for determining an amount of starting reagent using the polymerase chain reaction
DE102007041864B4 (de) 2007-09-04 2012-05-03 Sirs-Lab Gmbh Verfahren zum Nachweis von Bakterien und Pilzen
US20090119020A1 (en) 2007-09-25 2009-05-07 Roche Molecular Systems, Inc. Pcr elbow determination using quadratic test for curvature analysis of a double sigmoid
WO2009042851A1 (en) 2007-09-28 2009-04-02 3M Innovative Properties Company Dual oligonucleotide method of nucleic acid detection
BR122020017678B1 (pt) 2007-10-02 2021-08-03 Labrador Diagnostics Llc Sistema para detecção automática de um analito em uma amostra de fluido corporal
JP5178149B2 (ja) * 2007-10-31 2013-04-10 キヤノン株式会社 標的核酸のリアルタイムpcr方法及びその装置
DE102007063102B4 (de) 2007-12-28 2022-02-10 Robert Bosch Gmbh Verfahren zur Erfassung eines periodisch pulsierenden Betriebsparameters
EP2238459B1 (en) 2008-01-23 2019-05-08 Roche Diagnostics GmbH Integrated instrument performing synthesis and amplification
US20090203022A1 (en) * 2008-02-07 2009-08-13 Arizona Board Of Regents For And On Behalf Of Arizona State University Analysis
EP2252702B1 (en) 2008-02-08 2014-01-29 Mayo Foundation for Medical Education and Research Detection of clostridium difficile
DE102008010436A1 (de) * 2008-02-21 2009-09-03 Berthold Technologies Gmbh & Co. Kg Vorrichtung und Verfahren zur Messung von Lumineszenz und Fluoreszenz von transfizierten Zellen oder Organteilen
JP2009201444A (ja) * 2008-02-29 2009-09-10 Hitachi High-Technologies Corp 核酸分析装置
CA2658520C (en) 2008-03-19 2016-11-08 F. Hoffmann-La Roche Ag Nucleic acid amplification in the presence of modified randomers
GB0806676D0 (en) 2008-04-12 2008-05-14 Environment Agency The Environmental monitoring
ES2439951T3 (es) 2008-06-06 2014-01-27 F. Hoffmann-La Roche Ag Detección y cuantificación multiplex de ácidos nucleicos microbianos controlada de forma interna
EP2138588A1 (en) 2008-06-23 2009-12-30 Koninklijke Philips Electronics N.V. Melting curve measurement during amplification
US8097412B2 (en) 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
EP2148187A1 (de) 2008-07-25 2010-01-27 Roche Diagnostics GmbH Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion
CA2638458A1 (en) 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
WO2010012464A1 (en) 2008-08-01 2010-02-04 Roche Diagnostics Gmbh Improved lysis and reverse transcription for mrna quantification
US7910720B2 (en) 2008-09-09 2011-03-22 Roche Diagnostics Operations, Inc. Polyanion for improved nucleic acid amplification
US8219324B2 (en) 2008-09-12 2012-07-10 Roche Molecular Systems, Inc. Real-time PCR elbow calling by equation-less algorithm
CA2682439A1 (en) 2008-10-17 2010-04-17 F. Hoffmann-La Roche Ag Cell monitoring and molecular analysis
US8346485B2 (en) 2008-11-25 2013-01-01 Quest Diagnostics Investments Incorporated Methods and apparatuses for estimating initial target nucleic acid concentration in a sample by modeling background signal and cycle-dependent amplification efficiency of a polymerase chain reaction
CA2688174C (en) 2008-12-19 2018-08-07 F. Hoffmann-La Roche Ag Dry composition of reaction compounds with stabilized polymerase
KR101423936B1 (ko) * 2009-03-11 2014-07-29 (주)바이오니아 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법
JP5138093B2 (ja) * 2009-03-31 2013-02-06 財団法人神奈川科学技術アカデミー 液体還流型高速遺伝子増幅装置
US20120183965A1 (en) 2009-06-15 2012-07-19 David Ward Nucleic acid detection
US8219366B2 (en) 2009-08-26 2012-07-10 Roche Molecular Sytems, Inc. Determination of elbow values for PCR for parabolic shaped curves
US10288632B2 (en) * 2009-09-21 2019-05-14 Pocared Diagnostics Ltd. System for conducting the identification of bacteria in biological samples
FI20096021A0 (fi) 2009-10-06 2009-10-06 Wallac Oy Optinen mittausinstrumentti
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
US20110250598A1 (en) 2010-04-12 2011-10-13 Ulrike Fischer Detergent free polymerases
EP2754496A3 (en) 2010-07-23 2017-08-02 Beckman Coulter, Inc. System Or Method Of Including Analytical Units
EP2598656B1 (en) 2010-07-29 2017-07-12 F. Hoffmann-La Roche AG Control nucleic acids for multiple parameters
CN103025891A (zh) 2010-07-29 2013-04-03 霍夫曼-拉罗奇有限公司 通用样品制备
CA2802550C (en) 2010-07-29 2019-01-15 F. Hoffmann-La Roche Ag Generic pcr
CN103069007A (zh) 2010-07-29 2013-04-24 霍夫曼-拉罗奇有限公司 微生物核酸的定性和定量检测
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
WO2012045670A1 (en) 2010-10-04 2012-04-12 Roche Diagnostics Gmbh Method for cell lysis in a pcr reaction buffer
EP2625285B1 (en) 2010-10-04 2020-04-29 Roche Diagniostics GmbH Method for cell lysis and pcr within the same reaction vessel
CA2810291C (en) 2010-10-04 2016-09-27 F. Hoffmann-La Roche Ag Method for cell lysis and amplification of rna in a rt-pcr reaction buffer
KR101852646B1 (ko) 2010-10-15 2018-04-26 유니바사루 바이오 리사치 가부시키가이샤 다기능 분주 유닛을 이용한 핵산 자동 처리장치 및 그 방법
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
EP2465945A1 (en) 2010-12-17 2012-06-20 F. Hoffmann-La Roche AG Generic matrix for control nucleic acids
CN103547666B (zh) 2011-02-22 2016-04-27 环球生物研究株式会社 反应容器及其制造方法
TW202208825A (zh) 2011-01-21 2022-03-01 美商拉布拉多診斷有限責任公司 樣本使用最大化之系統及方法
EP2678664B1 (en) 2011-02-24 2019-08-07 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
WO2012158997A1 (en) 2011-05-18 2012-11-22 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
KR102110174B1 (ko) 2011-05-18 2020-05-14 디아소린 에스.피.에이. 샘플 처리 장치 상의 체적 계량을 위한 시스템 및 방법
WO2012158988A1 (en) 2011-05-18 2012-11-22 3M Innovative Properties Company Systems and methods for valving on a sample processing device
US9034581B2 (en) 2011-05-26 2015-05-19 Roche Molecular Systems, Inc. Compositions and methods for detection of Staphylococcus aureus
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) * 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
KR20140070649A (ko) 2011-09-30 2014-06-10 라이프 테크놀로지스 코포레이션 생물학적 분석을 위한 시스템 및 방법
BR112014010955A2 (pt) 2011-11-07 2017-06-06 Beckman Coulter Inc sistema e método para processar amostras
US8973736B2 (en) 2011-11-07 2015-03-10 Beckman Coulter, Inc. Magnetic damping for specimen transport system
BR112014011035A2 (pt) 2011-11-07 2017-06-13 Beckman Coulter, Inc. sistema de aliquotagem e fluxo de trabalho
EP2776845B1 (en) 2011-11-07 2020-11-04 Beckman Coulter, Inc. Robotic arm
EP2776843B1 (en) 2011-11-07 2019-03-27 Beckman Coulter, Inc. Centrifuge system and workflow
WO2013070744A2 (en) 2011-11-07 2013-05-16 Beckman Coulter, Inc. Specimen container detection
EP2828400B1 (en) 2012-03-21 2018-09-19 Roche Diagniostics GmbH Methods for assessing rna quality
US9982313B2 (en) 2012-08-17 2018-05-29 Roche Molecular Systems, Inc. Compositions and methods for detection of herpes simplex virus 1 and 2
DE102012108158B4 (de) * 2012-09-03 2016-03-17 Johann Wolfgang Goethe-Universität Kapillarzelle, Anordnung und Verfahren zur Aufnahme, zur Positionierung und zur Untersuchung einer mikroskopischen Probe
US10176293B2 (en) 2012-10-02 2019-01-08 Roche Molecular Systems, Inc. Universal method to determine real-time PCR cycle threshold values
EP2722399A1 (en) 2012-10-18 2014-04-23 Roche Diagniostics GmbH Method for preventing high molecular weight products during amplification
EP4480582A1 (en) 2013-01-18 2024-12-25 Biomeme, Inc. Analytic device
US10399057B2 (en) 2013-02-05 2019-09-03 Phc Holdings Corporation Analysis device, genetic analysis method, analysis receptacle, and control method for fuzzy control
AU2013202788B2 (en) * 2013-03-14 2015-10-01 Gen-Probe Incorporated Indexing signal detection module
WO2014189085A1 (ja) 2013-05-21 2014-11-27 ユニバーサル・バイオ・リサーチ株式会社 シーケンサ前処理装置およびその方法
US10072288B2 (en) 2013-11-11 2018-09-11 Roche Molecular Systems, Inc. Detecting single nucleotide polymorphism using overlapped primer and melting probe
US9745618B2 (en) 2014-11-19 2017-08-29 Roche Molecular Systems, Inc. Photoblocked probes and methods for sequential detection of nucleic acids
US9920381B2 (en) 2014-12-02 2018-03-20 Roche Molecular Systems, Inc. Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus
FR3035411A1 (fr) * 2015-04-23 2016-10-28 Morpho Procede d'amplification d'acide nucleique a des fins d'analyse, machine d'amplification correspondante et cartouche pour cette machine
US11266730B2 (en) 2015-09-29 2022-03-08 The General Hospital Corporation Methods of treating and diagnosing disease using biomarkers for BCG therapy
US10391498B2 (en) 2015-12-11 2019-08-27 Spartan Bioscience Inc. Systems and methods for nucleic acid amplification
CN108779500B (zh) 2016-03-11 2022-12-13 豪夫迈·罗氏有限公司 用于检测寨卡病毒的组合物和方法
ES2929367T3 (es) 2016-05-18 2022-11-28 Hoffmann La Roche Amplificación por PCR ultrarrápida cuantitativa usando un dispositivo basado en electrohumectación
JP7098536B2 (ja) 2016-05-27 2022-07-11 エフ.ホフマン-ラ ロシュ アーゲー 膣トリコモナスの検出のための組成物及び方法
US10612101B2 (en) 2016-05-27 2020-04-07 Roche Molecular Systems, Inc. Compositions and methods for detection of Mycoplasma genitalium
US20170356025A1 (en) 2016-06-14 2017-12-14 Roche Molecular Systems, Inc. Internal control probes for improving pcr assay performance
US11421287B2 (en) 2016-07-29 2022-08-23 Juno Therapeutics, Inc. Methods for assessing the presence or absence of replication competent virus
CN109642253A (zh) 2016-08-02 2019-04-16 豪夫迈·罗氏有限公司 用于提高核酸的扩增和检测/定量的效率的辅助寡核苷酸
CN107964507B (zh) * 2016-10-18 2022-09-27 财团法人工业技术研究院 热对流聚合酶连锁反应装置及其光学检测方法
US10793923B2 (en) 2016-11-09 2020-10-06 Roche Molecular Systems, Inc. Compositions and methods for detection of BK virus
US20190211377A1 (en) 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
US10793901B2 (en) 2016-12-28 2020-10-06 Roche Molecular Systems, Inc. Reversibly protected nucleotide reagents with high thermal stability
RU2018134774A (ru) 2016-12-28 2021-01-29 КАБУСИКИ КАЙСЯ Мираи Дженомикс Устройство для анализа
US20180363044A1 (en) 2017-06-14 2018-12-20 Roche Molecular Systems, Inc. Compositions and methods for improving the thermal stability of nucleic acid amplification reagents
US10760137B2 (en) 2017-07-18 2020-09-01 Roche Molecular Systems, Inc. Compositions and methods for detection of Babesia
WO2019055875A2 (en) 2017-09-15 2019-03-21 Biomeme, Inc. METHODS AND SYSTEMS FOR AUTOMATIC SAMPLE PROCESSING
WO2019063661A1 (en) 2017-09-29 2019-04-04 Roche Diagnostics Gmbh COMPOSITIONS AND METHODS FOR THE DETECTION OF TRICHOMONAS VAGINALIS
US11078534B2 (en) 2017-11-27 2021-08-03 Roche Molecular Systems, Inc. Photocleavable nucleotide reagents with high stability
TW201930844A (zh) 2017-12-15 2019-08-01 美商拜歐迷蜜公司 用於分析樣本之可攜帶式裝置及方法
US11535903B2 (en) 2018-01-31 2022-12-27 Juno Therapeutics, Inc. Methods and reagents for assessing the presence or absence of replication competent virus
US12383902B2 (en) 2018-02-07 2025-08-12 Jaydeep BHATTACHARYA Low cost microfluidic device for DNA/RNA isolation, purification and amplification using chip based PCR/RT-PCR for biosensing applications
US20190292596A1 (en) 2018-03-21 2019-09-26 Roche Molecular Systems, Inc. Modified nucleoside phosphates with high thermal stability
US11384376B2 (en) 2018-05-31 2022-07-12 Roche Molecular Systems, Inc. Reagents and methods for post-synthetic modification of nucleic acids
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
EP3835790A4 (en) 2018-08-10 2022-04-27 Kabushiki Kaisha Mirai Genomics ANALYSIS DEVICE
CN113166802A (zh) 2018-12-03 2021-07-23 豪夫迈·罗氏有限公司 用于检测耳道假丝酵母菌的组合物和方法
JP7483745B2 (ja) 2019-03-21 2024-05-15 バイオミーム インコーポレイテッド 多機能性分析デバイス
CN113874115A (zh) * 2019-05-01 2021-12-31 卢米耐克斯公司 用于对样品进行热循环的装置和方法
EP3963102A1 (en) 2019-05-02 2022-03-09 F. Hoffmann-La Roche AG Utilization of ditp for preferential/selective amplification of rna versus dna targets based on strand-separation temperature
CN113795596A (zh) 2019-05-07 2021-12-14 豪夫迈·罗氏有限公司 用于检测淋病奈瑟氏球菌的组合物和方法
CN114174540A (zh) 2019-07-25 2022-03-11 豪夫迈·罗氏有限公司 用于检测爱泼斯坦巴尔病毒(ebv)的组合物和方法
JP7677950B2 (ja) 2019-08-27 2025-05-15 エフ. ホフマン-ラ ロシュ アーゲー cccDNAから転写されたHBV RNAを含む、B型肝炎ウイルスRNAの増幅および検出のための組成物および方法
US11441167B2 (en) 2019-11-20 2022-09-13 Roche Molecular Systems, Inc. Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi
US20230050863A1 (en) 2019-12-09 2023-02-16 Roche Molecular Systems, Inc. Dicationic fluorescent dyes
EP4081666B1 (en) 2019-12-27 2024-08-21 F. Hoffmann-La Roche AG Compositions and methods for detecting methicillin-resistant staphylococcus aureus
EP4118239A1 (en) 2020-03-09 2023-01-18 F. Hoffmann-La Roche AG Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2), influenza a and influenza b
EP4213989A4 (en) 2020-09-18 2025-01-15 Biomeme, Inc. Portable devices and methods for analyzing samples
CN116615563A (zh) 2020-12-04 2023-08-18 豪夫迈·罗氏有限公司 用于检测疟疾的组合物和方法
JP7209980B2 (ja) 2020-12-11 2023-01-23 東洋紡株式会社 Dnaポリメラーゼの5’→3’エキソヌクレアーゼ活性ドメインに特異的に結合する抗体
JP2022099005A (ja) 2020-12-22 2022-07-04 船井電機株式会社 マイクロ流体デバイスおよび核酸増幅方法
US20220205020A1 (en) 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
JP2024505686A (ja) 2021-02-05 2024-02-07 エフ. ホフマン-ラ ロシュ アーゲー ヒトパラインフルエンザウイルス1-4(hpiv1-4)の検出のための組成物及び方法
US20220290221A1 (en) 2021-03-15 2022-09-15 Roche Molecular Systems, Inc. Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations
EP4308296A2 (en) 2021-03-19 2024-01-24 BG Research Ltd An apparatus and associated methods for thermal cycling
WO2022233930A1 (en) 2021-05-06 2022-11-10 F. Hoffmann-La Roche Ag Compositions and methods for detecting hepatitis delta virus by a dual-target assay
CN113355230B (zh) * 2021-07-06 2023-11-24 宁波胤瑞生物医学仪器有限责任公司 芯片锁紧装置
TWI844051B (zh) * 2021-07-08 2024-06-01 安盛生科股份有限公司 進行定量聚合酶鏈反應之系統、方法及非暫態電腦可讀取媒介
GB2617798B (en) * 2021-09-23 2025-02-12 N6 Tec Inc Methods and systems for sample analysis
WO2023079032A1 (en) 2021-11-05 2023-05-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of malaria
EP4437142A1 (en) 2021-11-22 2024-10-02 F. Hoffmann-La Roche AG Compositions and methods for detecting vana and/or vanb genes associated with multidrug resistance
US20250034662A1 (en) 2021-12-03 2025-01-30 Medicinal Genomics Corporation Psilocybe assay
WO2024003260A1 (en) 2022-06-30 2024-01-04 F. Hoffmann-La Roche Ag Compositions and methods for detecting lymphogranuloma venereum (lgv) serovars of chlamydia trachomatis
WO2024042042A1 (en) 2022-08-24 2024-02-29 F. Hoffmann-La Roche Ag Compositions and methods for detecting monkeypox virus
EP4587594A1 (en) 2022-09-13 2025-07-23 Medicinal Genomics Corporation <smallcapsilocybe assay
CN115555060B (zh) * 2022-09-22 2024-11-05 冰山松洋生物科技(大连)有限公司 一种环境试验箱
JP2025542121A (ja) 2022-12-25 2025-12-25 エフ. ホフマン-ラ ロシュ アーゲー カルバペネム耐性アシネトバクター・カルコアセチカス-バウマンニ(acinetobacter calcoaceticus-baumannii)(crab)を検出するための組成物および方法
CN120731278A (zh) 2023-02-25 2025-09-30 豪夫迈·罗氏有限公司 用于念珠菌属物种检测的组合物和方法
CN120917150A (zh) 2023-03-03 2025-11-07 豪夫迈·罗氏有限公司 用于检测b族链球菌(无乳链球菌)和克林霉素抗性基因决定子的组合物和方法
CN121263534A (zh) 2023-05-16 2026-01-02 罗氏分子系统公司 使用多模态信号探针检测靶标分析物
WO2025027080A1 (en) 2023-08-03 2025-02-06 F. Hoffmann-La Roche Ag Use of 5'-tailed long primers to improve amplification performance when targeting short primer-binding sites
WO2025202488A1 (en) 2024-03-28 2025-10-02 Roche Diagnostics Gmbh Enhancer of nucleic acid amplification
WO2025257247A1 (en) 2024-06-12 2025-12-18 Roche Diagnostics International Ag Automated pcr analyzer

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3219416A (en) * 1962-10-30 1965-11-23 Scientific Industries Apparatus for the automatic chemical sequential treatment and analysis of small quantities of material
US3556659A (en) * 1966-02-03 1971-01-19 Applied Physics Corp Laser-excited raman spectrometer
US3616264A (en) 1969-06-30 1971-10-26 Beckman Instruments Inc Temperature-controlled discrete sample analyzer
US3718133A (en) * 1971-01-12 1973-02-27 Damon Corp Container unit for liquid samples
CH587486A5 (cg-RX-API-DMAC10.html) * 1974-11-29 1977-05-13 Hoffmann La Roche
AU528259B2 (en) * 1978-09-14 1983-04-21 Union Carbide Corp Method and apparatus for assaying liquid materials
IT1101295B (it) 1978-11-22 1985-09-28 Erba Strumentazione Camera gas-cromatografica
US4420679A (en) 1982-02-26 1983-12-13 Delta Associates, Inc. Gas chromatographic oven using symmetrical flow of preheated - premixed ambient air
JPS60241884A (ja) * 1984-05-15 1985-11-30 Tokyo Daigaku 自動サイクリング反応装置およびこれを用いる自動分析装置
US4762413A (en) * 1984-09-07 1988-08-09 Olympus Optical Co., Ltd. Method and apparatus for measuring immunological reaction with the aid of fluctuation in intensity of scattered light
US4740472A (en) * 1985-08-05 1988-04-26 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
EP0404258B1 (en) * 1989-06-20 1994-09-28 Claudio Bonini Test-tube with lenticular outside surface particularly for automatized clinical analysis
US5449621A (en) * 1989-07-31 1995-09-12 Biotope, Inc. Method for measuring specific binding assays
US5455175A (en) * 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
WO1992020778A1 (en) * 1991-05-24 1992-11-26 Kindconi Pty Limited Biochemical reaction control
US5340715A (en) * 1991-06-07 1994-08-23 Ciba Corning Diagnostics Corp. Multiple surface evanescent wave sensor with a reference
DE4234086A1 (de) 1992-02-05 1993-08-12 Diagen Inst Molekularbio Verfahren zur bestimmung von in vitro amplifizierten nukleinsaeuresequenzen
DK0566751T3 (da) * 1992-03-23 1996-03-04 Hoffmann La Roche DNA-påvisningsmetode
EP0717779B1 (en) * 1992-04-06 2001-10-31 Abbott Laboratories Method and device for detection of nucleic acid or analyte using total internal reflectance
JPH0634546A (ja) * 1992-07-17 1994-02-08 Tosoh Corp 蛍光検出器
US5798215A (en) * 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
WO1994021780A1 (en) * 1993-03-18 1994-09-29 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture Apparatus for the quantitative determination of particulate analytes
CA2162996C (en) * 1993-05-18 2008-02-05 James N. Herron Apparatus and methods for multianalyte homogeneous fluoroimmunoassays
JP3598123B2 (ja) * 1993-07-15 2004-12-08 浜松ホトニクス株式会社 核酸の変性検出装置
ATE208658T1 (de) * 1993-07-28 2001-11-15 Pe Corp Ny Vorrichtung und verfahren zur nukleinsäurevervielfältigung
CA2129787A1 (en) * 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
PT728218E (pt) * 1993-11-12 2008-04-08 Phri Properties Inc Sondas de hibridação para detecção de ácidos nucleicos, troncos universais, métodos e estojos
US5654419A (en) * 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
CA2182513A1 (en) * 1994-02-01 1995-08-10 Robert E. Fields Molecular analyzer and method of use
CA2143365A1 (en) * 1994-03-14 1995-09-15 Hugh V. Cottingham Nucleic acid amplification method and apparatus
CA2159830C (en) * 1994-04-29 2001-07-03 Timothy M Woudenberg System for real time detection of nucleic acid amplification products
NZ266724A (en) * 1994-05-23 1998-08-26 Biotronics Corp Method for detecting target nucleic acid and kit therefor; using primers with at least 5 consecutive nucleotides matching or blocking polymerase composition
US5622821A (en) * 1994-06-29 1997-04-22 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
EP0711840B1 (en) * 1994-11-09 2002-06-19 Hitachi, Ltd. DNA analyzing method and device therefor
US5800996A (en) * 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence

Similar Documents

Publication Publication Date Title
JP2000502280A5 (cg-RX-API-DMAC10.html)
JP2000501771A5 (cg-RX-API-DMAC10.html)
JP2000501599A5 (cg-RX-API-DMAC10.html)
JP2000501018A5 (cg-RX-API-DMAC10.html)
JP2000500076A5 (cg-RX-API-DMAC10.html)
JP2000501324A5 (cg-RX-API-DMAC10.html)
JP2000500055A5 (cg-RX-API-DMAC10.html)
JP2000502472A5 (cg-RX-API-DMAC10.html)
JP2000501825A5 (cg-RX-API-DMAC10.html)
JP2000501338A5 (cg-RX-API-DMAC10.html)
JP2000500874A5 (cg-RX-API-DMAC10.html)
JP2000502425A5 (cg-RX-API-DMAC10.html)
JP2000502485A5 (cg-RX-API-DMAC10.html)
JP2000502568A5 (cg-RX-API-DMAC10.html)
JP2000501774A5 (cg-RX-API-DMAC10.html)
JP2000500912A5 (cg-RX-API-DMAC10.html)
JP2000502570A5 (cg-RX-API-DMAC10.html)
JP2000501876A5 (cg-RX-API-DMAC10.html)
JP2000501744A5 (cg-RX-API-DMAC10.html)
JP2000501229A5 (cg-RX-API-DMAC10.html)
JP2000502316A5 (cg-RX-API-DMAC10.html)
JP2000500857A5 (cg-RX-API-DMAC10.html)
JP2000502714A5 (cg-RX-API-DMAC10.html)
JP2000501569A5 (cg-RX-API-DMAC10.html)
JP2000500318A5 (cg-RX-API-DMAC10.html)