WO2008126827A1 - 温度制御装置および温度制御方法 - Google Patents

温度制御装置および温度制御方法 Download PDF

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Publication number
WO2008126827A1
WO2008126827A1 PCT/JP2008/056888 JP2008056888W WO2008126827A1 WO 2008126827 A1 WO2008126827 A1 WO 2008126827A1 JP 2008056888 W JP2008056888 W JP 2008056888W WO 2008126827 A1 WO2008126827 A1 WO 2008126827A1
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WO
WIPO (PCT)
Prior art keywords
temperature control
liquid
nozzles
sucking
control device
Prior art date
Application number
PCT/JP2008/056888
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English (en)
French (fr)
Inventor
Hideji Tajima
Original Assignee
Universal Bio Research Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universal Bio Research Co., Ltd. filed Critical Universal Bio Research Co., Ltd.
Priority to JP2009509340A priority Critical patent/JPWO2008126827A1/ja
Priority to US12/450,672 priority patent/US8418929B2/en
Priority to EP20080739991 priority patent/EP2145949A4/en
Publication of WO2008126827A1 publication Critical patent/WO2008126827A1/ja

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1888—Pipettes or dispensers with temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/103—General features of the devices using disposable tips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1039—Micropipettes, e.g. microcapillary tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1062—General features of the devices using the transfer device for another function for testing the liquid while it is in the transfer device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y10T137/0324—With control of flow by a condition or characteristic of a fluid
    • Y10T137/0329—Mixing of plural fluids of diverse characteristics or conditions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/6416—With heating or cooling of the system
    • Y10T137/6552—With diversion of part of fluid to heat or cool the device or its contents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

　液体中に含まれる空気の発泡やその膨張を阻止して、信頼性の高い液体の温度制御を行うことができる温度制御装置および温度制御方法に関し、先端からの液体の吸引および吐出、ならびに吸引した前記液体の保持が可能な１または複数連のノズルと、前記各ノズルを介して気体の吸引および吐出が可能な吸引吐出機構と、前記各ノズルに設けた１または２以上の所定の温度制御領域に関して、各々設定した１または２以上の所定温度に所定時間維持可能な温度調節器と、前記液体を収容可能な１または２以上の容器と前記ノズルとの間を相対的に移動可能とする移動機構と、前記移動機構、前記吸引吐出機構および前記温度調節器に対して前記ノズル内に吸引すべき液体とその液量、吸引した前記液体のノズル内での位置の調整、および温度制御を指示する制御部とを有するように構成する。
PCT/JP2008/056888 2007-04-06 2008-04-07 温度制御装置および温度制御方法 WO2008126827A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009509340A JPWO2008126827A1 (ja) 2007-04-06 2008-04-07 温度制御装置および温度制御方法
US12/450,672 US8418929B2 (en) 2007-04-06 2008-04-07 Temperature controlling apparatus and temperature controlling method
EP20080739991 EP2145949A4 (en) 2007-04-06 2008-04-07 DEVICE AND METHOD FOR CONTROLLING TEMPERATURE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-101135 2007-04-06
JP2007101135 2007-04-06

Publications (1)

Publication Number Publication Date
WO2008126827A1 true WO2008126827A1 (ja) 2008-10-23

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PCT/JP2008/056888 WO2008126827A1 (ja) 2007-04-06 2008-04-07 温度制御装置および温度制御方法

Country Status (4)

Country Link
US (1) US8418929B2 (ja)
EP (1) EP2145949A4 (ja)
JP (1) JPWO2008126827A1 (ja)
WO (1) WO2008126827A1 (ja)

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JP2011234693A (ja) * 2010-05-13 2011-11-24 Hitachi High-Technologies Corp 核酸検査装置
JP2013156256A (ja) * 2012-01-31 2013-08-15 Siemens Healthcare Diagnostics Products Gmbh 加熱されたピペット針部内の一定体積の液体を加熱する方法
JPWO2017104693A1 (ja) * 2015-12-15 2018-11-29 ユニバーサル・バイオ・リサーチ株式会社 吸光度測定装置およびその方法
CN112672641A (zh) * 2018-09-24 2021-04-16 莱利专利股份有限公司 带有检测系统的挤奶系统
WO2022260895A1 (en) * 2021-06-09 2022-12-15 Perkinelmer Health Sciences, Inc. Mixing liquids using an automated liquid handling system

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US8305648B2 (en) * 2009-05-29 2012-11-06 Eastman Kodak Company Adjusting the calibration of an imaging system
KR101368463B1 (ko) 2010-04-23 2014-03-03 나노바이오시스 주식회사 2개의 열 블록을 포함하는 ｐｃｒ 장치
CN103237880B (zh) * 2010-10-15 2016-08-03 环球生物研究株式会社 利用多功能分注单元的核酸自动处理装置及其方法
CN103534575B (zh) 2011-02-04 2016-08-10 环球生物研究株式会社 自动反应/光测定装置及其方法
JP2014176302A (ja) * 2013-03-13 2014-09-25 Seiko Epson Corp 核酸増幅反応装置及び核酸増幅方法
PL2971031T3 (pl) * 2013-03-15 2020-04-30 Drummond Scientific Company Urządzenie do szybkiego i cyklicznego ogrzewania i chłodzenia próbki płynu w czasie testu PCR
FR3009621B1 (fr) * 2013-08-09 2017-04-28 Novacyt Procede et appareil de preparation d'un contenant cellulaire comprenant des moyens de pre-analyse d'un echantillon preleve
JP2015181458A (ja) * 2014-03-26 2015-10-22 セイコーエプソン株式会社 核酸増幅反応装置及び核酸増幅方法
JP2015181457A (ja) * 2014-03-26 2015-10-22 セイコーエプソン株式会社 核酸増幅反応装置及び核酸増幅方法
JP6004149B1 (ja) * 2015-03-16 2016-10-05 パナソニック株式会社 ピペットチップ及びピペッティング方法
JP6758227B2 (ja) 2017-03-06 2020-09-23 テラメックス株式会社 温調システム
CN107737617B (zh) * 2017-10-09 2019-10-25 辽宁科技大学 一种高温加热移液枪及其使用方法
US20210138470A1 (en) * 2017-10-24 2021-05-13 Hewlett-Packard Development Company, L.P. Fluid dispenser
JP7278262B2 (ja) * 2018-04-05 2023-05-19 大塚製薬株式会社 温調システム及び温調方法
JP7139525B2 (ja) * 2019-05-17 2022-09-20 株式会社日立ハイテク 自動分析装置

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Title
See also references of EP2145949A4

Cited By (7)

* Cited by examiner, † Cited by third party
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JP2011234693A (ja) * 2010-05-13 2011-11-24 Hitachi High-Technologies Corp 核酸検査装置
JP2013156256A (ja) * 2012-01-31 2013-08-15 Siemens Healthcare Diagnostics Products Gmbh 加熱されたピペット針部内の一定体積の液体を加熱する方法
US9821305B2 (en) 2012-01-31 2017-11-21 Siemens Healthcare Diagnostics Products Gmbh Method for heating a volume of liquid in a heated pipetting needle
JPWO2017104693A1 (ja) * 2015-12-15 2018-11-29 ユニバーサル・バイオ・リサーチ株式会社 吸光度測定装置およびその方法
CN112672641A (zh) * 2018-09-24 2021-04-16 莱利专利股份有限公司 带有检测系统的挤奶系统
CN112672641B (zh) * 2018-09-24 2022-12-09 莱利专利股份有限公司 带有检测系统的挤奶系统
WO2022260895A1 (en) * 2021-06-09 2022-12-15 Perkinelmer Health Sciences, Inc. Mixing liquids using an automated liquid handling system

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JPWO2008126827A1 (ja) 2010-07-22

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