WO2009019658A3 - Integrated microfluidic device with local temperature control - Google Patents

Integrated microfluidic device with local temperature control Download PDF

Info

Publication number
WO2009019658A3
WO2009019658A3 PCT/IB2008/053157 IB2008053157W WO2009019658A3 WO 2009019658 A3 WO2009019658 A3 WO 2009019658A3 IB 2008053157 W IB2008053157 W IB 2008053157W WO 2009019658 A3 WO2009019658 A3 WO 2009019658A3
Authority
WO
WIPO (PCT)
Prior art keywords
heating
chamber
microfluidic device
integrated microfluidic
temperature control
Prior art date
Application number
PCT/IB2008/053157
Other languages
French (fr)
Other versions
WO2009019658A2 (en
Inventor
David A Fish
Paul L Collins
Original Assignee
Koninkl Philips Electronics Nv
David A Fish
Paul L Collins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv, David A Fish, Paul L Collins filed Critical Koninkl Philips Electronics Nv
Publication of WO2009019658A2 publication Critical patent/WO2009019658A2/en
Publication of WO2009019658A3 publication Critical patent/WO2009019658A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater

Abstract

An integrated microfluidic device having a chamber (11-MN) for heating a fluid, multiple heating elements for heating different parts of the chamber, multiple temperature sensing elements (Rs, D1) for localized sensing of temperature of fluid at different parts of the chamber, and a controller for controlling the heating elements according to temperatures of the different parts sensed by the temperature sensing elements. This can enable more uniform heating of the chamber. The device can be formed of low temperature poly silicon on a glass substrate. The heating element can be a resistor or a TFT transistor (T5).
PCT/IB2008/053157 2007-08-09 2008-08-06 Integrated microfluidic device with local temperature control WO2009019658A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07114105.5 2007-08-09
EP07114105 2007-08-09

Publications (2)

Publication Number Publication Date
WO2009019658A2 WO2009019658A2 (en) 2009-02-12
WO2009019658A3 true WO2009019658A3 (en) 2009-04-02

Family

ID=40257001

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/053157 WO2009019658A2 (en) 2007-08-09 2008-08-06 Integrated microfluidic device with local temperature control

Country Status (1)

Country Link
WO (1) WO2009019658A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009101584A2 (en) * 2008-02-15 2009-08-20 Koninklijke Philips Electronics N.V. Driver system for lab-on-a-chip cartridges
US8419273B2 (en) 2010-05-03 2013-04-16 Sharp Kabushiki Kaisha Array element for temperature sensor array circuit, temperature sensor array circuit utilizing such array element, and AM-EWOD device including such a temperature sensor array circuit
US8356514B2 (en) 2011-01-13 2013-01-22 Honeywell International Inc. Sensor with improved thermal stability
US8339711B2 (en) * 2011-04-22 2012-12-25 Sharp Kabushiki Kaisha Active matrix device and method of driving the same
DE102012219656A1 (en) * 2012-10-26 2014-04-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. SYSTEM FOR CARRYING OUT TOUCH-FREE MEASUREMENT ON A SAMPLE AND SAMPLE CARRIER
GB2533952A (en) * 2015-01-08 2016-07-13 Sharp Kk Active matrix device and method of driving
WO2016163946A1 (en) * 2015-04-07 2016-10-13 Cell Id Pte Ltd A dc heater
US10882042B2 (en) * 2017-10-18 2021-01-05 E Ink Corporation Digital microfluidic devices including dual substrates with thin-film transistors and capacitive sensing

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115200A1 (en) * 2001-02-16 2002-08-22 Institute Of Microelectronics Miniaturized thermal cycler
US20020150683A1 (en) * 2000-11-02 2002-10-17 Troian Sandra M. Method and device for controlling liquid flow on the surface of a microfluidic chip
WO2003045556A2 (en) * 2001-11-26 2003-06-05 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
EP1541237A2 (en) * 2003-12-10 2005-06-15 Samsung Electronics Co., Ltd. Polymerase chain reaction (pcr) module and multiple pcr system using the same
WO2005118773A2 (en) * 2004-05-28 2005-12-15 Wafergen, Inc. Apparatus and methods for multiplex analyses
WO2007034437A2 (en) * 2005-09-23 2007-03-29 Koninklijke Philips Electronics N.V. A micro-fluidic device based upon active matrix principles
EP1878503A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Temperature sensor element for monitoring heating and cooling
WO2008117210A1 (en) * 2007-03-23 2008-10-02 Koninklijke Philips Electronics N.V. Integrated microfluidic device with local temperature control

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150683A1 (en) * 2000-11-02 2002-10-17 Troian Sandra M. Method and device for controlling liquid flow on the surface of a microfluidic chip
US20020115200A1 (en) * 2001-02-16 2002-08-22 Institute Of Microelectronics Miniaturized thermal cycler
WO2003045556A2 (en) * 2001-11-26 2003-06-05 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
EP1541237A2 (en) * 2003-12-10 2005-06-15 Samsung Electronics Co., Ltd. Polymerase chain reaction (pcr) module and multiple pcr system using the same
WO2005118773A2 (en) * 2004-05-28 2005-12-15 Wafergen, Inc. Apparatus and methods for multiplex analyses
WO2007034437A2 (en) * 2005-09-23 2007-03-29 Koninklijke Philips Electronics N.V. A micro-fluidic device based upon active matrix principles
EP1878503A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Temperature sensor element for monitoring heating and cooling
WO2008117210A1 (en) * 2007-03-23 2008-10-02 Koninklijke Philips Electronics N.V. Integrated microfluidic device with local temperature control

Also Published As

Publication number Publication date
WO2009019658A2 (en) 2009-02-12

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