JP2000506726A - 組換えａａｖベクターに基づく形質導入系およびその使用 - Google Patents
組換えａａｖベクターに基づく形質導入系およびその使用Info
- Publication number
- JP2000506726A JP2000506726A JP9531353A JP53135397A JP2000506726A JP 2000506726 A JP2000506726 A JP 2000506726A JP 9531353 A JP9531353 A JP 9531353A JP 53135397 A JP53135397 A JP 53135397A JP 2000506726 A JP2000506726 A JP 2000506726A
- Authority
- JP
- Japan
- Prior art keywords
- rep
- transduction system
- cells
- dna
- aav
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 102000004169 proteins and genes Human genes 0.000 claims abstract description 27
- 210000004027 cell Anatomy 0.000 claims description 52
- 108020004414 DNA Proteins 0.000 claims description 42
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- 230000001939 inductive effect Effects 0.000 claims description 7
- 238000001415 gene therapy Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 102100021244 Integral membrane protein GPR180 Human genes 0.000 claims description 3
- 210000004881 tumor cell Anatomy 0.000 claims description 3
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- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 241000702421 Dependoparvovirus Species 0.000 description 20
- 241000700605 Viruses Species 0.000 description 9
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- 101100524321 Adeno-associated virus 2 (isolate Srivastava/1982) Rep68 gene Proteins 0.000 description 3
- 101100524324 Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 gene Proteins 0.000 description 3
- 239000004098 Tetracycline Substances 0.000 description 3
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- 101100524317 Adeno-associated virus 2 (isolate Srivastava/1982) Rep40 gene Proteins 0.000 description 2
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- 102100023321 Ceruloplasmin Human genes 0.000 description 1
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- 102000053602 DNA Human genes 0.000 description 1
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- 208000009292 Hemophilia A Diseases 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
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- 208000024556 Mendelian disease Diseases 0.000 description 1
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- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
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- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 239000002773 nucleotide Substances 0.000 description 1
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- 229920002714 polyornithine Polymers 0.000 description 1
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- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102220201851 rs143406017 Human genes 0.000 description 1
- 102220240796 rs553605556 Human genes 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 101150061166 tetR gene Proteins 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19608753.8 | 1996-03-06 | ||
| DE19608753A DE19608753C1 (de) | 1996-03-06 | 1996-03-06 | Transduktionssystem und seine Verwendung |
| PCT/DE1997/000447 WO1997032989A2 (de) | 1996-03-06 | 1997-03-06 | Transduktionssystem beruhend auf rekombinantem aav-vektor und seine verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000506726A true JP2000506726A (ja) | 2000-06-06 |
| JP2000506726A5 JP2000506726A5 (enExample) | 2004-11-25 |
Family
ID=7787450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9531353A Ceased JP2000506726A (ja) | 1996-03-06 | 1997-03-06 | 組換えａａｖベクターに基づく形質導入系およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US6207453B1 (enExample) |
| EP (1) | EP0891429A2 (enExample) |
| JP (1) | JP2000506726A (enExample) |
| DE (1) | DE19608753C1 (enExample) |
| WO (1) | WO1997032989A2 (enExample) |
Families Citing this family (198)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19608753C1 (de) * | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
| EP1623017B1 (en) * | 2003-05-08 | 2010-09-15 | Life Technologies Corporation | Generation and isolation of antigen-specific t cells |
| US20070032570A1 (en) * | 2003-11-11 | 2007-02-08 | Canon Kabushiki Kaisha | Ink comprising a block copolymer dispersing agent having a hydrophilic and a hydrophobic segment and an ink-applying process and apparatus using the same |
| US20050281786A1 (en) * | 2004-06-18 | 2005-12-22 | David Poulsen | AAV mediated gene delivery to cochlear cells |
| US20100080784A1 (en) * | 2008-09-12 | 2010-04-01 | Torrey Pines Institute For Molecular Studies | Methods for treating cachexia and lymphopenia |
| EP2841572B1 (en) | 2012-04-27 | 2019-06-19 | Duke University | Genetic correction of mutated genes |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| SG11201608862SA (en) | 2014-04-23 | 2016-11-29 | Juno Therapeutics Inc | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| ES2959683T3 (es) | 2014-07-15 | 2024-02-27 | Juno Therapeutics Inc | Células manipuladas para terapia celular adoptiva |
| TWI805109B (zh) | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
| JP7057669B2 (ja) | 2014-10-20 | 2022-04-20 | ジュノー セラピューティクス インコーポレイテッド | 養子細胞療法において投薬するための方法および組成物 |
| PL3215601T3 (pl) | 2014-11-05 | 2020-11-02 | Juno Therapeutics, Inc. | Sposoby transdukcji i przetwarzania komórek |
| ES2987087T3 (es) | 2014-12-03 | 2024-11-13 | Juno Therapeutics Inc | Métodos y composiciones para terapia celular adoptiva |
| JP6865688B2 (ja) | 2015-01-16 | 2021-04-28 | ジュノー セラピューティクス インコーポレイテッド | Ｒｏｒ１に特異的な抗体およびキメラ抗原受容体 |
| WO2016130600A2 (en) | 2015-02-09 | 2016-08-18 | Duke University | Compositions and methods for epigenome editing |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| CN108174607A (zh) | 2015-05-29 | 2018-06-15 | 朱诺治疗学股份有限公司 | 用于遗传工程改造的细胞中调节抑制性相互作用的组合物和方法 |
| MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| WO2017066497A2 (en) | 2015-10-13 | 2017-04-20 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| WO2017079703A1 (en) | 2015-11-05 | 2017-05-11 | Juno Therapeutics, Inc. | Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy |
| MA44314A (fr) | 2015-11-05 | 2018-09-12 | Juno Therapeutics Inc | Récepteurs chimériques contenant des domaines induisant traf, et compositions et méthodes associées |
| CN108779466B (zh) | 2015-11-30 | 2024-03-29 | 杜克大学 | 用于通过基因编辑修正人肌营养不良蛋白基因的治疗靶标和使用方法 |
| EP4212547A1 (en) | 2015-12-03 | 2023-07-19 | Juno Therapeutics, Inc. | Modified chimeric receptors and related compositions and methods |
| MA43378A (fr) | 2015-12-03 | 2018-10-10 | Juno Therapeutics Inc | Compositions et méthodes pour la reduction de la réponse immunitaire contre récepteurs d'antigène chimériques |
| US11815514B2 (en) | 2015-12-04 | 2023-11-14 | Juno Therapeutics, Inc. | Methods and compositions related to toxicity associated with cell therapy |
| US20190287013A1 (en) | 2016-03-16 | 2019-09-19 | Juno Therapeutics, Inc. | Methods for determining dosing of a therapeutic agent and related treatments |
| EP3430549A1 (en) | 2016-03-16 | 2019-01-23 | Juno Therapeutics, Inc. | Methods for adaptive design of a treatment regimen and related treatments |
| CA3018588A1 (en) | 2016-03-22 | 2017-09-28 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Early intervention methods to prevent or ameliorate toxicity |
| WO2017180915A2 (en) | 2016-04-13 | 2017-10-19 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| IL262772B2 (en) | 2016-05-06 | 2023-10-01 | Juno Therapeutics Inc | Genetically engineered cells and methods of making the same |
| JP2019517518A (ja) | 2016-06-03 | 2019-06-24 | メモリアル スローン ケタリング キャンサー センター | 早期治療選択肢としての養子細胞療法 |
| MA45341A (fr) | 2016-06-06 | 2019-04-10 | Hutchinson Fred Cancer Res | Procédés de traitement de malignités de lymphocytes b au moyen d'une thérapie cellulaire adoptive |
| WO2018005559A1 (en) | 2016-06-27 | 2018-01-04 | Juno Therapeutics, Inc. | Method of identifying peptide epitopes, molecules that bind such epitopes and related uses |
| MA45491A (fr) | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés |
| WO2018017754A1 (en) | 2016-07-19 | 2018-01-25 | Duke University | Therapeutic applications of cpf1-based genome editing |
| WO2018023100A2 (en) | 2016-07-29 | 2018-02-01 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies and related methods |
| CN110087672A (zh) | 2016-07-29 | 2019-08-02 | 朱诺治疗学股份有限公司 | 免疫调节多肽及相关组合物和方法 |
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| CN110290807B (zh) | 2016-12-03 | 2024-06-14 | 朱诺治疗学股份有限公司 | 确定car-t细胞给药的方法 |
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| BR112019019005A2 (pt) | 2017-03-14 | 2020-04-14 | Sara Elizabeth Church | métodos para armazenagem criogênica |
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| MX2020000900A (es) | 2017-07-29 | 2021-01-08 | Juno Therapeutics Inc | Reactivos para expandir celulas que expresan receptores recombinantes. |
| WO2019032929A1 (en) | 2017-08-09 | 2019-02-14 | Juno Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR PREPARING GENETICALLY MODIFIED CELLS |
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| WO2025147545A1 (en) | 2024-01-03 | 2025-07-10 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids and related methods and uses |
| WO2025163107A1 (en) | 2024-02-01 | 2025-08-07 | Institut Gustave Roussy | Immune cells defective for znf217 and uses thereof |
| WO2025184421A1 (en) | 2024-02-28 | 2025-09-04 | Juno Therapeutics, Inc. | Chimeric antigen receptors and antibodies specific for delta-like ligand 3 (dll3) and related methods |
| WO2026008700A1 (en) | 2024-07-03 | 2026-01-08 | Immunofusion Bv | Il7r alpha signalling domain, chimeric antigen receptor and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5436146A (en) * | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| AU7906691A (en) * | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
| US5587308A (en) * | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| US5478745A (en) * | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| WO1994021808A1 (de) * | 1993-03-19 | 1994-09-29 | Boehringer Ingelheim International Gmbh | Verfahren zur herstellung von krebsvakzinen |
| US5693531A (en) * | 1993-11-24 | 1997-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Vector systems for the generation of adeno-associated virus particles |
| FR2716893B1 (fr) * | 1994-03-03 | 1996-04-12 | Rhone Poulenc Rorer Sa | Virus recombinants, leur préparation et leur utilisation thérapeutique. |
| US6342390B1 (en) * | 1994-11-23 | 2002-01-29 | The United States Of America As Represented By The Secretary Of Health And Human Services | Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy |
| DE19608753C1 (de) * | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
-
1996
- 1996-03-06 DE DE19608753A patent/DE19608753C1/de not_active Expired - Fee Related
-
1997
- 1997-03-06 WO PCT/DE1997/000447 patent/WO1997032989A2/de not_active Ceased
- 1997-03-06 JP JP9531353A patent/JP2000506726A/ja not_active Ceased
- 1997-03-06 EP EP97918010A patent/EP0891429A2/de not_active Withdrawn
- 1997-03-06 US US09/142,289 patent/US6207453B1/en not_active Expired - Fee Related
-
2001
- 2001-01-31 US US09/773,302 patent/US6440742B1/en not_active Expired - Fee Related
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2002
- 2002-08-12 US US10/218,280 patent/US20020192826A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0891429A2 (de) | 1999-01-20 |
| US6440742B1 (en) | 2002-08-27 |
| WO1997032989A2 (de) | 1997-09-12 |
| US20020192826A1 (en) | 2002-12-19 |
| WO1997032989A3 (de) | 1998-01-15 |
| US6207453B1 (en) | 2001-03-27 |
| DE19608753C1 (de) | 1997-06-26 |
| US20020028514A1 (en) | 2002-03-07 |
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