IN2014MN00258A - - Google Patents
Info
- Publication number
- IN2014MN00258A IN2014MN00258A IN258MUN2014A IN2014MN00258A IN 2014MN00258 A IN2014MN00258 A IN 2014MN00258A IN 258MUN2014 A IN258MUN2014 A IN 258MUN2014A IN 2014MN00258 A IN2014MN00258 A IN 2014MN00258A
- Authority
- IN
- India
- Prior art keywords
- compounds
- present
- novel
- medicament
- concerned
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11174120 | 2011-07-15 | ||
PCT/EP2012/063667 WO2013010904A1 (en) | 2011-07-15 | 2012-07-12 | Novel substituted indole derivatives as gamma secretase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014MN00258A true IN2014MN00258A (sr) | 2015-09-25 |
Family
ID=46506432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN258MUN2014 IN2014MN00258A (sr) | 2011-07-15 | 2012-07-12 |
Country Status (16)
Country | Link |
---|---|
US (1) | US9115143B2 (sr) |
EP (1) | EP2731948B1 (sr) |
JP (1) | JP6068464B2 (sr) |
KR (1) | KR101913135B1 (sr) |
CN (1) | CN103874702B (sr) |
AR (1) | AR087182A1 (sr) |
AU (1) | AU2012285931B2 (sr) |
BR (1) | BR112014000713A2 (sr) |
CA (1) | CA2841102C (sr) |
EA (1) | EA023045B1 (sr) |
ES (1) | ES2555167T3 (sr) |
IL (1) | IL230422B (sr) |
IN (1) | IN2014MN00258A (sr) |
MX (1) | MX2014000626A (sr) |
TW (1) | TWI567079B (sr) |
WO (1) | WO2013010904A1 (sr) |
Families Citing this family (29)
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---|---|---|---|---|
US8946426B2 (en) | 2009-02-06 | 2015-02-03 | Janssen Pharmaceuticals, Inc. | Substituted bicyclic heterocyclic compounds as gamma secretase modulators |
NZ596843A (en) | 2009-05-07 | 2012-12-21 | Janssen Pharmaceuticals Inc | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators |
NZ597505A (en) | 2009-07-15 | 2013-05-31 | Janssen Pharmaceuticals Inc | Substituted triazole and imidazole derivatives as gamma secretase modulators |
MX2012008259A (es) | 2010-01-15 | 2012-08-17 | Janssen Pharmaceuticals Inc | Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa. |
AU2012230348A1 (en) | 2011-03-24 | 2013-08-29 | Cellzome Limited | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
CN103874702B (zh) | 2011-07-15 | 2015-12-09 | 杨森制药公司 | 作为γ分泌酶调节剂的经取代的吲哚衍生物 |
US9181245B2 (en) | 2012-05-16 | 2015-11-10 | Janssen Pharmaceuticals, Inc. | Substituted pyrido[1,2-a]pyrazines and substituted pyrido[1,2-a][1,4]diazepines for the treatment of (inter alia) Alzheimer's disease |
EP2738172A1 (en) * | 2012-11-28 | 2014-06-04 | Almirall, S.A. | New bicyclic compounds as crac channel modulators |
CA2889249C (en) | 2012-12-20 | 2021-02-16 | Francois Paul Bischoff | Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
AU2014206834B2 (en) | 2013-01-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
CN109715617B (zh) | 2016-07-30 | 2022-04-19 | 百时美施贵宝公司 | 作为tlr7、tlr8或tlr9抑制剂的二甲氧基苯基取代的吲哚化合物 |
US10660877B2 (en) | 2016-09-09 | 2020-05-26 | Bristol-Myers Squibb Company | Pyridyl substituted indole compounds |
JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
JP7266576B2 (ja) | 2017-08-04 | 2023-04-28 | ブリストル-マイヤーズ スクイブ カンパニー | [1,2,4]トリアゾロ[4,3-a]ピリジニル置換のインドール化合物 |
WO2019028302A1 (en) | 2017-08-04 | 2019-02-07 | Bristol-Myers Squibb Company | SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR7 / 8/9 INHIBITORS |
KR20200070297A (ko) | 2017-10-11 | 2020-06-17 | 에프. 호프만-라 로슈 아게 | Rip1 키나아제 억제제로서 사용하기 위한 이환형 화합물 |
JP7265554B2 (ja) * | 2017-11-14 | 2023-04-26 | ブリストル-マイヤーズ スクイブ カンパニー | 置換インドール化合物 |
DK3728252T3 (da) | 2017-12-18 | 2023-11-13 | Bristol Myers Squibb Co | 4-azaindolforbindelser |
EP3728225B1 (en) | 2017-12-19 | 2022-11-09 | Bristol-Myers Squibb Company | Substituted indole compounds useful as tlr inhibitors |
KR20200101956A (ko) | 2017-12-19 | 2020-08-28 | 브리스톨-마이어스 스큅 컴퍼니 | 6-아자인돌 화합물 |
EA202091483A1 (ru) | 2017-12-19 | 2020-10-28 | Бристол-Маерс Сквибб Компани | Амидзамещенные индольные соединения, пригодные в качестве ингибиторов tlr |
AU2018390610A1 (en) | 2017-12-20 | 2020-08-06 | Bristol-Myers Squibb Company | Amino indole compounds useful as TLR inhibitors |
CA3085942A1 (en) | 2017-12-20 | 2019-06-27 | Bristol-Myers Squibb Company | Aryl and heteroaryl substituted indole compounds |
SG11202005733QA (en) | 2017-12-20 | 2020-07-29 | Bristol Myers Squibb Co | Diazaindole compounds |
FI3846903T3 (fi) * | 2018-09-03 | 2023-12-19 | Hoffmann La Roche | Bisyklisiä hereoaryylijohdannaisia |
EP3628669A1 (en) * | 2018-09-28 | 2020-04-01 | GenKyoTex Suisse SA | Novel compounds as nadph oxidase inhibitors |
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CN1156445C (zh) | 1999-06-10 | 2004-07-07 | 沃尼尔·朗伯公司 | 采用二氢异吲哚衍生物抑制淀粉样蛋白聚集和使淀粉样蛋白沉积成像的方法 |
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JP4101852B2 (ja) | 2004-05-26 | 2008-06-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シンナミド化合物 |
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CN101370811A (zh) | 2005-11-10 | 2009-02-18 | 先灵公司 | 作为蛋白激酶抑制剂的咪唑并吡嗪化合物 |
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US7893058B2 (en) | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
US7951818B2 (en) | 2006-12-01 | 2011-05-31 | Galapagos Nv | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases |
EP2061771A1 (en) | 2006-12-12 | 2009-05-27 | Schering Corporation | Aspartyl protease inhibitors containing a tricyclic ring system |
CN101631786A (zh) | 2006-12-20 | 2010-01-20 | 先灵公司 | 新颖的jnk抑制剂 |
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AU2008216842A1 (en) | 2007-02-12 | 2008-08-21 | Merck Sharp & Dohme Corp. | Piperidine derivatives |
JP2010518064A (ja) | 2007-02-12 | 2010-05-27 | メルク・シャープ・エンド・ドーム・コーポレイション | Adおよび関連状態の治療のためのピペラジン誘導体 |
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WO2009032277A1 (en) | 2007-09-06 | 2009-03-12 | Schering Corporation | Gamma secretase modulators |
GB0720444D0 (en) | 2007-10-18 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
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WO2009076352A1 (en) | 2007-12-11 | 2009-06-18 | Schering Corporation | Gamma secretase modulators |
EP2257541B1 (en) | 2008-02-22 | 2013-08-14 | F. Hoffmann-La Roche AG | Modulators for amyloid beta |
US20100137320A1 (en) | 2008-02-29 | 2010-06-03 | Schering Corporation | Gamma secretase modulators |
WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
EP2340243B1 (en) | 2008-10-17 | 2014-10-08 | Boehringer Ingelheim International GmbH | Heteroaryl substituted indole compounds useful as mmp-13 inhibitors |
AU2009313527A1 (en) | 2008-11-06 | 2010-05-14 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
JP5378532B2 (ja) | 2008-11-10 | 2013-12-25 | エフ.ホフマン−ラ ロシュ アーゲー | 複素環γ−セクレターゼモジュレーター |
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PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
US8946426B2 (en) | 2009-02-06 | 2015-02-03 | Janssen Pharmaceuticals, Inc. | Substituted bicyclic heterocyclic compounds as gamma secretase modulators |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
JP2012051806A (ja) * | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
CA2753696A1 (en) * | 2009-02-26 | 2010-09-02 | Noritaka Kitazawa | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
CA2751534A1 (en) | 2009-03-03 | 2010-09-10 | Pfizer Inc. | Novel phenyl imidazoles and phenyl triazoles as gamma-secretase modulators |
US20110299830A1 (en) | 2009-03-16 | 2011-12-08 | Panasonic Corporation | Application running device |
WO2010114971A1 (en) * | 2009-04-03 | 2010-10-07 | Sepracor Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
WO2010126745A1 (en) * | 2009-04-27 | 2010-11-04 | High Point Pharmaceuticals, Llc | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS |
NZ596843A (en) | 2009-05-07 | 2012-12-21 | Janssen Pharmaceuticals Inc | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators |
JP2010274429A (ja) | 2009-05-26 | 2010-12-09 | Ihi Corp | アライメントステージ |
NZ597505A (en) | 2009-07-15 | 2013-05-31 | Janssen Pharmaceuticals Inc | Substituted triazole and imidazole derivatives as gamma secretase modulators |
MX2012008259A (es) | 2010-01-15 | 2012-08-17 | Janssen Pharmaceuticals Inc | Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa. |
TW201307347A (zh) * | 2010-11-01 | 2013-02-16 | Arqule Inc | 經取代苯並-咪唑並-吡啶並-二氮呯化合物 |
AU2012230348A1 (en) | 2011-03-24 | 2013-08-29 | Cellzome Limited | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
CA2830027C (en) | 2011-03-31 | 2016-04-26 | Pfizer Inc. | Novel bicyclic pyridinones |
CN103874702B (zh) | 2011-07-15 | 2015-12-09 | 杨森制药公司 | 作为γ分泌酶调节剂的经取代的吲哚衍生物 |
-
2012
- 2012-07-12 CN CN201280034912.XA patent/CN103874702B/zh not_active Expired - Fee Related
- 2012-07-12 WO PCT/EP2012/063667 patent/WO2013010904A1/en active Application Filing
- 2012-07-12 JP JP2014519557A patent/JP6068464B2/ja not_active Expired - Fee Related
- 2012-07-12 AU AU2012285931A patent/AU2012285931B2/en not_active Ceased
- 2012-07-12 EP EP12733754.1A patent/EP2731948B1/en active Active
- 2012-07-12 EA EA201490287A patent/EA023045B1/ru not_active IP Right Cessation
- 2012-07-12 KR KR1020147003465A patent/KR101913135B1/ko active IP Right Grant
- 2012-07-12 BR BR112014000713A patent/BR112014000713A2/pt active Search and Examination
- 2012-07-12 CA CA2841102A patent/CA2841102C/en not_active Expired - Fee Related
- 2012-07-12 IN IN258MUN2014 patent/IN2014MN00258A/en unknown
- 2012-07-12 MX MX2014000626A patent/MX2014000626A/es unknown
- 2012-07-12 ES ES12733754.1T patent/ES2555167T3/es active Active
- 2012-07-12 US US14/233,078 patent/US9115143B2/en not_active Expired - Fee Related
- 2012-07-12 TW TW101125035A patent/TWI567079B/zh not_active IP Right Cessation
- 2012-07-13 AR ARP120102548A patent/AR087182A1/es not_active Application Discontinuation
-
2014
- 2014-01-13 IL IL230422A patent/IL230422B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JP6068464B2 (ja) | 2017-01-25 |
KR101913135B1 (ko) | 2018-10-30 |
EP2731948A1 (en) | 2014-05-21 |
CN103874702A (zh) | 2014-06-18 |
EP2731948B1 (en) | 2015-09-09 |
JP2014518286A (ja) | 2014-07-28 |
BR112014000713A2 (pt) | 2017-01-10 |
AU2012285931B2 (en) | 2017-01-12 |
NZ619683A (en) | 2015-01-30 |
US9115143B2 (en) | 2015-08-25 |
CA2841102A1 (en) | 2013-01-24 |
CN103874702B (zh) | 2015-12-09 |
WO2013010904A1 (en) | 2013-01-24 |
IL230422B (en) | 2018-03-29 |
US20140148450A1 (en) | 2014-05-29 |
AR087182A1 (es) | 2014-02-26 |
ES2555167T3 (es) | 2015-12-29 |
EA201490287A1 (ru) | 2014-05-30 |
MX2014000626A (es) | 2014-04-30 |
KR20140063595A (ko) | 2014-05-27 |
CA2841102C (en) | 2019-08-13 |
EA023045B1 (ru) | 2016-04-29 |
TW201315736A (zh) | 2013-04-16 |
TWI567079B (zh) | 2017-01-21 |
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