ES2126636T3 - Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria. - Google Patents

Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria.

Info

Publication number
ES2126636T3
ES2126636T3 ES93401239T ES93401239T ES2126636T3 ES 2126636 T3 ES2126636 T3 ES 2126636T3 ES 93401239 T ES93401239 T ES 93401239T ES 93401239 T ES93401239 T ES 93401239T ES 2126636 T3 ES2126636 T3 ES 2126636T3
Authority
ES
Spain
Prior art keywords
derivatives
bencimidazole
aggregant
diabetic
platelet activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93401239T
Other languages
English (en)
Inventor
Vera Alekseevna Anisimova
Margarita Valentinov Levchenko
Tatyana Borisovna Korochina
Alexander Alexeyevich Spasov
Sergei Gennadyevich Kovalev
Galina Petrovna Dudchenko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9206036A external-priority patent/FR2691462B1/fr
Priority claimed from FR9209488A external-priority patent/FR2694293B1/fr
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2126636T3 publication Critical patent/ES2126636T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE FORMULA GENERAL (I): DONDE A, B, C D, N, R1, R2, R3, R4, X, Y, Z SON TALES COMO SE DEFINEN EN LA DESCRIPCION. MEDICAMENTOS.
ES93401239T 1992-05-19 1993-05-14 Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria. Expired - Lifetime ES2126636T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9206036A FR2691462B1 (fr) 1992-05-19 1992-05-19 Nouveaux derives du benzimidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR9209488A FR2694293B1 (fr) 1992-07-31 1992-07-31 Nouveau dérivé du benzimidazole, son procédé de préparation et les compositions pharmaceutiques qui le contiennent.

Publications (1)

Publication Number Publication Date
ES2126636T3 true ES2126636T3 (es) 1999-04-01

Family

ID=26229468

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93401239T Expired - Lifetime ES2126636T3 (es) 1992-05-19 1993-05-14 Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria.

Country Status (10)

Country Link
US (2) US5623073A (es)
EP (1) EP0571253B1 (es)
JP (1) JP2506263B2 (es)
AT (1) ATE172975T1 (es)
AU (1) AU656466B2 (es)
CA (1) CA2096475A1 (es)
DE (1) DE69321875T2 (es)
DK (1) DK0571253T3 (es)
ES (1) ES2126636T3 (es)
NZ (1) NZ247643A (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
CA2166059C (en) 1993-06-25 2005-08-16 Richard Carl Krauss Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
AUPN236595A0 (en) 1995-04-11 1995-05-11 Rescare Limited Monitoring of apneic arousals
FR2765223B1 (fr) * 1997-06-25 1999-08-27 Adir Nouveaux derives tricycliques du benzimidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6700012B2 (en) 1998-07-02 2004-03-02 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
JP3398121B2 (ja) 2000-05-16 2003-04-21 株式会社堀場製作所 粒度分布測定装置
EE200300342A (et) * 2001-01-26 2003-12-15 Bristol-Myers Squibb Company Imidasolüüli derivaadid kui kortikotropiini vabastava faktori inhibiitorid, nende saamismeetodid ning kasutamine
NZ551424A (en) * 2004-05-14 2009-10-30 Childrenaes Cancer Inst Austra Small molecule inhibitors for MRP1 and other multidrug transporters
KR101549364B1 (ko) 2006-03-17 2015-09-01 암비트 바이오사이언시즈 코포레이션 질환 치료용 이미다졸로티아졸 화합물
ES2573292T3 (es) * 2007-09-19 2016-06-07 Ambit Biosciences Corporation Formas sólidas que comprenden N-(5-terc-butil-isoxazol-3-il)-N'-{4-[7-(2-morfolin-4-il-etoxi)imidazo[2,1-b][1,3]benzotiazol-2-il]fenil}urea, composiciones de las mismas y usos de las mismas
CA2719767A1 (en) * 2008-03-27 2009-10-01 Burnham Institute For Medical Research Inhibitors of antigen receptor-induced nf-.kappa.b activation
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
ES2555167T3 (es) * 2011-07-15 2015-12-29 Janssen Pharmaceuticals, Inc. Nuevos derivados de indol sustituidos como moduladores de gamma secretasa
SI3340796T1 (sl) 2015-08-28 2022-02-28 Chdi Foundation, Inc. Sonde za slikanje proteina huntingtina
CN108250202B (zh) * 2018-01-15 2019-10-25 陕西师范大学 2,3-二取代苯并咪唑并[1,2-a]嘧啶类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732243A (en) * 1970-06-23 1973-05-08 Sankyo Co 2-(p-bromophenyl)-9-dimethyl-amino-propyl-9h-imidazo(1,2-a)benzimidazole
GB1476949A (en) * 1974-11-20 1977-06-16 Wyeth John & Brother Ltd Imidazo-1,2-a-benzimidazole and pyrimido-1,2-a-benzimidazole derivatives their preparation and their pharmaceutical compositions
US5008282A (en) * 1988-12-28 1991-04-16 Kotobuki Seiyaku Co. Ltd. Cyclic guanidine derivatives, anti-ulceratives and methods of manufacturing the same

Also Published As

Publication number Publication date
DE69321875T2 (de) 1999-06-17
EP0571253B1 (fr) 1998-11-04
US5639756A (en) 1997-06-17
EP0571253A1 (fr) 1993-11-24
DE69321875D1 (de) 1998-12-10
DK0571253T3 (da) 1999-07-19
ATE172975T1 (de) 1998-11-15
NZ247643A (en) 1995-07-26
JP2506263B2 (ja) 1996-06-12
JPH0687859A (ja) 1994-03-29
US5623073A (en) 1997-04-22
AU3860893A (en) 1993-11-25
AU656466B2 (en) 1995-02-02
CA2096475A1 (fr) 1993-11-20

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