IN2014DN09073A - - Google Patents
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- Publication number
- IN2014DN09073A IN2014DN09073A IN9073DEN2014A IN2014DN09073A IN 2014DN09073 A IN2014DN09073 A IN 2014DN09073A IN 9073DEN2014 A IN9073DEN2014 A IN 9073DEN2014A IN 2014DN09073 A IN2014DN09073 A IN 2014DN09073A
- Authority
- IN
- India
- Prior art keywords
- methods
- disease
- diagnose
- practicing
- toxicity
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000007431 microscopic evaluation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44743—Introducing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44747—Composition of gel or of carrier mixture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N2001/4038—Concentrating samples electric methods, e.g. electromigration, electrophoresis, ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Microscoopes, Condenser (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261681551P | 2012-08-09 | 2012-08-09 | |
| PCT/US2013/031066 WO2014025392A1 (en) | 2012-08-09 | 2013-03-13 | Methods and compositions for preparing biological specimens for microscopic analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN09073A true IN2014DN09073A (enExample) | 2015-05-22 |
Family
ID=50068460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN9073DEN2014 IN2014DN09073A (enExample) | 2012-08-09 | 2013-03-13 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10545075B2 (enExample) |
| EP (2) | EP4163617A1 (enExample) |
| JP (1) | JP6228205B2 (enExample) |
| KR (1) | KR102148747B1 (enExample) |
| CN (1) | CN104350372B (enExample) |
| AU (1) | AU2013300171B2 (enExample) |
| IN (1) | IN2014DN09073A (enExample) |
| WO (1) | WO2014025392A1 (enExample) |
Families Citing this family (173)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| EP3604555B1 (en) | 2011-10-14 | 2024-12-25 | President and Fellows of Harvard College | Sequencing by structure assembly |
| WO2014163886A1 (en) | 2013-03-12 | 2014-10-09 | President And Fellows Of Harvard College | Method of generating a three-dimensional nucleic acid containing matrix |
| ES2991004T3 (es) | 2011-12-22 | 2024-12-02 | Harvard College | Métodos para la detección de analitos |
| EP2794928B1 (en) | 2011-12-22 | 2019-02-20 | President and Fellows of Harvard College | Compositions and methods for analyte detection |
| WO2013184754A2 (en) | 2012-06-05 | 2013-12-12 | President And Fellows Of Harvard College | Spatial sequencing of nucleic acids using dna origami probes |
| IN2014DN09073A (enExample) | 2012-08-09 | 2015-05-22 | Univ Leland Stanford Junior | |
| WO2014060483A1 (en) | 2012-10-17 | 2014-04-24 | Spatial Transcriptomics Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| DE102013205115A1 (de) * | 2013-03-22 | 2014-09-25 | Leica Microsystems Cms Gmbh | SPIM-Anordnung |
| US9868979B2 (en) | 2013-06-25 | 2018-01-16 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
| DE102013216934A1 (de) * | 2013-08-26 | 2015-02-26 | Leica Microsystems Cms Gmbh | Verfahren und Vorrichtung zur Erhöhung der optischen Transparenz von Bereichen einer Gewebeprobe |
| US10794802B2 (en) * | 2013-09-20 | 2020-10-06 | California Institute Of Technology | Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping |
| WO2015041755A1 (en) * | 2013-09-20 | 2015-03-26 | California Institute Of Technology | Methods for phenotyping of intact whole tissues |
| CN103558055B (zh) * | 2013-09-29 | 2016-01-06 | 中国疾病预防控制中心病毒病预防控制所 | 一种针对感染病毒的病变细胞的定位超薄切片方法 |
| WO2015127183A2 (en) * | 2014-02-21 | 2015-08-27 | Massachusetts Institute Of Technology | Expansion microscopy |
| US10416116B2 (en) | 2014-04-04 | 2019-09-17 | Massachusetts Institute Of Technology | Active transport of charged molecules into, within, and/or from charged matrices |
| JP2017517761A (ja) * | 2014-05-30 | 2017-06-29 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 大きなインタクトな組織試料を撮像するための方法及び装置 |
| JP6778186B2 (ja) * | 2014-07-07 | 2020-10-28 | ロゴス バイオシステムズ， インコーポレイテッド | 電気泳動を使用する組織クリアリング装置 |
| WO2016007839A1 (en) | 2014-07-11 | 2016-01-14 | President And Fellows Of Harvard College | Methods for high-throughput labelling and detection of biological features in situ using microscopy |
| ES2968004T3 (es) | 2014-07-30 | 2024-05-06 | Harvard College | Construcción de bibliotecas de sondas |
| WO2016023009A1 (en) * | 2014-08-07 | 2016-02-11 | Wake Forest University Health Sciences | Compositions and methods for clearing a biological sample |
| KR101563826B1 (ko) * | 2014-12-31 | 2015-10-28 | 계명대학교 산학협력단 | 조직 투명화 방법 |
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| US10059990B2 (en) | 2015-04-14 | 2018-08-28 | Massachusetts Institute Of Technology | In situ nucleic acid sequencing of expanded biological samples |
| US10526649B2 (en) | 2015-04-14 | 2020-01-07 | Massachusetts Institute Of Technology | Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information |
| US11408890B2 (en) | 2015-04-14 | 2022-08-09 | Massachusetts Institute Of Technology | Iterative expansion microscopy |
| CN106198990A (zh) * | 2015-04-30 | 2016-12-07 | 上海交通大学 | 一种对组织样本进行免疫标记的方法 |
| CN104965016A (zh) * | 2015-06-15 | 2015-10-07 | 南昌大学 | 一体化的生物组织透明装置 |
| US10317321B2 (en) | 2015-08-07 | 2019-06-11 | Massachusetts Institute Of Technology | Protein retention expansion microscopy |
| WO2017027367A1 (en) * | 2015-08-07 | 2017-02-16 | Massachusetts Institute Of Technology | Nanoscale imaging of proteins and nucleic acids via expansion microscopy |
| WO2017031249A1 (en) * | 2015-08-17 | 2017-02-23 | California Institute Of Technology | Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping |
| WO2017075265A1 (en) * | 2015-10-28 | 2017-05-04 | The Broad Institute, Inc. | Multiplex analysis of single cell constituents |
| EP3371329B1 (en) | 2015-11-03 | 2026-03-25 | President and Fellows of Harvard College | Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix |
| US20190113423A1 (en) * | 2015-12-02 | 2019-04-18 | Clearlight Diagnostics, LLC | Methods for preparing and analyzing tumor tissue samples for detection and monitoring of cancers |
| CN108431664B (zh) * | 2015-12-23 | 2021-11-02 | 皇家飞利浦有限公司 | 荧光校准载片 |
| RU2746895C2 (ru) | 2015-12-24 | 2021-04-21 | Конинклейке Филипс Н.В. | Устройство для окрашивания трехмерной биопсийной ткани |
| CN105823807B (zh) * | 2016-01-04 | 2018-04-20 | 浙江农林大学 | 抗癌药物羟喜树碱药效检测装置及检测方法 |
| US11254974B2 (en) | 2016-02-10 | 2022-02-22 | The Board Of Trustees Of The Leland Stanford Junior University | RNA fixation and detection in clarity-based hydrogel tissue |
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| JP6721899B2 (ja) * | 2016-03-30 | 2020-07-15 | 国立大学法人 大分大学 | 高親水性高分子モノマーを主剤とする電子顕微鏡用包埋方法 |
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| US10324022B2 (en) | 2016-05-11 | 2019-06-18 | Bonraybio Co., Ltd. | Analysis accuracy improvement in automated testing apparatus |
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| WO2017205531A1 (en) * | 2016-05-25 | 2017-11-30 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for visualization and quantification of fiber-like structures |
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| CN107621462B (zh) * | 2016-07-13 | 2020-03-31 | 王志伟 | 一种组织透明化液sut及其制备和应用 |
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| JP7239465B2 (ja) | 2016-08-31 | 2023-03-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 蛍光ｉｎ ｓｉｔｕ配列決定による検出のための核酸配列ライブラリの作製法 |
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| US10538632B1 (en) | 2016-09-30 | 2020-01-21 | National Technology & Engineering Solutions Of Sandia, Llc | Shape-preserving polymeric replication of biological matter |
| JP6898720B2 (ja) * | 2016-10-14 | 2021-07-07 | 株式会社ファンケル | 皮膚内部構造評価方法 |
| EP3539036A4 (en) * | 2016-11-08 | 2020-06-17 | President and Fellows of Harvard College | MATRIX AND DELETE |
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| KR101866249B1 (ko) | 2016-11-29 | 2018-06-12 | 박순현 | 생체 조직 투명화용 조성물 및 이를 이용한 생체 조직 투명화 방법 |
| DE102016123458B3 (de) * | 2016-12-05 | 2018-03-15 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Verfahren zur Herstellung transparenter biologischer Präparate für eine lichtmikroskopische Untersuchung |
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| US10955322B2 (en) | 2017-01-18 | 2021-03-23 | California Institute Of Technology | Methods and devices for soft and osseous tissue clearing and fluorescent imaging |
| CN106769350B (zh) | 2017-01-20 | 2019-11-22 | 上海交通大学 | 一种用于富含脂滴组织快速完全透明化的方法 |
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| US11436719B2 (en) | 2017-02-16 | 2022-09-06 | Kyoto University | Cell evaluation method, cell evaluation device, and recording medium storing cell evaluation program |
| WO2018157048A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy |
| WO2018157074A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for diagnosing neoplastic lesions |
| WO2018155925A2 (ko) * | 2017-02-27 | 2018-08-30 | 고려대학교 산학협력단 | 하이드로겔 중합체를 이용한 탈세포화 조직의 제조방법 및 이로부터 제조된 탈세포화 조직 |
| KR20180099482A (ko) * | 2017-02-27 | 2018-09-05 | 고려대학교 산학협력단 | 하이드로겔 중합체를 이용한 탈세포화 조직의 제조방법 및 이로부터 제조된 탈세포화 조직 |
| TWI620927B (zh) * | 2017-04-21 | 2018-04-11 | 胡宇光 | 神經組織樣本染色之方法及套組與顯現神經元之方法 |
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| MX2017008919A (es) * | 2017-07-05 | 2018-03-01 | Gabriela Reyes Fuchs Carmen | Proceso para formar una imagen a color de materiales incinerados mediante tecnicas de microscopia. |
| JP7160350B2 (ja) * | 2017-07-06 | 2022-10-25 | 公立大学法人大阪 | 生体組織透明化法及びその試薬 |
| KR101996722B1 (ko) * | 2017-07-07 | 2019-07-04 | 재단법인대구경북과학기술원 | 다채널 박막전극을 이용한 전기적 생체분자 이동방법 |
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| KR102200618B1 (ko) * | 2018-01-12 | 2021-01-08 | 재단법인대구경북과학기술원 | 설포베타인계 쯔비터이온성 계면활성제를 포함하는 생물학적 분자의 조직침투용 조성물 및 이의 용도 |
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| KR102151128B1 (ko) * | 2018-08-24 | 2020-09-02 | 주식회사 바이나리 | 질소 가스 가압식 조직 투명화 및 항체 침투 증진용 장치 |
| JP7246752B2 (ja) * | 2018-08-29 | 2023-03-28 | 国立研究開発法人物質・材料研究機構 | 測定装置、及び、評価方法 |
| KR102368585B1 (ko) * | 2018-09-28 | 2022-03-03 | 서울대학교산학협력단 | 온도에 따라 가역적 팽창/초기화가 가능한 하이드로젤을 이용한 생체조직 이미징 |
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| WO2015022883A1 (ja) | 2013-08-14 | 2015-02-19 | 独立行政法人理化学研究所 | 光透過性に優れた生物材料を調製するための組成物およびその利用 |
| DE102013216934A1 (de) | 2013-08-26 | 2015-02-26 | Leica Microsystems Cms Gmbh | Verfahren und Vorrichtung zur Erhöhung der optischen Transparenz von Bereichen einer Gewebeprobe |
| WO2015041755A1 (en) | 2013-09-20 | 2015-03-26 | California Institute Of Technology | Methods for phenotyping of intact whole tissues |
| CN103513411B (zh) | 2013-09-27 | 2016-02-03 | 香港应用科技研究院有限公司 | 荧光显微镜中聚焦的装置和方法 |
| JP2017517761A (ja) | 2014-05-30 | 2017-06-29 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 大きなインタクトな組織試料を撮像するための方法及び装置 |
| WO2016023009A1 (en) | 2014-08-07 | 2016-02-11 | Wake Forest University Health Sciences | Compositions and methods for clearing a biological sample |
| WO2016073941A1 (en) | 2014-11-07 | 2016-05-12 | California Institute Of Technology | Methods for phenotyping of intact bones by tissue clearing and staining |
| WO2016117614A1 (ja) | 2015-01-20 | 2016-07-28 | 国立研究開発法人理化学研究所 | 生物材料用透明化試薬、システム及びその利用 |
| EP3273218A4 (en) | 2015-03-18 | 2018-12-26 | Riken | Method for observing biological material and clearing method |
| US20190113423A1 (en) | 2015-12-02 | 2019-04-18 | Clearlight Diagnostics, LLC | Methods for preparing and analyzing tumor tissue samples for detection and monitoring of cancers |
-
2013
- 2013-03-13 IN IN9073DEN2014 patent/IN2014DN09073A/en unknown
- 2013-03-13 EP EP22192548.0A patent/EP4163617A1/en not_active Withdrawn
- 2013-03-13 KR KR1020147033139A patent/KR102148747B1/ko not_active Expired - Fee Related
- 2013-03-13 EP EP13828542.4A patent/EP2883030B1/en active Active
- 2013-03-13 CN CN201380028711.3A patent/CN104350372B/zh not_active Expired - Fee Related
- 2013-03-13 AU AU2013300171A patent/AU2013300171B2/en not_active Ceased
- 2013-03-13 JP JP2015526521A patent/JP6228205B2/ja not_active Expired - Fee Related
- 2013-03-13 US US14/403,050 patent/US10545075B2/en active Active
- 2013-03-13 WO PCT/US2013/031066 patent/WO2014025392A1/en not_active Ceased
-
2017
- 2017-02-13 US US15/431,388 patent/US20170219465A1/en not_active Abandoned
-
2020
- 2020-11-17 US US16/950,640 patent/US20210215581A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP6228205B2 (ja) | 2017-11-08 |
| EP2883030B1 (en) | 2022-08-31 |
| EP2883030A4 (en) | 2016-03-02 |
| CN104350372B (zh) | 2018-03-02 |
| US20210215581A1 (en) | 2021-07-15 |
| KR20150043241A (ko) | 2015-04-22 |
| EP4163617A1 (en) | 2023-04-12 |
| US20170219465A1 (en) | 2017-08-03 |
| AU2013300171B2 (en) | 2017-09-14 |
| US20150144490A1 (en) | 2015-05-28 |
| CN104350372A (zh) | 2015-02-11 |
| JP2015533210A (ja) | 2015-11-19 |
| EP2883030A1 (en) | 2015-06-17 |
| KR102148747B1 (ko) | 2020-08-27 |
| US10545075B2 (en) | 2020-01-28 |
| HK1204677A1 (en) | 2015-11-27 |
| AU2013300171A1 (en) | 2014-11-06 |
| WO2014025392A1 (en) | 2014-02-13 |
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