IN2014DN09073A - - Google Patents

Download PDF

Info

Publication number
IN2014DN09073A
IN2014DN09073A IN9073DEN2014A IN2014DN09073A IN 2014DN09073 A IN2014DN09073 A IN 2014DN09073A IN 9073DEN2014 A IN9073DEN2014 A IN 9073DEN2014A IN 2014DN09073 A IN2014DN09073 A IN 2014DN09073A
Authority
IN
India
Prior art keywords
methods
disease
diagnose
practicing
toxicity
Prior art date
Application number
Inventor
Karl A Deisseroth
Kwanghun Chung
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of IN2014DN09073A publication Critical patent/IN2014DN09073A/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31Apparatus therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44743Introducing samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44747Composition of gel or of carrier mixture
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/34Microscope slides, e.g. mounting specimens on microscope slides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N2001/4038Concentrating samples electric methods, e.g. electromigration, electrophoresis, ionisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/4833Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Microscoopes, Condenser (AREA)

Abstract

Methods and compositions are provided for preparing a biological specimen for microscopic analysis. These methods find many uses for example in medicine and research e.g. to diagnose or monitor disease or graft transplantation to study healthy or diseased tissue to screen candidate agents for toxicity and efficacy in disease modification. Also provided are reagents devices kits and systems thereof that find use in practicing the subject methods.
IN9073DEN2014 2012-08-09 2013-03-13 IN2014DN09073A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261681551P 2012-08-09 2012-08-09
PCT/US2013/031066 WO2014025392A1 (en) 2012-08-09 2013-03-13 Methods and compositions for preparing biological specimens for microscopic analysis

Publications (1)

Publication Number Publication Date
IN2014DN09073A true IN2014DN09073A (en) 2015-05-22

Family

ID=50068460

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9073DEN2014 IN2014DN09073A (en) 2012-08-09 2013-03-13

Country Status (8)

Country Link
US (3) US10545075B2 (en)
EP (2) EP4163617A1 (en)
JP (1) JP6228205B2 (en)
KR (1) KR102148747B1 (en)
CN (1) CN104350372B (en)
AU (1) AU2013300171B2 (en)
IN (1) IN2014DN09073A (en)
WO (1) WO2014025392A1 (en)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
EP3604555B1 (en) 2011-10-14 2024-12-25 President and Fellows of Harvard College Sequencing by structure assembly
WO2014163886A1 (en) 2013-03-12 2014-10-09 President And Fellows Of Harvard College Method of generating a three-dimensional nucleic acid containing matrix
ES2991004T3 (en) 2011-12-22 2024-12-02 Harvard College Methods for the detection of analytes
EP2794928B1 (en) 2011-12-22 2019-02-20 President and Fellows of Harvard College Compositions and methods for analyte detection
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
IN2014DN09073A (en) 2012-08-09 2015-05-22 Univ Leland Stanford Junior
WO2014060483A1 (en) 2012-10-17 2014-04-24 Spatial Transcriptomics Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
DE102013205115A1 (en) * 2013-03-22 2014-09-25 Leica Microsystems Cms Gmbh SPIM arrangement
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
DE102013216934A1 (en) * 2013-08-26 2015-02-26 Leica Microsystems Cms Gmbh Method and device for increasing the optical transparency of regions of a tissue sample
US10794802B2 (en) * 2013-09-20 2020-10-06 California Institute Of Technology Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping
WO2015041755A1 (en) * 2013-09-20 2015-03-26 California Institute Of Technology Methods for phenotyping of intact whole tissues
CN103558055B (en) * 2013-09-29 2016-01-06 中国疾病预防控制中心病毒病预防控制所 A kind of locating super-thin dicing method for infecting viral sick cell
WO2015127183A2 (en) * 2014-02-21 2015-08-27 Massachusetts Institute Of Technology Expansion microscopy
US10416116B2 (en) 2014-04-04 2019-09-17 Massachusetts Institute Of Technology Active transport of charged molecules into, within, and/or from charged matrices
JP2017517761A (en) * 2014-05-30 2017-06-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Method and apparatus for imaging large intact tissue samples
JP6778186B2 (en) * 2014-07-07 2020-10-28 ロゴス バイオシステムズ, インコーポレイテッド Tissue clearing device using electrophoresis
WO2016007839A1 (en) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
ES2968004T3 (en) 2014-07-30 2024-05-06 Harvard College Building probe libraries
WO2016023009A1 (en) * 2014-08-07 2016-02-11 Wake Forest University Health Sciences Compositions and methods for clearing a biological sample
KR101563826B1 (en) * 2014-12-31 2015-10-28 계명대학교 산학협력단 Mothod for tissue clearing
EP3885762A1 (en) 2015-02-09 2021-09-29 Ventana Medical Systems, Inc. Methods for standardizing diffusion of a fluid into tissues
EP4282977B1 (en) 2015-04-10 2024-06-05 10x Genomics Sweden AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US10059990B2 (en) 2015-04-14 2018-08-28 Massachusetts Institute Of Technology In situ nucleic acid sequencing of expanded biological samples
US10526649B2 (en) 2015-04-14 2020-01-07 Massachusetts Institute Of Technology Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information
US11408890B2 (en) 2015-04-14 2022-08-09 Massachusetts Institute Of Technology Iterative expansion microscopy
CN106198990A (en) * 2015-04-30 2016-12-07 上海交通大学 A method for immunolabeling tissue samples
CN104965016A (en) * 2015-06-15 2015-10-07 南昌大学 Integrated biological tissue transparency device
US10317321B2 (en) 2015-08-07 2019-06-11 Massachusetts Institute Of Technology Protein retention expansion microscopy
WO2017027367A1 (en) * 2015-08-07 2017-02-16 Massachusetts Institute Of Technology Nanoscale imaging of proteins and nucleic acids via expansion microscopy
WO2017031249A1 (en) * 2015-08-17 2017-02-23 California Institute Of Technology Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping
WO2017075265A1 (en) * 2015-10-28 2017-05-04 The Broad Institute, Inc. Multiplex analysis of single cell constituents
EP3371329B1 (en) 2015-11-03 2026-03-25 President and Fellows of Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
US20190113423A1 (en) * 2015-12-02 2019-04-18 Clearlight Diagnostics, LLC Methods for preparing and analyzing tumor tissue samples for detection and monitoring of cancers
CN108431664B (en) * 2015-12-23 2021-11-02 皇家飞利浦有限公司 Fluorescence Calibration Slides
RU2746895C2 (en) 2015-12-24 2021-04-21 Конинклейке Филипс Н.В. Device for three-dimensional staining of biopsy tissue
CN105823807B (en) * 2016-01-04 2018-04-20 浙江农林大学 Cancer therapy drug Hydroxycamptothecin Composition analyzed device and detection method
US11254974B2 (en) 2016-02-10 2022-02-22 The Board Of Trustees Of The Leland Stanford Junior University RNA fixation and detection in clarity-based hydrogel tissue
EP3974387B1 (en) 2016-03-07 2025-10-29 X-Zell Inc. Compositions and methods for identifying rare cells
JP6721899B2 (en) * 2016-03-30 2020-07-15 国立大学法人 大分大学 Embedding method for electron microscope mainly composed of highly hydrophilic polymer monomer
CA3210120C (en) 2016-04-25 2024-04-09 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
US11397140B2 (en) * 2016-04-29 2022-07-26 Massachusetts Institute Of Technology Methods for reversible and tunable tissue magnification
US10324022B2 (en) 2016-05-11 2019-06-18 Bonraybio Co., Ltd. Analysis accuracy improvement in automated testing apparatus
US10281386B2 (en) * 2016-05-11 2019-05-07 Bonraybio Co., Ltd. Automated testing apparatus
US10852290B2 (en) 2016-05-11 2020-12-01 Bonraybio Co., Ltd. Analysis accuracy improvement in automated testing apparatus
EP3252452A1 (en) * 2016-05-25 2017-12-06 The Board of Trustees of the Leland Stanford Junior University Method for imaging and analysis of a biological specimen
WO2017205531A1 (en) * 2016-05-25 2017-11-30 The Board Of Trustees Of The Leland Stanford Junior University Methods for visualization and quantification of fiber-like structures
WO2017222453A1 (en) 2016-06-21 2017-12-28 Hauling Thomas Nucleic acid sequencing
CN107621462B (en) * 2016-07-13 2020-03-31 王志伟 Tissue clearing liquid SUT and preparation and application thereof
CN107674879A (en) * 2016-08-01 2018-02-09 深圳先进技术研究院 A kind of photogene plasmid and its application
US11480502B2 (en) 2016-08-29 2022-10-25 United States of America, as represented by the Secretary, Department of Heatlth and Human Service Method and composition for optical clearing of tissues
JP7239465B2 (en) 2016-08-31 2023-03-14 プレジデント アンド フェローズ オブ ハーバード カレッジ Methods for preparing nucleic acid sequence libraries for detection by fluorescence in situ sequencing
GB2569252A (en) 2016-08-31 2019-06-12 Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
US10538632B1 (en) 2016-09-30 2020-01-21 National Technology & Engineering Solutions Of Sandia, Llc Shape-preserving polymeric replication of biological matter
JP6898720B2 (en) * 2016-10-14 2021-07-07 株式会社ファンケル Skin internal structure evaluation method
EP3539036A4 (en) * 2016-11-08 2020-06-17 President and Fellows of Harvard College PRINTING AND ELIMINATION OF DIES
US20190276881A1 (en) * 2016-11-08 2019-09-12 President And Fellows Of Harvard College Multiplexed imaging using merfish, expansion microscopy, and related technologies
KR101866249B1 (en) 2016-11-29 2018-06-12 박순현 Composition for clrearing of biotissue and clarity method for biotissue using thereof
DE102016123458B3 (en) * 2016-12-05 2018-03-15 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Process for the preparation of transparent biological preparations for a light microscopic examination
CN106682453B (en) * 2016-12-28 2019-03-26 长春理工大学 A kind of fixed point edit methods of DNA molecular
US10955322B2 (en) 2017-01-18 2021-03-23 California Institute Of Technology Methods and devices for soft and osseous tissue clearing and fluorescent imaging
CN106769350B (en) 2017-01-20 2019-11-22 上海交通大学 A method for rapid and complete clearing of lipid droplet-rich tissue
US10995361B2 (en) * 2017-01-23 2021-05-04 Massachusetts Institute Of Technology Multiplexed signal amplified FISH via splinted ligation amplification and sequencing
KR101888782B1 (en) * 2017-02-07 2018-08-14 고려대학교 산학협력단 Method for clearing molecular structures in skins, method for three-dimensional imaging and method for diagnosis and evaluation using the same
US11436719B2 (en) 2017-02-16 2022-09-06 Kyoto University Cell evaluation method, cell evaluation device, and recording medium storing cell evaluation program
WO2018157048A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy
WO2018157074A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for diagnosing neoplastic lesions
WO2018155925A2 (en) * 2017-02-27 2018-08-30 고려대학교 산학협력단 Method for producing decellularized tissue using hydrogel polymer and decellularized tissue produced thereby
KR20180099482A (en) * 2017-02-27 2018-09-05 고려대학교 산학협력단 Method for preparing decellularized tissue using hydrogel polymer and decellularized tissue prepared therefrom
TWI620927B (en) * 2017-04-21 2018-04-11 胡宇光 Method and kit for staining neural tissue sample and method for visualizing neurons
WO2018218150A1 (en) 2017-05-26 2018-11-29 President And Fellows Of Harvard College Systems and methods for high-throughput image-based screening
MX2017008919A (en) * 2017-07-05 2018-03-01 Gabriela Reyes Fuchs Carmen Process for forming a color image of incinerated materials by microscopy techniques.
JP7160350B2 (en) * 2017-07-06 2022-10-25 公立大学法人大阪 Biological tissue clearing method and its reagent
KR101996722B1 (en) * 2017-07-07 2019-07-04 재단법인대구경북과학기술원 A method of electrically moving a biological molecule using multi-channel thin membrane electrodes
US11180804B2 (en) 2017-07-25 2021-11-23 Massachusetts Institute Of Technology In situ ATAC sequencing
EP4589017A3 (en) 2017-10-06 2025-10-08 10x Genomics, Inc. Rna templated ligation
KR102200618B1 (en) * 2018-01-12 2021-01-08 재단법인대구경북과학기술원 A composition comprising sulfobetainic zwitterionic detergents for tissue penetration of biological molecules and the use thereof
WO2019078655A1 (en) * 2017-10-19 2019-04-25 재단법인대구경북과학기술원 Composition for infiltrating biomolecule into tissue including sulfobetaine-based zwitterionic surfactant, and use thereof
US10488307B2 (en) * 2017-12-12 2019-11-26 Dignity Health Systems, devices, and methods for improved tissue treatment
KR102050248B1 (en) * 2017-12-29 2019-11-29 연세대학교 산학협력단 Method for analysis of tissue clarity measurement
CN107966477A (en) * 2018-01-22 2018-04-27 哈尔滨工业大学 a biological sensor
US11873374B2 (en) 2018-02-06 2024-01-16 Massachusetts Institute Of Technology Swellable and structurally homogenous hydrogels and methods of use thereof
GB2571544B (en) 2018-02-28 2022-05-18 Bright Instrument Co Ltd Sectioning macrotome
CN112188899B (en) * 2018-03-16 2025-02-07 克里约凯珀赛尔公司 Embedding media for biological samples for imaging by optical and/or electron microscopy
WO2020011735A2 (en) 2018-07-09 2020-01-16 Universität Zürich Systems, apparatuses, and methods for preparation of tissue samples
WO2020013833A1 (en) 2018-07-13 2020-01-16 Massachusetts Institute Of Technology Dimethylacrylamide (dmaa) hydrogel for expansion microscopy (exm)
WO2020028194A1 (en) 2018-07-30 2020-02-06 Readcoor, Inc. Methods and systems for sample processing or analysis
KR102151128B1 (en) * 2018-08-24 2020-09-02 주식회사 바이나리 Pressure device for enhancing of tissue clearing and antibody penetration using nitrogen gas
JP7246752B2 (en) * 2018-08-29 2023-03-28 国立研究開発法人物質・材料研究機構 Measuring device and evaluation method
KR102368585B1 (en) * 2018-09-28 2022-03-03 서울대학교산학협력단 Bioimaging technique using reversibly expandable/recoverable hydrogel dependent on temperature change
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
US11435302B2 (en) * 2018-11-13 2022-09-06 The Trustees Of Princeton University X-ray assisted electron microscopy staining procedure
GB201818567D0 (en) * 2018-11-14 2018-12-26 Francis Crick Institute Ltd Composition
CN113366116A (en) 2018-12-13 2021-09-07 哈佛学院院长及董事 Amplification methods and systems for MERISH and other applications
CN109612811A (en) * 2018-12-26 2019-04-12 华中科技大学苏州脑空间信息研究院 A hydrogel embedding method to protect biological tissue structure and fluorescence
CN109781493A (en) * 2018-12-26 2019-05-21 华中科技大学苏州脑空间信息研究院 It is a kind of can long-time continuous fine upper cut imaging biological tissue's hydrogel embedding method
WO2020172247A1 (en) 2019-02-22 2020-08-27 Massachusetts Institute Of Technology Iterative direct expansion microscopy
CN110006862B (en) * 2019-03-29 2020-09-08 华中科技大学 Swelling cutting microscopy imaging method and superabsorbent hydrogel suitable for the method
CN112740013A (en) * 2019-05-09 2021-04-30 科来旺科技公司 Method and apparatus for electrophoretic staining of biological samples using ion-conducting membranes
CN114174799A (en) * 2019-05-30 2022-03-11 贝克曼库尔特有限公司 Method and system for immobilizing a biological specimen for microscopic imaging
AU2020282024A1 (en) 2019-05-31 2021-11-11 10X Genomics, Inc. Method of detecting target nucleic acid molecules
US20220276139A1 (en) * 2019-07-08 2022-09-01 The University Of Hong Kong Compositions and methods for clearing tissue
US12265004B2 (en) 2019-11-05 2025-04-01 Massachusetts Institute Of Technology Membrane probes for expansion microscopy
JPWO2021095718A1 (en) * 2019-11-11 2021-05-20
US11802822B2 (en) 2019-12-05 2023-10-31 Massachusetts Institute Of Technology Multiplexed expansion (MultiExM) pathology
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
WO2021155063A1 (en) 2020-01-29 2021-08-05 Readcoor, Llc Compositions and methods for analyte detection
US12110548B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Bi-directional in situ analysis
US12215379B2 (en) 2020-02-17 2025-02-04 10X Genomics, Inc. In situ analysis of chromatin interaction
JP2023514749A (en) 2020-02-21 2023-04-07 10エックス ジェノミクス インコーポレイテッド Methods and compositions for integrated in situ spatial assays
US12188085B2 (en) 2020-03-05 2025-01-07 10X Genomics, Inc. Three-dimensional spatial transcriptomics with sequencing readout
EP4117820B1 (en) * 2020-03-13 2026-02-25 Yale University Methods for physical expansion and imaging of biological samples
WO2021226198A1 (en) * 2020-05-05 2021-11-11 Massachusetts Institute Of Technology Compositions and methods relating to reversibly compressible tissue-hydrogel hybrids
CN111397999B (en) * 2020-05-09 2021-12-03 中国科学院植物研究所 Simple method for enhancing contrast of micro-CT plant sample
US12209273B2 (en) 2020-06-12 2025-01-28 10X Genomics, Inc. Nucleic acid assays using click chemistry bioconjugation
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
US12297499B2 (en) 2020-08-17 2025-05-13 10X Genomics, Inc. Multicomponent nucleic acid probes for sample analysis
CN114129780B (en) * 2020-09-03 2022-06-28 天津大学 Preparation and application of a composite hydrogel for light-controlled release of nitric oxide
RU2752751C1 (en) * 2020-09-28 2021-08-02 Ахмеджан Атаханович Аллаберганов Method for obtaining digital duplicates of document in form of paper information medium or image of text document
US20220121900A1 (en) * 2020-10-19 2022-04-21 Arizona Board Of Regents On Behalf Of Northern Arizona University Methods and systems for generating unclonable optical tags
CN112284861B (en) * 2020-10-21 2023-02-17 上海市农业科学院 Fixing liquid for hypsizigus marmoreus basidiospore microscopic observation, preparation method, fixing method and application
US12071667B2 (en) 2020-11-04 2024-08-27 10X Genomics, Inc. Sequence analysis using meta-stable nucleic acid molecules
US11333588B1 (en) * 2020-12-07 2022-05-17 Nebulum Technologies Co., Ltd. Matrix-assisted methods and compositions to prepare biological samples for super-resolution imaging
EP4012046A1 (en) 2020-12-11 2022-06-15 10X Genomics, Inc. Methods and compositions for multimodal in situ analysis
CN112665951B (en) * 2020-12-22 2022-11-11 中国农业科学院作物科学研究所 Embryo milk tissue embedding method and application
WO2022140570A1 (en) 2020-12-23 2022-06-30 10X Genomics, Inc. Methods and compositions for analyte detection
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
EP4284945B1 (en) 2021-01-26 2024-10-23 10X Genomics, Inc. Nucleic acid analog probes for in situ analysis
KR102762387B1 (en) * 2021-02-24 2025-02-05 한국과학기술원 Method for optimization of chemical staining and expansion microscopy
US12275984B2 (en) 2021-03-02 2025-04-15 10X Genomics, Inc. Sequential hybridization and quenching
WO2022187366A1 (en) 2021-03-03 2022-09-09 10X Genomics, Inc. Analyte detection in situ using nucleic acid origami
CN113004885B (en) * 2021-03-08 2024-06-11 光华临港工程应用技术研发(上海)有限公司 DNA nanostructure dye for expansion super-resolution imaging and application thereof
WO2022256324A1 (en) 2021-06-01 2022-12-08 10X Genomics, Inc. Methods and compositions for analyte detection and probe resolution
WO2022256422A1 (en) 2021-06-02 2022-12-08 10X Genomics, Inc. Sample analysis using asymmetric circularizable probes
US20230012607A1 (en) 2021-07-09 2023-01-19 10X Genomics, Inc. Methods for detecting analytes using sparse labelling
CN117651855A (en) 2021-07-13 2024-03-05 10X基因组学有限公司 Method for preparing polymeric matrices with controllable thickness
US12139751B2 (en) 2021-07-30 2024-11-12 10X Genomics, Inc. Circularizable probes for in situ analysis
ES2988400T3 (en) 2021-07-30 2024-11-20 10X Genomics Inc Methods and compositions for synchronizing reactions in situ
WO2023015192A1 (en) 2021-08-03 2023-02-09 10X Genomics, Inc. Nucleic acid concatemers and methods for stabilizing and/or compacting the same
US12460251B2 (en) 2021-08-03 2025-11-04 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid molecules
US12529096B2 (en) 2021-08-03 2026-01-20 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid structures
US12391984B2 (en) 2021-08-03 2025-08-19 10X Genomics, Inc. Compositions and methods for rolling circle amplification
EP4446426B1 (en) 2021-08-16 2026-03-04 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
US20230242974A1 (en) 2021-12-27 2023-08-03 10X Genomics, Inc. Methods and compositions for rolling circle amplification
EP4466376B1 (en) 2022-01-21 2026-03-04 10X Genomics, Inc. Multiple readout signals for analyzing a sample
EP4490737A1 (en) 2022-03-08 2025-01-15 10X Genomics, Inc. In situ code design methods for minimizing optical crowding
CN119032271A (en) 2022-04-01 2024-11-26 10X基因组学有限公司 Compositions and methods for targeted masking of autofluorescence
WO2023196526A1 (en) 2022-04-06 2023-10-12 10X Genomics, Inc. Methods for multiplex cell analysis
WO2023204581A1 (en) * 2022-04-20 2023-10-26 동국대학교 산학협력단 Three-dimensional hydrogel composite having cancer cell killing effect and method for producing same
WO2023215603A1 (en) 2022-05-06 2023-11-09 10X Genomics, Inc. Methods and compositions for in situ analysis of v(d)j sequences
WO2023215612A1 (en) 2022-05-06 2023-11-09 10X Genomics, Inc. Analysis of antigen and antigen receptor interactions
US20240084378A1 (en) 2022-05-11 2024-03-14 10X Genomics, Inc. Compositions and methods for in situ sequencing
EP4540607A1 (en) 2022-06-17 2025-04-23 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
KR102582110B1 (en) * 2022-07-18 2023-09-21 (재)씨젠의료재단 Composition for clearing and image analysis of three-dimensional cell or tissue
CN119677873A (en) 2022-08-16 2025-03-21 10X基因组学有限公司 AP50 polymerase and its use
KR20240042887A (en) * 2022-09-26 2024-04-02 연세대학교 산학협력단 Cell film for high magnification analysis of cell expansion, composition and method for preparing the same
CN115656120B (en) * 2022-10-09 2024-07-23 中国科学院深圳先进技术研究院 A dark field reflected ultraviolet optical microscopy imaging method and system
WO2024081869A1 (en) 2022-10-14 2024-04-18 10X Genomics, Inc. Methods for analysis of biological samples
EP4573210A1 (en) 2022-11-16 2025-06-25 10X Genomics, Inc. Methods and compositions for assessing performance of in situ assays
EP4634404A1 (en) 2022-12-16 2025-10-22 10X Genomics, Inc. Methods and compositions for assessing performance
EP4638789A1 (en) 2022-12-21 2025-10-29 10X Genomics, Inc. Methods for tethering ribonucleic acids in biological samples
CN121014083A (en) * 2023-03-31 2025-11-25 富士胶片株式会社 Drug development support devices, their working methods, and their operating procedures.
US20240376521A1 (en) 2023-05-10 2024-11-14 10X Genomics, Inc. Boronic acid compositions and methods for tethering ribonucleic acids in biological samples
TWI887661B (en) * 2023-05-25 2025-06-21 國立清華大學 Electrode set and device for tissue transparentizing
WO2025029831A1 (en) 2023-07-31 2025-02-06 10X Genomics, Inc. Methods and systems for targeted rna cleavage and target rna-primed rolling circle amplification
US20250163502A1 (en) 2023-11-22 2025-05-22 10X Genomics, Inc. Methods for processing ribonucleic acids in biological samples
US20250207203A1 (en) 2023-12-20 2025-06-26 10X Genomics, Inc. In situ detection of copy number variations in biological samples
WO2025255457A1 (en) 2024-06-07 2025-12-11 10X Genomics, Inc. Compositions and methods for improved on-target spatial profiling
WO2025264702A1 (en) 2024-06-18 2025-12-26 10X Genomics, Inc. 3d hydrogels for nucleic acid sequencing
WO2026043885A1 (en) 2024-08-20 2026-02-26 10X Genomics, Inc. Methods and systems for preparing a nucleic acid library
WO2026055487A1 (en) 2024-09-06 2026-03-12 10X Genomics, Inc. Modified nucleotides with oligomer spacers

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129158A (en) 1961-01-24 1964-04-14 Raymond Samuel Process for gel electrophoresis
US3208929A (en) 1962-09-11 1965-09-28 Robert H Raymond Apparatus for gel electrophoresis
US3346479A (en) 1964-04-09 1967-10-10 Scientific Industries Preparative separation by a combination of gel separation and electrophoresis
US3375187A (en) 1965-05-13 1968-03-26 Buchler Instr Inc Apparatus for temperature controlled preparative and analytical electrophoresis
US3576727A (en) 1968-05-23 1971-04-27 Bruce Lee Evatt Gel electrophoresis process
US3563880A (en) 1968-08-28 1971-02-16 Arthur W Anderson Gel electrophoresis unit
SE328135B (en) 1968-09-19 1970-09-07 Lkb Produkter Ab
US3616454A (en) 1969-03-13 1971-10-26 Univ New York Method of and apparatus for electrophoretic separation in a gel column
US3674678A (en) 1970-10-28 1972-07-04 Millipore Corp Electrophoretic apparatus
US3865712A (en) 1972-04-13 1975-02-11 Lkb Produkter Ab Electrode arrangement for an electrophoretical separation performed in a gel plate
US3989613A (en) * 1973-05-16 1976-11-02 The Dow Chemical Company Continuous balanced flow fixed boundary electrophoresis
US4088561A (en) 1977-06-27 1978-05-09 The United States Of America As Represented By The United States Department Of Energy Apparatus for electrophoresis separation
US4151065A (en) 1978-01-30 1979-04-24 The Regents Of The University Of California Horizontal slab gel electrophoresis
US4292161A (en) 1979-01-03 1981-09-29 Hoefer Scientific Instruments Vertical gel slab electrophoresis apparatus
FR2496889A1 (en) 1980-12-22 1982-06-25 Hours Michel MIGRATION AND REACTION TANK USED FOR ELECTROPHORESIS ANALYZES
US4339327A (en) 1981-04-23 1982-07-13 Tyler Jonathan M Miniature slab gel electrophoresis system
US4375401A (en) 1981-05-20 1983-03-01 Nicholas Catsimpoolas Electrophoresis system
EP0101859B1 (en) 1982-07-23 1987-10-14 Matthias Hediger Apparatus for preparative gel electrophoresis, in particular for separating mixtures on a gradient gel polyacryl amide column
US4588491A (en) 1984-02-27 1986-05-13 International Biotechnologies, Inc. Horizontal gel electrophoresis device
EP0171676B1 (en) * 1984-07-31 1990-11-07 Hitachi, Ltd. Free-flow electrophoretic separation method and apparatus therefor
US4685025A (en) 1985-03-14 1987-08-04 Raychem Corporation Conductive polymer circuit protection devices having improved electrodes
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
JPH03167472A (en) * 1989-11-27 1991-07-19 Sumitomo Chem Co Ltd Method for dyeing embryo skeletal of experimental animal
JP3216907B2 (en) 1992-05-18 2001-10-09 株式会社日立製作所 Electronic zoom device and imaging device
JP3049537B2 (en) * 1995-02-03 2000-06-05 悌二 竹崎 Fixation support method for biopsy sample, fixation support agent and embedding cassette
US6722395B2 (en) 1998-01-13 2004-04-20 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
WO1999036559A1 (en) 1998-01-13 1999-07-22 Julien Jean Pierre Viral vectors expressing self-polymerizing neuronal intermediate filaments and their use
WO2000017355A2 (en) 1998-09-18 2000-03-30 Incyte Pharmaceuticals, Inc. Human cytoskeleton associated proteins
US6232092B1 (en) 1998-10-02 2001-05-15 Rogers Imaging Corporation Method for preparing biological specimens for visual analysis
US6219575B1 (en) 1998-10-23 2001-04-17 Babak Nemati Method and apparatus to enhance optical transparency of biological tissues
US6409774B1 (en) 1999-06-11 2002-06-25 Resolution Sciences Corporation Electrophoresis-assisted staining of materials
JP2004512845A (en) 2000-10-24 2004-04-30 オンコシス リミテッド ライアビリティ カンパニー Methods and devices for selectively targeting cells in a three-dimensional specimen
AUPR378001A0 (en) * 2001-03-16 2001-04-12 Proteome Systems Ltd Protein chip
US6472216B1 (en) 2001-07-24 2002-10-29 Ann-Shyn Chiang Aqueous tissue clearing solution
CN1257752C (en) * 2001-09-28 2006-05-31 生物药开发有限公司 Multifunctional biocompatible hydrogel and preparation method thereof
DE10209609A1 (en) 2002-03-05 2003-10-02 Europ Lab Molekularbiolog Method and device for parallel analysis of bio-molecules
EP1517715A2 (en) 2002-06-28 2005-03-30 Cardio, Inc. Decellularized tissue
US7319035B2 (en) 2002-10-17 2008-01-15 Vbi Technologies, L.L.C. Biological scaffolding material
JP4361057B2 (en) * 2003-04-30 2009-11-11 モイル,ウィリアム,アール Sensors for biomolecule detection and cell classification
US7713923B2 (en) 2003-06-25 2010-05-11 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US7326571B2 (en) 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
US7660620B2 (en) 2003-09-29 2010-02-09 Medtronic, Inc. Timing techniques for magnetic resonance imaging
US7955788B2 (en) 2003-10-30 2011-06-07 Medtronic, Inc. Bioprosthetic tissue preparation with synthetic hydrogels
WO2005062938A2 (en) 2003-12-23 2005-07-14 The Regents Of The University Of California Chemical agents and methods for optical clearing of skin and mucous membranes to improve light-based diagnostics and therapeutics
ATE480550T1 (en) 2004-03-25 2010-09-15 California Inst Of Techn HYBRIDIZATION CHAIN REACTION
US7452491B2 (en) * 2004-05-13 2008-11-18 Chung Yuan Christian University Method for forming scaffolds
GB0414825D0 (en) * 2004-07-02 2004-08-04 Biostatus Ltd Gel formulations and uses thereof
CN1256579C (en) * 2004-09-23 2006-05-17 上海交通大学 Preparation method of biological sample embedding block based on atomic force microscope observation
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
WO2007030012A2 (en) * 2005-09-05 2007-03-15 Stichting Voor De Technische Wetenscahappen Extracellular matrix imaging
US8163565B2 (en) 2005-12-08 2012-04-24 Cytyc Corporation Light curing fixative
EP1801573A1 (en) * 2005-12-21 2007-06-27 Boehringer Mannheim Gmbh Method and apparatus for parallel two-dimensional electrophoresis
EP2469263A1 (en) * 2006-01-13 2012-06-27 Ventana Medical Systems, Inc. Biological sample processing composition and method
EP2187985B1 (en) 2007-08-14 2016-09-28 Smith & Nephew PLC Scaffolds
DE102007045897A1 (en) 2007-09-26 2009-04-09 Carl Zeiss Microimaging Gmbh Method for the microscopic three-dimensional imaging of a sample
US9134521B2 (en) 2008-07-30 2015-09-15 The Regents Of The University Of California Multidirectional selective plane illumination microscopy
US20100055733A1 (en) 2008-09-04 2010-03-04 Lutolf Matthias P Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels
WO2010030358A1 (en) 2008-09-12 2010-03-18 Quickmbed, Inc. Scaffold for tissue sample orientation
WO2010094284A1 (en) * 2009-02-19 2010-08-26 Dako Denmark A/S Methods and compounds for detection of molecular targets
AU2010229858A1 (en) 2009-03-25 2011-09-22 Los Alamos National Security, Llc Fiber optical assembly for fluorescence spectrometry
CN102439398A (en) * 2009-04-27 2012-05-02 蛋白质发现公司 Programmable electrophoretic notch filter systems and methods
US8852614B2 (en) 2010-03-12 2014-10-07 The Board Of Trustees Of The Leland Stanford Junior University Hydrogels with network defects enhanced by nanoparticle incorporation
CN108061677B (en) 2010-03-12 2021-10-29 国立研究开发法人理化学研究所 Clarifying reagents for biological materials and their uses
US8867803B2 (en) 2010-04-20 2014-10-21 Eric J. Seibel Optical projection tomography microscopy (OPTM) for large specimen sizes
JP5848331B2 (en) 2010-05-14 2016-01-27 フジフィルム・イメイジング・カラランツ・リミテッド Dispersion, dispersion preparation method and ink jet printing ink
TWI425201B (en) 2010-10-01 2014-02-01 Nat Univ Tsing Hua Method for 3-dimensional microscopic visualization of thick biological tissues
CN102072836B (en) * 2010-11-12 2014-02-19 深圳华大基因科技有限公司 Method and kit for concentrating and desalting biological macromolecules
US20140030192A1 (en) 2011-01-28 2014-01-30 Karl A. Deisseroth Functional Targeted Brain Endoskeletonization
WO2012147965A1 (en) 2011-04-28 2012-11-01 独立行政法人理化学研究所 Method for making biological material transparent and use thereof
WO2012161143A1 (en) 2011-05-20 2012-11-29 独立行政法人理化学研究所 Clarifying reagent for biological materials and use thereof
US9359636B2 (en) 2011-07-27 2016-06-07 The Rockefeller University Methods for fixing and detecting RNA
JP5967528B2 (en) 2012-06-22 2016-08-10 国立研究開発法人理化学研究所 Biological material clarification method and biological material clarification treatment kit
DE102012211462A1 (en) 2012-07-03 2014-01-23 Carl Zeiss Microscopy Gmbh Method for preparing and performing image stacking of a sample from different orientation angles
IN2014DN09073A (en) 2012-08-09 2015-05-22 Univ Leland Stanford Junior
DE102012020240A1 (en) 2012-10-12 2014-04-17 Carl Zeiss Microscopy Gmbh Microscope and method for SPIM microscopy
EP2992115B2 (en) 2013-04-30 2025-03-12 California Institute of Technology Multiplex labeling of molecules by sequential hybridization barcoding
WO2015022883A1 (en) 2013-08-14 2015-02-19 独立行政法人理化学研究所 Composition for preparing biomaterial with excellent light-transmitting property, and use thereof
DE102013216934A1 (en) 2013-08-26 2015-02-26 Leica Microsystems Cms Gmbh Method and device for increasing the optical transparency of regions of a tissue sample
WO2015041755A1 (en) 2013-09-20 2015-03-26 California Institute Of Technology Methods for phenotyping of intact whole tissues
CN103513411B (en) 2013-09-27 2016-02-03 香港应用科技研究院有限公司 Apparatus and method for focusing in fluorescence microscopy
JP2017517761A (en) 2014-05-30 2017-06-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Method and apparatus for imaging large intact tissue samples
WO2016023009A1 (en) 2014-08-07 2016-02-11 Wake Forest University Health Sciences Compositions and methods for clearing a biological sample
WO2016073941A1 (en) 2014-11-07 2016-05-12 California Institute Of Technology Methods for phenotyping of intact bones by tissue clearing and staining
WO2016117614A1 (en) 2015-01-20 2016-07-28 国立研究開発法人理化学研究所 Biological-specimen transparentizing agent, system, and use therefor
EP3273218A4 (en) 2015-03-18 2018-12-26 Riken Method for observing biological material and clearing method
US20190113423A1 (en) 2015-12-02 2019-04-18 Clearlight Diagnostics, LLC Methods for preparing and analyzing tumor tissue samples for detection and monitoring of cancers

Also Published As

Publication number Publication date
JP6228205B2 (en) 2017-11-08
EP2883030B1 (en) 2022-08-31
EP2883030A4 (en) 2016-03-02
CN104350372B (en) 2018-03-02
US20210215581A1 (en) 2021-07-15
KR20150043241A (en) 2015-04-22
EP4163617A1 (en) 2023-04-12
US20170219465A1 (en) 2017-08-03
AU2013300171B2 (en) 2017-09-14
US20150144490A1 (en) 2015-05-28
CN104350372A (en) 2015-02-11
JP2015533210A (en) 2015-11-19
EP2883030A1 (en) 2015-06-17
KR102148747B1 (en) 2020-08-27
US10545075B2 (en) 2020-01-28
HK1204677A1 (en) 2015-11-27
AU2013300171A1 (en) 2014-11-06
WO2014025392A1 (en) 2014-02-13

Similar Documents

Publication Publication Date Title
IN2014DN09073A (en)
IN2014CN03228A (en)
Morgan et al. What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease
BR112014018970A8 (en) SAMPLE COLLECTION DEVICES WITH BLOOD STABILIZING AGENTS
MA52909A (en) METHODS FOR INCREASING RED BLOOD CELLS AND SICKLE CELL TREATMENT
MX362545B (en) Image analysis and measurement of biological samples.
MX2016014496A (en) Specimen collection device.
EP4491726A3 (en) Protein enriched microvesicles and methods of making and using the same
WO2016109813A3 (en) Human pluripotent stem cell-based models for predictive developmental neural toxicity
WO2014093838A3 (en) Automated robotic microscopy systems
CR20130175A (en) METHODS AND COMPOSITIONS CONTAINING JASMONATE OR RELATED COMPOUNDS TO PROMOTE BIODEFENSE ACTIVITY IN PLANTS
EP2864467A4 (en) BIOPSY TISSUE SAMPLE TRANSPORT DEVICE AND METHOD OF USING THE SAME
EA201101520A1 (en) METHODS OF DIAGNOSTICS OF ONCOLOGICAL DISEASES USING EPIMETABOLIC SWITCHES, MULTIPLE-DIFFERENT INTRACELLULAR MOLECULES OR IMPACT FACTORS
EA201590630A1 (en) METHODS OF TREATMENT AND DIAGNOSTICS ASSOCIATED WITH LYZYLOXIDE-LIKE PROTEIN 2 (LOXL2)
MX2018011832A (en) METHODS AND COMPOSITIONS FOR USE IN THE DIAGNOSIS OF PATIENTS WITH CANCER.
EP3526341A4 (en) COMPOSITIONS AND METHODS FOR DISEASE DIAGNOSIS USING SINGLE CELL ANALYSIS
EA201790504A1 (en) MONOLAYER MONONUKLEAR CELLS OF PERIPHERAL BLOOD OR BONE MARROW CELLS AND ITS APPLICATION
EP3260035A4 (en) BIOLOGICAL OBSERVATION SYSTEM
CR20130688A (en) METHOD, COMPOUNDS AND DEVICE FOR PREPARING CYTOLOGICAL SPECIMENS
AR088244A1 (en) oxMIF AS A DIAGNOSTIC MARKER
CO2017000056A2 (en) Molecules that have some pesticidal utility and related intermediates, compositions and processes
EP3705052A4 (en) BIOLOGICAL SAMPLE COLLECTION DEVICE
PH12015500662A1 (en) Antigens associated with inflammatory bowel disease
ZA201500584B (en) Matrix and system for preserving biological specimens for qualitative and quantitative analysis
GB2515713A (en) Methods, packaging and apparatus for collection of biological samples