IN2014DN09073A - - Google Patents
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- Publication number
- IN2014DN09073A IN2014DN09073A IN9073DEN2014A IN2014DN09073A IN 2014DN09073 A IN2014DN09073 A IN 2014DN09073A IN 9073DEN2014 A IN9073DEN2014 A IN 9073DEN2014A IN 2014DN09073 A IN2014DN09073 A IN 2014DN09073A
- Authority
- IN
- India
- Prior art keywords
- methods
- disease
- diagnose
- practicing
- toxicity
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000007431 microscopic evaluation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44743—Introducing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44747—Composition of gel or of carrier mixture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N2001/4038—Concentrating samples electric methods, e.g. electromigration, electrophoresis, ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Microscoopes, Condenser (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261681551P | 2012-08-09 | 2012-08-09 | |
| PCT/US2013/031066 WO2014025392A1 (en) | 2012-08-09 | 2013-03-13 | Methods and compositions for preparing biological specimens for microscopic analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN09073A true IN2014DN09073A (de) | 2015-05-22 |
Family
ID=50068460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN9073DEN2014 IN2014DN09073A (de) | 2012-08-09 | 2013-03-13 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10545075B2 (de) |
| EP (2) | EP4163617A1 (de) |
| JP (1) | JP6228205B2 (de) |
| KR (1) | KR102148747B1 (de) |
| CN (1) | CN104350372B (de) |
| AU (1) | AU2013300171B2 (de) |
| HK (1) | HK1204677A1 (de) |
| IN (1) | IN2014DN09073A (de) |
| WO (1) | WO2014025392A1 (de) |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| EP2766498B1 (de) | 2011-10-14 | 2019-06-19 | President and Fellows of Harvard College | Sequenzierung durch strukturanordnung |
| US11021737B2 (en) | 2011-12-22 | 2021-06-01 | President And Fellows Of Harvard College | Compositions and methods for analyte detection |
| EP4249605A3 (de) | 2011-12-22 | 2023-11-15 | President And Fellows Of Harvard College | Verfahren zum nachweis von analyten |
| WO2013184754A2 (en) | 2012-06-05 | 2013-12-12 | President And Fellows Of Harvard College | Spatial sequencing of nucleic acids using dna origami probes |
| CN104350372B (zh) | 2012-08-09 | 2018-03-02 | 斯坦福大学托管董事会 | 用于制备供显微镜分析的生物样本的方法和组合物 |
| EP3578666A1 (de) | 2013-03-12 | 2019-12-11 | President and Fellows of Harvard College | Verfahren zur erzeugung einer dreidimensionalen nukleinsäure mit matrix |
| DE102013205115A1 (de) * | 2013-03-22 | 2014-09-25 | Leica Microsystems Cms Gmbh | SPIM-Anordnung |
| US9868979B2 (en) | 2013-06-25 | 2018-01-16 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
| DE102013216934A1 (de) * | 2013-08-26 | 2015-02-26 | Leica Microsystems Cms Gmbh | Verfahren und Vorrichtung zur Erhöhung der optischen Transparenz von Bereichen einer Gewebeprobe |
| US10794802B2 (en) | 2013-09-20 | 2020-10-06 | California Institute Of Technology | Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping |
| CN105556309A (zh) * | 2013-09-20 | 2016-05-04 | 加州理工学院 | 用于完整全组织的表型分析的方法 |
| CN103558055B (zh) * | 2013-09-29 | 2016-01-06 | 中国疾病预防控制中心病毒病预防控制所 | 一种针对感染病毒的病变细胞的定位超薄切片方法 |
| WO2015127183A2 (en) * | 2014-02-21 | 2015-08-27 | Massachusetts Institute Of Technology | Expansion microscopy |
| EP3126037B1 (de) * | 2014-04-04 | 2020-11-18 | Massachusetts Institute Of Technology | Aktiver transport von geladenen molekülen in, innerhalb von und/oder aus geladene/n matrizen |
| JP2017517761A (ja) | 2014-05-30 | 2017-06-29 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 大きなインタクトな組織試料を撮像するための方法及び装置 |
| EP3168290B1 (de) * | 2014-07-07 | 2021-12-08 | Logos Biosystems, Inc. | Vorrichtung zur klärung von gewebe mittels elektrophorese |
| WO2016018960A1 (en) | 2014-07-30 | 2016-02-04 | President And Fellows Of Harvard College | Systems and methods for determining nucleic acids |
| WO2016023009A1 (en) * | 2014-08-07 | 2016-02-11 | Wake Forest University Health Sciences | Compositions and methods for clearing a biological sample |
| KR101563826B1 (ko) * | 2014-12-31 | 2015-10-28 | 계명대학교 산학협력단 | 조직 투명화 방법 |
| AU2016218055B2 (en) * | 2015-02-09 | 2019-05-16 | Ventana Medical Systems, Inc. | Materials and methods for standardizing diffusion of a fluid into tissues |
| ES2955916T3 (es) | 2015-04-10 | 2023-12-11 | Spatial Transcriptomics Ab | Análisis múltiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos |
| US11408890B2 (en) | 2015-04-14 | 2022-08-09 | Massachusetts Institute Of Technology | Iterative expansion microscopy |
| US10059990B2 (en) | 2015-04-14 | 2018-08-28 | Massachusetts Institute Of Technology | In situ nucleic acid sequencing of expanded biological samples |
| US10526649B2 (en) | 2015-04-14 | 2020-01-07 | Massachusetts Institute Of Technology | Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information |
| CN111579769B (zh) * | 2015-04-30 | 2023-10-27 | 李小卫 | 一种对组织样本进行免疫标记的方法 |
| CN104965016A (zh) * | 2015-06-15 | 2015-10-07 | 南昌大学 | 一体化的生物组织透明装置 |
| EP3332258B1 (de) | 2015-08-07 | 2020-01-01 | Massachusetts Institute of Technology | Expansionsmikroskopie unter proteinrückhaltung |
| US10364457B2 (en) | 2015-08-07 | 2019-07-30 | Massachusetts Institute Of Technology | Nanoscale imaging of proteins and nucleic acids via expansion microscopy |
| WO2017031249A1 (en) * | 2015-08-17 | 2017-02-23 | California Institute Of Technology | Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping |
| US11092607B2 (en) * | 2015-10-28 | 2021-08-17 | The Board Institute, Inc. | Multiplex analysis of single cell constituents |
| AU2016349288A1 (en) | 2015-11-03 | 2018-05-31 | President And Fellows Of Harvard College | Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix |
| WO2017096248A1 (en) * | 2015-12-02 | 2017-06-08 | Clearlight Diagnostics Llc | Methods for preparing and analyzing tumor tissue samples for detection and monitoring of cancers |
| WO2017109057A1 (en) | 2015-12-23 | 2017-06-29 | Koninklijke Philips N.V. | Fluorescence calibration slide |
| CN105823807B (zh) * | 2016-01-04 | 2018-04-20 | 浙江农林大学 | 抗癌药物羟喜树碱药效检测装置及检测方法 |
| US11254974B2 (en) | 2016-02-10 | 2022-02-22 | The Board Of Trustees Of The Leland Stanford Junior University | RNA fixation and detection in clarity-based hydrogel tissue |
| AU2017229088B2 (en) * | 2016-03-07 | 2021-05-13 | X-Zell Inc. | Compositions and methods for identifying rare cells |
| JP6721899B2 (ja) * | 2016-03-30 | 2020-07-15 | 国立大学法人 大分大学 | 高親水性高分子モノマーを主剤とする電子顕微鏡用包埋方法 |
| WO2017189525A1 (en) | 2016-04-25 | 2017-11-02 | President And Fellows Of Harvard College | Hybridization chain reaction methods for in situ molecular detection |
| US11397140B2 (en) * | 2016-04-29 | 2022-07-26 | Massachusetts Institute Of Technology | Methods for reversible and tunable tissue magnification |
| US10324022B2 (en) | 2016-05-11 | 2019-06-18 | Bonraybio Co., Ltd. | Analysis accuracy improvement in automated testing apparatus |
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| US10852290B2 (en) | 2016-05-11 | 2020-12-01 | Bonraybio Co., Ltd. | Analysis accuracy improvement in automated testing apparatus |
| WO2017205531A1 (en) * | 2016-05-25 | 2017-11-30 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for visualization and quantification of fiber-like structures |
| EP3252452A1 (de) | 2016-05-25 | 2017-12-06 | The Board of Trustees of the Leland Stanford Junior University | Verfahren zur abbildung und analyse einer biologischen probe |
| WO2017222453A1 (en) | 2016-06-21 | 2017-12-28 | Hauling Thomas | Nucleic acid sequencing |
| CN107621462B (zh) * | 2016-07-13 | 2020-03-31 | 王志伟 | 一种组织透明化液sut及其制备和应用 |
| CN107674879A (zh) * | 2016-08-01 | 2018-02-09 | 深圳先进技术研究院 | 一种光‑基因质粒及其应用 |
| US11480502B2 (en) | 2016-08-29 | 2022-10-25 | United States of America, as represented by the Secretary, Department of Heatlth and Human Service | Method and composition for optical clearing of tissues |
| WO2018045186A1 (en) | 2016-08-31 | 2018-03-08 | President And Fellows Of Harvard College | Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing |
| EP3507364A4 (de) | 2016-08-31 | 2020-05-20 | President and Fellows of Harvard College | Verfahren zur erstellung von bibliotheken von nukleinsäuresequenzen zur detektion mittels in-situ-fluoreszenzsequenzierung |
| US10538632B1 (en) | 2016-09-30 | 2020-01-21 | National Technology & Engineering Solutions Of Sandia, Llc | Shape-preserving polymeric replication of biological matter |
| JP6898720B2 (ja) * | 2016-10-14 | 2021-07-07 | 株式会社ファンケル | 皮膚内部構造評価方法 |
| EP4386761A2 (de) * | 2016-11-08 | 2024-06-19 | President and Fellows of Harvard College | Matrixdrucken und löschen |
| CN110168346B (zh) * | 2016-11-08 | 2023-03-03 | 哈佛学院院长及董事 | 使用merfish、扩展显微术和相关技术进行多重成像 |
| KR101866249B1 (ko) | 2016-11-29 | 2018-06-12 | 박순현 | 생체 조직 투명화용 조성물 및 이를 이용한 생체 조직 투명화 방법 |
| DE102016123458B3 (de) * | 2016-12-05 | 2018-03-15 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Verfahren zur Herstellung transparenter biologischer Präparate für eine lichtmikroskopische Untersuchung |
| CN106682453B (zh) * | 2016-12-28 | 2019-03-26 | 长春理工大学 | 一种dna分子的定点编辑方法 |
| US10955322B2 (en) | 2017-01-18 | 2021-03-23 | California Institute Of Technology | Methods and devices for soft and osseous tissue clearing and fluorescent imaging |
| CN106769350B (zh) | 2017-01-20 | 2019-11-22 | 上海交通大学 | 一种用于富含脂滴组织快速完全透明化的方法 |
| US10995361B2 (en) | 2017-01-23 | 2021-05-04 | Massachusetts Institute Of Technology | Multiplexed signal amplified FISH via splinted ligation amplification and sequencing |
| KR101888782B1 (ko) * | 2017-02-07 | 2018-08-14 | 고려대학교 산학협력단 | 피부 조직의 투명화 방법, 이를 이용한 피부 조직의 3차원 영상화 방법 및 평가 및 진단 방법 |
| JP6985684B2 (ja) * | 2017-02-16 | 2021-12-22 | 国立大学法人京都大学 | 細胞評価方法、細胞評価装置、及び細胞評価プログラム |
| WO2018157048A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy |
| KR20180099482A (ko) * | 2017-02-27 | 2018-09-05 | 고려대학교 산학협력단 | 하이드로겔 중합체를 이용한 탈세포화 조직의 제조방법 및 이로부터 제조된 탈세포화 조직 |
| WO2018155925A2 (ko) * | 2017-02-27 | 2018-08-30 | 고려대학교 산학협력단 | 하이드로겔 중합체를 이용한 탈세포화 조직의 제조방법 및 이로부터 제조된 탈세포화 조직 |
| TWI620927B (zh) * | 2017-04-21 | 2018-04-11 | 胡宇光 | 神經組織樣本染色之方法及套組與顯現神經元之方法 |
| WO2018218150A1 (en) | 2017-05-26 | 2018-11-29 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| MX2017008919A (es) * | 2017-07-05 | 2018-03-01 | Gabriela Reyes Fuchs Carmen | Proceso para formar una imagen a color de materiales incinerados mediante tecnicas de microscopia. |
| JP7160350B2 (ja) * | 2017-07-06 | 2022-10-25 | 公立大学法人大阪 | 生体組織透明化法及びその試薬 |
| KR101996722B1 (ko) * | 2017-07-07 | 2019-07-04 | 재단법인대구경북과학기술원 | 다채널 박막전극을 이용한 전기적 생체분자 이동방법 |
| US11180804B2 (en) | 2017-07-25 | 2021-11-23 | Massachusetts Institute Of Technology | In situ ATAC sequencing |
| EP3668998A1 (de) | 2017-10-06 | 2020-06-24 | Cartana AB | Rna-template-ligation |
| KR102200618B1 (ko) * | 2018-01-12 | 2021-01-08 | 재단법인대구경북과학기술원 | 설포베타인계 쯔비터이온성 계면활성제를 포함하는 생물학적 분자의 조직침투용 조성물 및 이의 용도 |
| WO2019078655A1 (ko) * | 2017-10-19 | 2019-04-25 | 재단법인대구경북과학기술원 | 설포베타인계 쯔비터이온성 계면활성제를 포함하는 생물학적 분자의 조직침투용 조성물 및 이의 용도 |
| US10488307B2 (en) * | 2017-12-12 | 2019-11-26 | Dignity Health | Systems, devices, and methods for improved tissue treatment |
| KR102050248B1 (ko) * | 2017-12-29 | 2019-11-29 | 연세대학교 산학협력단 | 조직 투명도 분석 방법 |
| CN107966477A (zh) * | 2018-01-22 | 2018-04-27 | 哈尔滨工业大学 | 一种生物敏感元件 |
| WO2019156957A1 (en) | 2018-02-06 | 2019-08-15 | Massachusetts Institute Of Technology | Swellable and structurally homogenous hydrogels and methods of use thereof |
| WO2020011735A2 (en) | 2018-07-09 | 2020-01-16 | Universität Zürich | Systems, apparatuses, and methods for preparation of tissue samples |
| SG11202101934SA (en) | 2018-07-30 | 2021-03-30 | Readcoor Llc | Methods and systems for sample processing or analysis |
| KR102151128B1 (ko) * | 2018-08-24 | 2020-09-02 | 주식회사 바이나리 | 질소 가스 가압식 조직 투명화 및 항체 침투 증진용 장치 |
| WO2020044978A1 (ja) * | 2018-08-29 | 2020-03-05 | 国立研究開発法人物質・材料研究機構 | 測定装置、及び、評価方法 |
| KR102368585B1 (ko) * | 2018-09-28 | 2022-03-03 | 서울대학교산학협력단 | 온도에 따라 가역적 팽창/초기화가 가능한 하이드로젤을 이용한 생체조직 이미징 |
| US11435302B2 (en) * | 2018-11-13 | 2022-09-06 | The Trustees Of Princeton University | X-ray assisted electron microscopy staining procedure |
| GB201818567D0 (en) * | 2018-11-14 | 2018-12-26 | Francis Crick Institute Ltd | Composition |
| CN109612811A (zh) * | 2018-12-26 | 2019-04-12 | 华中科技大学苏州脑空间信息研究院 | 一种保护生物组织结构和荧光的水凝胶包埋方法 |
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| US10545075B2 (en) | 2020-01-28 |
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| EP2883030B1 (de) | 2022-08-31 |
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| EP2883030A1 (de) | 2015-06-17 |
| KR20150043241A (ko) | 2015-04-22 |
| US20210215581A1 (en) | 2021-07-15 |
| US20170219465A1 (en) | 2017-08-03 |
| JP6228205B2 (ja) | 2017-11-08 |
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