IL68561A - Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof - Google Patents

Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof

Info

Publication number
IL68561A
IL68561A IL68561A IL6856183A IL68561A IL 68561 A IL68561 A IL 68561A IL 68561 A IL68561 A IL 68561A IL 6856183 A IL6856183 A IL 6856183A IL 68561 A IL68561 A IL 68561A
Authority
IL
Israel
Prior art keywords
polypeptide
dna
processes
preparation
making
Prior art date
Application number
IL68561A
Other languages
English (en)
Other versions
IL68561A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27409206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL68561(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/483,052 external-priority patent/US4766075A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL68561A0 publication Critical patent/IL68561A0/xx
Publication of IL68561A publication Critical patent/IL68561A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL68561A 1982-05-05 1983-05-03 Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof IL68561A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37486082A 1982-05-05 1982-05-05
US39800382A 1982-07-14 1982-07-14
US06/483,052 US4766075A (en) 1982-07-14 1983-04-07 Human tissue plasminogen activator

Publications (2)

Publication Number Publication Date
IL68561A0 IL68561A0 (en) 1983-09-30
IL68561A true IL68561A (en) 1991-01-31

Family

ID=27409206

Family Applications (1)

Application Number Title Priority Date Filing Date
IL68561A IL68561A (en) 1982-05-05 1983-05-03 Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof

Country Status (26)

Country Link
EP (1) EP0093619B2 (no)
JP (2) JPH0216981A (no)
AR (1) AR241654A1 (no)
BG (1) BG60253B2 (no)
BR (1) BR8302318A (no)
CA (1) CA1293211C (no)
CS (1) CS248705B2 (no)
CY (1) CY1341A (no)
DD (1) DD210303A5 (no)
DE (3) DE93619T1 (no)
DK (1) DK174236B1 (no)
ES (1) ES8501629A1 (no)
FR (1) FR2526443B1 (no)
GB (1) GB2119804B (no)
GR (1) GR79202B (no)
HK (1) HK88586A (no)
IE (1) IE54975B1 (no)
IL (1) IL68561A (no)
KE (1) KE3647A (no)
MY (1) MY8700119A (no)
NO (2) NO831575L (no)
OA (1) OA07419A (no)
PL (1) PL152438B1 (no)
PT (1) PT76636B (no)
RO (1) RO90639B (no)
ZW (1) ZW10483A1 (no)

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GR79202B (no) * 1982-05-05 1984-10-22 Genentech Inc
GB2138824B (en) * 1982-10-29 1986-12-31 Mitsui Toatsu Chemicals Novel plasminogen activator process for its preparation and thrombolytic drug containing the same
US5011795A (en) * 1983-01-19 1991-04-30 Genentech, Inc. Human tPA production using vectors coding for DHFR protein
US4713339A (en) * 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
IE56716B1 (en) * 1983-01-19 1991-11-20 Genentech Inc Method for producing human tpa and expression vectors therefor
AU2353384A (en) * 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US5010002A (en) * 1983-01-19 1991-04-23 Genentech, Inc. Human t-PA production using vectors coding DHFR protein
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
DD229151A5 (de) * 1983-11-21 1985-10-30 Ciba Geigy Ag Verfahren zur herstellung von gewebeplasminogenaktivatoren
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
JP2648301B2 (ja) * 1983-12-27 1997-08-27 ジエネテイツクス・インスチチユ−ト・インコ−ポレ−テツド 真核細胞の形質転換のための補助ｄｎａを含むベクター
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US4916071A (en) 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
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ES8106836A2 (es) * 1979-07-27 1981-10-01 Fabre Sa Pierre Procedimiento de obtencion de un activador del plasminogeno
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
KR840004781A (ko) * 1982-05-05 1984-10-24 월터 에이치·드레거 인체의 조직 플라스미노겐 활성화제
GR79202B (no) * 1982-05-05 1984-10-22 Genentech Inc

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EP0093619A1 (en) 1983-11-09
ES522085A0 (es) 1984-12-16
IE831024L (en) 1983-11-05
ES8501629A1 (es) 1984-12-16
ZW10483A1 (en) 1983-09-21
JPH0216981A (ja) 1990-01-19
BG60253B1 (bg) 1994-03-24
DK174236B1 (da) 2002-10-07
DK198883D0 (da) 1983-05-04
GB2119804A (en) 1983-11-23
NO831575L (no) 1983-11-07
HK88586A (en) 1986-11-28
JPH05137583A (ja) 1993-06-01
GB8312221D0 (en) 1983-06-08
FR2526443B1 (fr) 1985-12-06
FR2526443A1 (fr) 1983-11-10
KE3647A (en) 1986-07-25
PL152438B1 (en) 1990-12-31
DE3316297A1 (de) 1983-11-17
IL68561A0 (en) 1983-09-30
MY8700119A (en) 1987-12-31
GR79202B (no) 1984-10-22
IE54975B1 (en) 1990-04-11
DE3380567D1 (en) 1989-10-19
EP0093619B1 (en) 1989-09-13
BR8302318A (pt) 1984-01-10
PT76636A (en) 1983-06-01
DD210303A5 (de) 1984-06-06
AR241654A1 (es) 1992-10-30
CA1293211C (en) 1991-12-17
CS248705B2 (en) 1987-02-12
CY1341A (en) 1987-01-16
EP0093619B2 (en) 1996-09-18
RO90639A (ro) 1987-01-30
PT76636B (en) 1986-01-10
AU1414283A (en) 1983-11-10
JP2564444B2 (ja) 1996-12-18
DE3316297C2 (no) 1989-09-21
PL241805A1 (en) 1984-07-30
DE93619T1 (de) 1987-08-13
BG60253B2 (bg) 1994-03-24
OA07419A (fr) 1984-11-30
JPH0448440B2 (no) 1992-08-06
AU563031B2 (en) 1987-06-25
RO90639B (ro) 1987-01-31
GB2119804B (en) 1986-02-26
DK198883A (da) 1983-12-20
NO852065L (no) 1983-11-07

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