ES8106836A2 - Procedimiento de obtencion de un activador del plasminogeno - Google Patents

Procedimiento de obtencion de un activador del plasminogeno

Info

Publication number
ES8106836A2
ES8106836A2 ES494343A ES49434380A ES8106836A2 ES 8106836 A2 ES8106836 A2 ES 8106836A2 ES 494343 A ES494343 A ES 494343A ES 49434380 A ES49434380 A ES 49434380A ES 8106836 A2 ES8106836 A2 ES 8106836A2
Authority
ES
Spain
Prior art keywords
activator
plasminogen activator
medicine
improved method
fibrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494343A
Other languages
English (en)
Other versions
ES494343A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7919432A external-priority patent/FR2462165A2/fr
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Publication of ES8106836A2 publication Critical patent/ES8106836A2/es
Publication of ES494343A0 publication Critical patent/ES494343A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE UN ACTIVADOR TISULAR DEL PLASMINOGENO (CERTIFICADO DE ADICION DE LA PATENTE NUM. 432.404). CONSISTE EN REALIZAR UNA ABSORCION SELECTIVA DEL ACTIVADOR, SOBRE UN SOPORTE CONSTITUIDO POR FRAGMENTOS SOLUBLES DE FIBRINA FIJADOS CON COVALENCIA SOBRE UNA MATRIZ INSOLUBLE, Y POSTERIOR ELUCION DEL ACTIVADOR ABSORBIDO. COMO MATRIZ INSOLUBLE SE UTILIZA UN POLIMERO DE DEXTRANO ACTIVADO POR BROMURO DE CIANOGENO O POR UN VIDRIO POROSO. LA ABSORCION DEL ACTIVADOR SE REALIZA EN UNA SOLUCION ACUOSA DE PH COMPRNDIDO ENTRE 6 Y 8, Y LA ELUCION DEL MISMO SE EFECTUA POR LA PUESTA EN CONTACTO DEL SOPORTE CON UNA SOLUCION ACUOSA DE PH ENTRE 3 Y 5.
ES1980494343A 1979-07-27 1980-07-24 Procedimiento de obtencion de un activador del plasminogeno Granted ES494343A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7919432A FR2462165A2 (fr) 1973-12-03 1979-07-27 Procede perfectionne de preparation d'activateur du plasminogene

Publications (2)

Publication Number Publication Date
ES8106836A2 true ES8106836A2 (es) 1981-10-01
ES494343A0 ES494343A0 (es) 1981-10-01

Family

ID=9228380

Family Applications (1)

Application Number Title Priority Date Filing Date
ES1980494343A Granted ES494343A0 (es) 1979-07-27 1980-07-24 Procedimiento de obtencion de un activador del plasminogeno

Country Status (7)

Country Link
US (1) US4314994A (es)
EP (1) EP0023860B1 (es)
JP (1) JPS5620596A (es)
AT (1) ATE2090T1 (es)
CA (1) CA1154671A (es)
DE (1) DE3061429D1 (es)
ES (1) ES494343A0 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2121050B (en) * 1979-07-05 1986-03-26 Genentech Inc Preparation of functional human urokinase proteins
FR2483234A2 (fr) * 1980-05-29 1981-12-04 Fabre Sa Pierre Composition ophtalmique contenant un activateur du plasminogene
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
FI831484L (fi) 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
US4853330A (en) * 1983-04-07 1989-08-01 Genentech, Inc. Human tissue plasminogen activator
DE3348289C2 (de) * 1982-05-05 1994-05-05 Genentech Inc Verfahren zur Herstellung von Human-Gewebe-Plasminogen-Aktivator
MX197183A (es) * 1982-05-05 1994-02-28 Genentech Inc Activador de plasminogeno de tejido humano
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
DE3382389D1 (de) * 1982-12-14 1991-10-02 South African Inventions Plasminogenaktivator.
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
AT391812B (de) * 1985-05-28 1990-12-10 Wellcome Found Verfahren zur herstellung einer parenteralen t-pa-loesung
US4929560A (en) * 1988-02-03 1990-05-29 Damon Biotech, Inc. Recovery of tissue plasminogen activator
US6207151B1 (en) * 1989-09-21 2001-03-27 Mitsui Chemicals Inc. Aqueous solution of t-PA

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (es) * 1973-12-03 1977-11-04 Fabre Sa Pierre
FR2347048A2 (fr) * 1976-04-07 1977-11-04 Choay Sa Compositions constituees par des composes du type plasminogene, notamment d'origine placentaire, procede d'obtention des ces compositions, et medicaments contenant ces compositions
FR2310133A2 (fr) * 1975-05-05 1976-12-03 Fabre Sa Pierre Nouveau medicament comportant un activateur du plasminogene perfectionne

Also Published As

Publication number Publication date
ATE2090T1 (de) 1983-01-15
EP0023860B1 (fr) 1982-12-22
CA1154671A (fr) 1983-10-04
DE3061429D1 (en) 1983-01-27
JPS5620596A (en) 1981-02-26
US4314994A (en) 1982-02-09
EP0023860A3 (en) 1981-02-18
EP0023860A2 (fr) 1981-02-11
ES494343A0 (es) 1981-10-01

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