DK149786A - Proteolytisk enzym - Google Patents

Proteolytisk enzym Download PDF

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Publication number
DK149786A
DK149786A DK149786A DK149786A DK149786A DK 149786 A DK149786 A DK 149786A DK 149786 A DK149786 A DK 149786A DK 149786 A DK149786 A DK 149786A DK 149786 A DK149786 A DK 149786A
Authority
DK
Denmark
Prior art keywords
enzym
proteolytic
proteolytic enzym
Prior art date
Application number
DK149786A
Other languages
English (en)
Other versions
DK149786D0 (da
Inventor
Jeffery Hugh Robinson
Michael Joseph Browne
Arthur William Russell Tyrrell
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858508972A external-priority patent/GB8508972D0/en
Priority claimed from GB868604852A external-priority patent/GB8604852D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of DK149786D0 publication Critical patent/DK149786D0/da
Publication of DK149786A publication Critical patent/DK149786A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DK149786A 1985-04-04 1986-04-02 Proteolytisk enzym DK149786A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858508972A GB8508972D0 (en) 1985-04-04 1985-04-04 Compounds
GB868604852A GB8604852D0 (en) 1986-02-27 1986-02-27 Compounds

Publications (2)

Publication Number Publication Date
DK149786D0 DK149786D0 (da) 1986-04-02
DK149786A true DK149786A (da) 1986-10-04

Family

ID=26289098

Family Applications (1)

Application Number Title Priority Date Filing Date
DK149786A DK149786A (da) 1985-04-04 1986-04-02 Proteolytisk enzym

Country Status (6)

Country Link
EP (1) EP0207589A1 (da)
DK (1) DK149786A (da)
ES (5) ES8801374A1 (da)
GR (1) GR860875B (da)
NZ (1) NZ215660A (da)
PT (1) PT82326B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3687651T2 (de) * 1985-12-20 1993-06-24 Upjohn Co Analoge des gewebespezifischen plasminogenaktivators.
US5106741A (en) * 1985-12-20 1992-04-21 The Upjohn Company Tissue plasminogen activator (TPA) analogs
US5837518A (en) * 1986-01-31 1998-11-17 Genetics Institute, Inc. Thrombolytic proteins
US5258298A (en) * 1986-01-31 1993-11-02 Genetics Institute, Inc. Deletion and glycosylation mutant of human tissue plasminogen activator
US5002887A (en) * 1986-01-31 1991-03-26 Genetics Institute, Inc. Truncated thrombolytic proteins
EP0234051B1 (en) * 1986-02-17 1991-12-11 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Tissue-type plasminogen activator mutants; recombinant genetic information coding therefor and process for preparing said mutants; their use and pharmaceutical compositions
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
PT84588B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
PT84587B (pt) * 1986-04-02 1989-11-30 Beecham Group Plc Processo para preparacao de uma enzima fibrinolitica
DE3643158A1 (de) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung
EP0266032A1 (en) * 1986-08-29 1988-05-04 Beecham Group Plc Modified fibrinolytic enzyme
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
GB8701811D0 (en) * 1987-01-28 1987-03-04 Beecham Group Plc Compounds
JP2983997B2 (ja) * 1987-01-30 1999-11-29 アメリカン・ホーム・プロダクツ・コーポレイション 脱―表皮細胞成長因子プラスミノーゲンアクチベーター
NL8701021A (nl) * 1987-04-29 1988-11-16 Stichting Centraal Lab Humane t-pa(u-pa) substitutie-mutant eiwitten, daarvoor coderend recombinant dna, getransfecteerde gastheercellen, bereiding van de mutant eiwitten, en farmaceutische preparaten.
ES2058180T3 (es) * 1987-06-04 1994-11-01 Zymogenetics Inc T-pa mutante con reemplazo de kringle.
FI101306B (fi) * 1987-06-04 1998-05-29 Zymogenetics Inc Menetelmä kudostyyppisen plasminogeeniaktivaattorin analogien, joissa on muokatut kasvutekijädomeenit, valmistamiseksi
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
AU613942B2 (en) * 1987-06-30 1991-08-15 Genentech Inc. Improved processes for the treatment of vascular disease
EP0365597B2 (en) * 1987-06-30 2005-02-09 Genentech, Inc. Improved processes for the treatment of vascular disease
WO1989000191A1 (en) * 1987-07-06 1989-01-12 Genetics Institute, Inc. Novel thrombolytic proteins
GB8721023D0 (en) * 1987-09-07 1987-10-14 Lepetit Spa Modified plasminogen activators
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5037646A (en) * 1988-04-29 1991-08-06 Genentech, Inc. Processes for the treatment of vascular disease
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
PT786257E (pt) * 1992-06-03 2003-12-31 Genentech Inc Variantes de glicosilacao do activador de plasminogenio tissular com propriedades terapeuticas meloradas
GB9614871D0 (en) 1996-07-15 1996-09-04 Smithkline Beecham Plc Compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
AU572108B2 (en) * 1983-01-19 1988-05-05 Genentech Inc. Human tpa production using vectors coding for dhfr protein

Also Published As

Publication number Publication date
PT82326A (en) 1986-05-01
DK149786D0 (da) 1986-04-02
ES8801551A1 (es) 1987-12-16
ES8801374A1 (es) 1988-01-01
ES553651A0 (es) 1988-01-01
GR860875B (en) 1986-07-29
ES557675A0 (es) 1987-12-16
ES557674A0 (es) 1988-06-01
EP0207589A1 (en) 1987-01-07
ES8801552A1 (es) 1987-12-16
ES8802537A1 (es) 1988-07-16
AU5551486A (en) 1986-10-09
PT82326B (pt) 1988-10-14
ES8802442A1 (es) 1988-06-01
AU596093B2 (en) 1990-04-26
ES557677A0 (es) 1987-12-16
NZ215660A (en) 1990-03-27
ES557676A0 (es) 1988-07-16

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Legal Events

Date Code Title Description
PBP Patent lapsed
AHB Application shelved due to non-payment