IL225281A0 - Pro-drug ester of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]methanol Intraocular pressure lowering - Google Patents
Pro-drug ester of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]methanol Intraocular pressure loweringInfo
- Publication number
- IL225281A0 IL225281A0 IL225281A IL22528113A IL225281A0 IL 225281 A0 IL225281 A0 IL 225281A0 IL 225281 A IL225281 A IL 225281A IL 22528113 A IL22528113 A IL 22528113A IL 225281 A0 IL225281 A0 IL 225281A0
- Authority
- IL
- Israel
- Prior art keywords
- imidazol
- methylphenyl
- drugs
- methanol
- ethyl
- Prior art date
Links
- HTQCEFAVROSRIW-UHFFFAOYSA-N [3-[1-(1h-imidazol-5-yl)ethyl]-2-methylphenyl]methanol Chemical compound C=1C=CC(CO)=C(C)C=1C(C)C1=CNC=N1 HTQCEFAVROSRIW-UHFFFAOYSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 230000004410 intraocular pressure Effects 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38337010P | 2010-09-16 | 2010-09-16 | |
| PCT/US2011/051990 WO2012037490A1 (en) | 2010-09-16 | 2011-09-16 | Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for lowering intraocular pressure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL225281A0 true IL225281A0 (en) | 2013-06-27 |
Family
ID=44675870
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL225281A IL225281A0 (en) | 2010-09-16 | 2013-03-17 | Pro-drug ester of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]methanol Intraocular pressure lowering |
| IL225280A IL225280A0 (en) | 2010-09-16 | 2013-03-17 | A prodrug ester of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]methanol for the treatment of skin diseases and conditions |
| IL225278A IL225278A (en) | 2010-09-16 | 2013-03-17 | Aster drugs of [3 - (1 - (1h - imidazole-4-yl) ethyl) 2-methylphenyl] methanol |
| IL225282A IL225282A0 (en) | 2010-09-16 | 2013-03-17 | Prodrug ester of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]methanol for the treatment of retinal diseases |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL225280A IL225280A0 (en) | 2010-09-16 | 2013-03-17 | A prodrug ester of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]methanol for the treatment of skin diseases and conditions |
| IL225278A IL225278A (en) | 2010-09-16 | 2013-03-17 | Aster drugs of [3 - (1 - (1h - imidazole-4-yl) ethyl) 2-methylphenyl] methanol |
| IL225282A IL225282A0 (en) | 2010-09-16 | 2013-03-17 | Prodrug ester of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]methanol for the treatment of retinal diseases |
Country Status (28)
| Country | Link |
|---|---|
| US (9) | US8492422B2 (enExample) |
| EP (13) | EP3078376B1 (enExample) |
| JP (4) | JP2013537236A (enExample) |
| KR (7) | KR101952457B1 (enExample) |
| CN (5) | CN103209694A (enExample) |
| AR (4) | AR083019A1 (enExample) |
| AU (4) | AU2011301856C1 (enExample) |
| BR (4) | BR112013006362A2 (enExample) |
| CA (8) | CA2812197C (enExample) |
| CL (4) | CL2013000733A1 (enExample) |
| CY (3) | CY1121024T1 (enExample) |
| DK (9) | DK3078376T3 (enExample) |
| ES (10) | ES2781681T3 (enExample) |
| HU (5) | HUE048725T2 (enExample) |
| IL (4) | IL225281A0 (enExample) |
| MX (4) | MX2013003002A (enExample) |
| MY (4) | MY191369A (enExample) |
| NZ (1) | NZ608751A (enExample) |
| PL (7) | PL3050563T3 (enExample) |
| PT (7) | PT3348264T (enExample) |
| RU (4) | RU2612351C2 (enExample) |
| SG (4) | SG188573A1 (enExample) |
| SI (5) | SI3348264T1 (enExample) |
| TR (1) | TR201909249T4 (enExample) |
| TW (4) | TW201240662A (enExample) |
| UA (1) | UA112973C2 (enExample) |
| WO (4) | WO2012037484A1 (enExample) |
| ZA (4) | ZA201302193B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3566703B1 (en) * | 2009-02-13 | 2021-04-07 | Allergan, Inc. | Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol |
| CN102724878A (zh) | 2010-01-11 | 2012-10-10 | 奥雷西根治疗公司 | 在重度抑郁症患者中提供体重减轻疗法的方法 |
| US8492422B2 (en) * | 2010-09-16 | 2013-07-23 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions |
| AU2012287243A1 (en) * | 2011-07-22 | 2014-02-20 | Allergan, Inc. | Alpha-2 adrenergic modulators for treating visual disorders mediated by central visual projections from the eye |
| CA2856507C (en) | 2011-11-21 | 2017-03-21 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| USD794650S1 (en) | 2014-11-28 | 2017-08-15 | Samsung Electronics Co., Ltd. | Display screen or portion thereof with a graphical user interface |
| CN108310442B (zh) * | 2017-01-17 | 2021-08-27 | 台北科技大学 | 眼科用组合物 |
| KR102050506B1 (ko) | 2017-06-20 | 2019-11-29 | 한국식품연구원 | 망막 질환 예방, 개선, 완화 또는 치료용 조성물 |
| CN108872431B (zh) * | 2018-07-09 | 2021-03-23 | 成都倍特药业股份有限公司 | 一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法 |
| JP7584802B2 (ja) * | 2018-08-24 | 2024-11-18 | アドライ・ノーティ・バイオファーマ・カンパニー・リミテッド | 高活性ｓｔｉｎｇタンパク質アゴニスト |
| BR112023021140A2 (pt) * | 2021-04-16 | 2023-12-12 | Ads Therapeutics Llc | Cofármaco compreendendo uma fração de agonista muscarínico e uma fração de agonista alfa2 adrenérgico, ou um sal farmacêutico deste, composição farmacêutica e formulação farmacêutica |
| WO2024167962A1 (en) * | 2023-02-08 | 2024-08-15 | Whitecap Biosciences Llc | Alpha-2-adrenergic agonists for improving vision |
| WO2025179071A1 (en) * | 2024-02-20 | 2025-08-28 | Bausch + Lomb Ireland Limited | Sustained-release drug delivery compositions for treating ocular diseases |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2098739T3 (es) | 1992-05-13 | 1997-05-01 | Sandoz Ltd | Composiciones oftalmicas conteniendo una cyclosporin. |
| US5459133A (en) * | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| EP0729459B1 (en) | 1993-11-15 | 2003-03-12 | Schering Corporation | Phenyl-alkyl imidazoles as h3-receptor antagonists |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| EP0957073A1 (en) * | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
| US20040214829A1 (en) * | 2000-07-14 | 2004-10-28 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US20020198209A1 (en) | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
| ATE403649T1 (de) * | 2003-05-27 | 2008-08-15 | Sod Conseils Rech Applic | Neue imidazolderivative, deren herstellung und deren verwendung als medikament |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| WO2005006720A1 (en) * | 2003-07-14 | 2005-01-20 | Koninklijke Philips Electronics N.V. | Projection device |
| KR20060126448A (ko) * | 2003-09-12 | 2006-12-07 | 알러간, 인코포레이티드 | 통증 및 다른 알파 2 아드레날린 매개 증상을 치료하기위한 방법 및 조성물 |
| US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| DK1761266T3 (da) * | 2004-05-25 | 2013-08-05 | Galderma Pharma Sa | Forbindelser, formuleringer og fremgangsmåder til at behandle eller forebygge inflammatoriske hudsygdomme |
| US20050277584A1 (en) | 2004-06-09 | 2005-12-15 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| NZ553341A (en) | 2004-09-24 | 2010-11-26 | Allergan Inc | 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists |
| US7931909B2 (en) | 2005-05-10 | 2011-04-26 | Allergan, Inc. | Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates |
| US20070015691A1 (en) | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
| US7297679B2 (en) | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
| US20070082070A1 (en) * | 2005-10-11 | 2007-04-12 | Stookey Evangeline L | Treating skin disorders |
| US7902247B2 (en) | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
| JP2012517433A (ja) | 2009-02-06 | 2012-08-02 | アラーガン インコーポレイテッド | アルファ２ｂおよび／またはアルファ２ｃアドレナリンレセプターのサブタイプ選択的モジュレーターとしてのピリジン化合物 |
| EP3566703B1 (en) * | 2009-02-13 | 2021-04-07 | Allergan, Inc. | Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol |
| US8394800B2 (en) * | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| US8492422B2 (en) * | 2010-09-16 | 2013-07-23 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions |
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2011
- 2011-09-15 US US13/233,665 patent/US8492422B2/en active Active
- 2011-09-15 US US13/233,382 patent/US8653123B2/en active Active
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- 2011-09-15 US US13/233,844 patent/US8501796B2/en active Active
- 2011-09-16 RU RU2013116541A patent/RU2612351C2/ru active
- 2011-09-16 WO PCT/US2011/051979 patent/WO2012037484A1/en not_active Ceased
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- 2011-09-16 WO PCT/US2011/051990 patent/WO2012037490A1/en not_active Ceased
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- 2011-09-16 RU RU2013116403/15A patent/RU2013116403A/ru not_active Application Discontinuation
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- 2011-09-16 JP JP2013529371A patent/JP2013537236A/ja not_active Withdrawn
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- 2011-09-16 KR KR1020137009505A patent/KR20140005154A/ko not_active Withdrawn
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- 2011-09-16 CN CN2011800545690A patent/CN103221045A/zh active Pending
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- 2011-09-16 EP EP19217499.3A patent/EP3698789A1/en not_active Withdrawn
- 2011-09-16 BR BR112013006352A patent/BR112013006352A2/pt not_active IP Right Cessation
- 2011-09-16 CN CN201180053895XA patent/CN103200942A/zh active Pending
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- 2011-09-16 KR KR1020207021626A patent/KR102354097B1/ko active Active
- 2011-09-16 EP EP20153104.3A patent/EP3659600A1/en not_active Withdrawn
- 2011-09-16 BR BR112013006320-3A patent/BR112013006320B1/pt active IP Right Grant
- 2011-09-16 PL PL18157147T patent/PL3338777T3/pl unknown
- 2011-09-16 AR ARP110103389A patent/AR083017A1/es not_active Application Discontinuation
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- 2011-09-16 KR KR1020207011231A patent/KR102139905B1/ko active Active
- 2011-09-16 EP EP11760962.8A patent/EP2616068B1/en active Active
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