BR112023021140A2 - Cofármaco compreendendo uma fração de agonista muscarínico e uma fração de agonista alfa2 adrenérgico, ou um sal farmacêutico deste, composição farmacêutica e formulação farmacêutica - Google Patents
Cofármaco compreendendo uma fração de agonista muscarínico e uma fração de agonista alfa2 adrenérgico, ou um sal farmacêutico deste, composição farmacêutica e formulação farmacêuticaInfo
- Publication number
- BR112023021140A2 BR112023021140A2 BR112023021140A BR112023021140A BR112023021140A2 BR 112023021140 A2 BR112023021140 A2 BR 112023021140A2 BR 112023021140 A BR112023021140 A BR 112023021140A BR 112023021140 A BR112023021140 A BR 112023021140A BR 112023021140 A2 BR112023021140 A2 BR 112023021140A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical
- fraction
- agonist
- copharmaco
- muscarinic
- Prior art date
Links
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 title abstract 4
- 239000000472 muscarinic agonist Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 3
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
cofármaco compreendendo uma fração de agonista muscarínico e uma fração de agonista alfa2 adrenérgico, ou um sal farmacêutico deste, composição farmacêutica e formulação farmacêutica. um cofármaco ou um sal farmacêutico deste inclui uma fração de agonista muscarínico e uma fração de agonista alfa2 adrenérgico. a fração de agonista muscarínico e a fração de agonista alfa2 adrenérgico são conectadas covalentemente por meio de um ligante, e a ligação inclui um ligação de éster, uma ligação de amida, uma ligação de carbamato, ou uma combinação destes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163176149P | 2021-04-16 | 2021-04-16 | |
US202163272134P | 2021-10-26 | 2021-10-26 | |
PCT/US2022/022835 WO2022221071A1 (en) | 2021-04-16 | 2022-03-31 | Alpha2 adrenergic agonist codrugs conjugated with muscarinic agonist drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023021140A2 true BR112023021140A2 (pt) | 2023-12-12 |
Family
ID=83639682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023021140A BR112023021140A2 (pt) | 2021-04-16 | 2022-03-31 | Cofármaco compreendendo uma fração de agonista muscarínico e uma fração de agonista alfa2 adrenérgico, ou um sal farmacêutico deste, composição farmacêutica e formulação farmacêutica |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP4322943A1 (pt) |
JP (1) | JP2024514870A (pt) |
KR (1) | KR20230172529A (pt) |
AU (1) | AU2022258105A1 (pt) |
BR (1) | BR112023021140A2 (pt) |
CA (1) | CA3214876A1 (pt) |
WO (1) | WO2022221071A1 (pt) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8765177B2 (en) * | 1997-09-12 | 2014-07-01 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
GB0516313D0 (en) * | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
WO2009117042A1 (en) * | 2008-03-21 | 2009-09-24 | Adlyfe, Inc. | Use of pyrene to carry non-peptide agents across the blood brain barrier |
US8492422B2 (en) * | 2010-09-16 | 2013-07-23 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions |
-
2022
- 2022-03-31 KR KR1020237039067A patent/KR20230172529A/ko unknown
- 2022-03-31 JP JP2023562870A patent/JP2024514870A/ja active Pending
- 2022-03-31 EP EP22788647.0A patent/EP4322943A1/en active Pending
- 2022-03-31 AU AU2022258105A patent/AU2022258105A1/en active Pending
- 2022-03-31 CA CA3214876A patent/CA3214876A1/en active Pending
- 2022-03-31 BR BR112023021140A patent/BR112023021140A2/pt unknown
- 2022-03-31 WO PCT/US2022/022835 patent/WO2022221071A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP4322943A1 (en) | 2024-02-21 |
JP2024514870A (ja) | 2024-04-03 |
WO2022221071A1 (en) | 2022-10-20 |
AU2022258105A1 (en) | 2023-10-26 |
KR20230172529A (ko) | 2023-12-22 |
CA3214876A1 (en) | 2022-10-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Barman et al. | Amino acid conjugated polymers: antibacterial agents effective against drug-resistant Acinetobacter baumannii with no detectable resistance | |
Nahrwold et al. | Conjugates of modified cryptophycins and RGD-peptides enter target cells by endocytosis | |
Puthenveetil et al. | Natural product splicing inhibitors: a new class of antibody–drug conjugate (ADC) payloads | |
Lajiness et al. | Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation | |
MA38289A1 (fr) | Composition pharmaceutique à biodisponibilité ameliorée | |
US7176185B2 (en) | Short peptide carrier system for cellular delivery of agent | |
US10350217B2 (en) | Antifungal agents and uses thereof | |
MA35153B1 (fr) | Immunoconjugués, compositions les contenant, et procédés de préparation et d'utilisation correspondants | |
Sharma et al. | Discovery of a membrane-active, ring-modified histidine containing ultrashort amphiphilic peptide that exhibits potent inhibition of Cryptococcus neoformans | |
EA202091135A1 (ru) | Гидрофильные линкеры для конъюгатов антитело-лекарственное средство | |
BRPI0316732B8 (pt) | composto derivado de 3-aminopirrolidina e sua composição farmacêutica | |
Steinbuch et al. | Increased degree of unsaturation in the lipid of antifungal cationic amphiphiles facilitates selective fungal cell disruption | |
Leitheiser et al. | Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library | |
BR112022013255A2 (pt) | Conjugados anticorpo-fármaco específicos de sítio com ligantes contendo peptídeo | |
BR112023021140A2 (pt) | Cofármaco compreendendo uma fração de agonista muscarínico e uma fração de agonista alfa2 adrenérgico, ou um sal farmacêutico deste, composição farmacêutica e formulação farmacêutica | |
Sarkar et al. | Alkyl-aryl-vancomycins: multimodal glycopeptides with weak dependence on the bacterial metabolic state | |
Tovillas et al. | Tn antigen mimics by ring-opening of chiral cyclic sulfamidates with carbohydrate C1-S-and C1-O-nucleophiles | |
Chen et al. | Enantioselective synthesis of the R-enantiomer of the feeding deterrent (S)-Ypaoamide | |
MiáJeon et al. | Camptothecin delivery into hepatoma cell line by galactose-appended fluorescent drug delivery system | |
ECSP22027784A (es) | Derivados de 2azaespiro[3.4]octano como agonistas de m4 | |
Mandler et al. | Modifications in synthesis strategy improve the yield and efficacy of geldanamycin− herceptin immunoconjugates | |
DE60203491D1 (de) | Shiga-Toxin-Untereinheit B als Vektor zur Diagnose von Tumoren und zur Arzneimittelverabreichung an GB3-exprimierenden Tumoren | |
Pettit et al. | Antineoplastic agents. 605. isoquinstatins | |
Gutman et al. | Discovery of dolastatinol: A synthetic analog of dolastatin 10 and low nanomolar inhibitor of tubulin polymerization | |
Liu et al. | Investigation of the relative cellular permeability of DNA-binding pyrrole− imidazole polyamides |