ES2781681T3 - Profármacos de ésteres de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]-metanol para reducir la presión intraocular - Google Patents
Profármacos de ésteres de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]-metanol para reducir la presión intraocular Download PDFInfo
- Publication number
- ES2781681T3 ES2781681T3 ES18160174T ES18160174T ES2781681T3 ES 2781681 T3 ES2781681 T3 ES 2781681T3 ES 18160174 T ES18160174 T ES 18160174T ES 18160174 T ES18160174 T ES 18160174T ES 2781681 T3 ES2781681 T3 ES 2781681T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- intraocular pressure
- ethyl
- use according
- imidazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000004410 intraocular pressure Effects 0.000 title claims abstract 12
- HTQCEFAVROSRIW-UHFFFAOYSA-N [3-[1-(1h-imidazol-5-yl)ethyl]-2-methylphenyl]methanol Chemical class C=1C=CC(CO)=C(C)C=1C(C)C1=CNC=N1 HTQCEFAVROSRIW-UHFFFAOYSA-N 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 22
- 239000000203 mixture Substances 0.000 claims abstract 11
- 150000003839 salts Chemical class 0.000 claims abstract 7
- 150000004677 hydrates Chemical class 0.000 claims abstract 4
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000012453 solvate Substances 0.000 claims abstract 4
- 150000002148 esters Chemical class 0.000 claims abstract 3
- 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 3
- 239000008177 pharmaceutical agent Substances 0.000 claims 4
- 239000005022 packaging material Substances 0.000 claims 3
- 239000003755 preservative agent Substances 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- -1 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl ester Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 C[C@](*1c[n]cn1)c1c(C)c(C)ccc1 Chemical compound C[C@](*1c[n]cn1)c1c(C)c(C)ccc1 0.000 description 3
- NRIJNCQPNFQZAM-ZDUSSCGKSA-N C[C@H](c1c[nH]cn1)c1cccc(COC(C(C)(C)C)=O)c1C Chemical compound C[C@H](c1c[nH]cn1)c1cccc(COC(C(C)(C)C)=O)c1C NRIJNCQPNFQZAM-ZDUSSCGKSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38337010P | 2010-09-16 | 2010-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2781681T3 true ES2781681T3 (es) | 2020-09-04 |
Family
ID=44675870
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18160174T Active ES2781681T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de ésteres de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]-metanol para reducir la presión intraocular |
| ES11760962.8T Active ES2607084T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]-metanol para rebajar la presión intraocular |
| ES11760958.6T Active ES2593612T3 (es) | 2010-09-16 | 2011-09-16 | Pro-fármacos éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol para tratar enfermedades retinianas |
| ES18157147T Active ES2788051T3 (es) | 2010-09-16 | 2011-09-16 | Pro-fármacos éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol para tratar enfermedades retinianas |
| ES16161921T Active ES2737230T3 (es) | 2010-09-16 | 2011-09-16 | Pro-fármacos éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol para tratar enfermedades retinianas |
| ES19194325T Active ES2904479T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de ésteres de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol |
| ES16161923T Active ES2760920T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de ésteres de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol |
| ES11760963.6T Active ES2613509T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de ésteres de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol |
| ES16161920.0T Active ES2687420T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]-metanol para tratar enfermedades y afecciones de la piel |
| ES16161922.6T Active ES2684055T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]-metanol para reducir la presión intraocular |
Family Applications After (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11760962.8T Active ES2607084T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]-metanol para rebajar la presión intraocular |
| ES11760958.6T Active ES2593612T3 (es) | 2010-09-16 | 2011-09-16 | Pro-fármacos éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol para tratar enfermedades retinianas |
| ES18157147T Active ES2788051T3 (es) | 2010-09-16 | 2011-09-16 | Pro-fármacos éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol para tratar enfermedades retinianas |
| ES16161921T Active ES2737230T3 (es) | 2010-09-16 | 2011-09-16 | Pro-fármacos éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol para tratar enfermedades retinianas |
| ES19194325T Active ES2904479T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de ésteres de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol |
| ES16161923T Active ES2760920T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de ésteres de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol |
| ES11760963.6T Active ES2613509T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de ésteres de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol |
| ES16161920.0T Active ES2687420T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]-metanol para tratar enfermedades y afecciones de la piel |
| ES16161922.6T Active ES2684055T3 (es) | 2010-09-16 | 2011-09-16 | Profármacos de éster de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]-metanol para reducir la presión intraocular |
Country Status (28)
| Country | Link |
|---|---|
| US (9) | US8492422B2 (enExample) |
| EP (13) | EP3078376B1 (enExample) |
| JP (4) | JP2013537236A (enExample) |
| KR (7) | KR101952457B1 (enExample) |
| CN (5) | CN103209694A (enExample) |
| AR (4) | AR083019A1 (enExample) |
| AU (4) | AU2011301856C1 (enExample) |
| BR (4) | BR112013006362A2 (enExample) |
| CA (8) | CA2812197C (enExample) |
| CL (4) | CL2013000733A1 (enExample) |
| CY (3) | CY1121024T1 (enExample) |
| DK (9) | DK3078376T3 (enExample) |
| ES (10) | ES2781681T3 (enExample) |
| HU (5) | HUE048725T2 (enExample) |
| IL (4) | IL225281A0 (enExample) |
| MX (4) | MX2013003002A (enExample) |
| MY (4) | MY191369A (enExample) |
| NZ (1) | NZ608751A (enExample) |
| PL (7) | PL3050563T3 (enExample) |
| PT (7) | PT3348264T (enExample) |
| RU (4) | RU2612351C2 (enExample) |
| SG (4) | SG188573A1 (enExample) |
| SI (5) | SI3348264T1 (enExample) |
| TR (1) | TR201909249T4 (enExample) |
| TW (4) | TW201240662A (enExample) |
| UA (1) | UA112973C2 (enExample) |
| WO (4) | WO2012037484A1 (enExample) |
| ZA (4) | ZA201302193B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3566703B1 (en) * | 2009-02-13 | 2021-04-07 | Allergan, Inc. | Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol |
| CN102724878A (zh) | 2010-01-11 | 2012-10-10 | 奥雷西根治疗公司 | 在重度抑郁症患者中提供体重减轻疗法的方法 |
| US8492422B2 (en) * | 2010-09-16 | 2013-07-23 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions |
| AU2012287243A1 (en) * | 2011-07-22 | 2014-02-20 | Allergan, Inc. | Alpha-2 adrenergic modulators for treating visual disorders mediated by central visual projections from the eye |
| CA2856507C (en) | 2011-11-21 | 2017-03-21 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| USD794650S1 (en) | 2014-11-28 | 2017-08-15 | Samsung Electronics Co., Ltd. | Display screen or portion thereof with a graphical user interface |
| CN108310442B (zh) * | 2017-01-17 | 2021-08-27 | 台北科技大学 | 眼科用组合物 |
| KR102050506B1 (ko) | 2017-06-20 | 2019-11-29 | 한국식품연구원 | 망막 질환 예방, 개선, 완화 또는 치료용 조성물 |
| CN108872431B (zh) * | 2018-07-09 | 2021-03-23 | 成都倍特药业股份有限公司 | 一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法 |
| JP7584802B2 (ja) * | 2018-08-24 | 2024-11-18 | アドライ・ノーティ・バイオファーマ・カンパニー・リミテッド | 高活性ｓｔｉｎｇタンパク質アゴニスト |
| BR112023021140A2 (pt) * | 2021-04-16 | 2023-12-12 | Ads Therapeutics Llc | Cofármaco compreendendo uma fração de agonista muscarínico e uma fração de agonista alfa2 adrenérgico, ou um sal farmacêutico deste, composição farmacêutica e formulação farmacêutica |
| WO2024167962A1 (en) * | 2023-02-08 | 2024-08-15 | Whitecap Biosciences Llc | Alpha-2-adrenergic agonists for improving vision |
| WO2025179071A1 (en) * | 2024-02-20 | 2025-08-28 | Bausch + Lomb Ireland Limited | Sustained-release drug delivery compositions for treating ocular diseases |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2098739T3 (es) | 1992-05-13 | 1997-05-01 | Sandoz Ltd | Composiciones oftalmicas conteniendo una cyclosporin. |
| US5459133A (en) * | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| EP0729459B1 (en) | 1993-11-15 | 2003-03-12 | Schering Corporation | Phenyl-alkyl imidazoles as h3-receptor antagonists |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| EP0957073A1 (en) * | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
| US20040214829A1 (en) * | 2000-07-14 | 2004-10-28 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US20020198209A1 (en) | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
| ATE403649T1 (de) * | 2003-05-27 | 2008-08-15 | Sod Conseils Rech Applic | Neue imidazolderivative, deren herstellung und deren verwendung als medikament |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| WO2005006720A1 (en) * | 2003-07-14 | 2005-01-20 | Koninklijke Philips Electronics N.V. | Projection device |
| KR20060126448A (ko) * | 2003-09-12 | 2006-12-07 | 알러간, 인코포레이티드 | 통증 및 다른 알파 2 아드레날린 매개 증상을 치료하기위한 방법 및 조성물 |
| US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| DK1761266T3 (da) * | 2004-05-25 | 2013-08-05 | Galderma Pharma Sa | Forbindelser, formuleringer og fremgangsmåder til at behandle eller forebygge inflammatoriske hudsygdomme |
| US20050277584A1 (en) | 2004-06-09 | 2005-12-15 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| NZ553341A (en) | 2004-09-24 | 2010-11-26 | Allergan Inc | 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists |
| US7931909B2 (en) | 2005-05-10 | 2011-04-26 | Allergan, Inc. | Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates |
| US20070015691A1 (en) | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
| US7297679B2 (en) | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
| US20070082070A1 (en) * | 2005-10-11 | 2007-04-12 | Stookey Evangeline L | Treating skin disorders |
| US7902247B2 (en) | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
| JP2012517433A (ja) | 2009-02-06 | 2012-08-02 | アラーガン インコーポレイテッド | アルファ２ｂおよび／またはアルファ２ｃアドレナリンレセプターのサブタイプ選択的モジュレーターとしてのピリジン化合物 |
| EP3566703B1 (en) * | 2009-02-13 | 2021-04-07 | Allergan, Inc. | Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol |
| US8394800B2 (en) * | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| US8492422B2 (en) * | 2010-09-16 | 2013-07-23 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions |
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2011
- 2011-09-15 US US13/233,665 patent/US8492422B2/en active Active
- 2011-09-15 US US13/233,382 patent/US8653123B2/en active Active
- 2011-09-15 US US13/233,891 patent/US8492557B2/en active Active
- 2011-09-15 US US13/233,844 patent/US8501796B2/en active Active
- 2011-09-16 RU RU2013116541A patent/RU2612351C2/ru active
- 2011-09-16 WO PCT/US2011/051979 patent/WO2012037484A1/en not_active Ceased
- 2011-09-16 DK DK16161921.8T patent/DK3078376T3/da active
- 2011-09-16 MY MYPI2013000930A patent/MY191369A/en unknown
- 2011-09-16 ES ES18160174T patent/ES2781681T3/es active Active
- 2011-09-16 TW TW100133498A patent/TW201240662A/zh unknown
- 2011-09-16 CN CN2011800546049A patent/CN103209694A/zh active Pending
- 2011-09-16 CN CN201180053886.0A patent/CN103200941B/zh active Active
- 2011-09-16 MY MYPI2013000907A patent/MY173846A/en unknown
- 2011-09-16 EP EP16161921.8A patent/EP3078376B1/en active Active
- 2011-09-16 ES ES11760962.8T patent/ES2607084T3/es active Active
- 2011-09-16 HU HUE18157147A patent/HUE048725T2/hu unknown
- 2011-09-16 SG SG2013019591A patent/SG188573A1/en unknown
- 2011-09-16 EP EP11760958.6A patent/EP2616066B1/en active Active
- 2011-09-16 EP EP18160174.1A patent/EP3348264B1/en active Active
- 2011-09-16 HU HUE16161922A patent/HUE039090T2/hu unknown
- 2011-09-16 ES ES11760958.6T patent/ES2593612T3/es active Active
- 2011-09-16 SG SG2013019575A patent/SG188572A1/en unknown
- 2011-09-16 AU AU2011301856A patent/AU2011301856C1/en active Active
- 2011-09-16 TW TW100133487A patent/TW201305116A/zh unknown
- 2011-09-16 DK DK16161920.0T patent/DK3050563T3/en active
- 2011-09-16 CN CN201510767798.7A patent/CN105412092B/zh active Active
- 2011-09-16 DK DK11760962.8T patent/DK2616068T3/en active
- 2011-09-16 RU RU2013116763/15A patent/RU2013116763A/ru not_active Application Discontinuation
- 2011-09-16 AU AU2011301901A patent/AU2011301901B2/en active Active
- 2011-09-16 DK DK16161922.6T patent/DK3053576T3/en active
- 2011-09-16 TW TW100133491A patent/TWI591058B/zh active
- 2011-09-16 HU HUE18160174A patent/HUE049573T2/hu unknown
- 2011-09-16 BR BR112013006362A patent/BR112013006362A2/pt not_active IP Right Cessation
- 2011-09-16 AU AU2011301932A patent/AU2011301932C1/en active Active
- 2011-09-16 PL PL16161920T patent/PL3050563T3/pl unknown
- 2011-09-16 WO PCT/US2011/051990 patent/WO2012037490A1/en not_active Ceased
- 2011-09-16 PT PT181601741T patent/PT3348264T/pt unknown
- 2011-09-16 RU RU2013116403/15A patent/RU2013116403A/ru not_active Application Discontinuation
- 2011-09-16 CA CA2812197A patent/CA2812197C/en active Active
- 2011-09-16 HU HUE16161920A patent/HUE038698T2/hu unknown
- 2011-09-16 ES ES18157147T patent/ES2788051T3/es active Active
- 2011-09-16 CA CA2812191A patent/CA2812191C/en active Active
- 2011-09-16 AR ARP110103391A patent/AR083019A1/es unknown
- 2011-09-16 EP EP11760961.0A patent/EP2616067B1/en active Active
- 2011-09-16 UA UAA201304644A patent/UA112973C2/uk unknown
- 2011-09-16 PT PT181571472T patent/PT3338777T/pt unknown
- 2011-09-16 JP JP2013529371A patent/JP2013537236A/ja not_active Withdrawn
- 2011-09-16 ES ES16161921T patent/ES2737230T3/es active Active
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- 2011-09-16 EP EP16161923.4A patent/EP3050564B1/en active Active
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