HUE048725T2 - [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil] metanol észter elõvegyületei retina betegségek kezelésére - Google Patents

[3-(1-(1H-imidazol-4-il)etil)-2-metilfenil] metanol észter elõvegyületei retina betegségek kezelésére

Info

Publication number
HUE048725T2
HUE048725T2 HUE18157147A HUE18157147A HUE048725T2 HU E048725 T2 HUE048725 T2 HU E048725T2 HU E18157147 A HUE18157147 A HU E18157147A HU E18157147 A HUE18157147 A HU E18157147A HU E048725 T2 HUE048725 T2 HU E048725T2
Authority
HU
Hungary
Prior art keywords
imidazol
methylphenyl
drugs
methanol
ethyl
Prior art date
Application number
HUE18157147A
Other languages
English (en)
Hungarian (hu)
Inventor
Mohammed I Dibas
Daniel W Gil
Ken Chow
Liming Wang
Michael E Garst
John E Donello
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44675870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE048725(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of HUE048725T2 publication Critical patent/HUE048725T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUE18157147A 2010-09-16 2011-09-16 [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil] metanol észter elõvegyületei retina betegségek kezelésére HUE048725T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38337010P 2010-09-16 2010-09-16

Publications (1)

Publication Number Publication Date
HUE048725T2 true HUE048725T2 (hu) 2020-09-28

Family

ID=44675870

Family Applications (5)

Application Number Title Priority Date Filing Date
HUE18157147A HUE048725T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil] metanol észter elõvegyületei retina betegségek kezelésére
HUE16161922A HUE039090T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol észter pro-drogjai a szembelnyomás csökkentésére
HUE18160174A HUE049573T2 (hu) 2010-09-16 2011-09-16 3-[(S)-1-(1H-imidazol-4-il)-etil]-2-metilfenil]metanol észter elõvegyületei intraokuláris nyomás csökkentésére
HUE16161920A HUE038698T2 (hu) 2010-09-16 2011-09-16 [3-(l-(lH-imidazol-4-il)etil)-2-metilfenil]metanol észter elõvegyületei bõrbetegségek és állapotok kezelésére
HUE16161923A HUE047476T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1-(1H-imidazol-4-il)-etil-2-metilfenil] metanol észter prodrugjai

Family Applications After (4)

Application Number Title Priority Date Filing Date
HUE16161922A HUE039090T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol észter pro-drogjai a szembelnyomás csökkentésére
HUE18160174A HUE049573T2 (hu) 2010-09-16 2011-09-16 3-[(S)-1-(1H-imidazol-4-il)-etil]-2-metilfenil]metanol észter elõvegyületei intraokuláris nyomás csökkentésére
HUE16161920A HUE038698T2 (hu) 2010-09-16 2011-09-16 [3-(l-(lH-imidazol-4-il)etil)-2-metilfenil]metanol észter elõvegyületei bõrbetegségek és állapotok kezelésére
HUE16161923A HUE047476T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1-(1H-imidazol-4-il)-etil-2-metilfenil] metanol észter prodrugjai

Country Status (28)

Country Link
US (9) US8492422B2 (enExample)
EP (13) EP3078376B1 (enExample)
JP (4) JP2013537236A (enExample)
KR (7) KR101952457B1 (enExample)
CN (5) CN103209694A (enExample)
AR (4) AR083019A1 (enExample)
AU (4) AU2011301856C1 (enExample)
BR (4) BR112013006362A2 (enExample)
CA (8) CA2812197C (enExample)
CL (4) CL2013000733A1 (enExample)
CY (3) CY1121024T1 (enExample)
DK (9) DK3078376T3 (enExample)
ES (10) ES2781681T3 (enExample)
HU (5) HUE048725T2 (enExample)
IL (4) IL225281A0 (enExample)
MX (4) MX2013003002A (enExample)
MY (4) MY191369A (enExample)
NZ (1) NZ608751A (enExample)
PL (7) PL3050563T3 (enExample)
PT (7) PT3348264T (enExample)
RU (4) RU2612351C2 (enExample)
SG (4) SG188573A1 (enExample)
SI (5) SI3348264T1 (enExample)
TR (1) TR201909249T4 (enExample)
TW (4) TW201240662A (enExample)
UA (1) UA112973C2 (enExample)
WO (4) WO2012037484A1 (enExample)
ZA (4) ZA201302193B (enExample)

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US8492422B2 (en) * 2010-09-16 2013-07-23 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions
AU2012287243A1 (en) * 2011-07-22 2014-02-20 Allergan, Inc. Alpha-2 adrenergic modulators for treating visual disorders mediated by central visual projections from the eye
CA2856507C (en) 2011-11-21 2017-03-21 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
USD794650S1 (en) 2014-11-28 2017-08-15 Samsung Electronics Co., Ltd. Display screen or portion thereof with a graphical user interface
CN108310442B (zh) * 2017-01-17 2021-08-27 台北科技大学 眼科用组合物
KR102050506B1 (ko) 2017-06-20 2019-11-29 한국식품연구원 망막 질환 예방, 개선, 완화 또는 치료용 조성물
CN108872431B (zh) * 2018-07-09 2021-03-23 成都倍特药业股份有限公司 一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法
JP7584802B2 (ja) * 2018-08-24 2024-11-18 アドライ・ノーティ・バイオファーマ・カンパニー・リミテッド 高活性stingタンパク質アゴニスト
BR112023021140A2 (pt) * 2021-04-16 2023-12-12 Ads Therapeutics Llc Cofármaco compreendendo uma fração de agonista muscarínico e uma fração de agonista alfa2 adrenérgico, ou um sal farmacêutico deste, composição farmacêutica e formulação farmacêutica
WO2024167962A1 (en) * 2023-02-08 2024-08-15 Whitecap Biosciences Llc Alpha-2-adrenergic agonists for improving vision
WO2025179071A1 (en) * 2024-02-20 2025-08-28 Bausch + Lomb Ireland Limited Sustained-release drug delivery compositions for treating ocular diseases

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BR112013006320A2 (pt) 2016-06-21
TW201305117A (zh) 2013-02-01
PL3053576T3 (pl) 2018-11-30
IL225278A (en) 2015-11-30
ES2737230T3 (es) 2020-01-10
KR101840500B1 (ko) 2018-03-20
WO2012037453A1 (en) 2012-03-22
ES2781681T3 (es) 2020-09-04
DK3050563T3 (en) 2018-08-13
AR083018A1 (es) 2013-01-23
KR20200044147A (ko) 2020-04-28
KR20200091507A (ko) 2020-07-30
EP3698789A1 (en) 2020-08-26
PL2616068T3 (pl) 2016-11-30
TR201909249T4 (tr) 2019-07-22
CN105412092B (zh) 2020-11-17
AR083020A1 (es) 2013-01-23
EP3348264A1 (en) 2018-07-18
US8853251B2 (en) 2014-10-07
PT3338777T (pt) 2020-05-06
PL3050563T3 (pl) 2018-12-31
US8653123B2 (en) 2014-02-18
CA3116249A1 (en) 2012-03-22
EP3348264B1 (en) 2020-01-01
CL2013000735A1 (es) 2013-11-29
ES2684055T3 (es) 2018-10-01
US20120149746A1 (en) 2012-06-14
WO2012037499A1 (en) 2012-03-22
TWI591058B (zh) 2017-07-11
EP3050563B1 (en) 2018-05-09
EP2616066A1 (en) 2013-07-24
US8492557B2 (en) 2013-07-23
JP2013540749A (ja) 2013-11-07
SG188573A1 (en) 2013-04-30
MX2013003009A (es) 2013-06-28
PL3050564T3 (pl) 2020-06-01
BR112013006320B1 (pt) 2022-08-30
MY191369A (en) 2022-06-20
HK1257416A1 (en) 2019-10-18
KR20130105658A (ko) 2013-09-25
RU2013116763A (ru) 2014-10-27
US20160354346A1 (en) 2016-12-08
KR20140005154A (ko) 2014-01-14
ZA201302291B (en) 2013-11-27
AR083017A1 (es) 2013-01-23
BR112013006362A2 (pt) 2016-06-28
PT3348264T (pt) 2020-04-02
EP3078376B1 (en) 2019-03-27
US20120122945A1 (en) 2012-05-17
JP2013537236A (ja) 2013-09-30
AU2011301856C1 (en) 2016-09-08
US8501796B2 (en) 2013-08-06
MX2013003008A (es) 2013-06-28
EP3636263B1 (en) 2021-11-03
DK3636263T3 (da) 2022-01-10
AU2011301932C1 (en) 2016-09-01
RU2013116403A (ru) 2014-10-27
US20140057958A1 (en) 2014-02-27
HUE049573T2 (hu) 2020-10-28
PT3050564T (pt) 2019-12-11
CN103209694A (zh) 2013-07-17
JP6073229B2 (ja) 2017-02-01
EP3050564A1 (en) 2016-08-03
DK3050564T3 (da) 2019-11-25
EP2616067A1 (en) 2013-07-24
KR20140003407A (ko) 2014-01-09
KR102104760B1 (ko) 2020-04-27
EP3053576A1 (en) 2016-08-10
KR20130114140A (ko) 2013-10-16
ES2760920T3 (es) 2020-05-18
SI3338777T1 (sl) 2020-08-31
JP2013537237A (ja) 2013-09-30
ES2593612T3 (es) 2016-12-12
MY161607A (en) 2017-04-28
EP2616068A1 (en) 2013-07-24
EP3636263A1 (en) 2020-04-15
PT3053576T (pt) 2018-10-08
CY1122809T1 (el) 2021-05-05
HUE039090T2 (hu) 2018-12-28
SI3050564T1 (sl) 2020-02-28
EP2616066B1 (en) 2016-07-13
EP2616067B1 (en) 2016-05-18
IL225282A0 (en) 2013-06-27
SI3050563T1 (sl) 2018-10-30
US20130296394A1 (en) 2013-11-07
ZA201302288B (en) 2013-11-27
MY168763A (en) 2018-12-04
HUE047476T2 (hu) 2020-04-28
AU2011301901A1 (en) 2013-05-02
CA2812191C (en) 2021-04-13
IL225281A0 (en) 2013-06-27
JP6045495B2 (ja) 2016-12-14
AU2011301856A1 (en) 2013-05-02
KR101952457B1 (ko) 2019-02-26
PT2616068T (pt) 2016-09-13
IL225280A0 (en) 2013-06-27
CA2812195A1 (en) 2012-03-22
CA2812197A1 (en) 2012-03-22
RU2612351C2 (ru) 2017-03-07
ES2904479T3 (es) 2022-04-05
PT3050563T (pt) 2018-10-01
MY173846A (en) 2020-02-24
PL3338777T3 (pl) 2020-07-13
DK3053576T3 (en) 2018-08-20
ES2613509T3 (es) 2017-05-24
EP3053576B1 (en) 2018-05-16
ZA201302193B (en) 2013-11-27
CL2013000736A1 (es) 2013-07-12
BR112013006355A2 (pt) 2016-06-28
PT2616069T (pt) 2016-12-06
CN105412092A (zh) 2016-03-23
HK1185541A1 (zh) 2014-02-21
CL2013000733A1 (es) 2013-08-23
AU2011301847B2 (en) 2016-02-11
ES2607084T3 (es) 2017-03-29
CN103200941B (zh) 2015-12-16
AU2011301932A1 (en) 2013-05-02
EP3338777B1 (en) 2020-02-05
CY1122958T1 (el) 2021-10-29
US8492422B2 (en) 2013-07-23
EP3338777A1 (en) 2018-06-27
MX2013003004A (es) 2013-06-28
JP2013541527A (ja) 2013-11-14
KR101840501B1 (ko) 2018-05-04
WO2012037490A1 (en) 2012-03-22
US20120136036A1 (en) 2012-05-31
DK3348264T3 (da) 2020-03-23
HK1185538A1 (zh) 2014-02-21
EP2616069B1 (en) 2016-11-16
CA3079450A1 (en) 2012-03-22
TW201240662A (en) 2012-10-16
SG188572A1 (en) 2013-04-30
AR083019A1 (es) 2013-01-23
CY1121024T1 (el) 2019-12-11
KR102139905B1 (ko) 2020-07-31
DK3338777T3 (da) 2020-04-20
TW201240661A (en) 2012-10-16
SI3053576T1 (sl) 2018-11-30
EP3659600A1 (en) 2020-06-03
HUE038698T2 (hu) 2018-11-28
CA2811559A1 (en) 2012-03-22
NZ608751A (en) 2015-04-24
ES2788051T3 (es) 2020-10-20
DK2616069T3 (en) 2016-12-19
CA2812197C (en) 2024-01-02
CA2812191A1 (en) 2012-03-22
EP3078376A1 (en) 2016-10-12
ZA201302194B (en) 2013-11-27
EP3050563A1 (en) 2016-08-03
AU2011301932B2 (en) 2016-02-25
SG188570A1 (en) 2013-04-30
RU2013116405A (ru) 2014-10-27
HK1185539A1 (zh) 2014-02-21
AU2011301901B2 (en) 2016-02-11
RU2013116541A (ru) 2014-10-27
US20130289088A1 (en) 2013-10-31
KR102354097B1 (ko) 2022-01-20
US20150148394A1 (en) 2015-05-28
DK3078376T3 (da) 2019-06-24
WO2012037484A1 (en) 2012-03-22
CA3077732A1 (en) 2012-03-22
SI3348264T1 (sl) 2020-07-31
SG188571A1 (en) 2013-04-30
DK2616068T3 (en) 2016-08-29
EP3050564B1 (en) 2019-09-04
PL2616069T3 (pl) 2017-04-28
MX2013003002A (es) 2013-06-28
TW201305116A (zh) 2013-02-01
PL3348264T3 (pl) 2020-08-24
CN103200941A (zh) 2013-07-10
CL2013000734A1 (es) 2013-11-08
CN103200942A (zh) 2013-07-10
EP2616068B1 (en) 2016-07-13
HK1185540A1 (en) 2014-02-21
CN103221045A (zh) 2013-07-24
EP2616069A1 (en) 2013-07-24
KR20190022895A (ko) 2019-03-06
BR112013006352A2 (pt) 2016-06-28
CA3122745A1 (en) 2012-03-22
AU2011301847A1 (en) 2013-05-02
US20120142746A1 (en) 2012-06-07
UA112973C2 (uk) 2016-11-25
IL225278A0 (en) 2013-06-27
ES2687420T3 (es) 2018-10-25

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