IL124341A - Process for the preparation of 1-aryl- 1-cyanocyclobutane derivatives - Google Patents
Process for the preparation of 1-aryl- 1-cyanocyclobutane derivativesInfo
- Publication number
- IL124341A IL124341A IL12434196A IL12434196A IL124341A IL 124341 A IL124341 A IL 124341A IL 12434196 A IL12434196 A IL 12434196A IL 12434196 A IL12434196 A IL 12434196A IL 124341 A IL124341 A IL 124341A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- dimethyl sulphoxide
- present
- temperature
- solvent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9524681.5A GB9524681D0 (en) | 1995-12-02 | 1995-12-02 | Chemical process |
| PCT/EP1996/005246 WO1997020810A1 (en) | 1995-12-02 | 1996-11-28 | Process for the preparation of 1-aryl-1-cyanocyclobutane derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL124341A0 IL124341A0 (en) | 1998-12-06 |
| IL124341A true IL124341A (en) | 2001-09-13 |
Family
ID=10784817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12434196A IL124341A (en) | 1995-12-02 | 1996-11-28 | Process for the preparation of 1-aryl- 1-cyanocyclobutane derivatives |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6545173B1 (pl) |
| EP (1) | EP0863868B1 (pl) |
| JP (1) | JP2000501402A (pl) |
| KR (1) | KR19990071838A (pl) |
| CN (1) | CN1075057C (pl) |
| AT (1) | ATE199247T1 (pl) |
| AU (1) | AU717603B2 (pl) |
| BG (1) | BG63498B1 (pl) |
| BR (1) | BR9611683A (pl) |
| CA (1) | CA2235043A1 (pl) |
| CZ (1) | CZ164798A3 (pl) |
| DE (1) | DE69611835T2 (pl) |
| DK (1) | DK0863868T3 (pl) |
| ES (1) | ES2154848T3 (pl) |
| GB (1) | GB9524681D0 (pl) |
| GR (1) | GR3035572T3 (pl) |
| HU (1) | HUP9903481A3 (pl) |
| IL (1) | IL124341A (pl) |
| MX (1) | MX9804022A (pl) |
| NO (1) | NO309265B1 (pl) |
| NZ (1) | NZ323896A (pl) |
| PL (1) | PL185047B1 (pl) |
| PT (1) | PT863868E (pl) |
| RU (1) | RU2179168C2 (pl) |
| SI (1) | SI0863868T1 (pl) |
| SK (1) | SK282470B6 (pl) |
| TR (1) | TR199800987T2 (pl) |
| WO (1) | WO1997020810A1 (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19756091A1 (de) * | 1997-12-17 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Verfahren zur Alkylierung von Alkyl- oder Benzylcyanderivaten in Gegenwart von Trialkylaminen oder -phosphinen |
| US6974838B2 (en) | 1998-08-24 | 2005-12-13 | Sepracor Inc. | Methods of treating or preventing pain using sibutramine metabolites |
| US6476078B2 (en) | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
| US6331571B1 (en) | 1998-08-24 | 2001-12-18 | Sepracor, Inc. | Methods of treating and preventing attention deficit disorders |
| US6339106B1 (en) | 1999-08-11 | 2002-01-15 | Sepracor, Inc. | Methods and compositions for the treatment and prevention of sexual dysfunction |
| US6399826B1 (en) | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
| ATE294157T1 (de) * | 2001-02-28 | 2005-05-15 | Council Scient Ind Res | Verfahren zur herstellung von 1- (cyan(aryl)methyl)cyclohexanol |
| US6504044B2 (en) | 2001-02-28 | 2003-01-07 | Council Of Scientific And Industrial Research | Process for the preparation of 1-[cyano(aryl)methyl] cyclohexanol |
| US6610887B2 (en) | 2001-04-13 | 2003-08-26 | Sepracor Inc. | Methods of preparing didesmethylsibutramine and other sibutramine derivatives |
| AT503354B1 (de) * | 2006-02-22 | 2008-07-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen |
| CZ300903B6 (cs) * | 2008-06-09 | 2009-09-09 | Lucební závody Draslovka a. s. Kolín | Zpusob výroby cykloalkankarbonitrilu |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3526656A (en) | 1967-05-25 | 1970-09-01 | Parke Davis & Co | (1-arylcyclobutyl)carbonyl carbamic acid derivatives |
| US4220591A (en) | 1975-11-26 | 1980-09-02 | Commonwealth Scientific And Industrial Research Organization | Insecticidal esters |
| AU4244478A (en) | 1977-12-19 | 1979-06-28 | Commw Scient Ind Res Org | Cyclobutane carboxylic acids and esters and insecticides |
| IE52768B1 (en) | 1981-04-06 | 1988-02-17 | Boots Co Ltd | 1-arylcyclobutylalkylamine compounds useful as therapeutic agents |
| ZA821577B (en) * | 1981-04-06 | 1983-03-30 | Boots Co Plc | Therapeutic agents |
| GB8501192D0 (en) * | 1985-01-17 | 1985-02-20 | Boots Co Plc | Therapeutic agents |
| SU1705280A1 (ru) * | 1989-08-14 | 1992-01-15 | Новосибирский институт органической химии СО АН СССР | Способ получени пара-алкилбензонитрилов |
| ZA925185B (en) | 1991-07-18 | 1993-04-29 | Hoffmann La Roche | Dithianes. |
| GB9127306D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
| GB9309749D0 (en) | 1993-05-12 | 1993-06-23 | Boots Co Plc | Therapeutic agents |
| RO117377B1 (ro) | 1993-06-22 | 2002-02-28 | Boots Co Plc | Derivati de tetrahidroizochinolina, procedeu de preparare, compozitie farmaceutica care ii contine si metoda de tratament |
-
1995
- 1995-12-02 GB GBGB9524681.5A patent/GB9524681D0/en active Pending
-
1996
- 1996-11-28 US US09/077,698 patent/US6545173B1/en not_active Expired - Fee Related
- 1996-11-28 CZ CZ981647A patent/CZ164798A3/cs unknown
- 1996-11-28 HU HU9903481A patent/HUP9903481A3/hu unknown
- 1996-11-28 RU RU98112599/04A patent/RU2179168C2/ru active
- 1996-11-28 AT AT96941602T patent/ATE199247T1/de not_active IP Right Cessation
- 1996-11-28 KR KR1019980704120A patent/KR19990071838A/ko not_active Ceased
- 1996-11-28 BR BR9611683A patent/BR9611683A/pt not_active Application Discontinuation
- 1996-11-28 IL IL12434196A patent/IL124341A/en not_active IP Right Cessation
- 1996-11-28 DK DK96941602T patent/DK0863868T3/da active
- 1996-11-28 JP JP9520945A patent/JP2000501402A/ja active Pending
- 1996-11-28 SK SK626-98A patent/SK282470B6/sk unknown
- 1996-11-28 EP EP96941602A patent/EP0863868B1/en not_active Expired - Lifetime
- 1996-11-28 CN CN96198731A patent/CN1075057C/zh not_active Expired - Fee Related
- 1996-11-28 CA CA002235043A patent/CA2235043A1/en not_active Abandoned
- 1996-11-28 NZ NZ323896A patent/NZ323896A/xx unknown
- 1996-11-28 AU AU10939/97A patent/AU717603B2/en not_active Ceased
- 1996-11-28 PT PT96941602T patent/PT863868E/pt unknown
- 1996-11-28 DE DE69611835T patent/DE69611835T2/de not_active Expired - Fee Related
- 1996-11-28 ES ES96941602T patent/ES2154848T3/es not_active Expired - Lifetime
- 1996-11-28 SI SI9630254T patent/SI0863868T1/xx unknown
- 1996-11-28 TR TR1998/00987T patent/TR199800987T2/xx unknown
- 1996-11-28 WO PCT/EP1996/005246 patent/WO1997020810A1/en not_active Ceased
- 1996-11-28 PL PL96326926A patent/PL185047B1/pl unknown
-
1998
- 1998-05-21 MX MX9804022A patent/MX9804022A/es unknown
- 1998-05-21 BG BG102473A patent/BG63498B1/bg unknown
- 1998-05-29 NO NO982474A patent/NO309265B1/no not_active IP Right Cessation
-
2001
- 2001-03-13 GR GR20010400419T patent/GR3035572T3/el not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HCA | Change of name of proprietor(s) after amalgamation | ||
| RH1 | Patent not in force |