IL119590A - 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates - Google Patents

7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates

Info

Publication number
IL119590A
IL119590A IL11959092A IL11959092A IL119590A IL 119590 A IL119590 A IL 119590A IL 11959092 A IL11959092 A IL 11959092A IL 11959092 A IL11959092 A IL 11959092A IL 119590 A IL119590 A IL 119590A
Authority
IL
Israel
Prior art keywords
substituted
demethyl
intermediates
deoxytetracycline
substituted amino
Prior art date
Application number
IL11959092A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL119590(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL119590A publication Critical patent/IL119590A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Moulding By Coating Moulds (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL11959092A 1991-10-04 1992-10-01 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates IL119590A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04
IL10332092A IL103320A (en) 1991-10-04 1992-10-01 7-substituted-9-substituted amino-6- demethyl-6-deoxytetracyclines

Publications (1)

Publication Number Publication Date
IL119590A true IL119590A (en) 1999-03-12

Family

ID=25092264

Family Applications (3)

Application Number Title Priority Date Filing Date
IL10332092A IL103320A (en) 1991-10-04 1992-10-01 7-substituted-9-substituted amino-6- demethyl-6-deoxytetracyclines
IL11959092A IL119590A (en) 1991-10-04 1992-10-01 7-(Substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracycline intermediates
IL11959096A IL119590A0 (en) 1991-10-04 1996-11-10 Novel 7- (substituted) -9- (substituted amino(-6-demethyl -6- deoxytetracycline intermediates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL10332092A IL103320A (en) 1991-10-04 1992-10-01 7-substituted-9-substituted amino-6- demethyl-6-deoxytetracyclines

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11959096A IL119590A0 (en) 1991-10-04 1996-11-10 Novel 7- (substituted) -9- (substituted amino(-6-demethyl -6- deoxytetracycline intermediates

Country Status (27)

Country Link
EP (1) EP0536515B1 (en:Method)
JP (1) JP3186863B2 (en:Method)
KR (1) KR100269072B1 (en:Method)
CN (1) CN1048240C (en:Method)
AT (1) ATE211128T1 (en:Method)
AU (1) AU654049B2 (en:Method)
BR (1) BR1100853A (en:Method)
CA (1) CA2079692C (en:Method)
CL (1) CL2004001623A1 (en:Method)
CZ (2) CZ284209B6 (en:Method)
DE (4) DE69232302T4 (en:Method)
DK (1) DK0536515T3 (en:Method)
ES (1) ES2168254T3 (en:Method)
FI (1) FI114911B (en:Method)
HU (2) HU219973B (en:Method)
IL (3) IL103320A (en:Method)
LU (1) LU91279I2 (en:Method)
MX (1) MX9205532A (en:Method)
NL (1) NL300244I2 (en:Method)
NO (3) NO301472B1 (en:Method)
NZ (1) NZ244585A (en:Method)
PL (4) PL173311B1 (en:Method)
PT (1) PT536515E (en:Method)
SG (1) SG52361A1 (en:Method)
SK (2) SK280837B6 (en:Method)
TW (1) TW275616B (en:Method)
ZA (1) ZA927607B (en:Method)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
WO1995022529A1 (en) * 1994-02-17 1995-08-24 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
EA005118B1 (ru) 1999-09-14 2004-10-28 Трастис Оф Тафтс Коллидж Замещенный аналог тетрациклина (варианты) и способ его получения (варианты)
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
MXPA02009482A (es) 2000-03-31 2004-05-14 Tufts College Compuestos tetraciclinas sustituidos con grupos 7- y 9- carbamato, urea, tiourea, tiocarbamato y heteroaril-amino.
AU2001259701A1 (en) * 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EA201000496A1 (ru) * 2000-07-07 2010-10-29 Трастис Оф Тафтс Коллидж Замещенное соединение миноциклина, способ получения замещенных соединений миноциклина (варианты)
EP2301914A1 (en) 2001-03-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
WO2002085303A2 (en) * 2001-04-24 2002-10-31 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2301915A1 (en) 2001-07-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7-(diethylamino)methyl substituted tetracycline having target therapeutic activities
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
ES2551708T3 (es) 2002-01-08 2015-11-23 Paratek Pharmaceuticals, Inc. Compuestos de 4-desdimetilamino tetraciclina
CN102531948A (zh) * 2002-03-08 2012-07-04 帕拉特克药品公司 氨基-甲基取代的四环素类化合物
AU2004259659B2 (en) 2003-07-09 2011-11-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
SI1753713T1 (sl) * 2004-05-21 2017-01-31 President And Fellows Of Harvard College Sinteza tetraciklinov in njihovih analogov
US7534766B2 (en) 2004-11-05 2009-05-19 Wyeth Glucuronide metabolites and epimers thereof of tigecycline
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
KR20080041722A (ko) * 2005-08-31 2008-05-13 와이어쓰 글리실사이클린의 9-아미노카르보닐 치환된 유도체
CA2652347A1 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
WO2009069100A1 (en) 2007-11-29 2009-06-04 Actelion Pharmaceuticals Ltd Phosphonic acid derivates and their use as p2y12 receptor antagonists
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202021946A (zh) 2008-05-19 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
JP5496202B2 (ja) * 2008-08-08 2014-05-21 テトラフェース ファーマシューティカルズ，インコーポレイテッド Ｃ７−フルオロ置換テトラサイクリン化合物
EP2424834B1 (en) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthesis of tetracyclines and intermediates thereof
EP2427425B1 (en) 2009-05-08 2017-03-08 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
US9624166B2 (en) 2009-08-28 2017-04-18 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
JP6025712B2 (ja) 2010-05-12 2016-11-16 レンペックス・ファーマシューティカルズ・インコーポレイテッド テトラサイクリン組成物
WO2013013504A1 (zh) * 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 替加环素衍生物
AU2013308504B2 (en) 2012-08-31 2016-11-10 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
US20160143925A1 (en) 2013-11-12 2016-05-26 Galenicum Health S.L. Stable pharmaceutical compositions
CN110582486B (zh) 2016-10-19 2024-01-12 四相制药公司 艾若威四环素的结晶形式

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
HUT63145A (en) 1993-07-28
EP0536515A1 (en) 1993-04-14
IL103320A (en) 1998-12-06
CL2004001623A1 (es) 2005-06-03
CZ309397A3 (cs) 1998-09-16
CA2079692A1 (en) 1993-04-05
PL173311B1 (pl) 1998-02-27
NL300244I1 (nl) 2007-01-02
AU2618392A (en) 1993-04-08
SG52361A1 (en) 1998-09-28
SK284826B6 (sk) 2005-12-01
EP0536515B1 (en) 2001-12-19
DE122006000058I2 (de) 2007-09-13
HU211172A9 (en) 1995-11-28
NO2017037I1 (no) 2017-08-01
AU654049B2 (en) 1994-10-20
NO2017037I2 (no) 2017-08-01
KR100269072B1 (ko) 2000-10-16
CA2079692C (en) 2004-06-08
IL119590A0 (en) 1997-02-18
PL175957B1 (pl) 1999-03-31
HU219973B (hu) 2001-10-28
SK114999A3 (en) 2000-07-11
FI924454L (fi) 1993-04-05
CZ298492A3 (en) 1993-05-12
NO923857L (no) 1993-04-05
PL296143A1 (en) 1993-05-31
TW275616B (en:Method) 1996-05-11
IL103320A0 (en) 1993-03-15
CZ284209B6 (cs) 1998-09-16
ES2168254T3 (es) 2002-06-16
PL176333B1 (pl) 1999-05-31
NO2006015I1 (no) 2006-11-27
ATE211128T1 (de) 2002-01-15
DE122006000058I1 (de) 2007-01-18
DE69232302T4 (de) 2003-02-13
CZ284159B6 (cs) 1998-08-12
NL300244I2 (nl) 2007-01-02
ZA927607B (en) 1993-04-13
NO2006015I2 (no) 2011-03-14
KR930007894A (ko) 1993-05-20
DE69232302T2 (de) 2002-08-14
JPH05255219A (ja) 1993-10-05
FI114911B (fi) 2005-01-31
HU9203110D0 (en) 1992-12-28
NO923857D0 (no) 1992-10-02
MX9205532A (es) 1993-04-01
CN1072172A (zh) 1993-05-19
NO301472B1 (no) 1997-11-03
PL172282B1 (pl) 1997-08-29
HK1011348A1 (en) 1999-07-09
NZ244585A (en) 1995-07-26
PT536515E (pt) 2002-05-31
LU91279I2 (fr) 2006-12-11
DE69232302D1 (de) 2002-01-31
BR1100853A (pt) 1999-12-07
SK298492A3 (en) 1995-03-08
JP3186863B2 (ja) 2001-07-11
FI924454A0 (fi) 1992-10-02
DK0536515T3 (da) 2002-04-08
CN1048240C (zh) 2000-01-12
SK280837B6 (sk) 2000-08-14

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