IL110978A - Result of B71 - Anilide - 4 - Azea - A5 - Androst - 1 - Ann - 3 On, its preparation and pharmaceutical preparations containing it - Google Patents

Result of B71 - Anilide - 4 - Azea - A5 - Androst - 1 - Ann - 3 On, its preparation and pharmaceutical preparations containing it

Info

Publication number
IL110978A
IL110978A IL11097894A IL11097894A IL110978A IL 110978 A IL110978 A IL 110978A IL 11097894 A IL11097894 A IL 11097894A IL 11097894 A IL11097894 A IL 11097894A IL 110978 A IL110978 A IL 110978A
Authority
IL
Israel
Prior art keywords
compound
formula
aza
androst
bis
Prior art date
Application number
IL11097894A
Other languages
English (en)
Hebrew (he)
Other versions
IL110978A0 (en
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22407744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL110978(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of IL110978A0 publication Critical patent/IL110978A0/xx
Publication of IL110978A publication Critical patent/IL110978A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11097894A 1993-09-17 1994-09-16 Result of B71 - Anilide - 4 - Azea - A5 - Androst - 1 - Ann - 3 On, its preparation and pharmaceutical preparations containing it IL110978A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12328093A 1993-09-17 1993-09-17

Publications (2)

Publication Number Publication Date
IL110978A0 IL110978A0 (en) 1994-11-28
IL110978A true IL110978A (en) 1999-01-26

Family

ID=22407744

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11097894A IL110978A (en) 1993-09-17 1994-09-16 Result of B71 - Anilide - 4 - Azea - A5 - Androst - 1 - Ann - 3 On, its preparation and pharmaceutical preparations containing it

Country Status (41)

Country Link
US (2) US5565467A (ru)
EP (1) EP0719278B1 (ru)
JP (1) JP2904310B2 (ru)
KR (1) KR100364953B1 (ru)
CN (1) CN1057771C (ru)
AP (1) AP494A (ru)
AT (1) ATE162199T1 (ru)
AU (1) AU690925B2 (ru)
BG (1) BG62363B1 (ru)
BR (1) BR1100329A (ru)
CA (2) CA2462061A1 (ru)
CY (2) CY2219B1 (ru)
CZ (1) CZ286069B6 (ru)
DE (2) DE69407978T2 (ru)
DK (1) DK0719278T3 (ru)
EE (1) EE03241B1 (ru)
ES (1) ES2113127T3 (ru)
FI (1) FI115216B (ru)
GR (1) GR3026144T3 (ru)
HK (1) HK1004334A1 (ru)
HR (1) HRP940563B1 (ru)
HU (1) HU220060B (ru)
IL (1) IL110978A (ru)
IS (1) IS1713B (ru)
LU (1) LU91027I2 (ru)
MY (1) MY119778A (ru)
NL (1) NL300122I2 (ru)
NO (2) NO306117B1 (ru)
NZ (1) NZ274642A (ru)
OA (1) OA10575A (ru)
PE (1) PE15095A1 (ru)
PL (1) PL180002B1 (ru)
RO (1) RO117455B1 (ru)
RU (1) RU2140926C1 (ru)
SA (1) SA94150231B1 (ru)
SG (1) SG52650A1 (ru)
SI (1) SI0719278T1 (ru)
SK (1) SK281869B6 (ru)
TW (1) TW369521B (ru)
WO (1) WO1995007927A1 (ru)
ZA (2) ZA947119B (ru)

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TW382595B (en) * 1993-10-15 2000-02-21 Merck & Co Inc Pharmaceutical composition for use in arresting and reversing androgenic alopecia
US5547957A (en) 1993-10-15 1996-08-20 Merck & Co., Inc. Method of treating androgenic alopecia with 5-α reductase inhibitors
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US5817818A (en) * 1994-09-16 1998-10-06 Glaxo Wellcome Inc. Androstenones
US6001844A (en) * 1995-09-15 1999-12-14 Merck & Co., Inc. 4-Azasteroids for treatment of hyperandrogenic conditions
US5872126A (en) * 1996-09-06 1999-02-16 Merck & Co., Inc. Methods and compositions for treating preterm labor
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EP1321146A3 (en) * 1998-03-11 2004-06-02 Endorecherche Inc. Inhibitors of type 5 and 3 17beta-hydroxysteroid dehydrogenase and methods for their use
US5998427A (en) * 1998-05-14 1999-12-07 Glaxo Wellcome Inc. Androstenones
AU4701299A (en) * 1998-06-23 2000-01-10 Stuart R. Adler Therapeutic applications of estrogenic carboxylic acids
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ATE301129T1 (de) 1999-05-04 2005-08-15 Strakan Int Ltd Androgen glykoside und die androgenische aktivität davon
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
JP4490689B2 (ja) * 2001-10-03 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション アンドロゲン受容体調節剤としてのアンドロスタン１７β−カルボキサミド類
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CN113896607B (zh) * 2015-03-13 2024-04-16 陶氏环球技术有限责任公司 利用包含具有含有磷环的配体的铬络合物的催化剂的烯烃低聚反应方法
KR102503428B1 (ko) 2015-12-22 2023-02-24 한미약품 주식회사 두타스테라이드를 포함하는 경구용 연질 캡슐 제형용 포장재
WO2017160106A2 (ko) 2016-03-16 2017-09-21 한미약품 주식회사 두타스테라이드 및 탐수로신 함유 경질 캡슐 복합제 및 그 제조방법
KR101716878B1 (ko) 2016-05-12 2017-03-15 주식회사 유유제약 글리세롤 지방산에스테르유도체 또는 프로필렌글리콜 지방산에스테르유도체를 함유한 두타스테리드와 타다라필의 복합 캡슐제제 조성물 및 이의 제조방법
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CN118480009A (zh) 2017-02-06 2024-08-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
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KR101996597B1 (ko) 2017-10-13 2019-07-31 주식회사 유유제약 두타스테리드와 타다라필을 용해시킨 경구용 캡슐 제형의 복합제제
WO2019225924A1 (ko) * 2018-05-21 2019-11-28 (주)인벤티지랩 두타스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법
KR102281252B1 (ko) 2018-05-21 2021-07-23 (주)인벤티지랩 두타스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법
CA3120858A1 (en) 2018-11-21 2020-05-28 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
KR20200074759A (ko) 2018-12-17 2020-06-25 동국제약 주식회사 두타스테라이드를 함유하는 고형제제
CN116507626A (zh) 2020-05-20 2023-07-28 罗迪奥治疗公司 调节短链脱氢酶活性的组合物和方法
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