IL106877A - Rodinin derivatives for use as drugs for the treatment of Alzheimer's disease - Google Patents

Rodinin derivatives for use as drugs for the treatment of Alzheimer's disease

Info

Publication number
IL106877A
IL106877A IL106877A IL10687793A IL106877A IL 106877 A IL106877 A IL 106877A IL 106877 A IL106877 A IL 106877A IL 10687793 A IL10687793 A IL 10687793A IL 106877 A IL106877 A IL 106877A
Authority
IL
Israel
Prior art keywords
alkyl
thioxo
methylene
thiazolidinone
hydrogen
Prior art date
Application number
IL106877A
Other languages
English (en)
Hebrew (he)
Other versions
IL106877A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to IL11911993A priority Critical patent/IL119119A/en
Publication of IL106877A0 publication Critical patent/IL106877A0/xx
Publication of IL106877A publication Critical patent/IL106877A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
    • B65H2511/00—Dimensions; Position; Numbers; Identification; Occurrences
    • B65H2511/50—Occurence
    • B65H2511/51—Presence
    • B65H2511/512—Marks, e.g. invisible to the human eye; Patterns

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL106877A 1992-09-10 1993-09-02 Rodinin derivatives for use as drugs for the treatment of Alzheimer's disease IL106877A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL11911993A IL119119A (en) 1992-09-10 1993-09-02 Rodinin derivatives are a process for their preparation and pharmaceutical preparations containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94335392A 1992-09-10 1992-09-10

Publications (2)

Publication Number Publication Date
IL106877A0 IL106877A0 (en) 1993-12-28
IL106877A true IL106877A (en) 1998-03-10

Family

ID=25479507

Family Applications (1)

Application Number Title Priority Date Filing Date
IL106877A IL106877A (en) 1992-09-10 1993-09-02 Rodinin derivatives for use as drugs for the treatment of Alzheimer's disease

Country Status (20)

Country Link
US (3) US5523314A (fr)
EP (2) EP0915090A1 (fr)
JP (1) JPH06192091A (fr)
KR (1) KR940006590A (fr)
CN (1) CN1091006A (fr)
AU (1) AU676843B2 (fr)
CA (1) CA2105598A1 (fr)
CZ (1) CZ181493A3 (fr)
FI (1) FI933946A (fr)
HU (1) HUT70184A (fr)
IL (1) IL106877A (fr)
MX (1) MX9305444A (fr)
MY (1) MY131443A (fr)
NO (2) NO933198L (fr)
NZ (1) NZ248573A (fr)
PL (1) PL300335A1 (fr)
RU (1) RU2131251C1 (fr)
TW (1) TW274546B (fr)
YU (1) YU59593A (fr)
ZA (1) ZA936492B (fr)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005119252A2 (fr) * 2004-05-26 2005-12-15 Arena Pharmaceuticals, Inc. Gpr35 et modulateur de gpr35 utilises pour traiter des troubles metaboliques
EP0915090A1 (fr) * 1992-09-10 1999-05-12 Eli Lilly And Company Thiazolidinones comme agents hypoglycemiants et pour le traitement de la maladie d'Alzheimer
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
US6251928B1 (en) * 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
EP0787725B1 (fr) * 1994-10-20 2003-04-23 Nippon Chemiphar Co., Ltd. Derive de quinoline
US5563277A (en) * 1994-12-21 1996-10-08 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
IL117208A0 (en) * 1995-02-23 1996-06-18 Nissan Chemical Ind Ltd Indole type thiazolidines
EP0831920A4 (fr) * 1995-06-06 2003-03-19 Athena Neurosciences Inc Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine
US5783434A (en) * 1995-06-06 1998-07-21 Tung; Jay S. Cathepsin and methods and compositions for inhibition thereof
US5849711A (en) * 1995-06-06 1998-12-15 Athena Neurosciences, Inc. Cathepsin and methods and compositions for inhibition thereof
JPH09176162A (ja) * 1995-12-22 1997-07-08 Toubishi Yakuhin Kogyo Kk チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物
EP0914122B1 (fr) * 1996-07-11 2003-09-24 Warner-Lambert Company LLC Methode pour traiter et prevenir des troubles neurodegeneratifs par administration d'une thiazolidinone
US6005142A (en) 1996-09-03 1999-12-21 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
US6063799A (en) * 1996-09-03 2000-05-16 Eli Lilly And Company Alternate crystal form of Tazofelone
DE19641180A1 (de) * 1996-09-24 1998-03-26 Schering Ag Verfahren zur Darstellung von APP-Sekretase Modulation und deren Verwendung als Mittel zur Behandlung der Alzheimer'schen Erkrankung
WO1998039967A1 (fr) * 1997-03-12 1998-09-17 The General Hospital Corporation Procede de traitement ou de prevention de la maladie d'alzheimer
PT1014974E (pt) 1997-05-29 2004-12-31 Lundbeck & Co As H Tratamento da esquizofrenia e psicoses
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
WO1999055894A1 (fr) 1998-04-29 1999-11-04 Oklahoma Medical Research Foundation Elaboration de cellules productrices retrovirales a partir de vecteurs adenoviraux et retroviraux
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
WO2000018748A1 (fr) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Derives de rhodanine utiles pour le traitement et la prevention de troubles metaboliques des os
US6673816B1 (en) 1998-09-30 2004-01-06 Angelika Esswein Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
WO2000024392A1 (fr) * 1998-10-26 2000-05-04 Sumitomo Pharmaceuticals Company, Limited Inhibiteur de la formation de beta-amyloide
US6191154B1 (en) * 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
US6204288B1 (en) 1999-03-08 2001-03-20 The University Of Mississippi 1,2-dithiolane derivatives
US6127394A (en) * 1999-03-08 2000-10-03 The University Of Mississippi 1,2-Dithiolane derivatives
AU5311800A (en) * 1999-06-10 2001-01-02 Warner-Lambert Company Rhodanine derivatives for use in a method of inhibiting amyloid protein aggregation and imaging amyloid deposits
AU5455400A (en) * 1999-06-10 2001-01-02 Warner-Lambert Company Rhodanine derivatives and their use in inhibiting and imaging amyloids
EP1109808A1 (fr) 1999-07-01 2001-06-27 Geron Corporation Composes indole substitues et leur utilisation dans le traitement du cancer
EP1593677A3 (fr) * 1999-08-31 2006-01-04 Incyte San Diego Incorporated Benzylidene-thiazolidinediones et leurs analogues, utilisés dans le traitement du diabète
EA200200311A1 (ru) * 1999-08-31 2002-08-29 Максиа Фармасьютикалз, Инк. Бензилиден-тиазолидиндионы и аналоги и их применение для лечения диабета
US20070060606A1 (en) * 1999-10-07 2007-03-15 Robertson Harold A Compounds and methods for modulating phosphodiesterase 10A
US6706766B2 (en) * 1999-12-13 2004-03-16 President And Fellows Of Harvard College Small molecules used to increase cell death
DE60115132T2 (de) * 2000-04-21 2006-07-06 Pfizer Products Inc., Groton Thyroid-Rezeptorliganden
US6620830B2 (en) 2000-04-21 2003-09-16 Pfizer, Inc. Thyroid receptor ligands
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
EP1284958B1 (fr) * 2000-05-04 2005-09-14 Warner-Lambert Company Llc Procede d'inhibition de l'agregation de proteines amyloides et d'imagerie de depots amyloides faisant appel a des derives amino-indanes
GB0021421D0 (en) * 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
MXPA03008117A (es) 2001-03-07 2004-11-12 Incyte San Diego Inc Derivados heterociclicos para el tratamiento del cancer y otras enfermedades proliferativas.
EP1377559A4 (fr) * 2001-03-08 2005-09-28 Incyte San Diego Inc Molecules activant un recepteur rxr
CA2340824A1 (fr) * 2001-03-14 2002-09-14 Ibm Canada Limited-Ibm Canada Limitee Methode et systeme pour l'analyse du comportement des applications
US20030083357A1 (en) * 2001-08-17 2003-05-01 Magnus Pfahl Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia
WO2003043998A1 (fr) * 2001-11-15 2003-05-30 Incyte San Diego Incorporated Heterocycles n-substitues pour le traitement de l'hypercholesterolemie, de la dyslipidemie et autres troubles du metabolisme, du cancer et de pathologies diverses
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
US7196108B2 (en) * 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
WO2004007491A1 (fr) * 2002-07-10 2004-01-22 Applied Research Systems Ars Holding N.V. Derives de benzene a fusion azolidinone-vinyle
US7005523B2 (en) * 2002-08-30 2006-02-28 Pfizer Inc. Cycloalkyl-[4-(trifluorophenyl)-oxazol-5yl]-triazolo-pyridines
WO2004043955A1 (fr) * 2002-11-13 2004-05-27 Rigel Pharmaceuticals, Inc. Derives de rhodanine et compositions pharmaceutiques les contenant
EA008865B1 (ru) 2002-11-22 2007-08-31 Смитклайн Бичам Корпорейшн Производные 2-имино-4-оксотиазолидина
US20050014767A1 (en) * 2003-01-29 2005-01-20 Magnus Pfahl Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases
EP1608317B1 (fr) 2003-03-25 2012-09-26 Takeda Pharmaceutical Company Limited Inhibiteurs de dipeptidyle peptidase
AU2004232326A1 (en) * 2003-04-18 2004-11-04 Incyte San Diego Incorporated Substituted isochroman compounds for the treatment of metabolic disorders, cancer and other diseases
US20060106077A1 (en) * 2003-07-18 2006-05-18 Pintex Pharmaceuticals, Inc. Pin1-Modulating compounds and methods of use thereof
WO2005016911A1 (fr) 2003-08-13 2005-02-24 Takeda Pharmaceutical Company Limited Derives de 4-pyrimidone et leur utilisation en tant qu'inhibiteurs de la peptidyle peptidase
JP2007505121A (ja) 2003-09-08 2007-03-08 武田薬品工業株式会社 ジペプチジルぺプチダーゼ阻害剤
CN102127053A (zh) 2004-03-15 2011-07-20 武田药品工业株式会社 二肽基肽酶抑制剂
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
EP1828192B1 (fr) 2004-12-21 2014-12-03 Takeda Pharmaceutical Company Limited Inhibiteurs de dipeptidyle peptidase
DE102005022182A1 (de) * 2005-05-09 2006-11-16 Combinature Biopharm Ag Modulatoren der PDZ-Domäne
PE20070083A1 (es) * 2005-06-08 2007-01-27 Smithkline Beecham Corp (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona
EP1942898B2 (fr) 2005-09-14 2014-05-14 Takeda Pharmaceutical Company Limited Inhibiteurs de la dipeptidyl peptidase permettant de traiter le diabete
KR101368988B1 (ko) 2005-09-16 2014-02-28 다케다 야쿠힌 고교 가부시키가이샤 디펩티딜 펩티다제 억제제
KR100814109B1 (ko) * 2006-01-09 2008-03-14 한국생명공학연구원 로다닌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 약학적 조성물
DK1984333T3 (da) 2006-02-03 2012-07-23 Bionomics Ltd Substituerede benzofuraner, benzothiophener, benzoselenophener og indoler og deres anvendelse som inhibitorer af tubulinpolymerisering
US8101578B2 (en) 2006-04-28 2012-01-24 Kagoshima University Amyloid [β] Beta fibrillogenesis-inhibiting peptide
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US20100286041A1 (en) * 2007-03-22 2010-11-11 Smithkline Beecham Corporation (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one
EP2650379B1 (fr) 2007-07-31 2015-09-16 Accera, Inc. Utilisation d'essais génomiques et composés cétogéniques pour le traitement d'une fonction cognitive réduite
JP2011502998A (ja) * 2007-11-01 2011-01-27 ザ ユーエイビー リサーチ ファウンデイション ウイルス感染の治療および予防
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
SI2324126T1 (sl) * 2008-08-12 2014-07-31 Zinfandel Pharmaceuticals, Inc. Postopek identifikacije dejavnikov tveganja za Alzheimerjevo bolezen
CA2759187A1 (fr) * 2009-04-03 2010-10-07 Medisyn Technologies, Inc. Compositions pour le traitement de la maladie d'alzheimer
EP2516425B1 (fr) * 2009-12-23 2015-09-02 Jasco Pharmaceuticals LLC Aminopyrimidines comme inhibiteurs de la kinase
EP2399612B1 (fr) * 2009-12-25 2018-02-21 Canon Kabushiki Kaisha Composition pour marquer des tissus du système nerveux central, procédé pour marquer des tissus du système nerveux central, et procédé de criblage utilisant la composition pour marquer des tissus du système nerveux central
CN102558088A (zh) * 2010-12-31 2012-07-11 中国科学院上海药物研究所 联苯亚甲基-2-硫代-4-噻唑酮类化合物及其制备方法和用途
PE20140051A1 (es) 2011-01-10 2014-02-04 Zinfandel Pharmaceuticals Inc Metodos y productos de farmaco para tratar enfermedad de alzheimer
WO2012153775A1 (fr) 2011-05-10 2012-11-15 国立大学法人神戸大学 Dérivé de thioxothiazolidine ayant un effet inhibiteur sur la fonction ras
JPWO2013183718A1 (ja) * 2012-06-06 2016-02-01 国立大学法人京都大学 スクリーニング方法、タンパク質の不安定性及び／又は安定性を誘導する物質、及び、タンパク質の活性評価
DK2914250T3 (en) 2012-11-05 2018-06-18 Commissariat Energie Atomique COMBINATION OF ANTICANCER SUCH AS A TYROSINKINASE INHIBITOR AND A STAT5 ANTAGONIST, PRIOR TO A THIAZOLIDE INDION FOR ELIMINATING HEMATOLOGICAL CANCER STAM CELLS IN VIVO AND FOR THE PREVENTION OF RECIDIVISM OF RECIDIVES
WO2016077793A1 (fr) * 2014-11-14 2016-05-19 Children's Hospital Medical Center Inhibiteurs de sos1 pour le traitement du cancer
CN104557767B (zh) * 2015-01-14 2016-06-29 成都中医药大学 罗丹宁手性环己烷螺环化合物及其制备方法与用途
CN106008494B (zh) * 2016-05-31 2019-08-27 广东工业大学 一种含4-氧代-2-硫代噻唑烷基衍生物及其制备方法与应用
US20230129364A1 (en) * 2019-12-26 2023-04-27 Yonsei University, University - Industry Foundation (UIF) Pyrrolidine derivative, and pharmaceutical composition for preventing or treating beta-amyloid or tau protein-associated diseases containing same

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1038050B (de) * 1955-11-17 1958-09-04 Farmaceutici Italia S A Soc Verfahren zur Herstellung von 5-(3', 4'-Dioxybenzyliden)-Derivaten heterocyclischer Verbindungen
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS5697277A (en) * 1980-01-07 1981-08-05 Takeda Chem Ind Ltd Thiazolidine derivative
AU6610081A (en) * 1980-01-24 1981-07-30 Senju Pharmaceutical Co., Ltd. Thiazolidine derivatives
JPS5728074A (en) * 1980-07-28 1982-02-15 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation, and inhibitor for aldose reducing enzyme consisting essentially of it
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
US4636516A (en) * 1981-02-19 1987-01-13 Yamanouchi Pharmaceutical Co., Ltd. 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds
JPS58118577A (ja) * 1982-01-07 1983-07-14 Takeda Chem Ind Ltd チアゾリジン誘導体
US4617312A (en) * 1983-01-17 1986-10-14 Pfizer Inc. Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
US4552891A (en) * 1983-09-13 1985-11-12 Eli Lilly And Company Benzothiophene derivatives
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
HU210339B (en) * 1985-05-21 1995-03-28 Pfizer Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
JPS6212776A (ja) * 1985-07-10 1987-01-21 Taiho Yakuhin Kogyo Kk ロ−ダニン誘導体
CA1285572C (fr) * 1985-08-09 1991-07-02 Jill Ann Panetta Composes de type di-t-butylphenol
US5356917A (en) * 1985-08-09 1994-10-18 Eli Lilly And Company Aryl-substituted rhodanine derivatives
CA1325222C (fr) * 1985-08-23 1993-12-14 Lederle (Japan), Ltd. Procede pour la production d'acide 4-biphenylylacetique
KR870006897A (ko) * 1986-01-07 1987-08-13 모리오까 시게오 헤테로시클릭 화합물, 그의 제조 방법 및 이를 함유하는 제약 조성물
EP0304493B1 (fr) * 1987-03-11 1992-09-02 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Derives d'hydroxystyrene
FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
US5260445A (en) * 1987-09-04 1993-11-09 Beecham Group P.L.C. 2,4-thiazolidinediones
US5223522A (en) * 1988-03-08 1993-06-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents
US5330998A (en) * 1988-03-08 1994-07-19 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
US5208250A (en) * 1988-05-25 1993-05-04 Warner-Lambert Company Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents
IE940525L (en) * 1988-05-25 1989-11-25 Warner Lambert Co Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
US4863923A (en) * 1988-07-01 1989-09-05 Eli Lilly And Company Method of inhibiting superoxide release
DE69027472T2 (de) * 1989-04-07 1996-12-05 Lilly Co Eli Arylsubstituierte Rhodaninderivate
JPH02300119A (ja) * 1989-05-11 1990-12-12 Kanegafuchi Chem Ind Co Ltd 過酸化脂質生成抑制剤
EP0398179B1 (fr) * 1989-05-19 1996-01-17 Nisshin Flour Milling Co., Ltd. Dérivés de rhodanine et composés pharmaceutiques
GB8919434D0 (en) * 1989-08-25 1989-10-11 Beecham Group Plc Novel compounds
US4997948A (en) * 1989-10-27 1991-03-05 American Home Products 5-[(1- and 2-naphthalenyl) sulfonyl]-2,4-thiazolidinediones and derivatives thereof
IL96654A (en) * 1989-12-21 1995-06-29 Lilly Co Eli Sutral derivatives containing hydroxybenzyl and sulfur-converted, and pharmaceutical preparations containing them
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
DE4027038A1 (de) * 1990-08-27 1992-03-05 Wella Ag 3-amino-5-benzyliden-2-thioxo-thiazolidin-4- one, verfahren zu deren herstellung und diese enthaltendes kosmetisches mittel
US5158966A (en) * 1991-02-22 1992-10-27 The University Of Colorado Foundation, Inc. Method of treating type i diabetes
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
US5320770A (en) * 1992-04-27 1994-06-14 Dow Corning Corporation Electrorheological (ER) fluid based on amino acid containing metal polyoxo-salts
AU679675B2 (en) * 1992-05-11 1997-07-10 Bayer Corporation Methods for detecting beta amyloid precursor protein processing enzymes
US5236941A (en) * 1992-06-30 1993-08-17 American Home Products Corporation 5-(2-hydroxy-1-arylethylidene)- and 5-(2-oxo-1-arylethylidene)-2,4-thiazolidinediones and derivatives thereof
EP0915090A1 (fr) * 1992-09-10 1999-05-12 Eli Lilly And Company Thiazolidinones comme agents hypoglycemiants et pour le traitement de la maladie d'Alzheimer
US5506745A (en) * 1994-08-05 1996-04-09 Xerox Corporation Hollow conformable charge roll

Also Published As

Publication number Publication date
RU2131251C1 (ru) 1999-06-10
HUT70184A (en) 1995-09-28
US5523314A (en) 1996-06-04
PL300335A1 (en) 1994-03-21
FI933946A0 (fi) 1993-09-09
FI933946A (fi) 1994-03-11
MY131443A (en) 2007-08-30
EP0587377A3 (en) 1994-09-21
NO981911L (no) 1994-03-11
ZA936492B (en) 1995-03-02
NO933198L (no) 1994-03-11
US5661168A (en) 1997-08-26
TW274546B (fr) 1996-04-21
JPH06192091A (ja) 1994-07-12
KR940006590A (ko) 1994-04-25
MX9305444A (es) 1994-05-31
YU59593A (sh) 1997-01-08
AU676843B2 (en) 1997-03-27
HU9302551D0 (en) 1993-11-29
NO981911D0 (no) 1998-04-28
NZ248573A (en) 1996-02-27
CZ181493A3 (en) 1994-03-16
EP0587377A2 (fr) 1994-03-16
IL106877A0 (en) 1993-12-28
EP0915090A1 (fr) 1999-05-12
AU4621893A (en) 1994-03-17
CN1091006A (zh) 1994-08-24
US5716975A (en) 1998-02-10
CA2105598A1 (fr) 1994-03-11
NO933198D0 (no) 1993-09-08

Similar Documents

Publication Publication Date Title
US5716975A (en) Compounds useful as hypoglycemic agents and for treating Alzheimer's disease
AU2008214095B2 (en) Compositions and methods for the treatment of metabolic disorders
US5624937A (en) Chemical compounds as inhibitors of amyloid beta protein production
EP0753298B1 (fr) Combinaison synergique comprenant un sensibilisateur à l'insuline et un inhibiteur de la HMG-CoA reductase pour traiter l'artériosclérose
EP0677517A1 (fr) Traitement de la maladie d'Alzheimer employant des inhibiteurs de cathepsin
JP4500543B2 (ja) 筋萎縮性側索硬化症を処置するためのプラミペキソールの使用
US20040209891A1 (en) Treatment of type 2 diabetes with inhibitors of dipeptidyl peptidase IV
NO317989B1 (no) Nye dipeptidylpeptidase IV effektorer og anvendelse derav, samt farmasoytisk preparat
US20060178307A1 (en) Modulation of NMDA receptor currents via orexin receptor and/or CRF receptor
US20040006112A1 (en) Benzylidene thiazolidinediones and their use as antimycotic agents
US20180291013A1 (en) Compositions and methods for the treatment of metabolic and related disorders
JP2006507303A5 (fr)
US5158966A (en) Method of treating type i diabetes
EP0974348B1 (fr) Agent diminuant la graisse viscerale
EP1418910B1 (fr) Procedes visant a inhiber ou a inverser le processus de formation de filaments tau ou polymerisation
JP2002053557A (ja) アポリポ蛋白ａ−ｉ産生促進薬
IL119119A (en) Rodinin derivatives are a process for their preparation and pharmaceutical preparations containing them
KR20210015892A (ko) 통증 치료를 위한 화합물, 이를 포함하는 조성물 및 이를 사용하는 방법
KR20010108387A (ko) 당뇨병 치료제
JPH02104568A (ja) 神経成長因子産生促進作用剤
JP2000500490A (ja) 糖尿病治療用の４−ヒドロキシクマリン−３−カルボキシアミド
EP0946181B1 (fr) Utilisation de 2(2-morpholinophenyl)guanidine derives pour le traitement de complications aux differents diabetes

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH Patent void