EP0831920A4 - Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine - Google Patents

Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine

Info

Publication number
EP0831920A4
EP0831920A4 EP96913917A EP96913917A EP0831920A4 EP 0831920 A4 EP0831920 A4 EP 0831920A4 EP 96913917 A EP96913917 A EP 96913917A EP 96913917 A EP96913917 A EP 96913917A EP 0831920 A4 EP0831920 A4 EP 0831920A4
Authority
EP
European Patent Office
Prior art keywords
inhibition
compositions
methods
novel cathepsin
cathepsin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96913917A
Other languages
German (de)
English (en)
Other versions
EP0831920A1 (fr
Inventor
Jay S Tung
Sukanto Sinha
Lisa Mcconlogue
Gwen Tatsuno
John Anderson
Christopher M F Semko
Susanna Chrysler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perrigo Co PLC
Original Assignee
Athena Neurosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/467,607 external-priority patent/US5783434A/en
Priority claimed from US08/469,362 external-priority patent/US5849711A/en
Application filed by Athena Neurosciences Inc filed Critical Athena Neurosciences Inc
Publication of EP0831920A1 publication Critical patent/EP0831920A1/fr
Publication of EP0831920A4 publication Critical patent/EP0831920A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP96913917A 1995-06-06 1996-04-26 Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine Withdrawn EP0831920A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US469362 1995-06-06
US08/467,607 US5783434A (en) 1995-06-06 1995-06-06 Cathepsin and methods and compositions for inhibition thereof
US467607 1995-06-06
US08/469,362 US5849711A (en) 1995-06-06 1995-06-06 Cathepsin and methods and compositions for inhibition thereof
PCT/US1996/006211 WO1996039194A1 (fr) 1995-06-06 1996-04-26 Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine

Publications (2)

Publication Number Publication Date
EP0831920A1 EP0831920A1 (fr) 1998-04-01
EP0831920A4 true EP0831920A4 (fr) 2003-03-19

Family

ID=27042111

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96913917A Withdrawn EP0831920A4 (fr) 1995-06-06 1996-04-26 Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine

Country Status (4)

Country Link
EP (1) EP0831920A4 (fr)
JP (1) JPH11506923A (fr)
CA (1) CA2221684A1 (fr)
WO (1) WO1996039194A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE377006T1 (de) * 1995-11-28 2007-11-15 Cephalon Inc Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
US6191166B1 (en) 1997-11-21 2001-02-20 Elan Pharmaceuticals, Inc. Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
US5965614A (en) * 1996-11-22 1999-10-12 Athena Neurosciences, Inc. N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6207710B1 (en) 1996-11-22 2001-03-27 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6642261B2 (en) 1997-11-21 2003-11-04 Athena Neurosciences, Inc. N-(aryl/heteroarylacety) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
AR016751A1 (es) * 1996-11-22 2001-08-01 Athena Neurosciences Inc Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo
US6117901A (en) * 1996-11-22 2000-09-12 Athena Neurosciences, Inc. N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for use
US6211235B1 (en) 1996-11-22 2001-04-03 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
TR199901603T2 (xx) * 1996-11-22 2000-02-21 Elan Pharmaceuticals, Inc. N-(aril/heteroaril/alkilasetil) amino asit amidler, bunlar� i�eren farmas�tik bile�imler ve b�yle bile�ikler kullan�larak �-amiloid peptidinin sal�nmas�n� ve/veya sentezini inhibe etmek i�in y�ntemler.
US6153652A (en) 1996-11-22 2000-11-28 Elan Pharmaceuticals, Inc. N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
DE19648793A1 (de) * 1996-11-26 1998-05-28 Basf Ag Neue Benzamide und deren Anwendung
HRP980093A2 (en) * 1997-02-28 1998-12-31 Lilly Co Eli Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds
AU1926699A (en) * 1997-12-18 1999-07-05 Immunex Corporation Cathepsin dc proteins, dna encoding the proteins, and their use in human cancer prognosis
US6506782B1 (en) 1998-02-27 2003-01-14 Athena Neurosciences, Inc. Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
AU3818799A (en) * 1998-04-20 1999-11-08 Basf Aktiengesellschaft Novel heterocyclically substituted amides with cysteine protease-inhibiting effect
DE19818614A1 (de) * 1998-04-20 1999-10-21 Basf Ag Neue substituierte Amide, deren Herstellung und Anwendung
WO2000024392A1 (fr) * 1998-10-26 2000-05-04 Sumitomo Pharmaceuticals Company, Limited Inhibiteur de la formation de beta-amyloide
EP1336847B1 (fr) * 2002-02-14 2007-12-12 Biofrontera Pharmaceuticals AG Inhibiteurs de la Cathepsine Y pour le développement de médicaments pour le traitement de la douleur
US6974672B2 (en) 2002-03-19 2005-12-13 Amgen Inc. Gene amplification in cancer
EP1347059A1 (fr) * 2002-03-20 2003-09-24 Biofrontera Pharmaceuticals AG Cathepsin Y, une cible pour le développment de médicaments pour le traitement d'accidents vasculaires cérébraux
WO2007054776A2 (fr) * 2005-11-10 2007-05-18 Orchid Research Laboratories Limited Composes semblables au stilbene comme inhibiteurs hdac atypiques

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009838A1 (fr) * 1993-10-01 1995-04-13 Merrell Pharmaceuticals Inc. INHIBITEURS DE LA PRODUCTION DE PROTEINES DE β-AMYLOIDE
EP0652009A1 (fr) * 1993-08-09 1995-05-10 Eli Lilly And Company L'identification et l'utilisation des inhibiteurs de la protease aspartic
WO1995013084A1 (fr) * 1992-05-11 1995-05-18 Miles Inc. Identification de la cathepsine d comme protease amyloïdogene de la maladie d'alzheimer
EP0659418A1 (fr) * 1993-12-21 1995-06-28 Eli Lilly And Company 2-Phényl-3-azoylbenzothiophènes pour traiter la maladie d'Alzheimer
EP0670309A1 (fr) * 1992-11-20 1995-09-06 Japan Tobacco Inc. Compose inhibant la prolyle endopeptidase et utilisation pharmaceutique de ce dernier
WO1996020725A2 (fr) * 1995-01-06 1996-07-11 Sibia Neurosciences, Inc. Peptide, analogue peptidique et analogue d'acide amine agissant comme inhibiteurs de protease
WO1996022966A1 (fr) * 1995-01-23 1996-08-01 Biogen, Inc. Inhibiteurs de l'adherence cellulaire
EP0732399A2 (fr) * 1990-03-05 1996-09-18 Cephalon, Inc. Protéases analogues à la chymotrypsine et leurs inhibiteurs
WO1997030072A1 (fr) * 1996-02-20 1997-08-21 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Inhibiteurs peptidomimetiques de la cathepsine d et des plasmepsines i et ii

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221607A (en) * 1989-09-18 1993-06-22 Scios Nova Inc. Assays and reagents for amyloid deposition
US5242932A (en) * 1991-12-17 1993-09-07 The Rockefeller University Treatment of amyloidosis associated with alzheimer disease
US5164295A (en) * 1991-03-06 1992-11-17 The Upjohn Company Method for identifying amyloid protein-extracellular matrix protein affinity altering compounds
US5538845A (en) * 1992-02-05 1996-07-23 Athena Neurosciences, Inc. Beta-amyloid peptide production inhibitors and methods for their identification
US5441870A (en) * 1992-04-15 1995-08-15 Athena Neurosciences, Inc. Methods for monitoring cellular processing of β-amyloid precursor protein
CZ181493A3 (en) * 1992-09-10 1994-03-16 Lilly Co Eli The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease
US5478857A (en) * 1993-12-23 1995-12-26 Eli Lilly And Company Use of PLA2 inhibitors as treatment for alzheimer's disease
WO1995031192A1 (fr) * 1994-05-16 1995-11-23 Thomas Jefferson University Methode et utilisation d'agents pour inhiber la polymerisation de proteines et methodes pour identifier ces agents
CA2152765A1 (fr) * 1994-06-30 1995-12-31 Jeroen Elisabeth-Joseph Knops Methodes pour traiter un trouble physiologique associe a un peptide amyloide beta
US5523295A (en) * 1994-07-06 1996-06-04 Brandeis University Method for treating and preventing alzheimer's disease

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0732399A2 (fr) * 1990-03-05 1996-09-18 Cephalon, Inc. Protéases analogues à la chymotrypsine et leurs inhibiteurs
WO1995013084A1 (fr) * 1992-05-11 1995-05-18 Miles Inc. Identification de la cathepsine d comme protease amyloïdogene de la maladie d'alzheimer
EP0670309A1 (fr) * 1992-11-20 1995-09-06 Japan Tobacco Inc. Compose inhibant la prolyle endopeptidase et utilisation pharmaceutique de ce dernier
EP0652009A1 (fr) * 1993-08-09 1995-05-10 Eli Lilly And Company L'identification et l'utilisation des inhibiteurs de la protease aspartic
WO1995009838A1 (fr) * 1993-10-01 1995-04-13 Merrell Pharmaceuticals Inc. INHIBITEURS DE LA PRODUCTION DE PROTEINES DE β-AMYLOIDE
EP0659418A1 (fr) * 1993-12-21 1995-06-28 Eli Lilly And Company 2-Phényl-3-azoylbenzothiophènes pour traiter la maladie d'Alzheimer
WO1996020725A2 (fr) * 1995-01-06 1996-07-11 Sibia Neurosciences, Inc. Peptide, analogue peptidique et analogue d'acide amine agissant comme inhibiteurs de protease
WO1996022966A1 (fr) * 1995-01-23 1996-08-01 Biogen, Inc. Inhibiteurs de l'adherence cellulaire
WO1997030072A1 (fr) * 1996-02-20 1997-08-21 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Inhibiteurs peptidomimetiques de la cathepsine d et des plasmepsines i et ii

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9639194A1 *

Also Published As

Publication number Publication date
WO1996039194A1 (fr) 1996-12-12
CA2221684A1 (fr) 1996-12-12
EP0831920A1 (fr) 1998-04-01
JPH11506923A (ja) 1999-06-22

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20030131

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