EP0831920A4 - Novel cathepsin and methods and compositions for inhibition thereof - Google Patents

Novel cathepsin and methods and compositions for inhibition thereof

Info

Publication number
EP0831920A4
EP0831920A4 EP96913917A EP96913917A EP0831920A4 EP 0831920 A4 EP0831920 A4 EP 0831920A4 EP 96913917 A EP96913917 A EP 96913917A EP 96913917 A EP96913917 A EP 96913917A EP 0831920 A4 EP0831920 A4 EP 0831920A4
Authority
EP
European Patent Office
Prior art keywords
inhibition
compositions
methods
novel cathepsin
cathepsin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96913917A
Other languages
German (de)
French (fr)
Other versions
EP0831920A1 (en
Inventor
Jay S Tung
Sukanto Sinha
Lisa Mcconlogue
Gwen Tatsuno
John Anderson
Christopher M F Semko
Susanna Chrysler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perrigo Co PLC
Original Assignee
Athena Neurosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/469,362 external-priority patent/US5849711A/en
Priority claimed from US08/467,607 external-priority patent/US5783434A/en
Application filed by Athena Neurosciences Inc filed Critical Athena Neurosciences Inc
Publication of EP0831920A1 publication Critical patent/EP0831920A1/en
Publication of EP0831920A4 publication Critical patent/EP0831920A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP96913917A 1995-06-06 1996-04-26 Novel cathepsin and methods and compositions for inhibition thereof Withdrawn EP0831920A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US467607 1995-06-06
US08/469,362 US5849711A (en) 1995-06-06 1995-06-06 Cathepsin and methods and compositions for inhibition thereof
US469362 1995-06-06
US08/467,607 US5783434A (en) 1995-06-06 1995-06-06 Cathepsin and methods and compositions for inhibition thereof
PCT/US1996/006211 WO1996039194A1 (en) 1995-06-06 1996-04-26 Novel cathepsin and methods and compositions for inhibition thereof

Publications (2)

Publication Number Publication Date
EP0831920A1 EP0831920A1 (en) 1998-04-01
EP0831920A4 true EP0831920A4 (en) 2003-03-19

Family

ID=27042111

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96913917A Withdrawn EP0831920A4 (en) 1995-06-06 1996-04-26 Novel cathepsin and methods and compositions for inhibition thereof

Country Status (4)

Country Link
EP (1) EP0831920A4 (en)
JP (1) JPH11506923A (en)
CA (1) CA2221684A1 (en)
WO (1) WO1996039194A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU714324B2 (en) * 1995-11-28 2000-01-06 Cephalon, Inc. D-amino acid derived inhibitors of cysteine and serine proteases
US6191166B1 (en) 1997-11-21 2001-02-20 Elan Pharmaceuticals, Inc. Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6117901A (en) 1996-11-22 2000-09-12 Athena Neurosciences, Inc. N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for use
US6211235B1 (en) 1996-11-22 2001-04-03 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6642261B2 (en) 1997-11-21 2003-11-04 Athena Neurosciences, Inc. N-(aryl/heteroarylacety) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US5965614A (en) * 1996-11-22 1999-10-12 Athena Neurosciences, Inc. N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6153652A (en) * 1996-11-22 2000-11-28 Elan Pharmaceuticals, Inc. N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
AR016751A1 (en) * 1996-11-22 2001-08-01 Athena Neurosciences Inc METHOD FOR INHIBITING THE RELEASE OF THE BETA-AMYLOID PEPTIDE IN A CELL, PHARMACEUTICAL COMPOSITION AND USEFUL COMPOUNDS IN THIS METHOD
US6207710B1 (en) 1996-11-22 2001-03-27 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
KR20000069075A (en) * 1996-11-22 2000-11-25 진 엠. 듀발 N-(Aryl/Heteroaryl/Alkylacethyl)Amino Acid Amides, Pharmaceutical Compositions Comprising Same, and Methods for Inhibiting Beta-Amyloid Peptide Release and/or its Synthesis by Use of Such Compounds
DE19648793A1 (en) 1996-11-26 1998-05-28 Basf Ag New benzamides and their application
HRP980093A2 (en) * 1997-02-28 1998-12-31 Lilly Co Eli Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds
WO1999031256A2 (en) * 1997-12-18 1999-06-24 Immunex Corporation Cathepsin dc proteins, dna encoding the proteins, and their use in human cancer prognosis
US6506782B1 (en) 1998-02-27 2003-01-14 Athena Neurosciences, Inc. Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
SK15062000A3 (en) * 1998-04-20 2001-05-10 Basf Aktiengesellschaft Novel heterocyclically substituted amides with cysteine protease-inhibiting effect
DE19818614A1 (en) * 1998-04-20 1999-10-21 Basf Ag New benzamide derivatives useful as cysteine protease inhibitors for treating neurodegenerative diseases, neuronal damage, stroke, cranial trauma, Alzheimer's disease, etc.
WO2000024392A1 (en) * 1998-10-26 2000-05-04 Sumitomo Pharmaceuticals Company, Limited β-AMYLOID FORMATION INHIBITORS
ES2296834T3 (en) * 2002-02-14 2008-05-01 Biofrontera Pharmaceuticals Ag INHIBITORS OF CATEPSIN AND FOR THE DEVELOPMENT OF A MEDICINAL PRODUCT FOR THE TREATMENT OF PAIN.
CA2479724A1 (en) 2002-03-19 2003-10-02 Tularik Inc. Gene amplification in cancer
EP1347059A1 (en) * 2002-03-20 2003-09-24 Biofrontera Pharmaceuticals AG Cathepsin Y for the development of a medicament for the treatment of stroke
US8263044B2 (en) * 2005-11-10 2012-09-11 Orchid Research Laboratories Limited Stilbene like compounds as novel HDAC inhibitors

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009838A1 (en) * 1993-10-01 1995-04-13 Merrell Pharmaceuticals Inc. INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION
EP0652009A1 (en) * 1993-08-09 1995-05-10 Eli Lilly And Company Identification and use of protease inhibitors
WO1995013084A1 (en) * 1992-05-11 1995-05-18 Miles Inc. Cathepsin d is an amyloidogenic protease in alzheimer's disease
EP0659418A1 (en) * 1993-12-21 1995-06-28 Eli Lilly And Company 2-Phenyl-3-azoylbenzothiophene for treating Alzheimer's disease
EP0670309A1 (en) * 1992-11-20 1995-09-06 Japan Tobacco Inc. Compound with prolyl endopeptidase inhibitor activity and pharmaceutical use thereof
WO1996020725A2 (en) * 1995-01-06 1996-07-11 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
WO1996022966A1 (en) * 1995-01-23 1996-08-01 Biogen, Inc. Cell adhesion inhibitors
EP0732399A2 (en) * 1990-03-05 1996-09-18 Cephalon, Inc. Chymotrypsin-like proteases and their inhibitors
WO1997030072A1 (en) * 1996-02-20 1997-08-21 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Peptidomimetic inhibitors of cathepsin d and plasmepsins i and ii

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221607A (en) * 1989-09-18 1993-06-22 Scios Nova Inc. Assays and reagents for amyloid deposition
US5242932A (en) * 1991-12-17 1993-09-07 The Rockefeller University Treatment of amyloidosis associated with alzheimer disease
US5164295A (en) * 1991-03-06 1992-11-17 The Upjohn Company Method for identifying amyloid protein-extracellular matrix protein affinity altering compounds
US5538845A (en) * 1992-02-05 1996-07-23 Athena Neurosciences, Inc. Beta-amyloid peptide production inhibitors and methods for their identification
US5441870A (en) * 1992-04-15 1995-08-15 Athena Neurosciences, Inc. Methods for monitoring cellular processing of β-amyloid precursor protein
IL106877A (en) * 1992-09-10 1998-03-10 Lilly Co Eli Rhodanine derivatives for use as medicaments for the treatment of alzheimer's disease
US5478857A (en) * 1993-12-23 1995-12-26 Eli Lilly And Company Use of PLA2 inhibitors as treatment for alzheimer's disease
WO1995031192A1 (en) * 1994-05-16 1995-11-23 Thomas Jefferson University Method and use of agents to inhibit protein polymerization and methods of identifying these agents
CA2152765A1 (en) * 1994-06-30 1995-12-31 Jeroen Elisabeth-Joseph Knops Methods for treating a physiological disorder associated with beta amyloid peptide
US5523295A (en) * 1994-07-06 1996-06-04 Brandeis University Method for treating and preventing alzheimer's disease

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0732399A2 (en) * 1990-03-05 1996-09-18 Cephalon, Inc. Chymotrypsin-like proteases and their inhibitors
WO1995013084A1 (en) * 1992-05-11 1995-05-18 Miles Inc. Cathepsin d is an amyloidogenic protease in alzheimer's disease
EP0670309A1 (en) * 1992-11-20 1995-09-06 Japan Tobacco Inc. Compound with prolyl endopeptidase inhibitor activity and pharmaceutical use thereof
EP0652009A1 (en) * 1993-08-09 1995-05-10 Eli Lilly And Company Identification and use of protease inhibitors
WO1995009838A1 (en) * 1993-10-01 1995-04-13 Merrell Pharmaceuticals Inc. INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION
EP0659418A1 (en) * 1993-12-21 1995-06-28 Eli Lilly And Company 2-Phenyl-3-azoylbenzothiophene for treating Alzheimer's disease
WO1996020725A2 (en) * 1995-01-06 1996-07-11 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
WO1996022966A1 (en) * 1995-01-23 1996-08-01 Biogen, Inc. Cell adhesion inhibitors
WO1997030072A1 (en) * 1996-02-20 1997-08-21 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Peptidomimetic inhibitors of cathepsin d and plasmepsins i and ii

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9639194A1 *

Also Published As

Publication number Publication date
JPH11506923A (en) 1999-06-22
CA2221684A1 (en) 1996-12-12
EP0831920A1 (en) 1998-04-01
WO1996039194A1 (en) 1996-12-12

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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18D Application deemed to be withdrawn

Effective date: 20021101