IL102322A - Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments - Google Patents

Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments

Info

Publication number
IL102322A
IL102322A IL102322A IL10232292A IL102322A IL 102322 A IL102322 A IL 102322A IL 102322 A IL102322 A IL 102322A IL 10232292 A IL10232292 A IL 10232292A IL 102322 A IL102322 A IL 102322A
Authority
IL
Israel
Prior art keywords
tetrahydrocarbazole derivatives
medicaments
agonist
agonist medicaments
tetrahydrocarbazole
Prior art date
Application number
IL102322A
Other languages
English (en)
Other versions
IL102322A0 (en
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL102322(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to IL117105A priority Critical patent/IL117105A/en
Priority to IL11710596A priority patent/IL117105A0/xx
Priority to IL117104A priority patent/IL117104A/xx
Publication of IL102322A0 publication Critical patent/IL102322A0/xx
Publication of IL102322A publication Critical patent/IL102322A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL102322A 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments IL102322A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL117105A IL117105A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL11710596A IL117105A0 (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them
IL117104A IL117104A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments

Publications (2)

Publication Number Publication Date
IL102322A0 IL102322A0 (en) 1993-01-14
IL102322A true IL102322A (en) 1997-09-30

Family

ID=10697363

Family Applications (4)

Application Number Title Priority Date Filing Date
IL102322A IL102322A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments
IL11710596A IL117105A0 (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them
IL117105A IL117105A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL117104A IL117104A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL11710596A IL117105A0 (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them
IL117105A IL117105A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL117104A IL117104A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (34)

Country Link
US (2) US5464864A (enExample)
EP (1) EP0591280B1 (enExample)
JP (1) JP3261502B2 (enExample)
KR (1) KR100251571B1 (enExample)
CN (1) CN1034072C (enExample)
AP (1) AP344A (enExample)
AT (1) ATE170746T1 (enExample)
BR (2) BR9206237A (enExample)
CA (1) CA2113726C (enExample)
CZ (3) CZ150596A3 (enExample)
DE (2) DE69226953T2 (enExample)
DK (1) DK0591280T3 (enExample)
FI (1) FI103967B (enExample)
GB (1) GB9113802D0 (enExample)
HU (1) HU218907B (enExample)
IE (1) IE922062A1 (enExample)
IL (4) IL102322A (enExample)
LU (1) LU90939I2 (enExample)
MA (1) MA22563A1 (enExample)
MX (1) MX9203444A (enExample)
NL (1) NL300103I2 (enExample)
NO (2) NO304774B1 (enExample)
NZ (1) NZ243288A (enExample)
PL (3) PL171034B1 (enExample)
PT (1) PT100620B (enExample)
RU (1) RU2137474C1 (enExample)
SA (1) SA92130141B1 (enExample)
SG (1) SG47877A1 (enExample)
SI (1) SI9200125B (enExample)
SK (3) SK280907B6 (enExample)
TW (1) TW214544B (enExample)
UA (1) UA41254C2 (enExample)
WO (1) WO1993000086A1 (enExample)
ZA (1) ZA924658B (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
CA2179678A1 (en) * 1995-06-23 1996-12-24 Michael Edward Flaugh 6-substituted-1,2,3,4-tetrahydro-9h-carbazoles and 7-substituted-10h-cyclohepta¬7,6-b| indoles
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
WO2003029214A1 (en) * 2001-09-28 2003-04-10 F. Hoffmann-La Roche Ag Pseudopolymorphic forms of carvedilol
BR0312176A (pt) 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmaceutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediario e processo para a preparação de um novo intermediario
ES2336664T3 (es) 2002-06-21 2010-04-15 Suven Life Sciences Limited Arilaquil indoles que tienen afinidad por receptores de serotonina utiles como agentes terapeuticos, procesos para su preparacion y composiciones farmaceuticas que los contienen.
MXPA05005701A (es) 2002-11-28 2005-08-16 Suven Life Sciences Ltd N-arilsulfonil indoles sustituidos en la posicion 3 que tienen afinidad por el receptor de la serotonina, proceso para su preparacion y composiciones farmaceuticas que los contienen.
PT1567492E (pt) 2002-11-28 2013-07-22 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxi-indóis
EA009367B1 (ru) 2002-12-18 2007-12-28 Сувен Лайф Сайенсиз Лимитед ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА
RU2430088C2 (ru) * 2004-07-14 2011-09-27 Центарис Гмбх Производные тетрагидрокарбазола и фармацевтическая композиция на их основе
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
CA2658986C (en) * 2006-08-07 2014-11-25 Actelion Pharmaceuticals Ltd (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
PL2124556T3 (pl) 2006-10-09 2015-02-27 Charleston Laboratories Inc Kompozycje farmaceutyczne
ES2691033T3 (es) 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
CA3066426A1 (en) 2008-01-09 2009-07-16 Charleston Laboratories, Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
CA2767576C (en) 2009-07-08 2020-03-10 Charleston Laboratories Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
WO2011050140A1 (en) 2009-10-22 2011-04-28 Blue Fury Consulting, L.L.C. Posterior cervical fusion system and techniques
WO2013016223A2 (en) 2011-07-22 2013-01-31 The University Of Chicago Treatments for migraine and related disorders
EP2935280A4 (en) 2012-12-21 2016-05-25 Map Pharmaceuticals Inc 8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
CA3055170A1 (en) 2016-03-04 2017-09-08 Charleston Laboratories, Inc. Pharmaceutical compositions
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
WO2025038666A2 (en) * 2023-08-13 2025-02-20 GATC Health Corp Compounds and methods for treating addiction
CN119499195A (zh) * 2024-11-26 2025-02-25 青岛国信制药有限公司 一种快速吸收琥珀酸呋罗曲坦片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
CA2113726C (en) 2008-02-19
SG47877A1 (en) 1998-04-17
US5637611A (en) 1997-06-10
PL171034B1 (en) 1997-02-28
NL300103I1 (nl) 2002-12-02
FI103967B1 (fi) 1999-10-29
HU218907B (hu) 2000-12-28
NO934800D0 (no) 1993-12-23
CZ282061B6 (cs) 1997-05-14
GB9113802D0 (en) 1991-08-14
AP344A (en) 1994-07-05
SK280906B6 (sk) 2000-09-12
BR1100460A (pt) 2000-07-18
LU90939I2 (fr) 2002-09-24
RU2137474C1 (ru) 1999-09-20
SA92130141B1 (ar) 2005-12-18
WO1993000086A1 (en) 1993-01-07
PT100620B (pt) 1999-01-29
IL117104A (en) 1997-09-30
CA2113726A1 (en) 1993-01-07
IE922062A1 (en) 1992-12-30
JP3261502B2 (ja) 2002-03-04
UA41254C2 (uk) 2001-09-17
HK1014669A1 (en) 1999-09-30
MX9203444A (es) 1993-12-01
DK0591280T3 (da) 1999-02-15
PL169410B1 (pl) 1996-07-31
FI103967B (fi) 1999-10-29
DE10299042I2 (de) 2005-02-03
ATE170746T1 (de) 1998-09-15
FI935842A7 (fi) 1993-12-23
AU652842B2 (en) 1994-09-08
IL102322A0 (en) 1993-01-14
CZ150696A3 (en) 1997-06-11
JPH06508827A (ja) 1994-10-06
IL117105A (en) 1998-01-04
AP9200403A0 (en) 1992-07-31
DE69226953D1 (de) 1998-10-15
CN1069726A (zh) 1993-03-10
NZ243288A (en) 1994-09-27
NO304774B1 (no) 1999-02-15
AU1977592A (en) 1993-01-25
EP0591280B1 (en) 1998-09-09
NO2005011I2 (no) 2008-02-11
IL117105A0 (en) 1996-06-18
BR9206237A (pt) 1995-04-11
PT100620A (pt) 1993-09-30
SK280907B6 (sk) 2000-09-12
CZ282327B6 (cs) 1997-06-11
ZA924658B (en) 1993-12-24
NL300103I2 (nl) 2003-02-03
DE10299042I1 (de) 2003-02-20
MA22563A1 (fr) 1992-12-31
CZ150596A3 (en) 1997-05-14
SI9200125A (en) 1992-12-31
SK280905B6 (sk) 2000-09-12
DE69226953T2 (de) 1999-05-12
CZ286193A3 (en) 1994-07-13
NO934800L (no) 1993-12-23
NO2005011I1 (no) 2005-05-18
PL169392B1 (pl) 1996-07-31
TW214544B (enExample) 1993-10-11
CZ282083B6 (cs) 1997-05-14
EP0591280A1 (en) 1994-04-13
HUT68961A (en) 1995-08-28
SK131993A3 (en) 1994-06-08
CN1034072C (zh) 1997-02-19
KR100251571B1 (ko) 2000-07-01
IL117104A0 (en) 1996-06-18
FI935842A0 (fi) 1993-12-23
SI9200125B (en) 2001-12-31
US5464864A (en) 1995-11-07

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