JP3261502B2 - ５ｈｔ１レセプターアゴニストとしてのテトラヒドロカルバゾン誘導体の使用 - Google Patents

５ｈｔ１レセプターアゴニストとしてのテトラヒドロカルバゾン誘導体の使用

Info

Publication number
JP3261502B2
JP3261502B2 JP51108692A JP51108692A JP3261502B2 JP 3261502 B2 JP3261502 B2 JP 3261502B2 JP 51108692 A JP51108692 A JP 51108692A JP 51108692 A JP51108692 A JP 51108692A JP 3261502 B2 JP3261502 B2 JP 3261502B2
Authority
JP
Japan
Prior art keywords
tetrahydrocarbazole
formula
amino
alkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP51108692A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06508827A (ja
Inventor
キング，フランシス・デイビッド
ガスター，ララミー・メアリー
カウマン，アルベルト・ジュリオ
ヤング，ロドニー・クリストファー
Original Assignee
バーナリス・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP3261502(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by バーナリス・リミテッド filed Critical バーナリス・リミテッド
Publication of JPH06508827A publication Critical patent/JPH06508827A/ja
Application granted granted Critical
Publication of JP3261502B2 publication Critical patent/JP3261502B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP51108692A 1991-06-26 1992-06-17 ５ｈｔ１レセプターアゴニストとしてのテトラヒドロカルバゾン誘導体の使用 Expired - Lifetime JP3261502B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9113802.4 1991-06-26
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
US08/167,846 US5464864A (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists
PCT/GB1992/001082 WO1993000086A1 (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5ht1 receptor agonists

Publications (2)

Publication Number Publication Date
JPH06508827A JPH06508827A (ja) 1994-10-06
JP3261502B2 true JP3261502B2 (ja) 2002-03-04

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51108692A Expired - Lifetime JP3261502B2 (ja) 1991-06-26 1992-06-17 ５ｈｔ１レセプターアゴニストとしてのテトラヒドロカルバゾン誘導体の使用

Country Status (34)

Country Link
US (2) US5464864A (enExample)
EP (1) EP0591280B1 (enExample)
JP (1) JP3261502B2 (enExample)
KR (1) KR100251571B1 (enExample)
CN (1) CN1034072C (enExample)
AP (1) AP344A (enExample)
AT (1) ATE170746T1 (enExample)
BR (2) BR9206237A (enExample)
CA (1) CA2113726C (enExample)
CZ (3) CZ150596A3 (enExample)
DE (2) DE69226953T2 (enExample)
DK (1) DK0591280T3 (enExample)
FI (1) FI103967B1 (enExample)
GB (1) GB9113802D0 (enExample)
HU (1) HU218907B (enExample)
IE (1) IE922062A1 (enExample)
IL (4) IL117104A (enExample)
LU (1) LU90939I2 (enExample)
MA (1) MA22563A1 (enExample)
MX (1) MX9203444A (enExample)
NL (1) NL300103I2 (enExample)
NO (2) NO304774B1 (enExample)
NZ (1) NZ243288A (enExample)
PL (3) PL169410B1 (enExample)
PT (1) PT100620B (enExample)
RU (1) RU2137474C1 (enExample)
SA (1) SA92130141B1 (enExample)
SG (1) SG47877A1 (enExample)
SI (1) SI9200125B (enExample)
SK (3) SK280907B6 (enExample)
TW (1) TW214544B (enExample)
UA (1) UA41254C2 (enExample)
WO (1) WO1993000086A1 (enExample)
ZA (1) ZA924658B (enExample)

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GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
CA2179678A1 (en) * 1995-06-23 1996-12-24 Michael Edward Flaugh 6-substituted-1,2,3,4-tetrahydro-9h-carbazoles and 7-substituted-10h-cyclohepta¬7,6-b| indoles
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9808069D0 (en) 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
ES2291503T3 (es) * 2001-09-28 2008-03-01 F. Hoffmann-La Roche Ag Formas pseudopolimorficas de carvedilol.
JP4455992B2 (ja) 2002-06-21 2010-04-21 スベン ライフ サイエンシズ リミティド 治療薬剤として有用なセロトニン受容体親和性を有するアリールアルキル・インドール、その製造方法、並びにそれらを含む医薬組成物
NZ537770A (en) 2002-06-21 2007-03-30 Suven Life Sciences Ltd Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
EA009193B1 (ru) 2002-11-28 2007-12-28 Сувен Лайф Сайенсиз Лимитед N-арилсульфонил-3-аминоалкоксииндолы
DK1581492T3 (da) 2002-11-28 2008-11-10 Suven Life Sciences Ltd N-arylsulfonyl-3-substituerede indoler med serotoninreceptoraffinitet, fremgangsmåde til fremstilling heraf og en farmaceutisk sammensætning indeholdende disse
EA009367B1 (ru) 2002-12-18 2007-12-28 Сувен Лайф Сайенсиз Лимитед ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА
RU2430088C2 (ru) * 2004-07-14 2011-09-27 Центарис Гмбх Производные тетрагидрокарбазола и фармацевтическая композиция на их основе
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
KR101411820B1 (ko) * 2006-08-07 2014-06-24 액테리온 파마슈티칼 리미티드 (3-아미노-1,2,3,4-테트라하이드로-9ｈ-카르바졸-9-일)-아세트산 유도체
EP2813144A1 (en) 2006-10-09 2014-12-17 Charleston Laboratories, Inc. Analgesic compositions comprising an antihistamine
US8148377B2 (en) 2007-02-11 2012-04-03 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
JP5714910B2 (ja) 2008-01-09 2015-05-07 チャールストン ラボラトリーズ，インコーポレイテッド 薬学的組成物
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
WO2011006012A1 (en) 2009-07-08 2011-01-13 Charleston Laboratories Inc. Pharmaceutical compositions
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
US9204906B2 (en) 2009-10-22 2015-12-08 Nuvasive, Inc. Posterior cervical fusion system and techniques
EP3628325A1 (en) 2011-07-22 2020-04-01 The University of Chicago Treatments for migraine and related disorders
HK1216250A1 (zh) 2012-12-21 2016-10-28 Map Pharmaceuticals, Inc. 8'-羟基-二氢麦角胺化合物及组合物
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
JP2019507181A (ja) 2016-03-04 2019-03-14 チャールストン ラボラトリーズ，インコーポレイテッド 医薬組成物
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
WO2025038666A2 (en) * 2023-08-13 2025-02-20 GATC Health Corp Compounds and methods for treating addiction
CN119499195A (zh) * 2024-11-26 2025-02-25 青岛国信制药有限公司 一种快速吸收琥珀酸呋罗曲坦片及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959309A (en) 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959309A (en) 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｃｈｅｍｉｓｔｒｙ，（１９７７），２８（５），ｐ．９９５−１０００
Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｃｈｅｍｉｓｔｒｙ，（１９８１），３５（３），ｐ．９３１−７

Also Published As

Publication number Publication date
ZA924658B (en) 1993-12-24
CZ150696A3 (en) 1997-06-11
IL102322A (en) 1997-09-30
AU1977592A (en) 1993-01-25
SK280906B6 (sk) 2000-09-12
EP0591280B1 (en) 1998-09-09
NO934800L (no) 1993-12-23
AU652842B2 (en) 1994-09-08
CA2113726C (en) 2008-02-19
SI9200125A (en) 1992-12-31
SI9200125B (en) 2001-12-31
WO1993000086A1 (en) 1993-01-07
GB9113802D0 (en) 1991-08-14
EP0591280A1 (en) 1994-04-13
SG47877A1 (en) 1998-04-17
SK131993A3 (en) 1994-06-08
ATE170746T1 (de) 1998-09-15
IL117105A (en) 1998-01-04
IL102322A0 (en) 1993-01-14
FI935842A7 (fi) 1993-12-23
JPH06508827A (ja) 1994-10-06
CZ282327B6 (cs) 1997-06-11
LU90939I2 (fr) 2002-09-24
IE922062A1 (en) 1992-12-30
BR1100460A (pt) 2000-07-18
PL171034B1 (en) 1997-02-28
HUT68961A (en) 1995-08-28
CZ282083B6 (cs) 1997-05-14
SK280905B6 (sk) 2000-09-12
CZ282061B6 (cs) 1997-05-14
AP9200403A0 (en) 1992-07-31
US5464864A (en) 1995-11-07
NO2005011I1 (no) 2005-05-18
PT100620A (pt) 1993-09-30
NL300103I1 (nl) 2002-12-02
IL117104A0 (en) 1996-06-18
BR9206237A (pt) 1995-04-11
KR100251571B1 (ko) 2000-07-01
CN1034072C (zh) 1997-02-19
CZ150596A3 (en) 1997-05-14
DE10299042I2 (de) 2005-02-03
CN1069726A (zh) 1993-03-10
DE10299042I1 (de) 2003-02-20
SK280907B6 (sk) 2000-09-12
NL300103I2 (nl) 2003-02-03
DE69226953D1 (de) 1998-10-15
CA2113726A1 (en) 1993-01-07
DE69226953T2 (de) 1999-05-12
IL117104A (en) 1997-09-30
SA92130141B1 (ar) 2005-12-18
RU2137474C1 (ru) 1999-09-20
PL169410B1 (pl) 1996-07-31
FI103967B (fi) 1999-10-29
CZ286193A3 (en) 1994-07-13
HU218907B (hu) 2000-12-28
HK1014669A1 (en) 1999-09-30
UA41254C2 (uk) 2001-09-17
US5637611A (en) 1997-06-10
MX9203444A (es) 1993-12-01
NZ243288A (en) 1994-09-27
NO2005011I2 (no) 2008-02-11
AP344A (en) 1994-07-05
DK0591280T3 (da) 1999-02-15
NO934800D0 (no) 1993-12-23
MA22563A1 (fr) 1992-12-31
NO304774B1 (no) 1999-02-15
PL169392B1 (pl) 1996-07-31
TW214544B (enExample) 1993-10-11
FI935842A0 (fi) 1993-12-23
FI103967B1 (fi) 1999-10-29
PT100620B (pt) 1999-01-29
IL117105A0 (en) 1996-06-18

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