ID24565A - Metoda untuk integrasi gen pada tempat yang spesifik dalam sel mamalia melalui rekombinasi homolog dan vektor untuk pencapaian yang sama - Google Patents
Metoda untuk integrasi gen pada tempat yang spesifik dalam sel mamalia melalui rekombinasi homolog dan vektor untuk pencapaian yang samaInfo
- Publication number
- ID24565A ID24565A IDW991196A ID991196A ID24565A ID 24565 A ID24565 A ID 24565A ID W991196 A IDW991196 A ID W991196A ID 991196 A ID991196 A ID 991196A ID 24565 A ID24565 A ID 24565A
- Authority
- ID
- Indonesia
- Prior art keywords
- vector
- integration
- mamalia
- homologic
- recombinations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/819,866 US5830698A (en) | 1997-03-14 | 1997-03-14 | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
US09/023,715 US5998144A (en) | 1997-03-14 | 1998-02-13 | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
ID24565A true ID24565A (id) | 2000-07-27 |
Family
ID=26697516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW991196A ID24565A (id) | 1997-03-14 | 1998-03-09 | Metoda untuk integrasi gen pada tempat yang spesifik dalam sel mamalia melalui rekombinasi homolog dan vektor untuk pencapaian yang sama |
Country Status (21)
Country | Link |
---|---|
US (3) | US6413777B1 (id) |
EP (1) | EP0981637B1 (id) |
JP (1) | JP4128227B2 (id) |
CN (1) | CN1175111C (id) |
AT (1) | ATE296356T1 (id) |
AU (1) | AU737155B2 (id) |
BR (1) | BR9808584A (id) |
CA (1) | CA2283740C (id) |
CZ (1) | CZ293355B6 (id) |
DE (1) | DE69830312T2 (id) |
ES (1) | ES2242997T3 (id) |
ID (1) | ID24565A (id) |
IL (1) | IL131746A0 (id) |
IN (1) | IN189732B (id) |
NO (1) | NO994397L (id) |
PL (1) | PL191251B1 (id) |
PT (1) | PT981637E (id) |
RO (1) | RO120148B1 (id) |
RU (1) | RU2004107694A (id) |
TW (1) | TWI232239B (id) |
WO (1) | WO1998041645A1 (id) |
Families Citing this family (97)
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US5830698A (en) * | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
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GB9912965D0 (en) * | 1999-06-03 | 1999-08-04 | Oxford Biomedica Ltd | In vivo selection method |
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DK1297170T3 (en) * | 2000-06-23 | 2016-03-14 | Novozymes As | A process for stable chromosomal integration of multiple copies of the genes |
EP1411770A4 (en) | 2001-07-05 | 2006-05-10 | Chiron Corp | POLYNUCLEOTIDES CODING FOR ANTIGENIC C-TYPE HIV POLYPEPTIDES, POLYPEPTIDES AND THEIR USE |
CN1585822A (zh) | 2001-11-16 | 2005-02-23 | 拜奥根Idec公司 | 抗体的多顺反子表达 |
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CN110607326B (zh) * | 2018-06-15 | 2022-11-29 | 江苏省农业科学院 | 非强启动式的外源基因表达法及其在具有毒性的目标蛋白表达中的应用 |
JP2022513319A (ja) * | 2018-10-01 | 2022-02-07 | ロンザ リミテッド | 予測可能かつ安定な導入遺伝子発現を有するssi細胞および形成の方法 |
US11028176B2 (en) | 2019-02-13 | 2021-06-08 | The Brigham And Women's Hospital, Inc. | Anti-peripheral lymph node addressin antibodies and uses thereof |
TW202328174A (zh) | 2021-08-23 | 2023-07-16 | 美商百歐維拉提夫治療公司 | 以反向末端重覆序列製造封閉dna |
TW202323274A (zh) | 2021-08-23 | 2023-06-16 | 美商百歐維拉提夫治療公司 | 優化因子viii基因 |
CN118019758A (zh) | 2021-09-30 | 2024-05-10 | 比奥维拉迪维治疗股份有限公司 | 编码免疫原性降低的因子viii多肽的核酸 |
Family Cites Families (10)
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US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
CA2045175C (en) | 1989-11-06 | 2003-03-18 | Arthur I. Skoultchi | Production of proteins using homologous recombination |
PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
AU4401993A (en) * | 1992-06-04 | 1993-12-30 | Exemplar Corporation | Insertion of heterologous dna outside of known chromosomal genes |
MX9305183A (es) * | 1992-08-27 | 1994-05-31 | Us Agriculture | Intron portatil, molecula de adn genomico viral, virus vivo y vacuna que los contiene y metodo para su obtencion. |
US5648267A (en) * | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
US5830698A (en) * | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
CN1175111C (zh) * | 1997-03-14 | 2004-11-10 | 艾德药品公司 | 将基因整合至哺乳动物细胞特定位点的方法及所用载体 |
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1998
- 1998-03-09 CN CNB988049880A patent/CN1175111C/zh not_active Expired - Fee Related
- 1998-03-09 DE DE69830312T patent/DE69830312T2/de not_active Revoked
- 1998-03-09 PL PL335695A patent/PL191251B1/pl not_active IP Right Cessation
- 1998-03-09 PT PT98910109T patent/PT981637E/pt unknown
- 1998-03-09 AT AT98910109T patent/ATE296356T1/de not_active IP Right Cessation
- 1998-03-09 ID IDW991196A patent/ID24565A/id unknown
- 1998-03-09 JP JP54053998A patent/JP4128227B2/ja not_active Expired - Fee Related
- 1998-03-09 AU AU64435/98A patent/AU737155B2/en not_active Ceased
- 1998-03-09 RO RO99-00972A patent/RO120148B1/ro unknown
- 1998-03-09 ES ES98910109T patent/ES2242997T3/es not_active Expired - Lifetime
- 1998-03-09 CZ CZ19993162A patent/CZ293355B6/cs not_active IP Right Cessation
- 1998-03-09 WO PCT/US1998/003935 patent/WO1998041645A1/en active IP Right Grant
- 1998-03-09 CA CA002283740A patent/CA2283740C/en not_active Expired - Fee Related
- 1998-03-09 BR BR9808584-0A patent/BR9808584A/pt not_active Application Discontinuation
- 1998-03-09 IL IL13174698A patent/IL131746A0/xx not_active IP Right Cessation
- 1998-03-09 EP EP98910109A patent/EP0981637B1/en not_active Revoked
- 1998-03-10 IN IN616DE1998 patent/IN189732B/en unknown
- 1998-03-13 TW TW087103778A patent/TWI232239B/zh not_active IP Right Cessation
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1999
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IL131746A0 (en) | 2001-03-19 |
NO994397L (no) | 1999-11-09 |
US6841383B2 (en) | 2005-01-11 |
JP2001516221A (ja) | 2001-09-25 |
CN1255166A (zh) | 2000-05-31 |
IN189732B (id) | 2003-04-19 |
PL191251B1 (pl) | 2006-04-28 |
DE69830312T2 (de) | 2006-02-02 |
EP0981637B1 (en) | 2005-05-25 |
WO1998041645A1 (en) | 1998-09-24 |
CZ316299A3 (cs) | 2000-02-16 |
ATE296356T1 (de) | 2005-06-15 |
BR9808584A (pt) | 2000-05-23 |
PT981637E (pt) | 2005-09-30 |
PL335695A1 (en) | 2000-05-08 |
US7235360B2 (en) | 2007-06-26 |
ES2242997T3 (es) | 2005-11-16 |
NO994397D0 (no) | 1999-09-10 |
US20020192820A1 (en) | 2002-12-19 |
CA2283740C (en) | 2006-06-27 |
CA2283740A1 (en) | 1998-09-24 |
CN1175111C (zh) | 2004-11-10 |
US20040166528A1 (en) | 2004-08-26 |
US6413777B1 (en) | 2002-07-02 |
RU2004107694A (ru) | 2005-08-27 |
JP4128227B2 (ja) | 2008-07-30 |
TWI232239B (en) | 2005-05-11 |
EP0981637A1 (en) | 2000-03-01 |
AU6443598A (en) | 1998-10-12 |
RO120148B1 (ro) | 2005-09-30 |
CZ293355B6 (cs) | 2004-04-14 |
AU737155B2 (en) | 2001-08-09 |
DE69830312D1 (de) | 2005-06-30 |
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