HUE035599T2 - Humánellenanyag-farmakon konjugátum szöveti faktor ellen - Google Patents
Humánellenanyag-farmakon konjugátum szöveti faktor ellen Download PDFInfo
- Publication number
- HUE035599T2 HUE035599T2 HUE11725095A HUE11725095A HUE035599T2 HU E035599 T2 HUE035599 T2 HU E035599T2 HU E11725095 A HUE11725095 A HU E11725095A HU E11725095 A HUE11725095 A HU E11725095A HU E035599 T2 HUE035599 T2 HU E035599T2
- Authority
- HU
- Hungary
- Prior art keywords
- antibody
- cancer
- ser
- gly
- seq
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (12)
- I1UMÁNELLENANYAG-FARMAKON KONJUGÁTUM SZÖVETI FAKTOR ELLEN Szabadalmi igénypontok1. Ellenanyag-farmakon konjugátum, amely szöveti faktorhoz kőtödő ellenanyagot tartalmaz, ahol az ellenanyag línkeren keresztöl aurisztatttthoz vagy funkcionális peplidanalógjához vagy származékához konjugált, és ahol a konjugátumban lévő ellenanyag SEQ ID NO:6 szerinti ammosav-szekveneiájü CDRI régiót, SEQ 10 NO:7 szerinti amtnosav-szekvenciájó CI5R2 régiót és SEQ 1.0 NO:<? szerinti aminosav-szekvenctájá CDR3 régiót tartalmazó VH régiót és SEQ ID NO:46 szerinti sminösav-szekvenciájó CDRl régiót, SEQ 113 NO:47 szerinti antinösav-szekvenciájó CDR2 régiót és SEQ 10 NÜ:48 szerinti antinösav-szekvenciájó CDR3 régiót tartalmazó VL régiót tartaimaz.
- 2. Az 1. igénypont szerinti ellenanyag-farmakon konjugátum, ahol az ellenanyag SEQ 10 NQ: 5 szerinti aminosav-szekveneiát tartalmazó VH régiói és SEQ iO NO: 45 szerinti aminosav-szekvenciát tartalmazó VL régiót tartalmaz.
- 3. Az L vagy 2. igénypont szerinti ellenanyag-farmakon konjugátum, ahol az ellenanyag teljes hosszúságú ellenanyag;
- 4. Az előző igénypontok bármelyike szerinti ellenanyag-farmakon konjugátum, ahol az ellenanyag teljesen humán monoklonális IgGI ellenanyag, például lgOi,K.
- 5. Az előző igénypontok bármelyike szerinti ellenanyag-farmakon konjugátum, ahol az aorísztatin monometil-aurísztatin E (MMAE):altos a. hullámos vonal a linker kapcsolódásának helyéi jelzi. ó, Az 1-4. igénypontok bármelyike szerinti ellenanyag-farmakon konjugátum, ahol az aarisztatia monometil-aurisztaíin F tMMAE):ahol a hullámos vonal a linker kapcsolódásának helyét jelzi.
- 7, Az előző igénypontok bármelyike szerinti ellenanyag-farmakon konjugátum, ahol a linker a TF elleni ellenanyag szulíidrílcsoportjaihoz kapcsolódik, amelyek a TF elleni ellenanyag (részleges) redukálásával keletkeztek.
- 8. Az i-5. és 7. igénypontok bármelyike szerinti ellenanyag-farmakon konjugátum, ahol a íinker-auriszíatbi veMMAF vagy vcMMAE:AÍLMG-VC-PAB-MMÁF {vcMMAQ «Ab- MC-VC- PAKS- MMAE {veMMAE) ahol p jelentése 1-8 szám. S jeíentése TF elleni ellenanyag szuíihidrilesoportja és Ab a TF elleni ellenanyagé! jelöli. 9. A. 8. igénypont szerinti ellenanyag-fartnakon konjugátum, ahol a b'nker-auriszíatín a 8. igénypont szerinti megbatározott -vcMMAE.
- 10. Az 1-4, és 6-7. igénypontok bármelyike szerinti ellenanyag-fartnakon konjugáium, ahol a iíttker-konj ugátum meM MA F:Afcr-MÖ-MMAF (m cMMAF) ahol p jelentése szám 1-8., S jelentése TF elleni ellenanyag szuiihídrilesoportja és Ab a TF elleni ellenanyagot jelöli. ÍS, Gyógyászati készítmény, amely 1-iO. igénypontok bármelyike szerint meghatározott ellenanyag-fartnakon konjugátumot és gyógyászati Ság elfogadható hordozót tartalmaz.
- 12. Az 1-10, igénypontok bármelyike szerint meghatározót! el lettan vág-latinakon konjugátum gyógyszerként történő alkalmazásra, 13. f-TO. igénypontok bármelyike szerint meghatározott el tananyag-farinakon konjugáium rák. kezelésében történő alkalmazásra, 14. A 13. igény-pont szeriül t elienanyag-farmakon konjugátum az ott meghatározott alkalmazásra, ahol a rák a. kővetkezőkből álló csoportból választott: központi idegrendszeri tumorok, fej- és nyak! rák. tüdőrák, például NSCLC, mellrák, különösen tripla negatív mellrák, nyelöcsorák, gyomor- vagy hasi rák, máj - és epeóti rák, hasnyálmirígyrák, koíorektális rák, hólyagrák, veserák, prosztatarák, ínélmyálkahártyarák, petefészekrák, rosszindulatú tnelanónta, szarkóma, Ismeretlen primer eredetű tumorok, csontvelörák, akut limfoblasztos leukémia, AMI.,, krónikus limfoblasztos leukémia és non-Hodgkín límfőma. bőrrák, giíóma, agy, méh és rektum rákja.
- 15. Az 1-10. igénypontok bármelyike szerinti elienanyag-farmakon konjugátum rák kezelésében egy vagy- több további terápiás hatóanyaggal, például kemoterápiás hatóanyaggal együtt történő alkalmazásra.
- 16. Az 1-10. igénypontok bármelyike szerinti ellenanyag-fartnakon konjugáium alkalmazása rák kezelésére szolgáló gyógyszer előállítására.
- 17. A lő. igénypont szerinti alkalmazás a következőkből álló csoportból választott rák kezelésére szolgáló gyógyszer előállítására: központi idegrendszeri tumorok, fej- és nyak! rák, tüdőrák, például NSCLC, mellrák, különösen tripla negatív mellrák, nyelőcsőrák, gyomor- vagy hasi rák, máj- és epeáti rák, hasayáímirigyrák, koíorektális rák, bólyagrák, veserák, prosztatarák, méhnyáikahártyarák, petefészekrák, rosszindulatú melanóma, szarkóma, ismeretiét) primer eredetű tantorok, csontvelörák, akut limfoblasztos leukémia, AMI,, krónikus iimfobiaszios leukémia és non-ííodgkin limloma, bőrrák, glióma. agy, méh és rektum rákja.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35497010P | 2010-06-15 | 2010-06-15 | |
DKPA201000529 | 2010-06-15 | ||
US201161434776P | 2011-01-20 | 2011-01-20 | |
DKPA201100039 | 2011-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE035599T2 true HUE035599T2 (hu) | 2018-05-28 |
Family
ID=44534293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE11725095A HUE035599T2 (hu) | 2010-06-15 | 2011-06-15 | Humánellenanyag-farmakon konjugátum szöveti faktor ellen |
Country Status (24)
Country | Link |
---|---|
US (6) | US9168314B2 (hu) |
EP (3) | EP4434550A2 (hu) |
JP (1) | JP6055404B2 (hu) |
KR (1) | KR101935058B1 (hu) |
CN (3) | CN106084053B (hu) |
AU (1) | AU2011267106B2 (hu) |
BR (1) | BR112012031727B1 (hu) |
CA (1) | CA2802782C (hu) |
CY (1) | CY1119616T1 (hu) |
DK (1) | DK2582728T3 (hu) |
EA (1) | EA034675B1 (hu) |
ES (1) | ES2647388T3 (hu) |
HR (1) | HRP20171789T1 (hu) |
HU (1) | HUE035599T2 (hu) |
LT (1) | LT2582728T (hu) |
ME (1) | ME02919B (hu) |
MX (1) | MX347893B (hu) |
NO (1) | NO2582728T3 (hu) |
NZ (1) | NZ604718A (hu) |
PL (1) | PL2582728T3 (hu) |
PT (1) | PT2582728T (hu) |
RS (1) | RS56599B1 (hu) |
SI (1) | SI2582728T1 (hu) |
WO (1) | WO2011157741A2 (hu) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2401136T3 (es) | 2002-11-15 | 2013-04-17 | Genmab A/S | Anticuerpos monoclonales humanos contra CD25 |
UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
DK2582728T3 (da) | 2010-06-15 | 2017-11-27 | Genmab As | Humane antistof-lægemiddelkonjugater mod vævsfaktor |
UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
EP3632462A1 (en) | 2012-07-06 | 2020-04-08 | Genmab B.V. | Dimeric protein with triple mutations |
AU2013285355A1 (en) | 2012-07-06 | 2015-01-29 | Genmab B.V. | Dimeric protein with triple mutations |
CN105229026B (zh) | 2013-01-10 | 2021-07-30 | 根马布私人有限公司 | 人类IgG1 FC区变体及其用途 |
CN103342752B (zh) * | 2013-05-16 | 2014-07-09 | 太原博奥特生物技术有限公司 | 一种抗人组织因子单链抗体及其制备方法 |
KR102372245B1 (ko) * | 2013-11-21 | 2022-03-08 | 젠맵 에이/에스 | 항체-약물 접합체 동결건조 제제 |
US9920133B2 (en) | 2014-02-03 | 2018-03-20 | National Cancer Center | Anti-tissue factor monoclonal antibody |
TW202330606A (zh) * | 2014-03-21 | 2023-08-01 | 美商艾伯維有限公司 | 抗-egfr抗體及抗體藥物結合物 |
EP3129052B1 (en) * | 2014-04-08 | 2020-06-03 | Seattle Genetics, Inc. | Optimal dosing of a cd19-antibody drug conjugate |
CA2929542A1 (en) * | 2015-05-13 | 2016-11-13 | Pfizer Inc. | Treatment with anti-efna4 antibody-drug conjugates |
JP6787890B2 (ja) | 2015-06-29 | 2020-11-18 | 第一三共株式会社 | 抗体−薬物コンジュゲートの選択的製造方法 |
MX2018000869A (es) * | 2015-07-22 | 2018-07-06 | Iconic Therapeutics Inc | Metodos para tratar trastornos asociados con la angiogenesis y la neovascularizacion. |
WO2018036117A1 (zh) * | 2016-08-22 | 2018-03-01 | 复旦大学 | 靶向于组织因子的抗体、其制备方法和用途 |
WO2017028823A1 (zh) * | 2015-08-20 | 2017-02-23 | 复旦大学 | 靶向于组织因子的抗体、其制备方法和用途 |
DK3347054T3 (da) | 2015-09-11 | 2021-07-19 | Genmab As | Dosisregimer til anti-TF-antistoflægemiddelkonjugater |
MD3423105T2 (ro) | 2016-03-02 | 2021-10-31 | Eisai R&D Man Co Ltd | Conjugați anticorp-medicament pe bază de eribulină și metode de utilizare |
CA3017813C (en) * | 2016-03-17 | 2021-12-07 | Oslo Universitetssykehus Hf | Fusion proteins targeting tumour associated macrophages for treating cancer |
WO2017161414A1 (en) | 2016-03-22 | 2017-09-28 | Bionomics Limited | Administration of an anti-lgr5 monoclonal antibody |
CN106938051B (zh) * | 2016-08-22 | 2019-10-11 | 复旦大学 | 靶向于组织因子的抗体-药物偶联物 |
US20190276549A1 (en) | 2016-11-01 | 2019-09-12 | Genmab B.V. | Polypeptide variants and uses thereof |
MX2019008773A (es) * | 2017-01-24 | 2019-09-18 | Pfizer | Derivados de caliqueamicina y conjugados anticuerpo-farmaco de los mismos. |
MX2019009346A (es) | 2017-02-10 | 2019-10-02 | Genmab Bv | Variantes de polipeptidos y usos de los mismos. |
CN113512111B (zh) * | 2017-03-10 | 2023-08-15 | 北京天广实生物技术股份有限公司 | 抗埃博拉病毒单克隆抗体、其制备方法及用途 |
KR20200084874A (ko) * | 2017-11-02 | 2020-07-13 | 젠맵 에이/에스 | 항-조직 인자 항체-약물 접합체 및 암 치료에서의 그의 용도 |
CA3083345A1 (en) | 2017-11-27 | 2019-05-31 | Purdue Pharma L.P. | Humanized antibodies targeting human tissue factor |
JP2021509823A (ja) * | 2018-01-04 | 2021-04-08 | アイコニック セラピューティクス インコーポレイテッド | 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法 |
EP3743440A1 (en) | 2018-01-24 | 2020-12-02 | Genmab B.V. | Polypeptide variants and uses thereof |
BR112020018092A2 (pt) * | 2018-03-07 | 2020-12-22 | Genmab A/S | Método para tratar câncer em um sujeito, estojo, uso de um conjugado anticorpo-fármaco que se liga ao fator tecidual, e, conjugado anticorpo-fármaco. |
TWI841554B (zh) * | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體-藥物共軛物的組合治療癌症之方法 |
CN112839958A (zh) | 2018-05-03 | 2021-05-25 | 根马布私人有限公司 | 抗体变体组合及其用途 |
EP3814379A4 (en) * | 2018-05-07 | 2022-03-30 | Genmab A/S | METHOD OF TREATMENT OF CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE |
SG11202009986QA (en) * | 2018-05-07 | 2020-11-27 | Genmab As | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
BR112021001691A2 (pt) * | 2018-08-16 | 2021-05-04 | Genmab A/S | método de tratamento de câncer de ovário, câncer peritoneal ou câncer de trompa de falópio, e, kit |
TWI844571B (zh) * | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子(vegf)抗體與抗組織因子(tf)抗體-藥物共軛體之組合以治療癌症之方法 |
AU2020299398A1 (en) * | 2019-07-03 | 2022-02-24 | Exelixis, Inc. | Anti-tissue factor antibody-drug conjugates and related methods |
US20220411529A1 (en) | 2019-11-06 | 2022-12-29 | Genmab B.V. | Antibody variant combinations and uses thereof |
TW202131954A (zh) | 2019-11-07 | 2021-09-01 | 丹麥商珍美寶股份有限公司 | 利用鉑類劑與抗組織因子抗體-藥物共軛體之組合來治療癌症之方法 |
KR20220113685A (ko) | 2019-11-07 | 2022-08-16 | 젠맵 에이/에스 | 항-pd-1 항체와 항-조직 인자 항체-약물 접합체의 조합을 사용하여 암을 치료하는 방법 |
KR20220133198A (ko) * | 2019-12-26 | 2022-10-04 | 오하이오 스테이트 이노베이션 파운데이션 | 디하이드로오로테이트 탈수소효소를 항-cd38 치료제와 조합하여 억제하는 방법 및 조성물 |
KR20230028492A (ko) | 2020-06-29 | 2023-02-28 | 젠맵 에이/에스 | 항-조직 인자 항체-약물 접합체 및 암의 치료에서의 그의 용도 |
IL301254A (en) | 2020-09-11 | 2023-05-01 | Janssen Biotech Inc | Methods and compositions for modulating chain-mediated immunity in the cell |
US20220089736A1 (en) * | 2020-09-11 | 2022-03-24 | Janssen Biotech, Inc. | Immune targeting molecules and uses thereof |
JP2023548538A (ja) | 2020-11-08 | 2023-11-17 | シージェン インコーポレイテッド | 併用療法 |
CN113368232B (zh) * | 2021-06-02 | 2022-08-26 | 上海交通大学 | 多特异性抗原结合蛋白及其应用 |
KR20230019791A (ko) * | 2021-07-29 | 2023-02-09 | 주식회사 툴젠 | 혈액 적합성을 갖는 중간엽 줄기세포, 이의 제조방법 및 용도 |
WO2023160651A1 (zh) | 2022-02-24 | 2023-08-31 | 苏州信诺维医药科技股份有限公司 | 一种抗体及其药物偶联物和用途 |
WO2023213960A1 (en) | 2022-05-06 | 2023-11-09 | Genmab A/S | Methods of treating cancer with anti-tissue factor antibody-drug conjugates |
WO2024083162A1 (en) * | 2022-10-19 | 2024-04-25 | Multitude Therapeutics Inc. | Antibodies, antibody-drug conjugates, preparations and uses thereof |
Family Cites Families (139)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US505731A (en) | 1893-09-26 | Ice oeeam feeezee | ||
US835A (en) | 1838-07-12 | X i i i x | ||
US6077A (en) | 1849-01-30 | Improved hinged claw-wrench | ||
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
US4681581A (en) | 1983-12-05 | 1987-07-21 | Coates Fredrica V | Adjustable size diaper and folding method therefor |
US5981216A (en) | 1985-04-01 | 1999-11-09 | Alusuisse Holdings A.G. | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
WO1986005807A1 (en) | 1985-04-01 | 1986-10-09 | Celltech Limited | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US4735210A (en) | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
US5101827A (en) | 1985-07-05 | 1992-04-07 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
US5589173A (en) | 1986-11-04 | 1996-12-31 | Genentech, Inc. | Method and therapeutic compositions for the treatment of myocardial infarction |
US5223427A (en) | 1987-03-31 | 1993-06-29 | The Scripps Research Institute | Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain |
US5437864A (en) | 1987-03-31 | 1995-08-01 | The Scripps Research Institute | Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor |
US5750172A (en) | 1987-06-23 | 1998-05-12 | Pharming B.V. | Transgenic non human mammal milk |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
US5648471A (en) | 1987-12-03 | 1997-07-15 | Centocor, Inc. | One vial method for labeling antibodies with Technetium-99m |
GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
US5879936A (en) | 1988-04-18 | 1999-03-09 | Aluguisse Holding A.G. | Recombinant DNA methods, vectors and host cells |
JP2749167B2 (ja) | 1988-06-21 | 1998-05-13 | ジェネンテク,インコーポレイテッド | 心筋梗塞の処置のための方法および治療用組成物 |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
DK0486622T3 (da) | 1989-08-09 | 1999-07-19 | Rhomed Inc | Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium |
US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
JP3501286B2 (ja) | 1989-12-22 | 2004-03-02 | アプライド リサーチ システムズ,エーアールエス ホールディング ナームロゼ ベノートスハップ | 一定の細胞系又は微生物の内因性遺伝子の発現特徴の変性のための方法 |
US5891693A (en) | 1990-01-25 | 1999-04-06 | Alusuisse Holdings A.G. | Recombinant DNA methods vectors and host cells |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
WO1994025585A1 (en) | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5506134A (en) | 1990-10-22 | 1996-04-09 | Corvas International, Inc. | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
JP3149960B2 (ja) | 1991-01-24 | 2001-03-26 | 財団法人化学及血清療法研究所 | ヒト組織因子を定量する方法 |
WO1992022645A1 (en) | 1991-06-14 | 1992-12-23 | Genpharm International, Inc. | Transgenic immunodeficient non-human animals |
EP0593592B1 (en) | 1991-07-08 | 1998-03-25 | The University Of Massachusetts At Amherst | Thermotropic liquid crystal segmented block copolymer |
US5968502A (en) | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
US6063630A (en) | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
AU3328493A (en) | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
JPH05244988A (ja) | 1992-03-04 | 1993-09-24 | Green Cross Corp:The | 抗組織因子モノクローナル抗体、及びこれによる免疫抑制剤 |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
AU5093593A (en) * | 1992-08-28 | 1994-03-29 | Scripps Research Institute, The | Inhibition of tumor metastasis via neutralization of tissue factor function |
US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
US5879677A (en) | 1992-12-09 | 1999-03-09 | The Scripps Research Institute | Method for inhibition of cerebral tissue factor mediated reperfusion damage |
US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
PT804070E (pt) | 1993-03-09 | 2000-11-30 | Genzyme Corp | Isolamento de componentes de interesse a partir do leite. |
US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
US5879687A (en) | 1994-04-22 | 1999-03-09 | Corixa Corporation | Methods for enhancement of protective immune responses |
ES2153483T3 (es) | 1994-07-11 | 2001-03-01 | Univ Texas | Metodos y composiciones para la coagulacion especifica en los vasos tumorales. |
US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
US5703057A (en) | 1995-04-07 | 1997-12-30 | Board Of Regents The University Of Texas System | Expression library immunization |
WO1996040921A1 (en) | 1995-06-07 | 1996-12-19 | Ortho Farmaceutical Corporation | Cdr-grafted anti-tissue factor antibodies and methods of use thereof |
KR970029803A (ko) | 1995-11-03 | 1997-06-26 | 김광호 | 반도체 메모리장치의 프리차지 회로 |
JPH09302000A (ja) | 1996-05-16 | 1997-11-25 | Chemo Sero Therapeut Res Inst | 抗組織因子モノクローナル抗体及び当該モノクローナル抗体を用いた組織因子凝固活性の測定法 |
US6593291B1 (en) | 1997-02-06 | 2003-07-15 | Entremed, Inc. | Compositions and methods of use of ligands that bind components of the blood coagulation/clotting pathway for the treatment of cancer and angiogenic-based disease |
US7749498B2 (en) | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
US20040229282A1 (en) | 1997-03-10 | 2004-11-18 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
US5986065A (en) * | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
US6719977B1 (en) | 1998-02-12 | 2004-04-13 | The General Hospital Corporation | Methods to potentiate cancer therapies |
CA2347067C (en) | 1998-03-31 | 2013-09-17 | Geron Corporation | Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer |
US6677436B1 (en) | 1998-04-03 | 2004-01-13 | Chugai Seiyaku Kabushiki Kaisha | Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody |
DE69936784T2 (de) | 1998-09-04 | 2008-04-30 | Sanofi Pasteur Ltd., Toronto | Behandlung von gebärmutterhalskrebs |
US6387888B1 (en) | 1998-09-30 | 2002-05-14 | American Foundation For Biological Research, Inc. | Immunotherapy of cancer through expression of truncated tumor or tumor-associated antigen |
WO2000046147A2 (en) | 1999-02-03 | 2000-08-10 | Biosante Pharmaceuticals, Inc. | Therapeutic calcium phosphate particles and methods of manufacture and use |
US6281005B1 (en) | 1999-05-14 | 2001-08-28 | Copernicus Therapeutics, Inc. | Automated nucleic acid compaction device |
IL147765A0 (en) | 1999-07-29 | 2002-08-14 | Medarex Inc | HUMAN MONOCLONAL ANTIBODIES TO HER2/neu |
WO2001014424A2 (en) | 1999-08-24 | 2001-03-01 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
JP2001213804A (ja) | 2000-01-31 | 2001-08-07 | Chugai Pharmaceut Co Ltd | 抗組織因子抗体の複合体 |
WO2001070984A2 (en) | 2000-03-16 | 2001-09-27 | Genentech, Inc. | Anti-tissue factor antibodies with enhanced anticoagulant potency |
AU2002235141A1 (en) | 2000-11-27 | 2002-06-03 | Geron Corporation | Glycosyltransferase vectors for treating cancer |
US20040018194A1 (en) | 2000-11-28 | 2004-01-29 | Francisco Joseph A. | Recombinant anti-CD30 antibodies and uses thereof |
DE60131456T2 (de) | 2000-11-30 | 2008-07-10 | Medarex, Inc., Milpitas | Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern |
EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
JPWO2002078738A1 (ja) | 2001-03-26 | 2004-10-07 | 鈴木 宏治 | 血液レオロジー改善剤 |
US6989452B2 (en) | 2001-05-31 | 2006-01-24 | Medarex, Inc. | Disulfide prodrugs and linkers and stabilizers useful therefor |
JP4359503B2 (ja) | 2001-08-23 | 2009-11-04 | ゲンマブ エー/エス | インターロイキン15(il−15)に特異的なヒト抗体 |
US7247304B2 (en) | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
WO2003020111A2 (en) | 2001-08-30 | 2003-03-13 | Mount Sinai School Of Medicine Of New York University | Alternatively spliced circulating tissue factor |
WO2003029295A1 (en) * | 2001-10-02 | 2003-04-10 | Novo Nordisk A/S | Human tissue factor antibodies |
TWI338009B (en) | 2001-10-29 | 2011-03-01 | Genentech Inc | Antibodies for inhibiting blood coagulation and methods of use thereof |
JP2005507008A (ja) | 2001-11-02 | 2005-03-10 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | アポトーシスに関連した症状の治療のための、組織因子アゴニストまたは組織因子アンタゴニストの使用 |
IL163605A0 (en) | 2002-02-22 | 2005-12-18 | Prophy Med Ab | Use of an inhibitor or antagonist against tissue factor |
DK1549341T3 (da) | 2002-05-01 | 2009-07-06 | Bayer Schering Pharma Ag | Mod vævsfaktor rettede antistoffer som antikoagulanter |
AU2003242506A1 (en) * | 2002-07-12 | 2004-02-02 | Novo Nordisk A/S | Tf antagonist |
AU2003263964C1 (en) | 2002-07-31 | 2010-08-19 | Seagen Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
WO2004039842A2 (en) | 2002-10-31 | 2004-05-13 | Novo Nordisk A/S | Humanized tissue factor antibodies |
WO2004041302A1 (en) | 2002-11-06 | 2004-05-21 | Novo Nordisk A/S | Pharmaceutical composition comprising a tissue factor antagonist and a blood glucose regulator |
WO2004041296A2 (en) | 2002-11-06 | 2004-05-21 | Novo Nordisk A/S | Pharmaceutical composition comprising a tissue factor antagonist and protein c polypeptides |
CA2506080A1 (en) | 2002-11-14 | 2004-05-27 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
ES2401136T3 (es) | 2002-11-15 | 2013-04-17 | Genmab A/S | Anticuerpos monoclonales humanos contra CD25 |
ATE527278T1 (de) | 2002-12-16 | 2011-10-15 | Genmab As | Humane monoklonale antikörper gegen interleukin 8 (il-8) |
JP2006516564A (ja) | 2003-01-22 | 2006-07-06 | ノボ ノルディスク アクティーゼルスカブ | Tf結合薬剤及びそれらの使用 |
US20060034846A1 (en) | 2003-04-14 | 2006-02-16 | Mirella Ezban | Use of TF antagonists |
US7425328B2 (en) | 2003-04-22 | 2008-09-16 | Purdue Pharma L.P. | Tissue factor antibodies and uses thereof |
AU2004251161A1 (en) | 2003-05-30 | 2005-01-06 | Genentech, Inc. | Polypeptides that bind an anti-tissue factor antibody and uses thereof |
CN100528229C (zh) | 2003-05-30 | 2009-08-19 | 森托科尔公司 | 用抗组织因子抗体抑制肿瘤生长的方法 |
US7605235B2 (en) * | 2003-05-30 | 2009-10-20 | Centocor, Inc. | Anti-tissue factor antibodies and compositions |
AU2004255553B2 (en) | 2003-06-19 | 2009-08-20 | Genentech, Inc. | Compositions and methods for treating coagulation related disorders |
WO2005025623A2 (en) | 2003-07-28 | 2005-03-24 | Emory University | Ef-24-factor vii conjugates |
JP2007504167A (ja) | 2003-08-29 | 2007-03-01 | セントカー・インコーポレーテツド | 抗組織因子抗体を用いる移植片の生存を向上する方法 |
ES2579836T3 (es) | 2003-11-06 | 2016-08-17 | Seattle Genetics, Inc. | Compuestos de monometilvalina capaces de conjugación con ligandos |
ES2388435T3 (es) | 2003-12-10 | 2012-10-15 | Medarex, Inc. | Anticuerpos de IP-10 y sus usos |
WO2005079766A2 (en) | 2004-02-20 | 2005-09-01 | Novo Nordisk A/S | Therapeutic combination comprising a tissue factor antagonist and anti-cancer compounds |
WO2005118646A2 (en) | 2004-04-26 | 2005-12-15 | Centocor, Inc. | Epitope directed selection of antibodies to murine tissue factor |
AU2005249490B2 (en) | 2004-06-01 | 2010-07-29 | Genentech, Inc. | Antibody drug conjugates and methods |
US8911726B2 (en) | 2004-09-22 | 2014-12-16 | Kyowa Hakko Kirin Co., Ltd | Stabilized human Igg4 antibodies |
EP1676574A3 (en) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Methods for promoting survival of transplanted tissues and cells |
US8158590B2 (en) | 2005-08-05 | 2012-04-17 | Syntarga B.V. | Triazole-containing releasable linkers, conjugates thereof, and methods of preparation |
CA2626100A1 (en) | 2005-10-21 | 2007-08-30 | Genentech, Inc. | Treatment for antiphospholipid-syndrome-related pregnancy complications |
ZA200804082B (en) | 2005-11-07 | 2010-02-24 | Scripps Research Inst | Compositions and methods for controlling tissue factor signaling specificity |
US10155816B2 (en) | 2005-11-28 | 2018-12-18 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
WO2008030260A2 (en) | 2005-12-22 | 2008-03-13 | Genentech, Inc. | Treatment of variola viral infections using a tissue factor inhibitor |
US8940784B2 (en) | 2006-02-02 | 2015-01-27 | Syntarga B.V. | Water-soluble CC-1065 analogs and their conjugates |
KR101541550B1 (ko) * | 2006-10-27 | 2015-08-04 | 제넨테크, 인크. | 항체 및 면역접합체 및 이들의 용도 |
BRPI0806403A2 (pt) * | 2007-02-09 | 2011-09-06 | Genentech Inc | anticorpo anti-robo4, usode um anticorpo e método de obtenção de imagem |
US20080311034A1 (en) * | 2007-04-30 | 2008-12-18 | Anderson Glenn M | Anti-Tissue Factor Antibodies and Compositions with Enhanced Effector Function |
EP2164873B2 (en) | 2007-05-31 | 2018-09-12 | Genmab A/S | Stable igg4 antibodies |
ES2433379T3 (es) | 2007-08-01 | 2013-12-10 | Syntarga B.V. | Análogos de CC-1065 sustituidos y sus conjugados |
EP3255144A1 (en) | 2007-08-10 | 2017-12-13 | E. R. Squibb & Sons, L.L.C. | Recombineering construct for preparing transgenic mice capable of producing human immunoglobulin |
HUE035798T2 (hu) | 2008-11-03 | 2018-05-28 | Syntarga Bv | CC-1065 analógok és konjugátumaik |
AU2009316592B2 (en) * | 2008-11-20 | 2016-01-07 | Genentech, Inc. | Therapeutic protein formulations |
UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
JP5172811B2 (ja) | 2009-10-27 | 2013-03-27 | 株式会社ジェイエスピー | 発泡性スチレン系樹脂粒子及び該樹脂粒子の製造方法、並びにスチレン系樹脂発泡粒子成形体 |
DK2582728T3 (da) | 2010-06-15 | 2017-11-27 | Genmab As | Humane antistof-lægemiddelkonjugater mod vævsfaktor |
JP5244988B1 (ja) | 2012-02-20 | 2013-07-24 | 浜松ホトニクス株式会社 | 濃度測定装置および濃度測定方法 |
KR102372245B1 (ko) * | 2013-11-21 | 2022-03-08 | 젠맵 에이/에스 | 항체-약물 접합체 동결건조 제제 |
-
2011
- 2011-06-15 DK DK11725095.1T patent/DK2582728T3/da active
- 2011-06-15 ES ES11725095.1T patent/ES2647388T3/es active Active
- 2011-06-15 EA EA201300016A patent/EA034675B1/ru unknown
- 2011-06-15 JP JP2013514696A patent/JP6055404B2/ja active Active
- 2011-06-15 WO PCT/EP2011/059917 patent/WO2011157741A2/en active Application Filing
- 2011-06-15 CN CN201610455316.9A patent/CN106084053B/zh active Active
- 2011-06-15 PT PT117250951T patent/PT2582728T/pt unknown
- 2011-06-15 HU HUE11725095A patent/HUE035599T2/hu unknown
- 2011-06-15 CA CA2802782A patent/CA2802782C/en active Active
- 2011-06-15 MX MX2012014552A patent/MX347893B/es active IP Right Grant
- 2011-06-15 PL PL11725095T patent/PL2582728T3/pl unknown
- 2011-06-15 AU AU2011267106A patent/AU2011267106B2/en active Active
- 2011-06-15 EP EP24169283.9A patent/EP4434550A2/en active Pending
- 2011-06-15 US US13/704,388 patent/US9168314B2/en active Active
- 2011-06-15 EP EP11725095.1A patent/EP2582728B1/en active Active
- 2011-06-15 KR KR1020137000924A patent/KR101935058B1/ko active IP Right Grant
- 2011-06-15 NZ NZ604718A patent/NZ604718A/en unknown
- 2011-06-15 CN CN202010009498.3A patent/CN111012921A/zh active Pending
- 2011-06-15 CN CN201180039935.5A patent/CN103119065B/zh active Active
- 2011-06-15 RS RS20171169A patent/RS56599B1/sr unknown
- 2011-06-15 LT LTEP11725095.1T patent/LT2582728T/lt unknown
- 2011-06-15 ME MEP-2017-265A patent/ME02919B/me unknown
- 2011-06-15 SI SI201131339T patent/SI2582728T1/en unknown
- 2011-06-15 BR BR112012031727-0A patent/BR112012031727B1/pt active IP Right Grant
- 2011-06-15 EP EP17181367.8A patent/EP3281956A3/en not_active Withdrawn
- 2011-06-15 NO NO11725095A patent/NO2582728T3/no unknown
-
2015
- 2015-09-15 US US14/854,613 patent/US9492565B2/en active Active
-
2016
- 2016-09-27 US US15/277,626 patent/US20170136130A1/en not_active Abandoned
-
2017
- 2017-11-17 HR HRP20171789TT patent/HRP20171789T1/hr unknown
- 2017-11-23 CY CY20171101231T patent/CY1119616T1/el unknown
-
2019
- 2019-03-28 US US16/367,933 patent/US20190315880A1/en not_active Abandoned
-
2021
- 2021-03-10 US US17/198,199 patent/US20210395384A1/en not_active Abandoned
-
2023
- 2023-12-01 US US18/526,959 patent/US20240294661A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20240294661A1 (en) | Human antibody drug conjugates against tissue factor | |
US20220323582A1 (en) | Human antibodies and antibody-drug conjugates against cd74 | |
US20190169311A1 (en) | Human Antibodies Against Tissue Factor and Methods of Use Thereof | |
AU2013203136A1 (en) | Human antibody drug conjugates against tissue factor | |
NZ717560A (en) | Human antibodies and antibody-drug conjugates against cd74 |