HUE035599T2 - Humánellenanyag-farmakon konjugátum szöveti faktor ellen - Google Patents

Humánellenanyag-farmakon konjugátum szöveti faktor ellen Download PDF

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HUE035599T2
HUE035599T2 HUE11725095A HUE11725095A HUE035599T2 HU E035599 T2 HUE035599 T2 HU E035599T2 HU E11725095 A HUE11725095 A HU E11725095A HU E11725095 A HUE11725095 A HU E11725095A HU E035599 T2 HUE035599 T2 HU E035599T2
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antibody
cancer
ser
gly
seq
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David Satijn
Sandra Verploegen
Wim Bleeker
Steen Lisby
Jan Van De Winkel
Patrick Van Berkel
Paul Parren
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Genmab As
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Claims (12)

  1. I1UMÁNELLENANYAG-FARMAKON KONJUGÁTUM SZÖVETI FAKTOR ELLEN Szabadalmi igénypontok
    1. Ellenanyag-farmakon konjugátum, amely szöveti faktorhoz kőtödő ellenanyagot tartalmaz, ahol az ellenanyag línkeren keresztöl aurisztatttthoz vagy funkcionális peplidanalógjához vagy származékához konjugált, és ahol a konjugátumban lévő ellenanyag SEQ ID NO:6 szerinti ammosav-szekveneiájü CDRI régiót, SEQ 10 NO:7 szerinti amtnosav-szekvenciájó CI5R2 régiót és SEQ 1.0 NO:<? szerinti aminosav-szekvenctájá CDR3 régiót tartalmazó VH régiót és SEQ ID NO:46 szerinti sminösav-szekvenciájó CDRl régiót, SEQ 113 NO:47 szerinti antinösav-szekvenciájó CDR2 régiót és SEQ 10 NÜ:48 szerinti antinösav-szekvenciájó CDR3 régiót tartalmazó VL régiót tartaimaz.
  2. 2. Az 1. igénypont szerinti ellenanyag-farmakon konjugátum, ahol az ellenanyag SEQ 10 NQ: 5 szerinti aminosav-szekveneiát tartalmazó VH régiói és SEQ iO NO: 45 szerinti aminosav-szekvenciát tartalmazó VL régiót tartalmaz.
  3. 3. Az L vagy 2. igénypont szerinti ellenanyag-farmakon konjugátum, ahol az ellenanyag teljes hosszúságú ellenanyag;
  4. 4. Az előző igénypontok bármelyike szerinti ellenanyag-farmakon konjugátum, ahol az ellenanyag teljesen humán monoklonális IgGI ellenanyag, például lgOi,K.
  5. 5. Az előző igénypontok bármelyike szerinti ellenanyag-farmakon konjugátum, ahol az aorísztatin monometil-aurísztatin E (MMAE):
    altos a. hullámos vonal a linker kapcsolódásának helyéi jelzi. ó, Az 1-4. igénypontok bármelyike szerinti ellenanyag-farmakon konjugátum, ahol az aarisztatia monometil-aurisztaíin F tMMAE):
    ahol a hullámos vonal a linker kapcsolódásának helyét jelzi.
  6. 7, Az előző igénypontok bármelyike szerinti ellenanyag-farmakon konjugátum, ahol a linker a TF elleni ellenanyag szulíidrílcsoportjaihoz kapcsolódik, amelyek a TF elleni ellenanyag (részleges) redukálásával keletkeztek.
  7. 8. Az i-5. és 7. igénypontok bármelyike szerinti ellenanyag-farmakon konjugátum, ahol a íinker-auriszíatbi veMMAF vagy vcMMAE:
    AÍLMG-VC-PAB-MMÁF {vcMMAQ «
    Ab- MC-VC- PAKS- MMAE {veMMAE) ahol p jelentése 1-8 szám. S jeíentése TF elleni ellenanyag szuíihidrilesoportja és Ab a TF elleni ellenanyagé! jelöli. 9. A. 8. igénypont szerinti ellenanyag-fartnakon konjugátum, ahol a b'nker-auriszíatín a 8. igénypont szerinti megbatározott -vcMMAE.
  8. 10. Az 1-4, és 6-7. igénypontok bármelyike szerinti ellenanyag-fartnakon konjugáium, ahol a iíttker-konj ugátum meM MA F:
    Afcr-MÖ-MMAF (m cMMAF) ahol p jelentése szám 1-8., S jelentése TF elleni ellenanyag szuiihídrilesoportja és Ab a TF elleni ellenanyagot jelöli. ÍS, Gyógyászati készítmény, amely 1-iO. igénypontok bármelyike szerint meghatározott ellenanyag-fartnakon konjugátumot és gyógyászati Ság elfogadható hordozót tartalmaz.
  9. 12. Az 1-10, igénypontok bármelyike szerint meghatározót! el lettan vág-latinakon konjugátum gyógyszerként történő alkalmazásra, 13. f-TO. igénypontok bármelyike szerint meghatározott el tananyag-farinakon konjugáium rák. kezelésében történő alkalmazásra, 14. A 13. igény-pont szeriül t elienanyag-farmakon konjugátum az ott meghatározott alkalmazásra, ahol a rák a. kővetkezőkből álló csoportból választott: központi idegrendszeri tumorok, fej- és nyak! rák. tüdőrák, például NSCLC, mellrák, különösen tripla negatív mellrák, nyelöcsorák, gyomor- vagy hasi rák, máj - és epeóti rák, hasnyálmirígyrák, koíorektális rák, hólyagrák, veserák, prosztatarák, ínélmyálkahártyarák, petefészekrák, rosszindulatú tnelanónta, szarkóma, Ismeretlen primer eredetű tumorok, csontvelörák, akut limfoblasztos leukémia, AMI.,, krónikus limfoblasztos leukémia és non-Hodgkín límfőma. bőrrák, giíóma, agy, méh és rektum rákja.
  10. 15. Az 1-10. igénypontok bármelyike szerinti elienanyag-farmakon konjugátum rák kezelésében egy vagy- több további terápiás hatóanyaggal, például kemoterápiás hatóanyaggal együtt történő alkalmazásra.
  11. 16. Az 1-10. igénypontok bármelyike szerinti ellenanyag-fartnakon konjugáium alkalmazása rák kezelésére szolgáló gyógyszer előállítására.
  12. 17. A lő. igénypont szerinti alkalmazás a következőkből álló csoportból választott rák kezelésére szolgáló gyógyszer előállítására: központi idegrendszeri tumorok, fej- és nyak! rák, tüdőrák, például NSCLC, mellrák, különösen tripla negatív mellrák, nyelőcsőrák, gyomor- vagy hasi rák, máj- és epeáti rák, hasayáímirigyrák, koíorektális rák, bólyagrák, veserák, prosztatarák, méhnyáikahártyarák, petefészekrák, rosszindulatú melanóma, szarkóma, ismeretiét) primer eredetű tantorok, csontvelörák, akut limfoblasztos leukémia, AMI,, krónikus iimfobiaszios leukémia és non-ííodgkin limloma, bőrrák, glióma. agy, méh és rektum rákja.
HUE11725095A 2010-06-15 2011-06-15 Humánellenanyag-farmakon konjugátum szöveti faktor ellen HUE035599T2 (hu)

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Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2401136T3 (es) 2002-11-15 2013-04-17 Genmab A/S Anticuerpos monoclonales humanos contra CD25
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
DK2582728T3 (da) 2010-06-15 2017-11-27 Genmab As Humane antistof-lægemiddelkonjugater mod vævsfaktor
UA117901C2 (uk) 2011-07-06 2018-10-25 Ґенмаб Б.В. Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
EP3632462A1 (en) 2012-07-06 2020-04-08 Genmab B.V. Dimeric protein with triple mutations
AU2013285355A1 (en) 2012-07-06 2015-01-29 Genmab B.V. Dimeric protein with triple mutations
CN105229026B (zh) 2013-01-10 2021-07-30 根马布私人有限公司 人类IgG1 FC区变体及其用途
CN103342752B (zh) * 2013-05-16 2014-07-09 太原博奥特生物技术有限公司 一种抗人组织因子单链抗体及其制备方法
KR102372245B1 (ko) * 2013-11-21 2022-03-08 젠맵 에이/에스 항체-약물 접합체 동결건조 제제
US9920133B2 (en) 2014-02-03 2018-03-20 National Cancer Center Anti-tissue factor monoclonal antibody
TW202330606A (zh) * 2014-03-21 2023-08-01 美商艾伯維有限公司 抗-egfr抗體及抗體藥物結合物
EP3129052B1 (en) * 2014-04-08 2020-06-03 Seattle Genetics, Inc. Optimal dosing of a cd19-antibody drug conjugate
CA2929542A1 (en) * 2015-05-13 2016-11-13 Pfizer Inc. Treatment with anti-efna4 antibody-drug conjugates
JP6787890B2 (ja) 2015-06-29 2020-11-18 第一三共株式会社 抗体−薬物コンジュゲートの選択的製造方法
MX2018000869A (es) * 2015-07-22 2018-07-06 Iconic Therapeutics Inc Metodos para tratar trastornos asociados con la angiogenesis y la neovascularizacion.
WO2018036117A1 (zh) * 2016-08-22 2018-03-01 复旦大学 靶向于组织因子的抗体、其制备方法和用途
WO2017028823A1 (zh) * 2015-08-20 2017-02-23 复旦大学 靶向于组织因子的抗体、其制备方法和用途
DK3347054T3 (da) 2015-09-11 2021-07-19 Genmab As Dosisregimer til anti-TF-antistoflægemiddelkonjugater
MD3423105T2 (ro) 2016-03-02 2021-10-31 Eisai R&D Man Co Ltd Conjugați anticorp-medicament pe bază de eribulină și metode de utilizare
CA3017813C (en) * 2016-03-17 2021-12-07 Oslo Universitetssykehus Hf Fusion proteins targeting tumour associated macrophages for treating cancer
WO2017161414A1 (en) 2016-03-22 2017-09-28 Bionomics Limited Administration of an anti-lgr5 monoclonal antibody
CN106938051B (zh) * 2016-08-22 2019-10-11 复旦大学 靶向于组织因子的抗体-药物偶联物
US20190276549A1 (en) 2016-11-01 2019-09-12 Genmab B.V. Polypeptide variants and uses thereof
MX2019008773A (es) * 2017-01-24 2019-09-18 Pfizer Derivados de caliqueamicina y conjugados anticuerpo-farmaco de los mismos.
MX2019009346A (es) 2017-02-10 2019-10-02 Genmab Bv Variantes de polipeptidos y usos de los mismos.
CN113512111B (zh) * 2017-03-10 2023-08-15 北京天广实生物技术股份有限公司 抗埃博拉病毒单克隆抗体、其制备方法及用途
KR20200084874A (ko) * 2017-11-02 2020-07-13 젠맵 에이/에스 항-조직 인자 항체-약물 접합체 및 암 치료에서의 그의 용도
CA3083345A1 (en) 2017-11-27 2019-05-31 Purdue Pharma L.P. Humanized antibodies targeting human tissue factor
JP2021509823A (ja) * 2018-01-04 2021-04-08 アイコニック セラピューティクス インコーポレイテッド 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法
EP3743440A1 (en) 2018-01-24 2020-12-02 Genmab B.V. Polypeptide variants and uses thereof
BR112020018092A2 (pt) * 2018-03-07 2020-12-22 Genmab A/S Método para tratar câncer em um sujeito, estojo, uso de um conjugado anticorpo-fármaco que se liga ao fator tecidual, e, conjugado anticorpo-fármaco.
TWI841554B (zh) * 2018-03-21 2024-05-11 丹麥商珍美寶股份有限公司 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法
CN112839958A (zh) 2018-05-03 2021-05-25 根马布私人有限公司 抗体变体组合及其用途
EP3814379A4 (en) * 2018-05-07 2022-03-30 Genmab A/S METHOD OF TREATMENT OF CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
SG11202009986QA (en) * 2018-05-07 2020-11-27 Genmab As Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate
BR112021001691A2 (pt) * 2018-08-16 2021-05-04 Genmab A/S método de tratamento de câncer de ovário, câncer peritoneal ou câncer de trompa de falópio, e, kit
TWI844571B (zh) * 2018-10-30 2024-06-11 丹麥商珍美寶股份有限公司 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法
AU2020299398A1 (en) * 2019-07-03 2022-02-24 Exelixis, Inc. Anti-tissue factor antibody-drug conjugates and related methods
US20220411529A1 (en) 2019-11-06 2022-12-29 Genmab B.V. Antibody variant combinations and uses thereof
TW202131954A (zh) 2019-11-07 2021-09-01 丹麥商珍美寶股份有限公司 利用鉑類劑與抗組織因子抗體－藥物共軛體之組合來治療癌症之方法
KR20220113685A (ko) 2019-11-07 2022-08-16 젠맵 에이/에스 항-pd-1 항체와 항-조직 인자 항체-약물 접합체의 조합을 사용하여 암을 치료하는 방법
KR20220133198A (ko) * 2019-12-26 2022-10-04 오하이오 스테이트 이노베이션 파운데이션 디하이드로오로테이트 탈수소효소를 항-cd38 치료제와 조합하여 억제하는 방법 및 조성물
KR20230028492A (ko) 2020-06-29 2023-02-28 젠맵 에이/에스 항-조직 인자 항체-약물 접합체 및 암의 치료에서의 그의 용도
IL301254A (en) 2020-09-11 2023-05-01 Janssen Biotech Inc Methods and compositions for modulating chain-mediated immunity in the cell
US20220089736A1 (en) * 2020-09-11 2022-03-24 Janssen Biotech, Inc. Immune targeting molecules and uses thereof
JP2023548538A (ja) 2020-11-08 2023-11-17 シージェン インコーポレイテッド 併用療法
CN113368232B (zh) * 2021-06-02 2022-08-26 上海交通大学 多特异性抗原结合蛋白及其应用
KR20230019791A (ko) * 2021-07-29 2023-02-09 주식회사 툴젠 혈액 적합성을 갖는 중간엽 줄기세포, 이의 제조방법 및 용도
WO2023160651A1 (zh) 2022-02-24 2023-08-31 苏州信诺维医药科技股份有限公司 一种抗体及其药物偶联物和用途
WO2023213960A1 (en) 2022-05-06 2023-11-09 Genmab A/S Methods of treating cancer with anti-tissue factor antibody-drug conjugates
WO2024083162A1 (en) * 2022-10-19 2024-04-25 Multitude Therapeutics Inc. Antibodies, antibody-drug conjugates, preparations and uses thereof

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US505731A (en) 1893-09-26 Ice oeeam feeezee
US835A (en) 1838-07-12 X i i i x
US6077A (en) 1849-01-30 Improved hinged claw-wrench
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS5896026A (ja) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
DE3380726D1 (en) 1982-06-24 1989-11-23 Japan Chem Res Long-acting composition
US4681581A (en) 1983-12-05 1987-07-21 Coates Fredrica V Adjustable size diaper and folding method therefor
US5981216A (en) 1985-04-01 1999-11-09 Alusuisse Holdings A.G. Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
WO1986005807A1 (en) 1985-04-01 1986-10-09 Celltech Limited Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4735210A (en) 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5101827A (en) 1985-07-05 1992-04-07 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US5057313A (en) 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
US5589173A (en) 1986-11-04 1996-12-31 Genentech, Inc. Method and therapeutic compositions for the treatment of myocardial infarction
US5223427A (en) 1987-03-31 1993-06-29 The Scripps Research Institute Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
US5437864A (en) 1987-03-31 1995-08-01 The Scripps Research Institute Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor
US5750172A (en) 1987-06-23 1998-05-12 Pharming B.V. Transgenic non human mammal milk
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5648471A (en) 1987-12-03 1997-07-15 Centocor, Inc. One vial method for labeling antibodies with Technetium-99m
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US5879936A (en) 1988-04-18 1999-03-09 Aluguisse Holding A.G. Recombinant DNA methods, vectors and host cells
JP2749167B2 (ja) 1988-06-21 1998-05-13 ジェネンテク，インコーポレイテッド 心筋梗塞の処置のための方法および治療用組成物
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
DK0486622T3 (da) 1989-08-09 1999-07-19 Rhomed Inc Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
JP3501286B2 (ja) 1989-12-22 2004-03-02 アプライド リサーチ システムズ，エーアールエス ホールディング ナームロゼ ベノートスハップ 一定の細胞系又は微生物の内因性遺伝子の発現特徴の変性のための方法
US5891693A (en) 1990-01-25 1999-04-06 Alusuisse Holdings A.G. Recombinant DNA methods vectors and host cells
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
WO1994025585A1 (en) 1993-04-26 1994-11-10 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
JP3149960B2 (ja) 1991-01-24 2001-03-26 財団法人化学及血清療法研究所 ヒト組織因子を定量する方法
WO1992022645A1 (en) 1991-06-14 1992-12-23 Genpharm International, Inc. Transgenic immunodeficient non-human animals
EP0593592B1 (en) 1991-07-08 1998-03-25 The University Of Massachusetts At Amherst Thermotropic liquid crystal segmented block copolymer
US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6063630A (en) 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
AU3328493A (en) 1991-12-17 1993-07-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
JPH05244988A (ja) 1992-03-04 1993-09-24 Green Cross Corp:The 抗組織因子モノクローナル抗体、及びこれによる免疫抑制剤
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
AU5093593A (en) * 1992-08-28 1994-03-29 Scripps Research Institute, The Inhibition of tumor metastasis via neutralization of tissue factor function
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US5879677A (en) 1992-12-09 1999-03-09 The Scripps Research Institute Method for inhibition of cerebral tissue factor mediated reperfusion damage
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
PT804070E (pt) 1993-03-09 2000-11-30 Genzyme Corp Isolamento de componentes de interesse a partir do leite.
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US6077835A (en) 1994-03-23 2000-06-20 Case Western Reserve University Delivery of compacted nucleic acid to cells
US5879687A (en) 1994-04-22 1999-03-09 Corixa Corporation Methods for enhancement of protective immune responses
ES2153483T3 (es) 1994-07-11 2001-03-01 Univ Texas Metodos y composiciones para la coagulacion especifica en los vasos tumorales.
US5663149A (en) 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5703057A (en) 1995-04-07 1997-12-30 Board Of Regents The University Of Texas System Expression library immunization
WO1996040921A1 (en) 1995-06-07 1996-12-19 Ortho Farmaceutical Corporation Cdr-grafted anti-tissue factor antibodies and methods of use thereof
KR970029803A (ko) 1995-11-03 1997-06-26 김광호 반도체 메모리장치의 프리차지 회로
JPH09302000A (ja) 1996-05-16 1997-11-25 Chemo Sero Therapeut Res Inst 抗組織因子モノクローナル抗体及び当該モノクローナル抗体を用いた組織因子凝固活性の測定法
US6593291B1 (en) 1997-02-06 2003-07-15 Entremed, Inc. Compositions and methods of use of ligands that bind components of the blood coagulation/clotting pathway for the treatment of cancer and angiogenic-based disease
US7749498B2 (en) 1997-03-10 2010-07-06 Genentech, Inc. Antibodies for inhibiting blood coagulation and methods of use thereof
US20040229282A1 (en) 1997-03-10 2004-11-18 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US5986065A (en) * 1997-03-10 1999-11-16 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US6719977B1 (en) 1998-02-12 2004-04-13 The General Hospital Corporation Methods to potentiate cancer therapies
CA2347067C (en) 1998-03-31 2013-09-17 Geron Corporation Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer
US6677436B1 (en) 1998-04-03 2004-01-13 Chugai Seiyaku Kabushiki Kaisha Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody
DE69936784T2 (de) 1998-09-04 2008-04-30 Sanofi Pasteur Ltd., Toronto Behandlung von gebärmutterhalskrebs
US6387888B1 (en) 1998-09-30 2002-05-14 American Foundation For Biological Research, Inc. Immunotherapy of cancer through expression of truncated tumor or tumor-associated antigen
WO2000046147A2 (en) 1999-02-03 2000-08-10 Biosante Pharmaceuticals, Inc. Therapeutic calcium phosphate particles and methods of manufacture and use
US6281005B1 (en) 1999-05-14 2001-08-28 Copernicus Therapeutics, Inc. Automated nucleic acid compaction device
IL147765A0 (en) 1999-07-29 2002-08-14 Medarex Inc HUMAN MONOCLONAL ANTIBODIES TO HER2/neu
WO2001014424A2 (en) 1999-08-24 2001-03-01 Medarex, Inc. Human ctla-4 antibodies and their uses
JP2001213804A (ja) 2000-01-31 2001-08-07 Chugai Pharmaceut Co Ltd 抗組織因子抗体の複合体
WO2001070984A2 (en) 2000-03-16 2001-09-27 Genentech, Inc. Anti-tissue factor antibodies with enhanced anticoagulant potency
AU2002235141A1 (en) 2000-11-27 2002-06-03 Geron Corporation Glycosyltransferase vectors for treating cancer
US20040018194A1 (en) 2000-11-28 2004-01-29 Francisco Joseph A. Recombinant anti-CD30 antibodies and uses thereof
DE60131456T2 (de) 2000-11-30 2008-07-10 Medarex, Inc., Milpitas Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
JPWO2002078738A1 (ja) 2001-03-26 2004-10-07 鈴木　宏治 血液レオロジー改善剤
US6989452B2 (en) 2001-05-31 2006-01-24 Medarex, Inc. Disulfide prodrugs and linkers and stabilizers useful therefor
JP4359503B2 (ja) 2001-08-23 2009-11-04 ゲンマブ エー／エス インターロイキン１５（ｉｌ−１５）に特異的なヒト抗体
US7247304B2 (en) 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
WO2003020111A2 (en) 2001-08-30 2003-03-13 Mount Sinai School Of Medicine Of New York University Alternatively spliced circulating tissue factor
WO2003029295A1 (en) * 2001-10-02 2003-04-10 Novo Nordisk A/S Human tissue factor antibodies
TWI338009B (en) 2001-10-29 2011-03-01 Genentech Inc Antibodies for inhibiting blood coagulation and methods of use thereof
JP2005507008A (ja) 2001-11-02 2005-03-10 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト アポトーシスに関連した症状の治療のための、組織因子アゴニストまたは組織因子アンタゴニストの使用
IL163605A0 (en) 2002-02-22 2005-12-18 Prophy Med Ab Use of an inhibitor or antagonist against tissue factor
DK1549341T3 (da) 2002-05-01 2009-07-06 Bayer Schering Pharma Ag Mod vævsfaktor rettede antistoffer som antikoagulanter
AU2003242506A1 (en) * 2002-07-12 2004-02-02 Novo Nordisk A/S Tf antagonist
AU2003263964C1 (en) 2002-07-31 2010-08-19 Seagen Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
WO2004039842A2 (en) 2002-10-31 2004-05-13 Novo Nordisk A/S Humanized tissue factor antibodies
WO2004041302A1 (en) 2002-11-06 2004-05-21 Novo Nordisk A/S Pharmaceutical composition comprising a tissue factor antagonist and a blood glucose regulator
WO2004041296A2 (en) 2002-11-06 2004-05-21 Novo Nordisk A/S Pharmaceutical composition comprising a tissue factor antagonist and protein c polypeptides
CA2506080A1 (en) 2002-11-14 2004-05-27 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
ES2401136T3 (es) 2002-11-15 2013-04-17 Genmab A/S Anticuerpos monoclonales humanos contra CD25
ATE527278T1 (de) 2002-12-16 2011-10-15 Genmab As Humane monoklonale antikörper gegen interleukin 8 (il-8)
JP2006516564A (ja) 2003-01-22 2006-07-06 ノボ　ノルディスク　アクティーゼルスカブ Ｔｆ結合薬剤及びそれらの使用
US20060034846A1 (en) 2003-04-14 2006-02-16 Mirella Ezban Use of TF antagonists
US7425328B2 (en) 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
AU2004251161A1 (en) 2003-05-30 2005-01-06 Genentech, Inc. Polypeptides that bind an anti-tissue factor antibody and uses thereof
CN100528229C (zh) 2003-05-30 2009-08-19 森托科尔公司 用抗组织因子抗体抑制肿瘤生长的方法
US7605235B2 (en) * 2003-05-30 2009-10-20 Centocor, Inc. Anti-tissue factor antibodies and compositions
AU2004255553B2 (en) 2003-06-19 2009-08-20 Genentech, Inc. Compositions and methods for treating coagulation related disorders
WO2005025623A2 (en) 2003-07-28 2005-03-24 Emory University Ef-24-factor vii conjugates
JP2007504167A (ja) 2003-08-29 2007-03-01 セントカー・インコーポレーテツド 抗組織因子抗体を用いる移植片の生存を向上する方法
ES2579836T3 (es) 2003-11-06 2016-08-17 Seattle Genetics, Inc. Compuestos de monometilvalina capaces de conjugación con ligandos
ES2388435T3 (es) 2003-12-10 2012-10-15 Medarex, Inc. Anticuerpos de IP-10 y sus usos
WO2005079766A2 (en) 2004-02-20 2005-09-01 Novo Nordisk A/S Therapeutic combination comprising a tissue factor antagonist and anti-cancer compounds
WO2005118646A2 (en) 2004-04-26 2005-12-15 Centocor, Inc. Epitope directed selection of antibodies to murine tissue factor
AU2005249490B2 (en) 2004-06-01 2010-07-29 Genentech, Inc. Antibody drug conjugates and methods
US8911726B2 (en) 2004-09-22 2014-12-16 Kyowa Hakko Kirin Co., Ltd Stabilized human Igg4 antibodies
EP1676574A3 (en) 2004-12-30 2006-07-26 Johnson &amp; Johnson Vision Care, Inc. Methods for promoting survival of transplanted tissues and cells
US8158590B2 (en) 2005-08-05 2012-04-17 Syntarga B.V. Triazole-containing releasable linkers, conjugates thereof, and methods of preparation
CA2626100A1 (en) 2005-10-21 2007-08-30 Genentech, Inc. Treatment for antiphospholipid-syndrome-related pregnancy complications
ZA200804082B (en) 2005-11-07 2010-02-24 Scripps Research Inst Compositions and methods for controlling tissue factor signaling specificity
US10155816B2 (en) 2005-11-28 2018-12-18 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
WO2008030260A2 (en) 2005-12-22 2008-03-13 Genentech, Inc. Treatment of variola viral infections using a tissue factor inhibitor
US8940784B2 (en) 2006-02-02 2015-01-27 Syntarga B.V. Water-soluble CC-1065 analogs and their conjugates
KR101541550B1 (ko) * 2006-10-27 2015-08-04 제넨테크, 인크. 항체 및 면역접합체 및 이들의 용도
BRPI0806403A2 (pt) * 2007-02-09 2011-09-06 Genentech Inc anticorpo anti-robo4, usode um anticorpo e método de obtenção de imagem
US20080311034A1 (en) * 2007-04-30 2008-12-18 Anderson Glenn M Anti-Tissue Factor Antibodies and Compositions with Enhanced Effector Function
EP2164873B2 (en) 2007-05-31 2018-09-12 Genmab A/S Stable igg4 antibodies
ES2433379T3 (es) 2007-08-01 2013-12-10 Syntarga B.V. Análogos de CC-1065 sustituidos y sus conjugados
EP3255144A1 (en) 2007-08-10 2017-12-13 E. R. Squibb & Sons, L.L.C. Recombineering construct for preparing transgenic mice capable of producing human immunoglobulin
HUE035798T2 (hu) 2008-11-03 2018-05-28 Syntarga Bv CC-1065 analógok és konjugátumaik
AU2009316592B2 (en) * 2008-11-20 2016-01-07 Genentech, Inc. Therapeutic protein formulations
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
JP5172811B2 (ja) 2009-10-27 2013-03-27 株式会社ジェイエスピー 発泡性スチレン系樹脂粒子及び該樹脂粒子の製造方法、並びにスチレン系樹脂発泡粒子成形体
DK2582728T3 (da) 2010-06-15 2017-11-27 Genmab As Humane antistof-lægemiddelkonjugater mod vævsfaktor
JP5244988B1 (ja) 2012-02-20 2013-07-24 浜松ホトニクス株式会社 濃度測定装置および濃度測定方法
KR102372245B1 (ko) * 2013-11-21 2022-03-08 젠맵 에이/에스 항체-약물 접합체 동결건조 제제

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