MX2018000869A - Metodos para tratar trastornos asociados con la angiogenesis y la neovascularizacion. - Google Patents
Metodos para tratar trastornos asociados con la angiogenesis y la neovascularizacion.Info
- Publication number
- MX2018000869A MX2018000869A MX2018000869A MX2018000869A MX2018000869A MX 2018000869 A MX2018000869 A MX 2018000869A MX 2018000869 A MX2018000869 A MX 2018000869A MX 2018000869 A MX2018000869 A MX 2018000869A MX 2018000869 A MX2018000869 A MX 2018000869A
- Authority
- MX
- Mexico
- Prior art keywords
- neovascularization
- angiogenesis
- methods
- dimer
- disorders associated
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6815—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
En la presente se proporcionan métodos y composiciones de dímero inmunoconjugados para el tratamiento de enfermedades asociadas con la angiogónesis y la neovascularización. En un aspecto, la invención se relaciona con un método para tratar la degeneración macular húmeda relacionada con la edad (AMD) en un ojo de un paciente que necesite del mismo. El método comprende administrar al paciente en múltiples sesiones de dosificación, una composición que comprenda una cantidad efectiva de un dímero inmunoconjugado, en donde las subunidades monomóricas del dímero cada una comprenden una proteína del factor humano mutado VIIa (fVIIa) conjugada con el dominio Fc de la inmunoglobulina humana G1 (IgG1).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562195709P | 2015-07-22 | 2015-07-22 | |
PCT/US2016/043617 WO2017015582A1 (en) | 2015-07-22 | 2016-07-22 | Methods for treating disorders associated with angiogenesis and neovascularization |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018000869A true MX2018000869A (es) | 2018-07-06 |
Family
ID=57835306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018000869A MX2018000869A (es) | 2015-07-22 | 2016-07-22 | Metodos para tratar trastornos asociados con la angiogenesis y la neovascularizacion. |
Country Status (11)
Country | Link |
---|---|
US (2) | US20180207292A1 (es) |
EP (1) | EP3324960A4 (es) |
JP (1) | JP2018524391A (es) |
KR (1) | KR20180034518A (es) |
CN (1) | CN108024994A (es) |
AU (1) | AU2016297178A1 (es) |
BR (1) | BR112018001275A2 (es) |
CA (1) | CA2990837A1 (es) |
MX (1) | MX2018000869A (es) |
RU (1) | RU2018106348A (es) |
WO (1) | WO2017015582A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
CA3010056A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
EP3442554A4 (en) * | 2016-04-14 | 2019-12-04 | Iconic Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATING DISEASES RELATED TO NEOVASCULARIZATION |
TW201836646A (zh) * | 2017-01-25 | 2018-10-16 | 美商艾康尼醫療股份有限公司 | 治療與血管生成及血管新生相關病症的方法 |
US20200352996A1 (en) * | 2017-09-27 | 2020-11-12 | Ohio State Innovation Foundation | Tissue factor-targeting car-nk and car-t cell therapy |
KR102428619B1 (ko) | 2019-09-25 | 2022-08-04 | 대구가톨릭대학교산학협력단 | 망막병증 치료용 약물 방출 콘택트렌즈 및 이의 제조방법 |
EP4041312A4 (en) | 2019-10-10 | 2023-12-20 | Kodiak Sciences Inc. | METHOD FOR TREATING AN EYE DISORDER |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5833982A (en) * | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
US6924359B1 (en) * | 1999-07-01 | 2005-08-02 | Yale University | Neovascular-targeted immunoconjugates |
AU2003242507A1 (en) * | 2002-07-12 | 2004-02-02 | Novo Nordisk A/S | A tissue factor binding immunoconjugate comprising factor viia |
JP2006516564A (ja) * | 2003-01-22 | 2006-07-06 | ノボ ノルディスク アクティーゼルスカブ | Tf結合薬剤及びそれらの使用 |
JP2007511604A (ja) * | 2003-11-18 | 2007-05-10 | アイコニック セラピューティクス インコーポレイティッド | キメラタンパク質の均質製剤 |
WO2006020979A2 (en) * | 2004-08-13 | 2006-02-23 | Yale University | Factor vii conjugates for selectively treating neovascularization disorders |
US20070134244A1 (en) * | 2005-10-14 | 2007-06-14 | Alcon, Inc. | Combination treatment for pathologic ocular angiogenesis |
CA2802782C (en) * | 2010-06-15 | 2018-03-13 | Genmab A/S | Human antibody drug conjugates against tissue factor |
-
2016
- 2016-07-22 WO PCT/US2016/043617 patent/WO2017015582A1/en active Application Filing
- 2016-07-22 CN CN201680042066.4A patent/CN108024994A/zh active Pending
- 2016-07-22 KR KR1020187005162A patent/KR20180034518A/ko unknown
- 2016-07-22 EP EP16828623.5A patent/EP3324960A4/en not_active Withdrawn
- 2016-07-22 RU RU2018106348A patent/RU2018106348A/ru not_active Application Discontinuation
- 2016-07-22 US US15/746,545 patent/US20180207292A1/en not_active Abandoned
- 2016-07-22 AU AU2016297178A patent/AU2016297178A1/en not_active Abandoned
- 2016-07-22 CA CA2990837A patent/CA2990837A1/en not_active Abandoned
- 2016-07-22 BR BR112018001275A patent/BR112018001275A2/pt not_active Application Discontinuation
- 2016-07-22 JP JP2018503532A patent/JP2018524391A/ja active Pending
- 2016-07-22 MX MX2018000869A patent/MX2018000869A/es unknown
-
2020
- 2020-09-14 US US17/020,202 patent/US20210236649A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20210236649A1 (en) | 2021-08-05 |
EP3324960A1 (en) | 2018-05-30 |
AU2016297178A1 (en) | 2018-01-25 |
CN108024994A (zh) | 2018-05-11 |
WO2017015582A1 (en) | 2017-01-26 |
BR112018001275A2 (pt) | 2018-09-18 |
US20180207292A1 (en) | 2018-07-26 |
CA2990837A1 (en) | 2017-01-26 |
EP3324960A4 (en) | 2019-01-23 |
RU2018106348A (ru) | 2019-08-22 |
JP2018524391A (ja) | 2018-08-30 |
KR20180034518A (ko) | 2018-04-04 |
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