BR112018001275A2 - métodos para tratar transtornos associados à angiogênese e neovascularização - Google Patents
métodos para tratar transtornos associados à angiogênese e neovascularizaçãoInfo
- Publication number
- BR112018001275A2 BR112018001275A2 BR112018001275A BR112018001275A BR112018001275A2 BR 112018001275 A2 BR112018001275 A2 BR 112018001275A2 BR 112018001275 A BR112018001275 A BR 112018001275A BR 112018001275 A BR112018001275 A BR 112018001275A BR 112018001275 A2 BR112018001275 A2 BR 112018001275A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- dimer
- patient
- neovascularization
- angiogenesis
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6815—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
são aqui fornecidos métodos e composições de dímero de imunoconjugado para o tratamento de doenças associadas com angiogênese e neovascularização. em um aspecto, a invenção refere-se a um método para tratar a degeneração macular relacionada à idade úmida (dmri) em um olho de um paciente que dele necessite. o método compreende administrar ao paciente, em sessões de múltiplas dosagens, uma composição compreendendo uma quantidade eficaz de um dímero de imunoconjugado, em que as subunidades de monômero do dímero compreendem, cada uma, proteína do fator viia humana (fviia) mutada conjugada ao domínio fc da imunoglobulina humana g1 (igg1).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562195709P | 2015-07-22 | 2015-07-22 | |
PCT/US2016/043617 WO2017015582A1 (en) | 2015-07-22 | 2016-07-22 | Methods for treating disorders associated with angiogenesis and neovascularization |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018001275A2 true BR112018001275A2 (pt) | 2018-09-18 |
Family
ID=57835306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018001275A BR112018001275A2 (pt) | 2015-07-22 | 2016-07-22 | métodos para tratar transtornos associados à angiogênese e neovascularização |
Country Status (11)
Country | Link |
---|---|
US (2) | US20180207292A1 (pt) |
EP (1) | EP3324960A4 (pt) |
JP (1) | JP2018524391A (pt) |
KR (1) | KR20180034518A (pt) |
CN (1) | CN108024994A (pt) |
AU (1) | AU2016297178A1 (pt) |
BR (1) | BR112018001275A2 (pt) |
CA (1) | CA2990837A1 (pt) |
MX (1) | MX2018000869A (pt) |
RU (1) | RU2018106348A (pt) |
WO (1) | WO2017015582A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
BR112018013407A2 (pt) | 2015-12-30 | 2018-12-18 | Kodiak Sciences Inc | anticorpos e conjugados dos mesmos |
EP3442554A4 (en) * | 2016-04-14 | 2019-12-04 | Iconic Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATING DISEASES RELATED TO NEOVASCULARIZATION |
WO2018140611A1 (en) * | 2017-01-25 | 2018-08-02 | Iconic Therapeutics, Inc. | Methods for treating disorders associated with angiogenesis and neovascularization |
EP3687555A4 (en) * | 2017-09-27 | 2021-07-21 | Ohio State Innovation Foundation | TISSUE FACTOR TISSUE CAR-NK AND CAR-T-CELL THERAPY |
KR102428619B1 (ko) | 2019-09-25 | 2022-08-04 | 대구가톨릭대학교산학협력단 | 망막병증 치료용 약물 방출 콘택트렌즈 및 이의 제조방법 |
EP4041312A4 (en) | 2019-10-10 | 2023-12-20 | Kodiak Sciences Inc. | METHOD FOR TREATING AN EYE DISORDER |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5833982A (en) * | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
US6924359B1 (en) * | 1999-07-01 | 2005-08-02 | Yale University | Neovascular-targeted immunoconjugates |
AU2003242507A1 (en) * | 2002-07-12 | 2004-02-02 | Novo Nordisk A/S | A tissue factor binding immunoconjugate comprising factor viia |
WO2004064870A2 (en) * | 2003-01-22 | 2004-08-05 | Novo Nordisk A/S | Radiolabelled tissue factor binding agent and the use thereof |
US20080193441A1 (en) * | 2003-11-18 | 2008-08-14 | Iconic Therapeutics, Inc. | Homogeneous Preparations of Chimeric Protein |
US20060052286A1 (en) * | 2004-08-13 | 2006-03-09 | Yale University | Factor VII conjugates for selectively treating neovascularization disorders |
US20070134244A1 (en) * | 2005-10-14 | 2007-06-14 | Alcon, Inc. | Combination treatment for pathologic ocular angiogenesis |
RS56599B1 (sr) * | 2010-06-15 | 2018-02-28 | Genmab As | Konjugati humanog antitela sa lekom protiv tkivnog faktora |
-
2016
- 2016-07-22 JP JP2018503532A patent/JP2018524391A/ja active Pending
- 2016-07-22 US US15/746,545 patent/US20180207292A1/en not_active Abandoned
- 2016-07-22 BR BR112018001275A patent/BR112018001275A2/pt not_active Application Discontinuation
- 2016-07-22 KR KR1020187005162A patent/KR20180034518A/ko unknown
- 2016-07-22 MX MX2018000869A patent/MX2018000869A/es unknown
- 2016-07-22 CN CN201680042066.4A patent/CN108024994A/zh active Pending
- 2016-07-22 CA CA2990837A patent/CA2990837A1/en not_active Abandoned
- 2016-07-22 RU RU2018106348A patent/RU2018106348A/ru not_active Application Discontinuation
- 2016-07-22 WO PCT/US2016/043617 patent/WO2017015582A1/en active Application Filing
- 2016-07-22 EP EP16828623.5A patent/EP3324960A4/en not_active Withdrawn
- 2016-07-22 AU AU2016297178A patent/AU2016297178A1/en not_active Abandoned
-
2020
- 2020-09-14 US US17/020,202 patent/US20210236649A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3324960A4 (en) | 2019-01-23 |
WO2017015582A1 (en) | 2017-01-26 |
CN108024994A (zh) | 2018-05-11 |
KR20180034518A (ko) | 2018-04-04 |
US20210236649A1 (en) | 2021-08-05 |
RU2018106348A (ru) | 2019-08-22 |
US20180207292A1 (en) | 2018-07-26 |
AU2016297178A1 (en) | 2018-01-25 |
JP2018524391A (ja) | 2018-08-30 |
MX2018000869A (es) | 2018-07-06 |
EP3324960A1 (en) | 2018-05-30 |
CA2990837A1 (en) | 2017-01-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |